FURIN (furin, paired basic amino acid cleaving enzyme) - Rat Genome Database

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Gene: FURIN (furin, paired basic amino acid cleaving enzyme) Sus scrofa
Analyze
Symbol: FURIN
Name: furin, paired basic amino acid cleaving enzyme
RGD ID: 14191259
Description: ENCODES a protein that exhibits endopeptidase activity (ortholog); peptidase activity (ortholog); serine-type endopeptidase activity (ortholog); INVOLVED IN aging (ortholog); negative regulation of nerve growth factor production (ortholog); positive regulation of cell migration (ortholog); PARTICIPATES IN glypican signaling pathway; hypoxia inducible factor pathway; Notch signaling pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); arteriosclerosis (ortholog); Bloom syndrome (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog); extracellular space (ortholog); Golgi cisterna (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl753,460,017 - 53,472,790 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1753,455,634 - 53,472,791 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2758,486,815 - 58,503,979 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:25972540  


Genomics

Comparative Map Data
FURIN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl753,460,017 - 53,472,790 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1753,455,634 - 53,472,791 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2758,486,815 - 58,503,979 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FURIN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1590,868,588 - 90,883,564 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1590,868,588 - 90,883,458 (+)EnsemblGRCh38hg38GRCh38
GRCh381590,868,588 - 90,883,457 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371591,411,818 - 91,426,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361589,212,889 - 89,227,691 (+)NCBINCBI36hg18NCBI36
Build 341589,212,888 - 89,227,691NCBI
Celera1567,820,515 - 67,835,658 (+)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1567,523,022 - 67,538,192 (+)NCBIHuRef
CHM1_11591,253,391 - 91,268,262 (+)NCBICHM1_1
Furin
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39780,038,942 - 80,055,188 (-)NCBIGRCm39mm39
GRCm39 Ensembl780,038,333 - 80,055,184 (-)Ensembl
GRCm38780,389,194 - 80,405,441 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,388,585 - 80,405,436 (-)EnsemblGRCm38mm10GRCm38
MGSCv37787,534,080 - 87,550,317 (-)NCBIGRCm37mm9NCBIm37
MGSCv36780,262,709 - 80,276,275 (-)NCBImm8
Celera777,789,167 - 77,805,351 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map745.65NCBI
Furin
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21134,348,142 - 134,361,182 (-)NCBI
Rnor_6.0 Ensembl1142,185,094 - 142,197,182 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01142,185,092 - 142,198,167 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01143,137,721 - 143,153,628 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,209,969 - 136,222,057 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11136,288,374 - 136,300,463NCBI
Celera1126,407,744 - 126,419,832 (-)NCBICelera
RH 3.4 Map11074.0RGD
Cytogenetic Map1q31NCBI
Furin
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541614,936,546 - 14,949,252 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541614,915,031 - 14,947,634 (+)NCBIChiLan1.0ChiLan1.0
FURIN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11588,759,729 - 88,774,023 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1588,763,269 - 88,774,023 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01569,560,774 - 69,576,007 (+)NCBIMhudiblu_PPA_v0panPan3
FURIN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,357,491 - 53,368,285 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,358,045 - 53,365,423 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha355,995,115 - 56,006,746 (-)NCBI
ROS_Cfam_1.0353,773,528 - 53,785,153 (-)NCBI
UMICH_Zoey_3.1353,292,643 - 53,304,269 (-)NCBI
UNSW_CanFamBas_1.0353,503,862 - 53,515,505 (-)NCBI
UU_Cfam_GSD_1.0353,844,352 - 53,855,974 (-)NCBI
Furin
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640130,182,463 - 130,198,421 (+)NCBI
SpeTri2.0NW_00493648316,136,099 - 16,147,945 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FURIN
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1298,980,367 - 8,992,257 (-)NCBI
ChlSab1.1 Ensembl298,979,720 - 8,988,235 (-)Ensembl
Vero_WHO_p1.0NW_02366605937,732,423 - 37,745,148 (+)NCBI
Furin
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476817,372,754 - 17,387,732 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 2 2 2
Low 8 4 3 3 2 23 2 3 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_001929347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005653503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005653504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005653506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021098913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021098914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021098915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021098916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021098917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021098918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021098919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021098920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021098921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021098922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_021098923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AEMK02000056 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK397965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBZA01000234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GFLN01092261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSSSCT00000048292   ⟹   ENSSSCP00000054519
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl753,460,017 - 53,472,783 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000050479   ⟹   ENSSSCP00000055096
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl753,460,691 - 53,472,790 (+)Ensembl
RefSeq Acc Id: XM_001929347   ⟹   XP_001929382
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1753,455,642 - 53,472,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005653503   ⟹   XP_005653560
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1753,459,261 - 53,472,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005653504   ⟹   XP_005653561
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1753,459,235 - 53,472,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005653506   ⟹   XP_005653563
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1753,460,536 - 53,472,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098913   ⟹   XP_020954572
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1753,459,874 - 53,472,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098914   ⟹   XP_020954573
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1753,459,261 - 53,472,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098915   ⟹   XP_020954574
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1753,459,874 - 53,472,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098916   ⟹   XP_020954575
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1753,455,634 - 53,472,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098917   ⟹   XP_020954576
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1753,459,236 - 53,472,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098918   ⟹   XP_020954577
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1753,456,212 - 53,472,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098919   ⟹   XP_020954578
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1753,460,197 - 53,472,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098920   ⟹   XP_020954579
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1753,459,874 - 53,472,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098921   ⟹   XP_020954580
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1753,459,874 - 53,472,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098922   ⟹   XP_020954581
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1753,460,695 - 53,472,791 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098923   ⟹   XP_020954582
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1753,459,278 - 53,472,791 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020954575   ⟸   XM_021098916
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_001929382   ⟸   XM_001929347
- Peptide Label: isoform X2
- UniProtKB: F1RMJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020954577   ⟸   XM_021098918
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005653561   ⟸   XM_005653504
- Peptide Label: isoform X2
- UniProtKB: F1RMJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020954576   ⟸   XM_021098917
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020954573   ⟸   XM_021098914
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005653560   ⟸   XM_005653503
- Peptide Label: isoform X2
- UniProtKB: F1RMJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020954582   ⟸   XM_021098923
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020954574   ⟸   XM_021098915
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020954580   ⟸   XM_021098921
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020954572   ⟸   XM_021098913
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020954579   ⟸   XM_021098920
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020954578   ⟸   XM_021098919
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005653563   ⟸   XM_005653506
- Peptide Label: isoform X2
- UniProtKB: F1RMJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020954581   ⟸   XM_021098922
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSSSCP00000055096   ⟸   ENSSSCT00000050479
RefSeq Acc Id: ENSSSCP00000054519   ⟸   ENSSSCT00000048292
Protein Domains
P/Homo B


