OPRD1 (opioid receptor delta 1) - Rat Genome Database

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Gene: OPRD1 (opioid receptor delta 1) Homo sapiens
Analyze
Symbol: OPRD1
Name: opioid receptor delta 1
RGD ID: 731961
HGNC Page HGNC:8153
Description: Enables G protein-coupled enkephalin receptor activity. Involved in several processes, including G protein-coupled opioid receptor signaling pathway; cellular response to hypoxia; and positive regulation of peptidyl-serine phosphorylation. Located in plasma membrane. Implicated in alcohol dependence; drug dependence (multiple); opioid abuse; and withdrawal disorder. Biomarker of opioid abuse.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: D-OR-1; delta opioid receptor 1; delta-type opioid receptor; DOP; DOR; DOR-1; DOR1; opioid receptor delta 1 isoform DOR-1B; opioid receptor delta 1 isoform DOR-1C; opioid receptor delta 1 isoform DOR-1D; opioid receptor delta 1 isoform DOR-1E; opioid receptor, delta 1; OPRD
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38128,812,170 - 28,871,267 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl128,812,170 - 28,871,267 (+)EnsemblGRCh38hg38GRCh38
GRCh37129,138,682 - 29,197,779 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36129,011,241 - 29,062,795 (+)NCBINCBI36Build 36hg18NCBI36
Build 34128,959,269 - 29,010,821NCBI
Celera127,534,800 - 27,586,335 (+)NCBICelera
Cytogenetic Map1p35.3NCBI
HuRef127,391,067 - 27,442,611 (+)NCBIHuRef
CHM1_1129,254,016 - 29,305,583 (+)NCBICHM1_1
T2T-CHM13v2.0128,654,162 - 28,713,229 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin  (ISO)
(R)-noradrenaline  (ISO)
(R,R)-tramadol  (ISO)
(S)-amphetamine  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
7-Hydroxymitragynine  (EXP,ISO)
acetylmethadol  (ISO)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP)
buprenorphine  (EXP,ISO)
butorphanol  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cannabidiol  (ISO)
CGP 52608  (EXP)
chlorpyrifos  (ISO)
clofibrate  (ISO)
cocaine  (ISO)
codeine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
Deltorphin B  (ISO)
dextran sulfate  (ISO)
dextromethorphan  (ISO)
dextropropoxyphene  (ISO)
dextrorphan  (ISO)
dibutyl phthalate  (ISO)
DPDPE  (EXP,ISO)
DSLET  (ISO)
dynorphin A  (EXP)
eluxadoline  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
ethylparaben  (EXP)
fentanyl  (ISO)
hydralazine  (EXP)
hydrocodone  (ISO)
Leu-enkephalin  (EXP)
Levallorphan  (ISO)
Levorphanol  (ISO)
lipopolysaccharide  (EXP)
loperamide  (ISO)
magnesium atom  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
mesalamine  (ISO)
methadone  (ISO)
methylmercury chloride  (EXP)
Mitragynine  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morphine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
naloxone  (ISO)
naltrexone  (ISO)
Naltrindole  (ISO)
nicotine  (ISO)
Nonylphenol  (ISO)
oxycodone  (ISO)
paraquat  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
resveratrol  (EXP)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
serotonin  (ISO)
sulfadimethoxine  (ISO)
tapentadol  (ISO)
thioglycolic acid  (ISO)
titanium dioxide  (ISO)
tramadol  (ISO)
trichloroethene  (ISO)
triptonide  (ISO)
U69593  (ISO)
valproic acid  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Delta and kappa opioid receptor polymorphisms influence the effects of naltrexone on subjective responses to alcohol. Ashenhurst JR, etal., Pharmacol Biochem Behav. 2012 Dec;103(2):253-9. doi: 10.1016/j.pbb.2012.08.019. Epub 2012 Aug 27.
2. Association of polymorphisms in pharmacogenetic candidate genes (OPRD1, GAL, ABCB1, OPRM1) with opioid dependence in European population: a case-control study. Beer B, etal., PLoS One. 2013 Sep 25;8(9):e75359. doi: 10.1371/journal.pone.0075359. eCollection 2013.
3. Genetic variation in OPRD1 and the response to treatment for opioid dependence with buprenorphine in European-American females. Clarke TK, etal., Pharmacogenomics J. 2014 Jun;14(3):303-8. doi: 10.1038/tpj.2013.30. Epub 2013 Oct 15.
