ARRB2 (arrestin beta 2) - Rat Genome Database

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Gene: ARRB2 (arrestin beta 2) Pan paniscus
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Symbol: ARRB2
Name: arrestin beta 2
RGD ID: 11940756
Description: ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); alpha-1A adrenergic receptor binding (ortholog); alpha-1B adrenergic receptor binding (ortholog); INVOLVED IN adult walking behavior (ortholog); brain development (ortholog); cell chemotaxis (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; calcium signaling pathway via the calcium-sensing receptor; corticotropin-releasing hormone signaling pathway; ASSOCIATED WITH amphetamine abuse (ortholog); Arteriovenous Fistula (ortholog); Experimental Arthritis (ortholog); FOUND IN basolateral plasma membrane (ortholog); cytoplasm (ortholog); cytoplasmic vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: beta-arrestin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1174,757,048 - 4,767,517 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl174,757,048 - 4,767,517 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0174,766,616 - 4,777,253 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult walking behavior  (ISO)
brain development  (ISO)
cell chemotaxis  (ISO)
desensitization of G protein-coupled receptor signaling pathway by arrestin  (ISO)
detection of temperature stimulus involved in sensory perception of pain  (ISO)
endocytosis  (ISO)
follicle-stimulating hormone signaling pathway  (ISO)
G protein-coupled receptor internalization  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of GTPase activity  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of interleukin-12 production  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of natural killer cell mediated cytotoxicity  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of protein ubiquitination  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO)
negative regulation of smooth muscle cell apoptotic process  (ISO)
negative regulation of toll-like receptor signaling pathway  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
positive regulation of calcium ion transport  (ISO)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of epithelial cell apoptotic process  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of receptor internalization  (ISO)
positive regulation of synaptic transmission, dopaminergic  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (ISO)
protein ubiquitination  (ISO)
receptor internalization  (ISO)
regulation of G protein-coupled receptor signaling pathway  (ISO)
regulation of protein phosphorylation  (ISO)
transcription by RNA polymerase II  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
ARRB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1174,757,048 - 4,767,517 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl174,757,048 - 4,767,517 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0174,766,616 - 4,777,253 (+)NCBIMhudiblu_PPA_v0panPan3
ARRB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl174,710,596 - 4,721,499 (+)EnsemblGRCh38hg38GRCh38
GRCh38174,710,619 - 4,721,500 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37174,613,927 - 4,624,792 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36174,560,538 - 4,571,544 (+)NCBINCBI36hg18NCBI36
Build 34174,560,537 - 4,571,543NCBI
Celera174,629,166 - 4,639,975 (+)NCBI
Cytogenetic Map17p13.2NCBI
HuRef174,502,952 - 4,513,866 (+)NCBIHuRef
CHM1_1174,622,557 - 4,633,518 (+)NCBICHM1_1
Arrb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,323,051 - 70,331,654 (+)NCBIGRCm39mm39
GRCm39 Ensembl1170,323,461 - 70,331,654 (+)Ensembl
GRCm381170,432,485 - 70,440,828 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,432,635 - 70,440,828 (+)EnsemblGRCm38mm10GRCm38
MGSCv371170,246,155 - 70,254,176 (+)NCBIGRCm37mm9NCBIm37
MGSCv361170,248,893 - 70,257,018 (+)NCBImm8
Celera1177,978,619 - 77,986,640 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.99NCBI
Arrb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21055,146,887 - 55,154,854 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl1057,040,267 - 57,048,134 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01057,040,252 - 57,048,045 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01056,797,489 - 56,805,282 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41057,244,071 - 57,284,166 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11057,289,995 - 57,297,789 (+)NCBI
Celera1054,285,120 - 54,301,063 (+)NCBICelera
Cytogenetic Map10q24NCBI
Arrb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546710,110,003 - 10,123,022 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546710,109,985 - 10,118,687 (+)NCBIChiLan1.0ChiLan1.0
ARRB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1531,831,208 - 31,838,875 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl531,829,864 - 31,839,454 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha531,968,270 - 31,977,918 (-)NCBI
ROS_Cfam_1.0531,934,052 - 31,943,706 (-)NCBI
UMICH_Zoey_3.1531,900,361 - 31,910,009 (-)NCBI
UNSW_CanFamBas_1.0531,860,046 - 31,869,691 (-)NCBI
UU_Cfam_GSD_1.0532,036,284 - 32,045,935 (-)NCBI
Arrb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560252,719,545 - 52,727,921 (+)NCBI
SpeTri2.0NW_0049366773,173,054 - 3,181,475 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARRB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,161,776 - 52,170,344 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,161,776 - 52,170,362 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21254,280,938 - 54,286,249 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARRB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1164,191,040 - 4,202,382 (+)NCBI
ChlSab1.1 Ensembl164,191,172 - 4,202,385 (+)Ensembl
Vero_WHO_p1.0NW_02366605917,439,881 - 17,451,765 (-)NCBI
Arrb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247868,568,102 - 8,576,445 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000055718   ⟹   ENSPPAP00000032848
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl174,757,048 - 4,767,517 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000055720   ⟹   ENSPPAP00000032850
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl174,757,048 - 4,767,517 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000055723   ⟹   ENSPPAP00000032853
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl174,757,147 - 4,767,517 (+)Ensembl
RefSeq Acc Id: XM_003810205   ⟹   XP_003810253
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1174,757,048 - 4,767,517 (+)NCBI
Mhudiblu_PPA_v0174,766,624 - 4,777,253 (+)NCBI
Sequence:
RefSeq Acc Id: XM_003810208   ⟹   XP_003810256
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1174,757,048 - 4,767,517 (+)NCBI
Mhudiblu_PPA_v0174,766,623 - 4,777,253 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008962572   ⟹   XP_008960820
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1174,757,048 - 4,767,517 (+)NCBI
Mhudiblu_PPA_v0174,766,616 - 4,777,253 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008962573   ⟹   XP_008960821
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1174,757,048 - 4,766,646 (+)NCBI
Mhudiblu_PPA_v0174,766,620 - 4,776,381 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034941326   ⟹   XP_034797217
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0174,766,623 - 4,777,253 (+)NCBI
RefSeq Acc Id: XM_034941327   ⟹   XP_034797218
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0174,766,621 - 4,777,253 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_003810253   ⟸   XM_003810205
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_003810256   ⟸   XM_003810208
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008960821   ⟸   XM_008962573
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_008960820   ⟸   XM_008962572
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_034797218   ⟸   XM_034941327
- Peptide Label: isoform X3
RefSeq Acc Id: XP_034797217   ⟸   XM_034941326
- Peptide Label: isoform X1
RefSeq Acc Id: ENSPPAP00000032850   ⟸   ENSPPAT00000055720
RefSeq Acc Id: ENSPPAP00000032853   ⟸   ENSPPAT00000055723
RefSeq Acc Id: ENSPPAP00000032848   ⟸   ENSPPAT00000055718


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000039283 Ensembl, ENTREZGENE
Ensembl Protein ENSPPAP00000032848 ENTREZGENE
  ENSPPAP00000032850 ENTREZGENE
NCBI Gene ARRB2 ENTREZGENE