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001817 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070016709 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000054519 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000055096 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070028003 UniProtKB/TrEMBL
  ENSSSCP00070028016 UniProtKB/TrEMBL
  ENSSSCP00070028020 UniProtKB/TrEMBL
  ENSSSCP00070028029 UniProtKB/TrEMBL
  ENSSSCP00070028035 UniProtKB/TrEMBL
  ENSSSCP00070028041 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000048292 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000050479 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070033526 UniProtKB/TrEMBL
  ENSSSCT00070033554 UniProtKB/TrEMBL
  ENSSSCT00070033561 UniProtKB/TrEMBL
  ENSSSCT00070033574 UniProtKB/TrEMBL
  ENSSSCT00070033583 UniProtKB/TrEMBL
  ENSSSCT00070033598 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.260 UniProtKB/TrEMBL
  3.30.70.850 UniProtKB/TrEMBL
  3.40.50.200 UniProtKB/TrEMBL
InterPro Furin_repeat UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  Kexin/furin UniProtKB/TrEMBL
  P_dom UniProtKB/TrEMBL
  Peptidase_S8/S53_dom UniProtKB/TrEMBL
  Peptidase_S8/S53_dom_sf UniProtKB/TrEMBL
  Peptidase_S8_Asp-AS UniProtKB/TrEMBL
  Peptidase_S8_His-AS UniProtKB/TrEMBL
  Peptidase_S8_Ser-AS UniProtKB/TrEMBL
  Peptidase_S8_subtilisin-rel UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/TrEMBL
  S8_pro-domain_sf UniProtKB/TrEMBL
KEGG Report ssc:100156882 UniProtKB/TrEMBL
NCBI Gene FURIN ENTREZGENE
Pfam P_proprotein UniProtKB/TrEMBL
  Peptidase_S8 UniProtKB/TrEMBL
  S8_pro-domain UniProtKB/TrEMBL
PRINTS SUBTILISIN UniProtKB/TrEMBL
PROSITE P_HOMO_B UniProtKB/TrEMBL
  SUBTILASE_ASP UniProtKB/TrEMBL
  SUBTILASE_HIS UniProtKB/TrEMBL
  SUBTILASE_SER UniProtKB/TrEMBL
SMART SM00261 UniProtKB/TrEMBL
Superfamily-SCOP SSF49785 UniProtKB/TrEMBL
  SSF52743 UniProtKB/TrEMBL
  SSF57184 UniProtKB/TrEMBL
UniProt A0A287BDX3_PIG UniProtKB/TrEMBL
  A0A4X1UIU9_PIG UniProtKB/TrEMBL
  F1RMJ1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:88266 ENTREZGENE