IGFBP3 (insulin like growth factor binding protein 3) - Rat Genome Database

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Gene: IGFBP3 (insulin like growth factor binding protein 3) Pan paniscus
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Symbol: IGFBP3
Name: insulin like growth factor binding protein 3
RGD ID: 11828829
Description: ENCODES a protein that exhibits insulin-like growth factor binding (ortholog); insulin-like growth factor II binding (ortholog); protein tyrosine phosphatase activator activity (ortholog); INVOLVED IN cellular response to estradiol stimulus (ortholog); cellular response to Thyroglobulin triiodothyronine (ortholog); female pregnancy (ortholog); PARTICIPATES IN insulin-like growth factor signaling pathway; ASSOCIATED WITH acoustic neuroma (ortholog); Acute-Phase Reaction (ortholog); Alzheimer's disease (ortholog); FOUND IN extracellular space (ortholog); heterochromatin (ortholog); insulin-like growth factor binary complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: insulin-like growth factor-binding protein 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2650,797,505 - 50,806,866 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1799,122,231 - 99,131,164 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0746,564,234 - 46,573,145 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1746,681,856 - 46,690,240 (-)NCBIpanpan1.1PanPan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
Acute-Phase Reaction  (ISO)
Alzheimer's disease  (ISO)
ankylosing spondylitis  (ISO)
arteriosclerosis  (ISO)
autistic disorder  (ISO)
Barrett's esophagus  (ISO)
beta thalassemia  (ISO)
Brain Hypoxia-Ischemia  (ISO)
breast cancer  (ISO)
Burns  (ISO)
cervix uteri carcinoma in situ  (ISO)
Closed Head Injuries  (ISO)
Colorectal Neoplasms  (ISO)
Congenital Adrenal Hyperplasia due to 21 Hydroxylase Deficiency  (ISO)
congenital diaphragmatic hernia  (ISO)
congenital disorder of glycosylation Ia  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
cystic fibrosis  (ISO)
Down syndrome  (ISO)
Dwarfism  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
Endotoxemia  (ISO)
epidermolysis bullosa dystrophica  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fetal Growth Retardation  (ISO)
Fetal Macrosomia  (ISO)
genetic disease  (ISO)
high grade glioma  (ISO)
ichthyosis  (ISO)
impotence  (ISO)
inflammatory bowel disease  (ISO)
Insulin Resistance  (ISO)
Malocclusion  (ISO)
McCune Albright syndrome  (ISO)
Metabolic Bone Diseases  (ISO)
myeloid leukemia  (ISO)
Myocardial Ischemia  (ISO)
obesity  (ISO)
ornithine carbamoyltransferase deficiency  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
Ovarian Neoplasms  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
primary progressive multiple sclerosis  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary fibrosis  (ISO)
renal cell carcinoma  (ISO)
retinopathy of prematurity  (ISO)
rheumatoid arthritis  (ISO)
Spinal Fractures  (ISO)
Spontaneous Abortions  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
systemic scleroderma  (ISO)
tonsillitis  (ISO)
transitional cell carcinoma  (ISO)
Turner syndrome  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
IGFBP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2650,797,505 - 50,806,866 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1799,122,231 - 99,131,164 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0746,564,234 - 46,573,145 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1746,681,856 - 46,690,240 (-)NCBIpanpan1.1PanPan1.1panPan2
IGFBP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38745,912,245 - 45,921,272 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl745,912,245 - 45,921,874 (-)EnsemblGRCh38hg38GRCh38
GRCh37745,951,844 - 45,960,871 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36745,918,369 - 45,927,396 (-)NCBINCBI36Build 36hg18NCBI36
Build 34745,725,189 - 45,734,057NCBI
Celera746,050,761 - 46,059,785 (-)NCBICelera
Cytogenetic Map7p12.3NCBI
HuRef745,836,799 - 45,845,824 (-)NCBIHuRef
CHM1_1745,956,047 - 45,965,072 (-)NCBICHM1_1
T2T-CHM13v2.0746,073,961 - 46,082,986 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2745,991,173 - 46,000,198 (-)NCBI
Igfbp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39117,156,086 - 7,165,498 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl117,156,086 - 7,163,923 (-)EnsemblGRCm39 Ensembl
GRCm38117,206,086 - 7,215,498 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl117,206,086 - 7,213,923 (-)EnsemblGRCm38mm10GRCm38
MGSCv37117,106,089 - 7,113,926 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36117,108,384 - 7,113,834 (-)NCBIMGSCv36mm8
Celera117,681,286 - 7,689,161 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map114.75NCBI
Igfbp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81486,270,208 - 86,277,944 (-)NCBIGRCr8
mRatBN7.21482,056,347 - 82,064,083 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1482,056,347 - 82,064,083 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1486,457,400 - 86,465,160 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01487,697,249 - 87,705,011 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01484,145,931 - 84,153,669 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01487,457,647 - 87,465,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1487,457,647 - 87,465,374 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01481,091,987 - 81,099,675 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41487,959,153 - 87,967,085 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11487,978,297 - 87,986,223 (-)NCBI
Celera1481,130,767 - 81,138,473 (-)NCBICelera
RH 3.4 Map14598.5RGD
Cytogenetic Map14q21NCBI
Igfbp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554566,795,604 - 6,800,845 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554566,795,560 - 6,802,147 (+)NCBIChiLan1.0ChiLan1.0
IGFBP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1161,021,855 - 1,027,604 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl161,021,972 - 1,026,392 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha161,797,939 - 1,804,689 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0161,008,571 - 1,015,327 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl161,008,253 - 1,015,330 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.116999,220 - 1,005,969 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.016934,846 - 941,592 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.016233,123 - 239,875 (-)NCBIUU_Cfam_GSD_1.0
Igfbp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118101,299,235 - 101,306,540 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647820,510,137 - 20,518,306 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647820,511,490 - 20,518,251 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGFBP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1850,003,022 - 50,010,690 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11850,002,921 - 50,009,425 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21854,851,168 - 54,855,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap18q24NCBI
IGFBP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12112,905,309 - 12,914,199 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2112,905,280 - 12,914,205 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660629,622,694 - 9,631,602 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igfbp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247406,877,348 - 6,886,512 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247406,878,818 - 6,886,512 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008975545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_008975545   ⟹   XP_008973793
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2650,797,505 - 50,806,866 (-)NCBI
NHGRI_mPanPan1799,122,231 - 99,131,164 (-)NCBI
Mhudiblu_PPA_v0746,564,234 - 46,573,145 (-)NCBI
PanPan1.1746,681,856 - 46,690,240 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008973793 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000017051.1
RefSeq Acc Id: XP_008973793   ⟸   XM_008975545
- Sequence:
Protein Domains
Thyroglobulin type-1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000031608 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000039750.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.800.10 UniProtKB/TrEMBL
InterPro Thyroglobulin_1 UniProtKB/TrEMBL
  Thyroglobulin_1_sf UniProtKB/TrEMBL
NCBI Gene IGFBP3 ENTREZGENE
PANTHER INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN UniProtKB/TrEMBL
  PTHR11551:SF3 UniProtKB/TrEMBL
Pfam Thyroglobulin_1 UniProtKB/TrEMBL
PROSITE THYROGLOBULIN_1_1 UniProtKB/TrEMBL
  THYROGLOBULIN_1_2 UniProtKB/TrEMBL
SMART SM00211 UniProtKB/TrEMBL
Superfamily-SCOP SSF57610 UniProtKB/TrEMBL
UniProt A0A2R9AI67_PANPA UniProtKB/TrEMBL