NPM1 (nucleophosmin 1) - Rat Genome Database

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Gene: NPM1 (nucleophosmin 1) Pan paniscus
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Symbol: NPM1
Name: nucleophosmin 1
RGD ID: 11735948
Description: ENCODES a protein that exhibits ATP binding (ortholog); core promoter sequence-specific DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN cardiac muscle hypertrophy (ortholog); cell volume homeostasis (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH Acute Erythroleukemia (ortholog); acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); FOUND IN cytosol (ortholog); granular component (ortholog); large ribosomal subunit (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nucleophosmin
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24166,524,239 - 166,544,710 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15164,663,846 - 164,684,265 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05166,735,904 - 166,756,321 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15173,490,197 - 173,510,657 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5173,490,197 - 173,510,656 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac muscle hypertrophy  (ISO)
cell volume homeostasis  (ISO)
cellular response to hypoxia  (ISO)
cellular response to testosterone stimulus  (ISO)
cellular response to UV  (ISO)
cellular senescence  (ISO)
centrosome cycle  (ISO)
chromatin remodeling  (IEA)
cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)  (ISO)
DNA repair  (ISO)
liver regeneration  (ISO)
macrophage differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of centrosome duplication  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of mRNA splicing, via spliceosome  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein kinase activity by regulation of protein phosphorylation  (ISO)
nucleocytoplasmic transport  (ISO)
nucleosome assembly  (ISO)
positive regulation of biosynthetic process  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell cycle G2/M phase transition  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of centrosome duplication  (ISO)
positive regulation of DNA metabolic process  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of DNA-directed DNA polymerase activity  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein localization to nucleolus  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of translation  (ISO)
post-transcriptional regulation of gene expression  (ISO)
protein destabilization  (ISO)
protein import into nucleus  (ISO)
protein localization  (ISO)
protein stabilization  (ISO)
regulation of cell cycle  (ISO)
regulation of cell growth  (ISO)
regulation of centriole replication  (ISO)
regulation of centrosome duplication  (IEA,ISO)
regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
regulation of eIF2 alpha phosphorylation by dsRNA  (ISO)
regulation of endodeoxyribonuclease activity  (ISO)
regulation of endoribonuclease activity  (ISO)
regulation of mRNA stability involved in cellular response to UV  (ISO)
regulation of neuron apoptotic process  (ISO)
regulation of protein stability  (ISO)
ribosomal large subunit biogenesis  (IEA,ISO)
ribosomal large subunit export from nucleus  (IEA,ISO)
ribosomal small subunit biogenesis  (IEA,ISO)
ribosomal small subunit export from nucleus  (IEA,ISO)
rRNA transcription  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
NPM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24166,524,239 - 166,544,710 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15164,663,846 - 164,684,265 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05166,735,904 - 166,756,321 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15173,490,197 - 173,510,657 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5173,490,197 - 173,510,656 (+)Ensemblpanpan1.1panPan2
NPM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385171,387,116 - 171,410,900 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5171,387,116 - 171,411,810 (+)EnsemblGRCh38hg38GRCh38
GRCh375170,814,120 - 170,837,904 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365170,747,403 - 170,770,493 (+)NCBINCBI36Build 36hg18NCBI36
Build 345170,747,461 - 170,770,492NCBI
Celera5166,847,258 - 166,870,233 (+)NCBICelera
Cytogenetic Map5q35.1NCBI
HuRef5165,912,826 - 165,935,666 (+)NCBIHuRef
CHM1_15170,247,232 - 170,270,413 (+)NCBICHM1_1
T2T-CHM13v2.05171,927,442 - 171,951,228 (+)NCBIT2T-CHM13v2.0
Npm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391133,102,498 - 33,114,143 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1133,102,287 - 33,113,206 (-)EnsemblGRCm39 Ensembl
GRCm381133,152,498 - 33,164,142 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,152,287 - 33,163,206 (-)EnsemblGRCm38mm10GRCm38
MGSCv371133,052,511 - 33,063,056 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361133,052,511 - 33,063,056 (-)NCBIMGSCv36mm8
Celera1135,564,831 - 35,575,324 (-)NCBICelera
Cytogenetic Map11A4NCBI
cM Map1119.21NCBI
Npm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81018,245,739 - 18,255,913 (-)NCBIGRCr8
