GJA5 (gap junction protein alpha 5) - Rat Genome Database

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Gene: GJA5 (gap junction protein alpha 5) Pan paniscus
Analyze
Symbol: GJA5
Name: gap junction protein alpha 5
RGD ID: 11856222
Description: ENCODES a protein that exhibits connexin binding (ortholog); disordered domain specific binding (ortholog); gap junction channel activity (ortholog); INVOLVED IN artery morphogenesis (ortholog); atrial septum morphogenesis (ortholog); atrial ventricular junction remodeling (ortholog); PARTICIPATES IN connexin signaling pathway; ASSOCIATED WITH atrial fibrillation (ortholog); atrial standstill 1 (ortholog); autism spectrum disorder (ortholog); FOUND IN cell projection (ortholog); connexin complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21101,927,011 - 101,952,954 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11101,515,393 - 101,539,948 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01123,200,111 - 123,224,626 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11112,306,880 - 112,331,358 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1112,328,337 - 112,329,413 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
artery morphogenesis  (ISO)
atrial cardiac muscle cell to AV node cell communication by electrical coupling  (IEA)
atrial septum development  (IEA)
atrial septum morphogenesis  (ISO)
atrial ventricular junction remodeling  (ISO)
AV node cell to bundle of His cell communication  (ISO)
AV node cell to bundle of His cell communication by electrical coupling  (IEA)
blood vessel development  (ISO)
blood vessel diameter maintenance  (ISO)
bundle of His cell to Purkinje myocyte communication by electrical coupling  (IEA)
cardiac conduction  (ISO)
cardiac conduction system development  (ISO)
cell communication  (IEA)
cell communication by chemical coupling  (ISO)
cell communication by electrical coupling  (ISO)
cell communication by electrical coupling involved in cardiac conduction  (IEA,ISO)
cell communication involved in cardiac conduction  (ISO)
cell-cell signaling  (IEA)
cellular response to platelet-derived growth factor stimulus  (ISO)
embryonic heart tube development  (ISO)
embryonic limb morphogenesis  (ISO)
endothelium development  (ISO)
foramen ovale closure  (ISO)
gap junction assembly  (IEA)
heart development  (IEA,ISO)
mitral valve development  (IEA)
negative regulation of blood pressure  (ISO)
negative regulation of glomerular filtration  (ISO)
outflow tract morphogenesis  (IEA)
positive regulation of cell communication by chemical coupling  (ISO)
positive regulation of vasoconstriction  (ISO)
potassium ion transport  (ISO)
pulmonary valve formation  (IEA)
regulation of atrial cardiac muscle cell action potential  (IEA)
regulation of atrial cardiac muscle cell membrane depolarization  (IEA,ISO)
regulation of AV node cell action potential  (IEA)
regulation of bundle of His cell action potential  (IEA)
regulation of cardiac muscle contraction  (IEA)
regulation of cell communication by electrical coupling  (ISO)
regulation of heart rate by cardiac conduction  (ISO)
regulation of membrane depolarization during cardiac muscle cell action potential  (ISO)
regulation of Purkinje myocyte action potential  (IEA)
regulation of renin secretion into blood stream  (ISO)
regulation of systemic arterial blood pressure  (ISO)
regulation of ventricular cardiac muscle cell membrane depolarization  (ISO)
regulation of ventricular cardiac muscle cell membrane repolarization  (ISO)
renal system process involved in regulation of systemic arterial blood pressure  (ISO)
SA node cell action potential  (ISO)
septum primum development  (ISO)
skeletal system development  (ISO)
transmembrane transport  (IEA)
vasodilation  (ISO)
vasomotion  (ISO)
ventricular cardiac muscle cell action potential  (ISO)
ventricular septum development  (IEA)
ventricular septum morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GJA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21101,927,011 - 101,952,954 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11101,515,393 - 101,539,948 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01123,200,111 - 123,224,626 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11112,306,880 - 112,331,358 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1112,328,337 - 112,329,413 (+)Ensemblpanpan1.1panPan2
GJA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,756,199 - 147,773,351 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,756,199 - 147,773,362 (-)EnsemblGRCh38hg38GRCh38
GRCh371147,228,332 - 147,245,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361145,694,956 - 145,712,108 (-)NCBINCBI36Build 36hg18NCBI36
Build 341144,453,708 - 144,457,501NCBI
Celera1121,738,476 - 121,755,641 (+)NCBICelera
Cytogenetic Map1q21.2NCBI
HuRef1120,641,850 - 120,658,997 (-)NCBIHuRef
CHM1_11149,124,325 - 149,141,488 (-)NCBICHM1_1
T2T-CHM13v2.01147,034,309 - 147,051,468 (+)NCBIT2T-CHM13v2.0
Gja5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,939,718 - 96,960,950 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl396,812,009 - 96,984,732 (+)EnsemblGRCm39 Ensembl
GRCm38397,032,402 - 97,053,634 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,904,693 - 97,077,416 (+)EnsemblGRCm38mm10GRCm38
MGSCv37396,836,339 - 96,857,557 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36397,117,821 - 97,139,039 (+)NCBIMGSCv36mm8
Celera398,439,607 - 98,460,828 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map342.04NCBI
