Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Pcsk2 (proprotein convertase subtilisin/kexin type 2) Rattus norvegicus
Analyze
Symbol: Pcsk2
Name: proprotein convertase subtilisin/kexin type 2
Description: Exhibits serine-type endopeptidase activity. Involved in islet amyloid polypeptide processing. Localizes to the dendrite and perikaryon. Colocalizes with the secretory granule. Used to study chronic kidney disease. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: KEX2-like endoprotease 2; NEC 2; neuroendocrine convertase 2; PC2; prohormone convertase 2; proprotein convertase 2
Orthologs:
Homo sapiens (human) : PCSK2 (proprotein convertase subtilisin/kexin type 2)  HGNC  Alliance
Mus musculus (house mouse) : Pcsk2 (proprotein convertase subtilisin/kexin type 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pcsk2 (proprotein convertase subtilisin/kexin type 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PCSK2 (proprotein convertase subtilisin/kexin type 2)
Canis lupus familiaris (dog) : PCSK2 (proprotein convertase subtilisin/kexin type 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pcsk2 (proprotein convertase subtilisin/kexin type 2)
Sus scrofa (pig) : PCSK2 (proprotein convertase subtilisin/kexin type 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03137,618,891 - 137,923,385 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3137,618,898 - 137,925,605 (+)Ensembl
Rnor_5.03144,059,121 - 144,362,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43131,925,648 - 132,256,178 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13131,831,220 - 132,161,751 (+)NCBI
Celera3129,792,699 - 130,080,973 (+)NCBICelera
Cytogenetic Map3q41NCBI
RH 3.4 Map31176.7RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Pcsk2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3273
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.