Pcsk2 (proprotein convertase subtilisin/kexin type 2) - Rat Genome Database

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Gene: Pcsk2 (proprotein convertase subtilisin/kexin type 2) Rattus norvegicus
Analyze
Symbol: Pcsk2
Name: proprotein convertase subtilisin/kexin type 2
RGD ID: 3273
Description: Exhibits serine-type endopeptidase activity. Involved in islet amyloid polypeptide processing. Localizes to dendrite and perikaryon. Colocalizes with secretory granule. Used to study chronic kidney disease. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: KEX2-like endoprotease 2; NEC 2; neuroendocrine convertase 2; PC2; prohormone convertase 2; proprotein convertase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23130,880,422 - 131,183,127 (+)NCBI
Rnor_6.0 Ensembl3137,618,898 - 137,925,605 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03137,618,891 - 137,923,385 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03144,059,121 - 144,362,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43131,925,648 - 132,256,178 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13131,831,220 - 132,161,751 (+)NCBI
Celera3129,792,699 - 130,080,973 (+)NCBICelera
RH 3.4 Map31176.7RGD
Cytogenetic Map3q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
melanocortin system pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References

References - curated
1. Arias AE, etal., J Cell Sci. 2000 Jun;113 ( Pt 11):2075-83.
2. Billova S, etal., Neuroscience. 2007 Jun 29;147(2):403-18. Epub 2007 Jun 1.
3. Bloomquist BT, etal., Mol Endocrinol 1991 Dec;5(12):2014-24.
4. Cain BM, etal., J Comp Neurol 2003 Dec 15;467(3):307-25.
5. Davidson HW, etal., Nature. 1988 May 5;333(6168):93-6. doi: 10.1038/333093a0.
6. Deboer MD, etal., Endocrinology. 2008 Feb;149(2):827-35. Epub 2007 Nov 26.
7. Fujimaki T, etal., Atherosclerosis. 2010 Jun;210(2):468-73. Epub 2009 Dec 5.
8. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. GOA data from the GO Consortium
10. Hakes DJ, etal., Endocrinology 1991 Dec;129(6):3053-63.
11. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. Lansac G, etal., J Neuroimmunol. 2006 Feb;171(1-2):57-71. Epub 2005 Dec 5.
13. Lee SN, etal., J Biol Chem. 2006 Feb 10;281(6):3312-20. Epub 2005 Nov 14.
14. Malide D, etal., J Histochem Cytochem. 1995 Jan;43(1):11-9.
15. MGD data from the GO Consortium
16. Mousa SA, etal., Endocrinology. 2004 Mar;145(3):1331-41. Epub 2003 Nov 20.
17. Nakashima M, etal., Regul Pept. 2001 Dec 15;102(2-3):135-45.
18. NCBI rat LocusLink and RefSeq merged data July 26, 2002
19. Niquet J, etal., Brain Res Dev Brain Res. 2000 Mar 15;120(1):49-56.
20. Paulsson JF and Westermark GT, Diabetes. 2005 Jul;54(7):2117-25.
21. Perello M, etal., Endocrinology. 2006 Jun;147(6):2705-16. Epub 2006 Feb 23.
22. Pipeline to import SMPDB annotations from SMPDB into RGD
23. Pritchard LE, etal., J Endocrinol 2002 Mar;172(3):411-21.
24. RGD automated data pipeline
25. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. RGD automated import pipeline for gene-chemical interactions
27. Rhodes CJ, etal., J Biol Chem. 1992 Nov 15;267(32):22719-27.
28. Sanchez VC, etal., J Clin Invest. 2004 Aug;114(3):357-69.
29. Shen X, etal., Am J Physiol Endocrinol Metab. 2005 Jan;288(1):E236-45.
30. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
31. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
32. Yoshida H, etal., Diabetes. 1995 Apr;44(4):389-93.
33. Zhan S, etal., J Cereb Blood Flow Metab. 2009 Apr;29(4):698-706. Epub 2009 Jan 14.
34. Zheng M, etal., J Neurosci. 1994 Aug;14(8):4656-73.
Additional References at PubMed
PMID:7626024   PMID:8034613   PMID:8262946   PMID:8397508   PMID:9020868   PMID:9242664   PMID:12859669   PMID:16893422   PMID:17531155   PMID:17556096   PMID:19428990   PMID:19628676  
PMID:24625528   PMID:26755731   PMID:28719828  


