GJA5 (gap junction protein alpha 5) - Rat Genome Database

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Gene: GJA5 (gap junction protein alpha 5) Sus scrofa
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Symbol: GJA5
Name: gap junction protein alpha 5
RGD ID: 14068516
Description: ENCODES a protein that exhibits connexin binding (ortholog); disordered domain specific binding (ortholog); gap junction channel activity (ortholog); INVOLVED IN cellular response to platelet-derived growth factor stimulus; artery morphogenesis (ortholog); atrial septum morphogenesis (ortholog); PARTICIPATES IN connexin signaling pathway; ASSOCIATED WITH atrial fibrillation (ortholog); atrial standstill 1 (ortholog); autism spectrum disorder (ortholog); FOUND IN cell projection (ortholog); connexin complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: gap junction alpha-5 protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,854,392 - 99,871,288 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1499,854,129 - 99,871,288 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24109,687,517 - 109,704,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
artery morphogenesis  (ISO)
atrial cardiac muscle cell to AV node cell communication by electrical coupling  (IEA)
atrial septum development  (IEA)
atrial septum morphogenesis  (ISO)
atrial ventricular junction remodeling  (ISO)
AV node cell to bundle of His cell communication  (ISO)
AV node cell to bundle of His cell communication by electrical coupling  (IEA)
blood vessel development  (ISO)
blood vessel diameter maintenance  (ISO)
bundle of His cell to Purkinje myocyte communication by electrical coupling  (IEA)
cardiac conduction  (ISO)
cardiac conduction system development  (ISO)
cell communication  (IEA)
cell communication by chemical coupling  (ISO)
cell communication by electrical coupling  (ISO)
cell communication by electrical coupling involved in cardiac conduction  (IEA,ISO)
cell communication involved in cardiac conduction  (ISO)
cell-cell signaling  (IBA)
cellular response to platelet-derived growth factor stimulus  (IDA)
embryonic heart tube development  (ISO)
embryonic limb morphogenesis  (ISO)
endothelium development  (ISO)
foramen ovale closure  (ISO)
gap junction assembly  (IEA)
heart development  (ISO)
mitral valve development  (IEA)
negative regulation of blood pressure  (ISO)
negative regulation of glomerular filtration  (ISO)
outflow tract morphogenesis  (IEA)
positive regulation of cell communication by chemical coupling  (ISO)
positive regulation of vasoconstriction  (ISO)
potassium ion transport  (ISO)
pulmonary valve formation  (IEA)
regulation of atrial cardiac muscle cell action potential  (IEA)
regulation of atrial cardiac muscle cell membrane depolarization  (IEA,ISO)
regulation of AV node cell action potential  (IEA)
regulation of bundle of His cell action potential  (IEA)
regulation of cardiac muscle contraction  (IEA)
regulation of cell communication by electrical coupling  (ISO)
regulation of heart rate by cardiac conduction  (ISO)
regulation of membrane depolarization during cardiac muscle cell action potential  (ISO)
regulation of Purkinje myocyte action potential  (IEA)
regulation of renin secretion into blood stream  (ISO)
regulation of systemic arterial blood pressure  (ISO)
regulation of ventricular cardiac muscle cell membrane depolarization  (ISO)
regulation of ventricular cardiac muscle cell membrane repolarization  (ISO)
renal system process involved in regulation of systemic arterial blood pressure  (ISO)
SA node cell action potential  (ISO)
septum primum development  (ISO)
skeletal system development  (ISO)
transmembrane transport  (IEA)
vasodilation  (ISO)
vasomotion  (ISO)
ventricular cardiac muscle cell action potential  (ISO)
ventricular septum development  (IEA)
ventricular septum morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
