FURIN (furin, paired basic amino acid cleaving enzyme) - Rat Genome Database

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Gene: FURIN (furin, paired basic amino acid cleaving enzyme) Pan paniscus
Analyze
Symbol: FURIN
Name: furin, paired basic amino acid cleaving enzyme
RGD ID: 11852929
Description: ENCODES a protein that exhibits serine-type endopeptidase activity (ortholog); INVOLVED IN cholesterol homeostasis (ortholog); negative regulation of nerve growth factor production (ortholog); positive regulation of cell migration (ortholog); PARTICIPATES IN glypican signaling pathway; hypoxia inducible factor pathway; Notch signaling pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); arteriosclerosis (ortholog); Breast Cancer, Familial (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); extracellular region (ortholog); Golgi cisterna (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21680,423,872 - 80,436,846 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11584,121,785 - 84,134,845 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01569,560,774 - 69,576,007 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11588,759,729 - 88,774,023 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1588,763,269 - 88,774,023 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FURIN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21680,423,872 - 80,436,846 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11584,121,785 - 84,134,845 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01569,560,774 - 69,576,007 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11588,759,729 - 88,774,023 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1588,763,269 - 88,774,023 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
FURIN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381590,868,588 - 90,883,457 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1590,868,588 - 90,883,564 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh371591,411,818 - 91,426,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361589,212,889 - 89,227,691 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341589,212,888 - 89,227,691NCBI
Celera1567,820,515 - 67,835,658 (+)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1567,523,022 - 67,538,192 (+)NCBIHuRef
CHM1_11591,253,454 - 91,268,261 (+)NCBICHM1_1
T2T-CHM13v2.01588,627,830 - 88,643,054 (+)NCBIT2T-CHM13v2.0
Furin
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39780,038,942 - 80,055,188 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl780,038,333 - 80,055,184 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38780,389,194 - 80,405,441 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,388,585 - 80,405,436 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv37787,534,080 - 87,550,317 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36780,262,709 - 80,276,275 (-)NCBIMGSCv36mm8
Celera777,789,167 - 77,805,351 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.65NCBI
Furin
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81143,757,389 - 143,770,430 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1143,757,391 - 143,773,497 (-)EnsemblGRCr8
mRatBN7.21134,348,142 - 134,361,182 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,348,144 - 134,364,314 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1142,257,013 - 142,269,107 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,426,407 - 149,438,502 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,344,416 - 142,356,506 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1142,752,103 - 142,764,192 (-)NCBI
Lyon_Normotensive1147,689,713 - 147,701,811 (-)NCBI
Lyon_Hypertensive1144,349,573 - 144,361,667 (-)NCBI
F344_StmMcwi1142,888,101 - 142,900,197 (-)NCBI
Rnor_6.01142,185,092 - 142,198,167 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,185,094 - 142,197,182 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01143,137,721 - 143,153,628 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41136,209,969 - 136,222,057 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1126,407,744 - 126,419,832 (-)NCBICelera
RGSC_v3.11136,288,374 - 136,300,463NCBI
RH 3.4 Map11074.0RGD
Cytogenetic Map1q31NCBI
Furin
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541614,936,546 - 14,949,252 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495541614,915,031 - 14,947,634 (+)NCBIChiLan1.0ChiLan1.0
FURIN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,357,491 - 53,368,285 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,358,045 - 53,365,423 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha355,995,115 - 56,006,746 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0353,773,528 - 53,785,153 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,773,530 - 53,785,145 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,292,643 - 53,304,269 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,503,862 - 53,515,505 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0353,844,352 - 53,855,974 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Furin