Genomics

Comparative Map Data
Pcsk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23130,880,422 - 131,183,127 (+)NCBI
Rnor_6.0 Ensembl3137,618,898 - 137,925,605 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03137,618,891 - 137,923,385 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03144,059,121 - 144,362,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43131,925,648 - 132,256,178 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13131,831,220 - 132,161,751 (+)NCBI
Celera3129,792,699 - 130,080,973 (+)NCBICelera
RH 3.4 Map31176.7RGD
Cytogenetic Map3q41NCBI
PCSK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2017,226,107 - 17,484,578 (+)EnsemblGRCh38hg38GRCh38
GRCh382017,226,107 - 17,484,578 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372017,206,752 - 17,465,223 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362017,155,631 - 17,413,223 (+)NCBINCBI36hg18NCBI36
Build 342017,155,630 - 17,413,223NCBI
Celera2017,282,082 - 17,539,671 (+)NCBI
Cytogenetic Map20p12.1NCBI
HuRef2017,169,857 - 17,428,162 (+)NCBIHuRef
CHM1_12017,206,780 - 17,465,251 (+)NCBICHM1_1
Pcsk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392143,388,053 - 143,658,204 (+)NCBIGRCm39mm39
GRCm39 Ensembl2143,388,076 - 143,658,205 (+)Ensembl
GRCm382143,546,133 - 143,816,284 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2143,546,156 - 143,816,285 (+)EnsemblGRCm38mm10GRCm38
MGSCv372143,371,869 - 143,642,020 (+)NCBIGRCm37mm9NCBIm37
MGSCv362143,237,620 - 143,507,725 (+)NCBImm8
Celera2144,735,342 - 144,999,086 (+)NCBICelera
Cytogenetic Map2G1NCBI
cM Map270.89NCBI
Pcsk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541526,266,484 - 26,497,001 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541526,266,513 - 26,496,905 (+)NCBIChiLan1.0ChiLan1.0
PCSK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12017,163,675 - 17,421,157 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2017,163,675 - 17,421,157 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02017,184,878 - 17,443,355 (+)NCBIMhudiblu_PPA_v0panPan3
PCSK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1245,507,997 - 5,765,911 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl245,508,714 - 5,766,153 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha245,440,841 - 5,698,548 (-)NCBI
ROS_Cfam_1.0245,915,819 - 6,173,890 (-)NCBI
UMICH_Zoey_3.1245,528,990 - 5,786,629 (-)NCBI
UNSW_CanFamBas_1.0245,622,926 - 5,880,531 (-)NCBI
UU_Cfam_GSD_1.0245,898,980 - 6,157,570 (-)NCBI
Pcsk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640154,177,620 - 154,434,915 (-)NCBI
SpeTri2.0NW_0049364852,611,313 - 2,866,260 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PCSK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1725,681,102 - 25,923,004 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11725,681,424 - 25,920,690 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21729,095,048 - 29,329,854 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PCSK2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1246,293,983 - 46,548,902 (+)NCBI
ChlSab1.1 Ensembl246,294,005 - 46,549,609 (+)Ensembl
Pcsk2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474118,368,976 - 18,643,151 (+)NCBI

Position Markers
RH94811  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23131,182,804 - 131,182,981 (+)MAPPER
Rnor_6.03137,923,063 - 137,923,239NCBIRnor6.0
Rnor_5.03144,362,439 - 144,362,615UniSTSRnor5.0
RGSC_v3.43132,255,856 - 132,256,032UniSTSRGSC3.4
Celera3130,080,651 - 130,080,827UniSTS
Cytogenetic Map3q42UniSTS
M55669  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23131,182,965 - 131,183,124 (+)MAPPER
Rnor_6.03137,923,224 - 137,923,382NCBIRnor6.0
Rnor_5.03144,362,600 - 144,362,758UniSTSRnor5.0
RGSC_v3.43132,256,017 - 132,256,175UniSTSRGSC3.4
Celera3130,080,812 - 130,080,970UniSTS
Cytogenetic Map3q42UniSTS
RH143576  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21554,877,277 - 54,877,390 (+)MAPPER
mRatBN7.23130,893,725 - 130,893,838 (+)MAPPER
Rnor_6.01561,759,128 - 61,759,240NCBIRnor6.0
Rnor_6.03137,632,193 - 137,632,305NCBIRnor6.0
Rnor_5.01565,423,167 - 65,423,279UniSTSRnor5.0
Rnor_5.03144,072,423 - 144,072,535UniSTSRnor5.0
RGSC_v3.43131,938,950 - 131,939,062UniSTSRGSC3.4
RGSC_v3.41561,530,065 - 61,530,177UniSTSRGSC3.4
Celera1554,458,637 - 54,458,749UniSTS
Celera3129,806,006 - 129,806,118UniSTS
RH 3.4 Map15459.9UniSTS
Cytogenetic Map15q12UniSTS
Cytogenetic Map3q42UniSTS
RH94397  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23131,182,932 - 131,183,092 (+)MAPPER
Rnor_6.03137,923,191 - 137,923,350NCBIRnor6.0
Rnor_5.03144,362,567 - 144,362,726UniSTSRnor5.0
RGSC_v3.43132,255,984 - 132,256,143UniSTSRGSC3.4
Celera3130,080,779 - 130,080,938UniSTS
RH 3.4 Map31176.7UniSTS
Cytogenetic Map3q42UniSTS
BE117645  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23130,894,126 - 130,894,280 (+)MAPPER
Rnor_6.03137,632,594 - 137,632,747NCBIRnor6.0
Rnor_5.03144,072,824 - 144,072,977UniSTSRnor5.0
RGSC_v3.43131,939,351 - 131,939,504UniSTSRGSC3.4
Celera3129,806,407 - 129,806,560UniSTS
RH 3.4 Map31173.8UniSTS
Cytogenetic Map3q42UniSTS
Cytogenetic Map15q12UniSTS
RH136607  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23130,880,462 - 130,880,590 (+)MAPPER
Rnor_6.03137,618,932 - 137,619,059NCBIRnor6.0
Rnor_5.03144,059,162 - 144,059,289UniSTSRnor5.0
RGSC_v3.43131,925,689 - 131,925,816UniSTSRGSC3.4
Celera3129,792,740 - 129,792,867UniSTS
Cytogenetic Map3q42UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)330846101172879276Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)339248391140271184Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)343295930163640485Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)343295930163640485Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)345406058177699992Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)348561928155263151Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)358204463170534769Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)361241033165369047Rat
1581546Pur13Proteinuria QTL 132.930.0335total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)381136227154416635Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)394788365139788365Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)397009185142009185Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)399465522168732722Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3101058963146058963Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3102152812155263151Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3102466149147466149Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)3103141814176418101Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)3103141814176418101Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3103141814176418101Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3103141944170934860Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3114376250159376250Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3117303473141971336Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3119471263164471263Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3120917788141971336Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)3120917788141971336Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3125848628170848628Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3126575595153412619Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3126575595165355668Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3128986468173986468Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3129787213177699992Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3130006659175006659Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3132875075176418101Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3136876155170935007Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:124
Count of miRNA genes:85
Interacting mature miRNAs:92
Transcripts:ENSRNOT00000007249
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 58
Low 3 23 7 17 7 1 1 16 17 22 9 1
Below cutoff 18 9 9 2 9 7 9 17 15 2 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007249   ⟹   ENSRNOP00000007249
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3137,618,898 - 137,925,605 (+)Ensembl
RefSeq Acc Id: NM_012746   ⟹   NP_036878
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23130,880,422 - 131,183,127 (+)NCBI
Rnor_6.03137,618,891 - 137,923,385 (+)NCBI
Rnor_5.03144,059,121 - 144,362,761 (+)NCBI
RGSC_v3.43131,925,648 - 132,256,178 (+)RGD
Celera3129,792,699 - 130,080,973 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_036878 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40946 (Get FASTA)   NCBI Sequence Viewer  
  AAA41477 (Get FASTA)   NCBI Sequence Viewer  
  EDL95184 (Get FASTA)   NCBI Sequence Viewer  
  P28841 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_036878   ⟸   NM_012746
- Peptide Label: precursor
- UniProtKB: P28841 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007249   ⟸   ENSRNOT00000007249
Protein Domains
P/Homo B   Peptidase S8