GJA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,854,392 - 99,871,288 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1499,854,129 - 99,871,288 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24109,687,517 - 109,704,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GJA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,756,199 - 147,773,351 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1147,756,199 - 147,773,362 (-)EnsemblGRCh38hg38GRCh38
GRCh371147,228,332 - 147,245,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361145,694,956 - 145,712,108 (-)NCBINCBI36hg18NCBI36
Build 341144,453,708 - 144,457,501NCBI
Celera1121,738,476 - 121,755,641 (+)NCBI
Cytogenetic Map1q21.2NCBI
HuRef1120,641,850 - 120,658,997 (-)NCBIHuRef
CHM1_11149,124,325 - 149,141,488 (-)NCBICHM1_1
Gja5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,939,718 - 96,960,950 (+)NCBIGRCm39mm39
GRCm39 Ensembl396,812,009 - 96,984,732 (+)Ensembl
GRCm38397,032,402 - 97,053,634 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,904,693 - 97,077,416 (+)EnsemblGRCm38mm10GRCm38
MGSCv37396,836,339 - 96,857,557 (+)NCBIGRCm37mm9NCBIm37
MGSCv36397,117,821 - 97,139,039 (+)NCBImm8
Celera398,439,607 - 98,460,828 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map342.04NCBI
Gja5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22184,602,407 - 184,621,952 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2184,564,475 - 184,621,952 (+)Ensembl
Rnor_6.02199,162,745 - 199,184,942 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2199,162,745 - 199,184,939 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02218,648,368 - 218,669,354 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,824,118 - 191,843,867 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12191,786,871 - 191,806,619 (+)NCBI
Celera2177,098,223 - 177,117,685 (+)NCBICelera
Cytogenetic Map2q34NCBI
Gja5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955568635,042 - 653,349 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955568635,319 - 652,692 (+)NCBIChiLan1.0ChiLan1.0
GJA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11112,306,880 - 112,331,358 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1112,328,337 - 112,329,413 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01123,200,111 - 123,224,626 (-)NCBIMhudiblu_PPA_v0panPan3
GJA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11758,289,327 - 58,305,315 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1758,289,327 - 58,305,315 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1757,757,715 - 57,773,685 (-)NCBI
ROS_Cfam_1.01759,286,062 - 59,301,971 (-)NCBI
ROS_Cfam_1.0 Ensembl1759,285,495 - 59,302,023 (-)Ensembl
UMICH_Zoey_3.11758,159,018 - 58,175,010 (-)NCBI
UNSW_CanFamBas_1.01758,219,654 - 58,235,621 (-)NCBI
UU_Cfam_GSD_1.01758,946,248 - 58,962,243 (-)NCBI
Gja5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505820,393,289 - 20,403,471 (-)NCBI
SpeTri2.0NW_004936867269,477 - 279,549 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603814,460,790 - 14,478,590 (+)NCBIVero_WHO_p1.0
Gja5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477216,810,723 - 16,828,328 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 6 4 5 2 7 2 2 1
Below cutoff 4 1 12 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000007335   ⟹   ENSSSCP00000007140
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl499,854,392 - 99,871,288 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000085228   ⟹   ENSSSCP00000065635
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl499,854,392 - 99,871,285 (+)Ensembl
RefSeq Acc Id: XM_001928300   ⟹   XP_001928335
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1499,854,138 - 99,871,288 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005653068   ⟹   XP_005653125
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1499,854,129 - 99,871,288 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013993317   ⟹   XP_013848771
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1499,854,129 - 99,871,288 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_001928335 (Get FASTA)   NCBI Sequence Viewer  