mRatBN7.21017,741,512 - 17,751,626 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1017,739,941 - 17,751,645 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1022,489,548 - 22,499,561 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01021,978,148 - 21,988,161 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01017,466,819 - 17,476,835 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01018,080,949 - 18,091,062 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1018,080,950 - 18,090,950 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01017,965,977 - 17,975,978 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41018,051,990 - 18,062,714 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11018,053,038 - 18,063,763 (-)NCBI
Celera1017,382,029 - 17,392,033 (-)NCBICelera
Cytogenetic Map10q12NCBI
Npm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540824,151,070 - 24,218,783 (+)NCBIChiLan1.0ChiLan1.0
NPM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1440,756,464 - 40,770,174 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl440,756,465 - 40,770,175 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha440,705,264 - 40,718,971 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0441,134,159 - 41,147,850 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl441,134,159 - 41,147,893 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1440,949,115 - 40,962,816 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0441,139,397 - 41,153,096 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0441,649,467 - 41,663,173 (-)NCBIUU_Cfam_GSD_1.0
Npm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721394,989,965 - 95,002,964 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366093,712,628 - 3,725,635 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1652,765,298 - 52,781,771 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11652,767,263 - 52,781,862 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21656,963,998 - 56,978,524 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12373,555,020 - 73,575,910 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2373,555,260 - 73,575,925 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660345,065,310 - 5,086,261 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473318,645,269 - 18,655,073 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000061248   ⟹   ENSPPAP00000038345
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5173,490,197 - 173,510,656 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000061250   ⟹   ENSPPAP00000038346
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5173,490,197 - 173,506,486 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000061255   ⟹   ENSPPAP00000038352
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5173,490,498 - 173,510,323 (+)Ensembl
RefSeq Acc Id: XM_003810932   ⟹   XP_003810980
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24166,524,239 - 166,544,710 (+)NCBI
NHGRI_mPanPan15164,663,846 - 164,684,265 (+)NCBI
Mhudiblu_PPA_v05166,736,031 - 166,756,321 (+)NCBI
PanPan1.15173,490,197 - 173,510,657 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003810933   ⟹   XP_003810981
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24166,524,380 - 166,540,548 (+)NCBI
NHGRI_mPanPan15164,663,951 - 164,680,087 (+)NCBI
Mhudiblu_PPA_v05166,735,904 - 166,752,144 (+)NCBI
PanPan1.15173,490,197 - 173,506,486 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055112865   ⟹   XP_054968840
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24166,524,415 - 166,544,710 (+)NCBI
NHGRI_mPanPan15164,663,967 - 164,684,265 (+)NCBI
RefSeq Acc Id: XM_055112866   ⟹   XP_054968841
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24166,524,415 - 166,540,548 (+)NCBI
NHGRI_mPanPan15164,663,977 - 164,680,087 (+)NCBI
RefSeq Acc Id: XM_057302377   ⟹   XP_057158360
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24166,524,451 - 166,544,710 (+)NCBI
NHGRI_mPanPan15164,664,005 - 164,684,265 (+)NCBI
RefSeq Acc Id: XP_003810980   ⟸   XM_003810932
- Peptide Label: isoform X1
- UniProtKB: A0A2R9C8S0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003810981   ⟸   XM_003810933
- Peptide Label: isoform X3
- UniProtKB: A0A2R9C8S7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000038346   ⟸   ENSPPAT00000061250
Ensembl Acc Id: ENSPPAP00000038352   ⟸   ENSPPAT00000061255
Ensembl Acc Id: ENSPPAP00000038345   ⟸   ENSPPAT00000061248
RefSeq Acc Id: XP_054968840   ⟸   XM_055112865
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054968841   ⟸   XM_055112866
- Peptide Label: isoform X4
RefSeq Acc Id: XP_057158360   ⟸   XM_057302377
- Peptide Label: isoform X5
Protein Domains
Nucleophosmin C-terminal   Nucleoplasmin core


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000041884 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000061248.1 UniProtKB/TrEMBL
  ENSPPAT00000061250.1 UniProtKB/TrEMBL
  ENSPPAT00000061255.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.2100 UniProtKB/TrEMBL
  Nucleoplasmin core domain UniProtKB/TrEMBL
InterPro NPM1_C UniProtKB/TrEMBL
  Nucleoplasmin UniProtKB/TrEMBL
  Nucleoplasmin_core_dom UniProtKB/TrEMBL
  Nucleoplasmin_core_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100979661 UniProtKB/TrEMBL
NCBI Gene NPM1 ENTREZGENE
PANTHER NUCLEOPHOSMIN UniProtKB/TrEMBL
  PTHR22747 UniProtKB/TrEMBL
Pfam NPM1-C UniProtKB/TrEMBL
  Nucleoplasmin UniProtKB/TrEMBL
Superfamily-SCOP SSF69203 UniProtKB/TrEMBL
UniProt A0A2R9C8S0 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9C8S7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CJH1_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-07-11 NPM1  nucleophosmin 1    nucleophosmin  Symbol and/or name change 5135510 APPROVED