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692478
Promoter ID:EPDNEW_R3001
Type:initiation region
Name:Pcsk2_1
Description:proprotein convertase subtilisin/kexin type 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03137,618,928 - 137,618,988EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3273 AgrOrtholog
Ensembl Genes ENSRNOG00000005438 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000007249 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007249 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.260 UniProtKB/Swiss-Prot
  3.30.70.850 UniProtKB/Swiss-Prot
  3.40.50.200 UniProtKB/Swiss-Prot
InterPro Galactose-bd-like_sf UniProtKB/Swiss-Prot
  Kexin/furin UniProtKB/Swiss-Prot
  P_dom UniProtKB/Swiss-Prot
  Peptidase_S8/S53_dom UniProtKB/Swiss-Prot
  Peptidase_S8/S53_dom_sf UniProtKB/Swiss-Prot
  Peptidase_S8_Asp-AS UniProtKB/Swiss-Prot
  Peptidase_S8_His-AS UniProtKB/Swiss-Prot
  Peptidase_S8_Ser-AS UniProtKB/Swiss-Prot
  Peptidase_S8_subtilisin-rel UniProtKB/Swiss-Prot
  S8_pro-domain UniProtKB/Swiss-Prot
  S8_pro-domain_sf UniProtKB/Swiss-Prot
KEGG Report rno:25121 UniProtKB/Swiss-Prot
NCBI Gene 25121 ENTREZGENE
Pfam P_proprotein UniProtKB/Swiss-Prot
  Peptidase_S8 UniProtKB/Swiss-Prot
  S8_pro-domain UniProtKB/Swiss-Prot
PhenoGen Pcsk2 PhenoGen
PRINTS SUBTILISIN UniProtKB/Swiss-Prot
PROSITE P_HOMO_B UniProtKB/Swiss-Prot
  SUBTILASE UniProtKB/Swiss-Prot
  SUBTILASE_ASP UniProtKB/Swiss-Prot
  SUBTILASE_HIS UniProtKB/Swiss-Prot
  SUBTILASE_SER UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49785 UniProtKB/Swiss-Prot
  SSF52743 UniProtKB/Swiss-Prot
TIGR TC208898
UniProt NEC2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Pcsk2  proprotein convertase subtilisin/kexin type 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed at high levels in the islets of Langerhans 70278
gene_expression expressed in endocrine and neuroendocrine tissues 70278
gene_function releases protein hormones and neuropeptides from their precursors, usually by cleavage of -lys-arg- 70278
gene_process involved in the maturation and processing of hormones and other protein precursors 70278
gene_protein during secretion, immature 75-kD protein cleaved to produce active 68-kD protein 70278