RGD Reference Report - [Contribution of delta1-opioid receptors in regulation of cardiac resistance to ischemia-reperfusion] - Rat Genome Database

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[Contribution of delta1-opioid receptors in regulation of cardiac resistance to ischemia-reperfusion]

Authors: Lasukova, TV  Maslov, LN  Lishmanov, IUB  Gross, GL 
Citation: Lasukova TV, etal., Ross Fiziol Zh Im I M Sechenova. 2002 May;88(5):568-80.
RGD ID: 2316590
Pubmed: PMID:12136724   (View Abstract at PubMed)

It has been found that pretreatment with a delta 1-opioid receptor agonist, DPDPE, in dose of 0.1 mg/kg intravenously 15 min before heart isolation, prevents appearance of reperfusion, ventricular arrhythmias during total global ischemia (45 min) and reperfusion (10 min) of isolated rat heart. This effect was dose-dependent. Addition of DPDPE to the perfusion solution in a final concentration of 0.1 mg/L and/or 0.5 mg/L 15 min before ischemia also decreased the incidence of reperfusion arrhythmias in a concentration-dependent manner. Addition of DPDPE to the perfusion solution in a final concentration of 0.1 mg/L also decreased creatine kinase levels in the coronary sinus. However DPDPE had no cardio-protective effect in concentration of 0.5 mg/L or after intravenous administration. A previous intravenous injection of DPDPE in dose of 0.5 mg/kg exacerbated reperfusion-induced contractile dysfunction of isolated heart but exerted no effect in dose of 0.1 mg/kg. Previous perfusion of the rat isolated heart by DPDPE in concentration of 0.1 mg/L and 0.5 mg/L 15 min before ischemia also exacerbated myocardial contractile dysfunction during reperfusion. It is proposed that the antiarrhythmic, cardio-protective and negative inotropic effect of DPDPE during reperfusion may be due to stimulation of cardiac delta-1 receptors.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
OPRD1HumanMyocardial Reperfusion Injury  ISOOprd1 (Rattus norvegicus) RGD 
Oprd1RatMyocardial Reperfusion Injury  IDA  RGD 
Oprd1MouseMyocardial Reperfusion Injury  ISOOprd1 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Oprd1  (opioid receptor, delta 1)

Genes (Mus musculus)
Oprd1  (opioid receptor, delta 1)

Genes (Homo sapiens)
OPRD1  (opioid receptor delta 1)


Additional Information