Npm1 (nucleophosmin 1) - Rat Genome Database

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Gene: Npm1 (nucleophosmin 1) Chinchilla lanigera
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Symbol: Npm1
Name: nucleophosmin 1
RGD ID: 8955464
Description: ENCODES a protein that exhibits ATP binding (ortholog); core promoter sequence-specific DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN cardiac muscle hypertrophy (ortholog); cell aging (ortholog); cell volume homeostasis (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH Acute Erythroleukemia (ortholog); acute myeloid leukemia (ortholog); acute promyelocytic leukemia (ortholog); FOUND IN centrosome (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: nucleophosmin; nucleophosmin (nucleolar phosphoprotein B23, numatrin)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540824,151,070 - 24,218,783 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cardiac muscle hypertrophy  (ISO)
cell aging  (ISO)
cell volume homeostasis  (ISO)
cellular response to hypoxia  (ISO)
cellular response to testosterone stimulus  (ISO)
cellular response to UV  (ISO)
centrosome cycle  (ISO)
cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)  (ISO)
DNA repair  (ISO)
liver regeneration  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of centrosome duplication  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of mRNA splicing, via spliceosome  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein kinase activity by regulation of protein phosphorylation  (ISO)
nucleocytoplasmic transport  (ISO)
nucleosome assembly  (ISO)
positive regulation of catalytic activity  (ISO)
positive regulation of cell cycle G2/M phase transition  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cellular biosynthetic process  (ISO)
positive regulation of centrosome duplication  (ISO)
positive regulation of DNA metabolic process  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of DNA-directed DNA polymerase activity  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein localization to nucleolus  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of translation  (ISO)
posttranscriptional regulation of gene expression  (ISO)
protein destabilization  (ISO)
protein localization  (ISO)
protein stabilization  (ISO)
regulation of cell cycle  (ISO)
regulation of cell growth  (ISO)
regulation of centriole replication  (ISO)
regulation of centrosome duplication  (ISO)
regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
regulation of eIF2 alpha phosphorylation by dsRNA  (ISO)
regulation of endodeoxyribonuclease activity  (ISO)
regulation of endoribonuclease activity  (ISO)
regulation of mRNA stability involved in cellular response to UV  (ISO)
regulation of neuron apoptotic process  (ISO)
regulation of protein stability  (ISO)
ribosomal large subunit biogenesis  (ISO)
ribosomal large subunit export from nucleus  (ISO)
ribosomal small subunit biogenesis  (ISO)
ribosomal small subunit export from nucleus  (ISO)
rRNA export from nucleus  (ISO)
rRNA transcription  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References


Genomics

Comparative Map Data
Npm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540824,151,070 - 24,218,783 (+)NCBIChiLan1.0ChiLan1.0
NPM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5171,387,116 - 171,411,810 (+)EnsemblGRCh38hg38GRCh38
GRCh385171,387,116 - 171,410,900 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375170,814,120 - 170,837,904 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365170,747,403 - 170,770,493 (+)NCBINCBI36hg18NCBI36
Build 345170,747,461 - 170,770,492NCBI
Celera5166,847,258 - 166,870,233 (+)NCBI
Cytogenetic Map5q35.1NCBI
HuRef5165,912,826 - 165,935,666 (+)NCBIHuRef
CHM1_15170,247,232 - 170,270,413 (+)NCBICHM1_1
Npm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391133,102,498 - 33,114,143 (-)NCBIGRCm39mm39
GRCm39 Ensembl1133,102,287 - 33,113,206 (-)Ensembl
GRCm381133,152,498 - 33,164,142 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,152,287 - 33,163,206 (-)EnsemblGRCm38mm10GRCm38
MGSCv371133,052,511 - 33,063,056 (-)NCBIGRCm37mm9NCBIm37
MGSCv361133,052,511 - 33,063,056 (-)NCBImm8
Celera1135,564,831 - 35,575,324 (-)NCBICelera
Cytogenetic Map11A4NCBI
Npm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21017,741,512 - 17,751,626 (-)NCBI
Rnor_6.0 Ensembl1018,080,950 - 18,090,950 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01018,080,949 - 18,091,062 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01017,965,977 - 17,975,978 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41018,051,990 - 18,062,714 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11018,053,038 - 18,063,763 (-)NCBI
Celera1017,382,029 - 17,392,033 (-)NCBICelera
Cytogenetic Map10q12NCBI
NPM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15173,490,197 - 173,510,657 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5173,490,197 - 173,510,656 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05166,735,904 - 166,756,321 (+)NCBIMhudiblu_PPA_v0panPan3
NPM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1440,756,464 - 40,770,174 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl440,756,465 - 40,770,175 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha440,705,264 - 40,718,971 (-)NCBI
ROS_Cfam_1.0441,134,159 - 41,147,850 (-)NCBI
UMICH_Zoey_3.1440,949,115 - 40,962,816 (-)NCBI
UNSW_CanFamBas_1.0441,139,397 - 41,153,096 (-)NCBI
UU_Cfam_GSD_1.0441,649,467 - 41,663,173 (-)NCBI
Npm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721394,989,965 - 95,002,964 (-)NCBI
SpeTri2.0NW_0049366093,712,628 - 3,725,635 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1652,765,296 - 52,781,740 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11652,767,263 - 52,781,862 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21656,963,998 - 56,978,524 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NPM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12373,555,020 - 73,575,910 (+)NCBI
ChlSab1.1 Ensembl2373,555,260 - 73,575,925 (+)Ensembl
Vero_WHO_p1.0NW_0236660345,065,310 - 5,086,261 (-)NCBI
Npm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473318,645,269 - 18,655,073 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_013509269   ⟹   XP_013364723
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540824,151,070 - 24,218,783 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013364723 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013364723   ⟸   XM_013509269
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014392 ENTREZGENE
Ensembl Protein ENSCLAP00000021005 ENTREZGENE
Ensembl Transcript ENSCLAT00000021206 ENTREZGENE
NCBI Gene Npm1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-07-11 Npm1  nucleophosmin 1    nucleophosmin  Symbol and/or name change 5135510 APPROVED
2016-08-03 Npm1  nucleophosmin    nucleophosmin (nucleolar phosphoprotein B23, numatrin)  Symbol and/or name change 5135510 APPROVED