RGD Reference Report - The Association Study between Twenty One Polymorphisms in Seven Candidate Genes and Coronary Heart Diseases in Chinese Han Population. - Rat Genome Database

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The Association Study between Twenty One Polymorphisms in Seven Candidate Genes and Coronary Heart Diseases in Chinese Han Population.

Authors: Alobeidy, Barrak F  Li, Cong  Alzobair, Alya A  Liu, Tao  Zhao, Junzhang  Fang, Yuan  Zheng, Fang 
Citation: Alobeidy BF, etal., PLoS One. 2013 Jun 26;8(6):e66976. doi: 10.1371/journal.pone.0066976. Print 2013.
RGD ID: 401794443
Pubmed: PMID:23840567   (View Abstract at PubMed)
PMCID: PMC3694109   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.pone.0066976   (Journal Full-text)

Previous genome-wide association studies (GWAS) in multiple populations identified several genetic loci for coronary heart diseases (CHD). Here we utilized a 2-stage candidate gene association strategy in Chinese Han population to shed light on the putative association between several metabolic-related candidate genes and CHD. At the 1(st) stage, 190 patients with CHD and 190 controls were genotyped through the MassARRAY platform. At the 2(nd) stage, a larger sample including 400 patients and 392 controls was genotyped by the High Resolution Melt (HRM) method to confirm or rule out the associations with CHD. MLXIP expression level was quantified by the real time PCR in 65 peripheral blood samples. From the 21 studied single nucleotide polymorphisms (SNPs) of seven candidate genes: MLXIPL, MLXIP, MLX, ADIPOR1, VDR, SREBF1 and NR1H3, only one tag SNP rs4758685 (T->C) was found to be statistically associated with CHD (P-value = 0.02, Odds ratio (OR) of 0.83). After adjustment for the age, sex, lipid levels and diabetes, the association remained significant (P-value = 0.03). After adjustment for the hypertension, P-value became 0.20 although there was a significant difference in the allele distribution between the CHD patients with hypertension and the controls (P-value = 0.04, 406 vs 582). In conclusion, among the 21 tested SNPs, we identified a novel association between rs4758685 of MLXIP gene and CHD. The C allele of common variant rs4758685 interacted with hypertension, and was found to be protective against CHD in both allelic and genotypic models in Chinese Han population.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MLXIPHumanCoronary Disease susceptibilityIAGP DNA:SNP:3'utr: (rs4758685) (human)RGD 
MlxipRatCoronary Disease susceptibilityISOMLXIP (Homo sapiens)DNA:SNP:3'utr: (rs4758685) (human)RGD 
MlxipMouseCoronary Disease susceptibilityISOMLXIP (Homo sapiens)DNA:SNP:3'utr: (rs4758685) (human)RGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MLXIPHumanCoronary artery atherosclerosis susceptibilityIAGP DNA:SNP:3'utr: (rs4758685) (human)RGD 
Objects Annotated

Genes (Rattus norvegicus)
Mlxip  (MLX interacting protein)

Genes (Mus musculus)
Mlxip  (MLX interacting protein)

Genes (Homo sapiens)
MLXIP  (MLX interacting protein)


Additional Information