  XP_005653125 (Get FASTA)   NCBI Sequence Viewer  
  XP_013848771 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005653125   ⟸   XM_005653068
- UniProtKB: F1SDC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013848771   ⟸   XM_013993317
- UniProtKB: F1SDC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_001928335   ⟸   XM_001928300
- UniProtKB: F1SDC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000065635   ⟸   ENSSSCT00000085228
RefSeq Acc Id: ENSSSCP00000007140   ⟸   ENSSSCT00000007335
Protein Domains
CNX   Connexin_CCC


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000006696 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00005000119 UniProtKB/TrEMBL
  ENSSSCG00015059816 UniProtKB/TrEMBL
  ENSSSCG00025062004 UniProtKB/TrEMBL
  ENSSSCG00030072671 UniProtKB/TrEMBL
  ENSSSCG00035074850 UniProtKB/TrEMBL
  ENSSSCG00040044693 UniProtKB/TrEMBL
  ENSSSCG00045026310 UniProtKB/TrEMBL
  ENSSSCG00050005847 UniProtKB/TrEMBL
  ENSSSCG00055029612 UniProtKB/TrEMBL
  ENSSSCG00060032506 UniProtKB/TrEMBL
  ENSSSCG00065002835 UniProtKB/TrEMBL
  ENSSSCG00070002140 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000007140 UniProtKB/TrEMBL
  ENSSSCP00000065635 UniProtKB/TrEMBL
  ENSSSCP00005000049 UniProtKB/TrEMBL
  ENSSSCP00005000054 UniProtKB/TrEMBL
  ENSSSCP00015032248 UniProtKB/TrEMBL
  ENSSSCP00015032286 UniProtKB/TrEMBL
  ENSSSCP00025036910 UniProtKB/TrEMBL
  ENSSSCP00025036929 UniProtKB/TrEMBL
  ENSSSCP00030046929 UniProtKB/TrEMBL
  ENSSSCP00030046936 UniProtKB/TrEMBL
  ENSSSCP00035043339 UniProtKB/TrEMBL
  ENSSSCP00035043341 UniProtKB/TrEMBL
  ENSSSCP00040025123 UniProtKB/TrEMBL
  ENSSSCP00040025140 UniProtKB/TrEMBL
  ENSSSCP00045031041 UniProtKB/TrEMBL
  ENSSSCP00045031060 UniProtKB/TrEMBL
  ENSSSCP00050003366 UniProtKB/TrEMBL
  ENSSSCP00050003370 UniProtKB/TrEMBL
  ENSSSCP00055047110 UniProtKB/TrEMBL
  ENSSSCP00055047118 UniProtKB/TrEMBL
  ENSSSCP00060018776 UniProtKB/TrEMBL
  ENSSSCP00060018777 UniProtKB/TrEMBL
  ENSSSCP00065001374 UniProtKB/TrEMBL
  ENSSSCP00065001377 UniProtKB/TrEMBL
  ENSSSCP00070003297 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000007335 UniProtKB/TrEMBL
  ENSSSCT00000085228 UniProtKB/TrEMBL
  ENSSSCT00005000128 UniProtKB/TrEMBL
  ENSSSCT00005000135 UniProtKB/TrEMBL
  ENSSSCT00015079841 UniProtKB/TrEMBL
  ENSSSCT00015079921 UniProtKB/TrEMBL
  ENSSSCT00025084874 UniProtKB/TrEMBL
  ENSSSCT00025084929 UniProtKB/TrEMBL
  ENSSSCT00030101747 UniProtKB/TrEMBL
  ENSSSCT00030101758 UniProtKB/TrEMBL
  ENSSSCT00035101702 UniProtKB/TrEMBL
  ENSSSCT00035101710 UniProtKB/TrEMBL
  ENSSSCT00040059923 UniProtKB/TrEMBL
  ENSSSCT00040059952 UniProtKB/TrEMBL
  ENSSSCT00045044747 UniProtKB/TrEMBL
  ENSSSCT00045044769 UniProtKB/TrEMBL
  ENSSSCT00050007939 UniProtKB/TrEMBL
  ENSSSCT00050007944 UniProtKB/TrEMBL
  ENSSSCT00055058830 UniProtKB/TrEMBL
  ENSSSCT00055058839 UniProtKB/TrEMBL
  ENSSSCT00060044013 UniProtKB/TrEMBL
  ENSSSCT00060044015 UniProtKB/TrEMBL
  ENSSSCT00065003667 UniProtKB/TrEMBL
  ENSSSCT00065003673 UniProtKB/TrEMBL
  ENSSSCT00070003980 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1440.80 UniProtKB/TrEMBL
InterPro Connexin UniProtKB/TrEMBL
  Connexin40 UniProtKB/TrEMBL
  Connexin_C UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/TrEMBL
  Connexin_CS UniProtKB/TrEMBL
  Connexin_N UniProtKB/TrEMBL
  Connexin_N_sf UniProtKB/TrEMBL
  Cx40_C UniProtKB/TrEMBL
KEGG Report ssc:100157795 UniProtKB/TrEMBL
NCBI Gene GJA5 ENTREZGENE
PANTHER PTHR11984 UniProtKB/TrEMBL
  PTHR11984:SF13 UniProtKB/TrEMBL
Pfam Connexin UniProtKB/TrEMBL
  Connexin40_C UniProtKB/TrEMBL
PRINTS CONNEXIN UniProtKB/TrEMBL
  CONNEXINA5 UniProtKB/TrEMBL
PROSITE CONNEXINS_1 UniProtKB/TrEMBL
  CONNEXINS_2 UniProtKB/TrEMBL
SMART CNX UniProtKB/TrEMBL
  Connexin_CCC UniProtKB/TrEMBL
Superfamily-SCOP SSF118220 UniProtKB/TrEMBL
UniProt A0A4X1SLG1_PIG UniProtKB/TrEMBL
  F1SDC3 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:88460 ENTREZGENE