GJA5 (gap junction protein alpha 5) - Rat Genome Database

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Gene: GJA5 (gap junction protein alpha 5) Canis lupus familiaris
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Symbol: GJA5
Name: gap junction protein alpha 5
RGD ID: 12324020
Description: ENCODES a protein that exhibits connexin binding (ortholog); disordered domain specific binding (ortholog); gap junction channel activity (ortholog); INVOLVED IN atrial septum development (ortholog); atrial septum morphogenesis (ortholog); atrial ventricular junction remodeling (ortholog); PARTICIPATES IN connexin signaling pathway; ASSOCIATED WITH atrial fibrillation (ortholog); atrial standstill 1 (ortholog); autism spectrum disorder (ortholog); FOUND IN connexin complex; cell projection (ortholog); gap junction (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: connexin 40; Cx40; gap junction alpha-5 protein; gap junction protein, alpha 5, 40kDa (connexin 40)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11758,289,327 - 58,305,315 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1758,289,327 - 58,305,315 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1757,757,715 - 57,773,685 (-)NCBI
ROS_Cfam_1.01759,286,062 - 59,301,971 (-)NCBI
UMICH_Zoey_3.11758,159,018 - 58,175,010 (-)NCBI
UNSW_CanFamBas_1.01758,219,654 - 58,235,621 (-)NCBI
UU_Cfam_GSD_1.01758,946,248 - 58,962,243 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA)
artery morphogenesis  (IEA)
atrial cardiac muscle cell to AV node cell communication by electrical coupling  (IEA)
atrial septum development  (ISO)
atrial septum morphogenesis  (IEA,ISO)
atrial ventricular junction remodeling  (IEA,ISO)
AV node cell to bundle of His cell communication  (ISO)
AV node cell to bundle of His cell communication by electrical coupling  (IEA)
blood vessel development  (ISO)
blood vessel diameter maintenance  (IEA,ISO)
bundle of His cell to Purkinje myocyte communication by electrical coupling  (IEA)
cardiac conduction  (ISO)
cardiac conduction system development  (IEA,ISO)
cell communication by chemical coupling  (ISO)
cell communication by electrical coupling  (ISO)
cell communication by electrical coupling involved in cardiac conduction  (ISO)
cell communication involved in cardiac conduction  (ISO)
cell-cell signaling  (IBA)
cellular response to platelet-derived growth factor stimulus  (ISO)
embryonic heart tube development  (IEA,ISO)
embryonic limb morphogenesis  (IEA,ISO)
endothelium development  (ISO)
foramen ovale closure  (IEA,ISO)
gap junction assembly  (IEA)
heart development  (ISO)
mitral valve development  (IEA)
negative regulation of blood pressure  (ISO)
negative regulation of glomerular filtration  (ISO)
outflow tract morphogenesis  (IEA)
positive regulation of cell communication by chemical coupling  (ISO)
positive regulation of vasoconstriction  (ISO)
potassium ion transport  (ISO)
pulmonary valve formation  (IEA)
regulation of atrial cardiac muscle cell action potential  (IEA)
regulation of atrial cardiac muscle cell membrane depolarization  (IEA,ISO)
regulation of AV node cell action potential  (IEA)
regulation of bundle of His cell action potential  (IEA)
regulation of cardiac muscle contraction  (ISO)
regulation of cell communication by electrical coupling  (ISO)
regulation of heart rate by cardiac conduction  (IEA,ISO)
regulation of membrane depolarization during cardiac muscle cell action potential  (IEA,ISO)
regulation of Purkinje myocyte action potential  (IEA)
regulation of renin secretion into blood stream  (IEA,ISO)
regulation of systemic arterial blood pressure  (ISO)
regulation of ventricular cardiac muscle cell membrane depolarization  (IEA,ISO)
regulation of ventricular cardiac muscle cell membrane repolarization  (IEA,ISO)
renal system process involved in regulation of systemic arterial blood pressure  (IEA,ISO)
SA node cell action potential  (IEA,ISO)
septum primum development  (IEA,ISO)
skeletal system development  (IEA,ISO)
transmembrane transport  (IEA)
vasodilation  (ISO)
vasomotion  (ISO)
ventricular cardiac muscle cell action potential  (IEA,ISO)
ventricular septum development  (ISO)
ventricular septum morphogenesis  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:1310450   PMID:7930207   PMID:17434983   PMID:17939028   PMID:18577882   PMID:19875729   PMID:21426757  


