Furin (furin (paired basic amino acid cleaving enzyme)) - Rat Genome Database

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Gene: Furin (furin (paired basic amino acid cleaving enzyme)) Rattus norvegicus
Analyze
Symbol: Furin
Name: furin (paired basic amino acid cleaving enzyme)
RGD ID: 3274
Description: Enables serine-type endopeptidase activity. Involved in positive regulation of cell migration; positive regulation of transforming growth factor beta receptor signaling pathway; and protein processing. Located in Golgi cisterna and endoplasmic reticulum membrane. Orthologous to human FURIN (furin, paired basic amino acid cleaving enzyme); PARTICIPATES IN glypican signaling pathway; hypoxia inducible factor pathway; Notch signaling pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dibasic-processing enzyme; LOC360309; Pace; Paired basic amino acid cleaving enzyme (furin); paired basic amino acid residue cleaving enzyme; paired basic amino acid residue-cleaving enzyme; Pcsk3; prohormone convertase 3; Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme furin membrane associated receptor protein); Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein); proprotein convertase subtilisin/kexin type3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21134,348,142 - 134,361,182 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,348,144 - 134,364,314 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,257,013 - 142,269,107 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,426,407 - 149,438,502 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,344,416 - 142,356,506 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01142,185,092 - 142,198,167 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,185,094 - 142,197,182 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01143,137,721 - 143,153,628 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,209,969 - 136,222,057 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11136,288,374 - 136,300,463NCBI
Celera1126,407,744 - 126,419,832 (-)NCBICelera
RH 3.4 Map11074.0RGD
Cytogenetic Map1q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
apomorphine  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
batimastat  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGS 15943  (ISO)
chlorpyrifos  (ISO)
chromium atom  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
ethanol  (ISO)
fenthion  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
kenpaullone  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methidathion  (ISO)
methimazole  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (ISO)
nickel dichloride  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
PhIP  (EXP)
potassium dichromate  (ISO)
rac-lactic acid  (ISO)
Rutecarpine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression and localization of MT1-MMP and furin in the glomerular wall of short- and long-term diabetic rats. Boucher E, etal., Kidney Int. 2006 May;69(9):1570-7.
2. Furin proteolytically processes the heparin-binding region of extracellular superoxide dismutase. Bowler RP, etal., J Biol Chem 2002 May 10;277(19):16505-11.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
6. Gene-gene interactions among genetic variants from obesity candidate genes for nonobese and obese populations in type 2 diabetes. Lin E, etal., Genet Test Mol Biomarkers. 2009 Aug;13(4):485-93.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Sequence of the cDNA encoding rat furin, a possible propeptide-processing endoprotease. Misumi Y, etal., Nucleic Acids Res 1990 Nov 25;18(22):6719.
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase. Stawowy P, etal., Cardiovasc Res. 2004 Jul 1;63(1):87-97.
15. Immunohistochemical localization of subtilisin/kexin-like proprotein convertases in human atherosclerosis. Stawowy P, etal., Virchows Arch. 2005 Apr;446(4):351-9. Epub 2005 Mar 9.
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:7737999   PMID:8262946   PMID:8615794   PMID:8940009   PMID:9130696   PMID:9242664   PMID:9695949   PMID:10526337   PMID:10567353   PMID:11799113   PMID:12447384   PMID:12665557  
PMID:14744861   PMID:15078902   PMID:15082773   PMID:15146101   PMID:15358140   PMID:15606899   PMID:15899807   PMID:16239403   PMID:16537537   PMID:16912035   PMID:17010968   PMID:17936261  
PMID:17938254   PMID:19199708   PMID:19946888   PMID:20076849   PMID:20375258   PMID:20489134   PMID:20530870   PMID:21147780   PMID:21763278   PMID:23418414   PMID:23686857   PMID:23918928  
PMID:26416966   PMID:31336100   PMID:36063111  


