RGD Reference Report - Plasma endoglin as a marker to predict cardiovascular events in patients with chronic coronary artery diseases. - Rat Genome Database

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Plasma endoglin as a marker to predict cardiovascular events in patients with chronic coronary artery diseases.

Authors: Ikemoto, T  Hojo, Y  Kondo, H  Takahashi, N  Hirose, M  Nishimura, Y  Katsuki, T  Shimada, K  Kario, K 
Citation: Ikemoto T, etal., Heart Vessels. 2012 Jul;27(4):344-51. doi: 10.1007/s00380-011-0163-z. Epub 2011 Jun 11.
RGD ID: 7248776
Pubmed: PMID:21667051   (View Abstract at PubMed)
DOI: DOI:10.1007/s00380-011-0163-z   (Journal Full-text)

Recent clinical studies have revealed that the expression of endoglin, an accessory protein for the TGF-beta receptor, is increased in patients with atherosclerotic diseases. The plasma endoglin level is thought to represent endothelial activation, inflammation, and senescence. To clarify the significance of plasma endoglin in chronic coronary artery disease. Human umbilical vein endothelial cells (HUVECs) were cultured to examine changes in soluble endoglin (s-endoglin) levels caused by atherogenic stimulation in vitro. We studied 318 patients with stable coronary artery disease who underwent a successful percutaneous coronary intervention (PCI). Patients with acute coronary syndrome were excluded. Major adverse cardiovascular events (MACE) were congestive heart failure, acute myocardial infarction, stroke, and sudden cardiac death. All patients were followed-up to examine MACE after the procedure. We confirmed that the levels of s-endoglin was increased in the culture medium of HUVECs by senescence, tumor necrosis factor-alpha and hydrogen peroxide. In a clinical study, mean follow-up period was 1055 +/- 612 days (49-2136 days) with 27 incidents of MACE (8.5%). We divided patients into three groups according to the plasma s-endoglin levels. Kaplan-Meier curves revealed that the highest endoglin group had a significantly higher MACE rate than the lowest endoglin group (log-rank test, p = 0.009). A Cox proportional hazards model showed that chronic kidney disease, left ventricular ejection fraction and s-endoglin level were significant factors to predict MACE. Plasma endoglin could be a marker to predict cardiovascular events in patients with chronic coronary artery disease after PCI.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ENGHumancoronary artery disease severityIEP protein:increased expression:plasma (human)RGD 
EngRatcoronary artery disease severityISOENG (Homo sapiens)protein:increased expression:plasma (human)RGD 
EngMousecoronary artery disease severityISOENG (Homo sapiens)protein:increased expression:plasma (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Eng  (endoglin)

Genes (Mus musculus)
Eng  (endoglin)

Genes (Homo sapiens)
ENG  (endoglin)


Additional Information