RB1 (RB transcriptional corepressor 1) - Rat Genome Database

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Gene: RB1 (RB transcriptional corepressor 1) Homo sapiens
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Symbol: RB1
Name: RB transcriptional corepressor 1
RGD ID: 731712
HGNC Page HGNC
Description: Enables several functions, including disordered domain specific binding activity; enzyme binding activity; and importin-alpha family protein binding activity. Involved in several processes, including regulation of chromosome organization; regulation of kinase activity; and sister chromatid segregation. Acts upstream of or within negative regulation of gene expression and positive regulation of transcription regulatory region DNA binding activity. Located in PML body. Part of Rb-E2F complex. Colocalizes with cyclin/CDK positive transcription elongation factor complex. Implicated in nervous system cancer (multiple); osteosarcoma; prostate cancer; small cell carcinoma; and urinary bladder cancer. Biomarker of germ cell cancer (multiple); glioblastoma proneural subtype; in situ carcinoma (multiple); obesity; and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: exon 17 tumor GOS561 substitution mutation causes premature stop; GOS563 exon 17 substitution mutation causes premature stop; OSRC; p105-Rb; p110-RB1; pp110; PPP1R130; pRb; prepro-retinoblastoma-associated protein; RB; retinoblastoma 1; retinoblastoma suspectibility protein; retinoblastoma-associated protein
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1348,303,744 - 48,599,436 (+)EnsemblGRCh38hg38GRCh38
GRCh381348,303,751 - 48,481,890 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371348,877,887 - 49,056,026 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361347,775,884 - 47,954,027 (+)NCBINCBI36hg18NCBI36
Build 341347,775,911 - 47,954,023NCBI
Celera1329,932,627 - 30,110,747 (+)NCBI
Cytogenetic Map13q14.2NCBI
HuRef1329,670,144 - 29,848,118 (+)NCBIHuRef
CHM1_11348,845,597 - 49,023,603 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model