Genomics

Comparative Map Data
Furin
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21134,348,142 - 134,361,182 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,348,144 - 134,364,314 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,257,013 - 142,269,107 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,426,407 - 149,438,502 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,344,416 - 142,356,506 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01142,185,092 - 142,198,167 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,185,094 - 142,197,182 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01143,137,721 - 143,153,628 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,209,969 - 136,222,057 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11136,288,374 - 136,300,463NCBI
Celera1126,407,744 - 126,419,832 (-)NCBICelera
RH 3.4 Map11074.0RGD
Cytogenetic Map1q31NCBI
FURIN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381590,868,588 - 90,883,457 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1590,868,588 - 90,883,564 (+)EnsemblGRCh38hg38GRCh38
GRCh371591,411,818 - 91,426,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361589,212,889 - 89,227,691 (+)NCBINCBI36Build 36hg18NCBI36
Build 341589,212,888 - 89,227,691NCBI
Celera1567,820,515 - 67,835,658 (+)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1567,523,022 - 67,538,192 (+)NCBIHuRef
CHM1_11591,253,454 - 91,268,261 (+)NCBICHM1_1
T2T-CHM13v2.01588,627,830 - 88,643,054 (+)NCBIT2T-CHM13v2.0
Furin
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39780,038,942 - 80,055,188 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl780,038,333 - 80,055,184 (-)EnsemblGRCm39 Ensembl
GRCm38780,389,194 - 80,405,441 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,388,585 - 80,405,436 (-)EnsemblGRCm38mm10GRCm38
MGSCv37787,534,080 - 87,550,317 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36780,262,709 - 80,276,275 (-)NCBIMGSCv36mm8
Celera777,789,167 - 77,805,351 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.65NCBI
Furin
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541614,936,546 - 14,949,252 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541614,915,031 - 14,947,634 (+)NCBIChiLan1.0ChiLan1.0
FURIN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11584,121,785 - 84,134,845 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01569,560,774 - 69,576,007 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11588,759,729 - 88,774,023 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1588,763,269 - 88,774,023 (+)Ensemblpanpan1.1panPan2
FURIN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,357,491 - 53,368,285 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,358,045 - 53,365,423 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha355,995,115 - 56,006,746 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0353,773,528 - 53,785,153 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl353,773,530 - 53,785,145 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,292,643 - 53,304,269 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,503,862 - 53,515,505 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0353,844,352 - 53,855,974 (-)NCBIUU_Cfam_GSD_1.0
Furin
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,182,463 - 130,198,421 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648316,136,099 - 16,144,635 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648316,136,099 - 16,147,945 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FURIN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl753,460,017 - 53,472,787 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1753,455,634 - 53,472,791 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2758,486,815 - 58,503,979 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FURIN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,980,367 - 8,992,257 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl298,979,720 - 8,988,235 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605937,732,423 - 37,745,148 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Furin
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476817,371,628 - 17,387,881 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476817,372,754 - 17,387,732 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Furin
30 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:471
Count of miRNA genes:249
Interacting mature miRNAs:306
Transcripts:ENSRNOT00000015521
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192184926137184926Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123479780142990467Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat

Markers in Region
D1Smu12  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,357,949 - 134,358,075 (+)MAPPERmRatBN7.2
Rnor_6.01142,194,900 - 142,195,025NCBIRnor6.0
Rnor_5.01143,147,913 - 143,148,038UniSTSRnor5.0
Celera1126,417,550 - 126,417,675UniSTS
Cytogenetic Map1q31UniSTS
D1Bda27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,348,264 - 134,348,555 (+)MAPPERmRatBN7.2
Rnor_6.01142,185,215 - 142,185,505NCBIRnor6.0
Rnor_5.01143,137,844 - 143,138,134UniSTSRnor5.0
RGSC_v3.41136,210,090 - 136,210,380UniSTSRGSC3.4
Celera1126,407,865 - 126,408,155UniSTS
Cytogenetic Map1q31UniSTS
PMC156147P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,355,760 - 134,356,479 (+)MAPPERmRatBN7.2
Rnor_6.01142,192,711 - 142,193,429NCBIRnor6.0
Rnor_5.01143,145,340 - 143,146,442UniSTSRnor5.0
Rnor_5.01143,145,340 - 143,146,058UniSTSRnor5.0
RGSC_v3.41136,217,586 - 136,218,304UniSTSRGSC3.4
Celera1126,415,361 - 126,416,079UniSTS
Cytogenetic Map1q31UniSTS
RH94589  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,348,147 - 134,348,343 (+)MAPPERmRatBN7.2
Rnor_6.01142,185,098 - 142,185,293NCBIRnor6.0
Rnor_5.01143,137,727 - 143,137,922UniSTSRnor5.0
RGSC_v3.41136,209,973 - 136,210,168UniSTSRGSC3.4
Celera1126,407,748 - 126,407,943UniSTS
RH 3.4 Map11074.0UniSTS
Cytogenetic Map1q31UniSTS
Pcsk3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,355,488 - 134,356,700 (+)MAPPERmRatBN7.2
Rnor_6.01142,192,439 - 142,193,650NCBIRnor6.0
Rnor_5.01143,145,068 - 143,146,663UniSTSRnor5.0
RGSC_v3.41136,217,314 - 136,218,525UniSTSRGSC3.4
Celera1126,415,089 - 126,416,300UniSTS
Cytogenetic Map1q31UniSTS
FURIN  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,357,114 - 134,357,271 (+)MAPPERmRatBN7.2
Rnor_6.01142,194,065 - 142,194,221NCBIRnor6.0
Rnor_5.01143,147,078 - 143,147,234UniSTSRnor5.0
RGSC_v3.41136,218,940 - 136,219,096UniSTSRGSC3.4
Celera1126,416,715 - 126,416,871UniSTS
Cytogenetic Map1q31UniSTS
FURIN  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,354,199 - 134,354,764 (+)MAPPERmRatBN7.2
Rnor_6.01142,191,150 - 142,191,714NCBIRnor6.0
Rnor_5.01143,143,779 - 143,144,343UniSTSRnor5.0
RGSC_v3.41136,216,025 - 136,216,589UniSTSRGSC3.4
Celera1126,413,800 - 126,414,364UniSTS
Cytogenetic Map1q31UniSTS
Furin  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21134,350,129 - 134,351,453 (+)MAPPERmRatBN7.2
Rnor_6.01142,187,080 - 142,188,403NCBIRnor6.0
Rnor_5.01143,139,709 - 143,141,032UniSTSRnor5.0
Celera1126,409,730 - 126,411,053UniSTS
Cytogenetic Map1q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 6 9 68 35 36 11 6
Low 2 2 6 5 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015521   ⟹   ENSRNOP00000015521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1134,348,144 - 134,360,188 (-)Ensembl
Rnor_6.0 Ensembl1142,185,094 - 142,197,182 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102738   ⟹   ENSRNOP00000088681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1134,348,144 - 134,364,314 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116325   ⟹   ENSRNOP00000088247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1134,348,144 - 134,361,046 (-)Ensembl
RefSeq Acc Id: NM_019331   ⟹   NP_062204
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21134,348,144 - 134,360,232 (-)NCBI
Rnor_6.01142,185,094 - 142,197,182 (-)NCBI
Rnor_5.01143,137,721 - 143,153,628 (-)NCBI
RGSC_v3.41136,209,969 - 136,222,057 (-)RGD
Celera1126,407,744 - 126,419,832 (-)RGD
Sequence:
RefSeq Acc Id: XM_008759555   ⟹   XP_008757777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21134,348,142 - 134,361,182 (-)NCBI
Rnor_6.01142,185,092 - 142,198,167 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_062204   ⟸   NM_019331
- Peptide Label: precursor
- UniProtKB: P23377 (UniProtKB/Swiss-Prot),   G3V7I9 (UniProtKB/TrEMBL),   A6JCC0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757777   ⟸   XM_008759555
- Peptide Label: isoform X1
- UniProtKB: P23377 (UniProtKB/Swiss-Prot),   G3V7I9 (UniProtKB/TrEMBL),   A6JCC0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015521   ⟸   ENSRNOT00000015521
RefSeq Acc Id: ENSRNOP00000088247   ⟸   ENSRNOT00000116325
RefSeq Acc Id: ENSRNOP00000088681   ⟸   ENSRNOT00000102738
Protein Domains
P/Homo B   Peptidase S8

