FURIN (furin, paired basic amino acid cleaving enzyme) - Rat Genome Database

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Gene: FURIN (furin, paired basic amino acid cleaving enzyme) Pan paniscus
Analyze
Symbol: FURIN
Name: furin, paired basic amino acid cleaving enzyme
RGD ID: 11852929
Description: ENCODES a protein that exhibits serine-type endopeptidase activity (ortholog); INVOLVED IN aging (ortholog); negative regulation of nerve growth factor production (ortholog); positive regulation of cell migration (ortholog); PARTICIPATES IN glypican signaling pathway; hypoxia inducible factor pathway; Notch signaling pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); arteriosclerosis (ortholog); Bloom syndrome (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); extracellular space (ortholog); Golgi cisterna (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11588,759,729 - 88,774,023 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1588,763,269 - 88,774,023 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01569,560,774 - 69,576,007 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
FURIN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11588,759,729 - 88,774,023 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1588,763,269 - 88,774,023 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01569,560,774 - 69,576,007 (+)NCBIMhudiblu_PPA_v0panPan3
FURIN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1590,868,588 - 90,883,564 (+)EnsemblGRCh38hg38GRCh38
GRCh381590,868,588 - 90,883,457 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371591,411,818 - 91,426,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361589,212,889 - 89,227,691 (+)NCBINCBI36hg18NCBI36
Build 341589,212,888 - 89,227,691NCBI
Celera1567,820,515 - 67,835,658 (+)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1567,523,022 - 67,538,192 (+)NCBIHuRef
CHM1_11591,253,454 - 91,268,261 (+)NCBICHM1_1
Furin
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39780,038,942 - 80,055,188 (-)NCBIGRCm39mm39
GRCm39 Ensembl780,038,333 - 80,055,184 (-)Ensembl
GRCm38780,389,194 - 80,405,441 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,388,585 - 80,405,436 (-)EnsemblGRCm38mm10GRCm38
MGSCv37787,534,080 - 87,550,317 (-)NCBIGRCm37mm9NCBIm37
MGSCv36780,262,709 - 80,276,275 (-)NCBImm8
Celera777,789,167 - 77,805,351 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.65NCBI
Furin
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21134,348,142 - 134,361,182 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1134,348,144 - 134,364,314 (-)Ensembl
Rnor_6.01142,185,092 - 142,198,167 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,185,094 - 142,197,182 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01143,137,721 - 143,153,628 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,209,969 - 136,222,057 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11136,288,374 - 136,300,463NCBI
Celera1126,407,744 - 126,419,832 (-)NCBICelera
RH 3.4 Map11074.0RGD
Cytogenetic Map1q31NCBI
Furin
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541614,936,546 - 14,949,252 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541614,915,031 - 14,947,634 (+)NCBIChiLan1.0ChiLan1.0
FURIN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,357,491 - 53,368,285 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,358,045 - 53,365,423 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha355,995,115 - 56,006,746 (-)NCBI
ROS_Cfam_1.0353,773,528 - 53,785,153 (-)NCBI
ROS_Cfam_1.0 Ensembl353,773,530 - 53,785,145 (-)Ensembl
UMICH_Zoey_3.1353,292,643 - 53,304,269 (-)NCBI
UNSW_CanFamBas_1.0353,503,862 - 53,515,505 (-)NCBI
UU_Cfam_GSD_1.0353,844,352 - 53,855,974 (-)NCBI
Furin
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,182,463 - 130,198,421 (+)NCBI
SpeTri2.0NW_00493648316,136,099 - 16,147,945 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FURIN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl753,460,017 - 53,472,790 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1753,455,634 - 53,472,791 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2758,486,815 - 58,503,979 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FURIN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,980,367 - 8,992,257 (-)NCBIChlSab1.1chlSab2
ChlSab1.1298,980,367 - 8,992,257 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl298,979,720 - 8,988,235 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605937,732,423 - 37,745,148 (+)NCBIVero_WHO_p1.0
Furin
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476817,372,754 - 17,387,732 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000045291   ⟹   ENSPPAP00000022481
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1588,763,269 - 88,774,023 (+)Ensembl
RefSeq Acc Id: XM_003807719   ⟹   XP_003807767
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11588,759,729 - 88,774,023 (+)NCBI
Mhudiblu_PPA_v01569,560,774 - 69,576,007 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034939430   ⟹   XP_034795321
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01569,564,008 - 69,576,007 (+)NCBI
RefSeq Acc Id: XM_034939431   ⟹   XP_034795322
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01569,564,634 - 69,576,007 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003807767 (Get FASTA)   NCBI Sequence Viewer  
  XP_034795321 (Get FASTA)   NCBI Sequence Viewer  
  XP_034795322 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003807767   ⟸   XM_003807719
- Sequence:
RefSeq Acc Id: XP_034795321   ⟸   XM_034939430
RefSeq Acc Id: XP_034795322   ⟸   XM_034939431
RefSeq Acc Id: ENSPPAP00000022481   ⟸   ENSPPAT00000045291
Protein Domains
P/Homo B


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034430 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000022481 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000045291 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.850 UniProtKB/TrEMBL
  3.40.50.200 UniProtKB/TrEMBL
InterPro Furin_repeat UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Kexin/furin UniProtKB/TrEMBL
  P_dom UniProtKB/TrEMBL
  Peptidase_S8/S53_dom UniProtKB/TrEMBL
  Peptidase_S8/S53_dom_sf UniProtKB/TrEMBL
  Peptidase_S8_Asp-AS UniProtKB/TrEMBL
  Peptidase_S8_His-AS UniProtKB/TrEMBL
  Peptidase_S8_Ser-AS UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-rel UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/TrEMBL
  S8_pro-domain_sf UniProtKB/TrEMBL
KEGG Report pps:100978848 UniProtKB/TrEMBL
NCBI Gene FURIN ENTREZGENE
Pfam P_proprotein UniProtKB/TrEMBL
  Peptidase_S8 UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/TrEMBL
PRINTS SUBTILISIN UniProtKB/TrEMBL
PROSITE P_HOMO_B UniProtKB/TrEMBL
  SUBTILASE_ASP UniProtKB/TrEMBL
  SUBTILASE_HIS UniProtKB/TrEMBL
  SUBTILASE_SER UniProtKB/TrEMBL
SMART SM00261 UniProtKB/TrEMBL
Superfamily-SCOP SSF49785 UniProtKB/TrEMBL
  SSF52743 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A2R9B4W5_PANPA UniProtKB/TrEMBL