Genomics

Comparative Map Data
GJA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11758,289,327 - 58,305,315 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1758,289,327 - 58,305,315 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1757,757,715 - 57,773,685 (-)NCBI
ROS_Cfam_1.01759,286,062 - 59,301,971 (-)NCBI
UMICH_Zoey_3.11758,159,018 - 58,175,010 (-)NCBI
UNSW_CanFamBas_1.01758,219,654 - 58,235,621 (-)NCBI
UU_Cfam_GSD_1.01758,946,248 - 58,962,243 (-)NCBI
GJA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1147,756,199 - 147,773,362 (-)EnsemblGRCh38hg38GRCh38
GRCh381147,756,199 - 147,781,127 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371147,228,332 - 147,245,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361145,694,956 - 145,712,108 (-)NCBINCBI36hg18NCBI36
Build 341144,453,708 - 144,457,501NCBI
Celera1121,738,476 - 121,755,641 (+)NCBI
Cytogenetic Map1q21.2NCBI
HuRef1120,641,850 - 120,658,997 (-)NCBIHuRef
CHM1_11149,124,325 - 149,141,488 (-)NCBICHM1_1
Gja5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39396,939,718 - 96,960,950 (+)NCBIGRCm39mm39
GRCm39 Ensembl396,812,009 - 96,984,732 (+)Ensembl
GRCm38397,032,402 - 97,053,634 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,904,693 - 97,077,416 (+)EnsemblGRCm38mm10GRCm38
MGSCv37396,836,339 - 96,857,557 (+)NCBIGRCm37mm9NCBIm37
MGSCv36397,117,821 - 97,139,039 (+)NCBImm8
Celera398,439,607 - 98,460,828 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
cM Map342.04NCBI
Gja5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22184,602,407 - 184,621,952 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2184,564,475 - 184,621,952 (+)Ensembl
Rnor_6.02199,162,745 - 199,184,942 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2199,162,745 - 199,184,939 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02218,648,368 - 218,669,354 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42191,824,118 - 191,843,867 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12191,786,871 - 191,806,619 (+)NCBI
Celera2177,098,223 - 177,117,685 (+)NCBICelera
Cytogenetic Map2q34NCBI
Gja5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955568635,042 - 653,349 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955568635,319 - 652,692 (+)NCBIChiLan1.0ChiLan1.0
GJA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11112,306,880 - 112,331,358 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1112,328,337 - 112,329,413 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01123,200,111 - 123,224,626 (-)NCBIMhudiblu_PPA_v0panPan3
Gja5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505820,393,289 - 20,403,471 (-)NCBI
SpeTri2.0NW_004936867269,477 - 279,549 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GJA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl499,854,392 - 99,871,288 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1499,854,129 - 99,871,288 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24109,687,517 - 109,704,699 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GJA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366603814,460,790 - 14,478,590 (+)NCBIVero_WHO_p1.0
Gja5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477216,810,723 - 16,828,328 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 2 5 1
Low 5 3 16 3 6 3 6 6 9 8 5 5
Below cutoff 6 3 3 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000017606   ⟹   ENSCAFP00000016302
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1758,289,327 - 58,305,315 (-)Ensembl
RefSeq Acc Id: NM_001017442   ⟹   NP_001017442
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11758,289,327 - 58,305,315 (-)NCBI
Dog10K_Boxer_Tasha1757,757,715 - 57,773,685 (-)NCBI
ROS_Cfam_1.01759,286,062 - 59,301,971 (-)NCBI
UMICH_Zoey_3.11758,159,018 - 58,175,010 (-)NCBI
UNSW_CanFamBas_1.01758,219,654 - 58,235,621 (-)NCBI
UU_Cfam_GSD_1.01758,946,248 - 58,962,243 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001017442 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT10275 (Get FASTA)   NCBI Sequence Viewer  
  ABG75571 (Get FASTA)   NCBI Sequence Viewer  
  ABQ97017 (Get FASTA)   NCBI Sequence Viewer  
  P33725 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001017442   ⟸   NM_001017442
- UniProtKB: P33725 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000016302   ⟸   ENSCAFT00000017606

Promoters
RGD ID:13686357
Promoter ID:EPDNEW_C4427
Type:single initiation site
Name:GJA5_1
Description:gap junction protein alpha 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11758,305,329 - 58,305,389EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011069 Ensembl
NCBI Gene GJA5 ENTREZGENE
UniProt P33725 ENTREZGENE
VGNC ID VGNC:41235 ENTREZGENE