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap15135,594,577 - 135,602,299 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_024408640130,182,463 - 130,198,421 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648316,136,099 - 16,144,635 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648316,136,099 - 16,147,945 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FURIN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl753,460,017 - 53,472,787 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1753,455,634 - 53,472,791 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2758,486,815 - 58,503,979 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FURIN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap12915,921,988 - 15,934,649 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366605937,732,423 - 37,745,148 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.1298,980,367 - 8,992,257 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl298,979,720 - 8,988,235 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Furin
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476817,372,754 - 17,387,732 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_00462476817,371,628 - 17,387,881 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl1537,895,895 - 37,910,418 (+)Ensembl
Furin
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12119,842,424 - 119,855,895 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000045291   ⟹   ENSPPAP00000022481
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1588,763,269 - 88,774,023 (+)Ensembl
RefSeq Acc Id: XM_034939430   ⟹   XP_034795321
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21680,424,828 - 80,436,846 (+)NCBI
NHGRI_mPanPan11584,122,847 - 84,134,845 (+)NCBI
Mhudiblu_PPA_v01569,564,008 - 69,576,007 (+)NCBI
RefSeq Acc Id: XM_034939431   ⟹   XP_034795322
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21680,425,293 - 80,436,846 (+)NCBI
NHGRI_mPanPan11584,123,297 - 84,134,845 (+)NCBI
Mhudiblu_PPA_v01569,564,634 - 69,576,007 (+)NCBI
RefSeq Acc Id: XM_057299866   ⟹   XP_057155849
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21680,423,872 - 80,436,846 (+)NCBI
NHGRI_mPanPan11584,121,785 - 84,134,845 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034795321 (Get FASTA)   NCBI Sequence Viewer  
  XP_034795322 (Get FASTA)   NCBI Sequence Viewer  
  XP_057155849 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000022481.1
  ENSPPAP00050028840
RefSeq Acc Id: XP_034795321   ⟸   XM_034939430
- UniProtKB: A0A2R9B4W5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034795322   ⟸   XM_034939431
- UniProtKB: A0A2R9B4W5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000022481   ⟸   ENSPPAT00000045291
RefSeq Acc Id: XP_057155849   ⟸   XM_057299866
- UniProtKB: A0A2R9B4W5 (UniProtKB/TrEMBL)
Protein Domains
P/Homo B


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034430 Ensembl, UniProtKB/TrEMBL
  ENSPPAG00050021405 ENTREZGENE
Ensembl Transcript ENSPPAT00000045291.1 UniProtKB/TrEMBL
  ENSPPAT00050045141 ENTREZGENE
Gene3D-CATH 3.30.70.850 UniProtKB/TrEMBL
  3.40.50.200 UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
  Hormone Receptor, Insulin-like Growth Factor Receptor 1, Chain A, domain 2 UniProtKB/TrEMBL
InterPro Furin_repeat UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Kexin/furin UniProtKB/TrEMBL
  P_dom UniProtKB/TrEMBL
  Peptidase_S8/S53_dom UniProtKB/TrEMBL
  Peptidase_S8/S53_dom_sf UniProtKB/TrEMBL
  Peptidase_S8_Asp-AS UniProtKB/TrEMBL
  Peptidase_S8_His-AS UniProtKB/TrEMBL
  Peptidase_S8_Ser-AS UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-rel UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/TrEMBL
  S8_pro-domain_sf UniProtKB/TrEMBL
KEGG Report pps:100978848 UniProtKB/TrEMBL
NCBI Gene FURIN ENTREZGENE
PANTHER FURIN UniProtKB/TrEMBL
  PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED UniProtKB/TrEMBL
Pfam P_proprotein UniProtKB/TrEMBL
  Peptidase_S8 UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/TrEMBL
PRINTS SUBTILISIN UniProtKB/TrEMBL
PROSITE P_HOMO_B UniProtKB/TrEMBL
  SUBTILASE UniProtKB/TrEMBL
  SUBTILASE_ASP UniProtKB/TrEMBL
  SUBTILASE_HIS UniProtKB/TrEMBL
  SUBTILASE_SER UniProtKB/TrEMBL
SMART SM00261 UniProtKB/TrEMBL
Superfamily-SCOP Protease propeptides/inhibitors UniProtKB/TrEMBL
  SSF49785 UniProtKB/TrEMBL
  SSF52743 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A2R9B4W5 ENTREZGENE, UniProtKB/TrEMBL