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23377-F1-model_v2 AlphaFold P23377 1-793 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690149
Promoter ID:EPDNEW_R671
Type:multiple initiation site
Name:Furin_1
Description:furin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01142,197,256 - 142,197,316EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3274 AgrOrtholog
BioCyc Gene G2FUF-58730 BioCyc
Ensembl Genes ENSRNOG00000011352 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000015521 ENTREZGENE
  ENSRNOT00000015521.3 UniProtKB/TrEMBL
  ENSRNOT00000102738 ENTREZGENE
  ENSRNOT00000102738.1 UniProtKB/TrEMBL
  ENSRNOT00000116325.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.70.850 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Furin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kexin/furin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8/S53_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8/S53_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_Asp-AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_His-AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_Ser-AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S8_pro-domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54281 UniProtKB/Swiss-Prot
NCBI Gene 54281 ENTREZGENE
PANTHER FURIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam P_proprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Furin PhenoGen
PRINTS SUBTILISIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE P_HOMO_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE_ASP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUBTILASE_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011352 RatGTEx
SMART SM00261 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Protease propeptides/inhibitors UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52743 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204992
UniProt A0A8I6A642_RAT UniProtKB/TrEMBL
  A0A8I6A6N7_RAT UniProtKB/TrEMBL
  A6JCC0 ENTREZGENE, UniProtKB/TrEMBL
  FURIN_RAT UniProtKB/Swiss-Prot
  G3V7I9 ENTREZGENE, UniProtKB/TrEMBL
  P23377 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-15 Furin  furin (paired basic amino acid cleaving enzyme)  Pcsk3  proprotein convertase subtilisin/kexin type3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-23 Pcsk3  proprotein convertase subtilisin/kexin type3  Furin_predicted  furin (paired basic amino acid cleaving enzyme) (predicted)  Data merged from RGD:1311616 737654 APPROVED
2005-01-12 Furin_predicted  furin (paired basic amino acid cleaving enzyme) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Pcsk3  Proprotein convertase subtilisin/kexin type 3 (paired basic amino acid cleaving enzyme, furin, membrane associated receptor protein)      Symbol and Name status set to approved 70586 APPROVED