Gja5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82187,291,227 - 187,310,770 (+)NCBIGRCr8
mRatBN7.22184,602,407 - 184,621,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2184,564,475 - 184,621,952 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2192,244,465 - 192,263,988 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02190,042,684 - 190,062,193 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02184,877,034 - 184,896,564 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02199,162,745 - 199,184,942 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2199,162,745 - 199,184,939 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02218,648,368 - 218,669,354 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,824,118 - 191,843,867 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12191,786,871 - 191,806,619 (+)NCBI
Celera2177,098,223 - 177,117,685 (+)NCBICelera
Cytogenetic Map2q34NCBI
Gja5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955568635,042 - 653,349 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955568635,319 - 652,692 (+)NCBIChiLan1.0ChiLan1.0
GJA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11758,289,327 - 58,305,315 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1758,289,327 - 58,305,315 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1757,757,715 - 57,773,685 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01759,286,062 - 59,301,971 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1759,285,495 - 59,302,023 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11758,159,018 - 58,175,010 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01758,219,654 - 58,235,621 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01758,946,248 - 58,962,243 (-)NCBIUU_Cfam_GSD_1.0
Gja5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505820,393,289 - 20,403,471 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936867269,477 - 279,549 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,854,392 - 99,871,286 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1499,854,129 - 99,871,288 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24109,687,517 - 109,704,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GJA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603814,460,790 - 14,478,590 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gja5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477216,813,011 - 16,814,084 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477216,810,723 - 16,828,328 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000011731   ⟹   ENSPPAP00000002431
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1112,328,337 - 112,329,413 (+)Ensembl
RefSeq Acc Id: XM_003809189   ⟹   XP_003809237
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21101,934,401 - 101,952,954 (+)NCBI
NHGRI_mPanPan11101,522,774 - 101,539,948 (+)NCBI
Mhudiblu_PPA_v01123,200,111 - 123,217,344 (-)NCBI
PanPan1.11112,313,948 - 112,331,358 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024926256   ⟹   XP_024782024
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21101,927,011 - 101,952,954 (+)NCBI
NHGRI_mPanPan11101,515,396 - 101,539,948 (+)NCBI
Mhudiblu_PPA_v01123,200,111 - 123,224,626 (-)NCBI
PanPan1.11112,306,880 - 112,331,358 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055102271   ⟹   XP_054958246
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21101,927,011 - 101,952,954 (+)NCBI
NHGRI_mPanPan11101,515,393 - 101,539,948 (+)NCBI
RefSeq Acc Id: XM_055102272   ⟹   XP_054958247
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21101,938,509 - 101,952,954 (+)NCBI
NHGRI_mPanPan11101,526,877 - 101,539,948 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003809237 (Get FASTA)   NCBI Sequence Viewer  
  XP_024782024 (Get FASTA)   NCBI Sequence Viewer  
  XP_054958246 (Get FASTA)   NCBI Sequence Viewer  
  XP_054958247 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000002431.1
RefSeq Acc Id: XP_003809237   ⟸   XM_003809189
- UniProtKB: A0A2R8ZBI8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024782024   ⟸   XM_024926256
- UniProtKB: A0A2R8ZBI8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000002431   ⟸   ENSPPAT00000011731
RefSeq Acc Id: XP_054958246   ⟸   XM_055102271
- UniProtKB: A0A2R8ZBI8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054958247   ⟸   XM_055102272
- UniProtKB: A0A2R8ZBI8 (UniProtKB/TrEMBL)
Protein Domains
Connexin N-terminal   Gap junction protein cysteine-rich


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000010838 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000011731.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1440.80 UniProtKB/TrEMBL
InterPro Connexin UniProtKB/TrEMBL
  Connexin40 UniProtKB/TrEMBL
  Connexin_C UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/TrEMBL
  Connexin_CS UniProtKB/TrEMBL
  Connexin_N UniProtKB/TrEMBL
  Connexin_N_sf UniProtKB/TrEMBL
  Cx40_C UniProtKB/TrEMBL
KEGG Report pps:100969927 UniProtKB/TrEMBL
NCBI Gene GJA5 ENTREZGENE
PANTHER PTHR11984 UniProtKB/TrEMBL
  PTHR11984:SF13 UniProtKB/TrEMBL
Pfam Connexin UniProtKB/TrEMBL
  Connexin40_C UniProtKB/TrEMBL
PRINTS CONNEXIN UniProtKB/TrEMBL
  CONNEXINA5 UniProtKB/TrEMBL
PROSITE CONNEXINS_1 UniProtKB/TrEMBL
  CONNEXINS_2 UniProtKB/TrEMBL
SMART CNX UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/TrEMBL
Superfamily-SCOP SSF118220 UniProtKB/TrEMBL
UniProt A0A2R8ZBI8 ENTREZGENE, UniProtKB/TrEMBL