4. Case-control association analysis of polymorphisms in the δ-opioid receptor, OPRD1, with cocaine and opioid addicted populations. Crist RC, etal., Drug Alcohol Depend. 2013 Jan 1;127(1-3):122-8. doi: 10.1016/j.drugalcdep.2012.06.023. Epub 2012 Jul 12.
5. A delta-opioid receptor genetic variant is associated with abstinence prior to and during cocaine dependence treatment. Crist RC, etal., Drug Alcohol Depend. 2016 Sep 1;166:268-71. doi: 10.1016/j.drugalcdep.2016.07.008. Epub 2016 Jul 14.
6. An intronic variant in OPRD1 predicts treatment outcome for opioid dependence in African-Americans. Crist RC, etal., Neuropsychopharmacology. 2013 Sep;38(10):2003-10. doi: 10.1038/npp.2013.99. Epub 2013 Apr 23.
7. Genetic polymorphisms in the opioid receptor delta 1 (OPRD1) gene are associated with methadone dose in methadone maintenance treatment for heroin dependence. Fang CP, etal., J Hum Genet. 2020 Apr;65(4):381-386. doi: 10.1038/s10038-019-0718-x. Epub 2020 Jan 7.
8. Opioid-induced cardioprotection against myocardial infarction and arrhythmias: mitochondrial versus sarcolemmal ATP-sensitive potassium channels. Fryer RM, etal., J Pharmacol Exp Ther. 2000 Aug;294(2):451-7.
9. Contribution of Genetic Polymorphisms and Haplotypes in DRD2, BDNF, and Opioid Receptors to Heroin Dependence and Endophenotypes Among the Han Chinese. Gao X, etal., OMICS. 2017 Jul;21(7):404-412. doi: 10.1089/omi.2017.0057.
10. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
11. The expression of opioid genes in non-classical reward areas depends on early life conditions and ethanol intake. Granholm L, etal., Brain Res. 2017 Aug 1;1668:36-45. doi: 10.1016/j.brainres.2017.05.006. Epub 2017 May 13.
12. Ovarian hormones ameliorate memory impairment, cholinergic deficit, neuronal apoptosis and astrogliosis in a rat model of Alzheimer's disease. Hu Z, etal., Exp Ther Med. 2016 Jan;11(1):89-97. doi: 10.3892/etm.2015.2868. Epub 2015 Nov 13.
13. OPRD1 gene affects disease vulnerability and environmental stress in patients with heroin dependence in Han Chinese. Huang CC, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2019 Mar 8;89:109-116. doi: 10.1016/j.pnpbp.2018.08.028. Epub 2018 Aug 30.
14. Spinal pharmacology of antinociception produced by microinjection of mu or delta opioid receptor agonists in the ventromedial medulla of the rat. Hurley RW, etal., Neuroscience. 2003;118(3):789-96.
15. OPRD1 rs569356 polymorphism has an effect on plasma norbuprenorphine levels and dose/kg-normalized norbuprenorphine values in individuals with opioid use disorder. Kaya-Akyüzlü D, etal., Environ Toxicol Pharmacol. 2023 Jun;100:104143. doi: 10.1016/j.etap.2023.104143. Epub 2023 May 3.
16. The delta 2-opioid receptor antagonist naltriben selectively attenuates alcohol intake in rats bred for alcohol preference. Krishnan-Sarin S, etal., Pharmacol Biochem Behav. 1995 Sep;52(1):153-9. doi: 10.1016/0091-3057(95)00080-g.
17. [Contribution of delta1-opioid receptors in regulation of cardiac resistance to ischemia-reperfusion] Lasukova TV, etal., Ross Fiziol Zh Im I M Sechenova. 2002 May;88(5):568-80.
18. Morphine withdrawal precipitated by specific mu, delta or kappa opioid receptor antagonists: a c-Fos protein study in the rat central nervous system. Le Guen S, etal., Eur J Neurosci. 2003 Jun;17(11):2425-37. doi: 10.1046/j.1460-9568.2003.02678.x.
19. Morphine-6beta-glucuronide-induced hyperphagia: characterization of opioid action by selective antagonists and antisense mapping in rats. Leventhal L, etal., J Pharmacol Exp Ther. 1998 Nov;287(2):538-44.
20. OPRD1 SNPs associated with opioid addiction are cis-eQTLs for the phosphatase and actin regulator 4 gene, PHACTR4, a mediator of cytoskeletal dynamics. Levran O, etal., Transl Psychiatry. 2021 May 25;11(1):316. doi: 10.1038/s41398-021-01439-y.
21. Analyzing Interaction of μ-, δ- and κ-opioid Receptor Gene Variants on Alcohol or Drug Dependence Using a Pattern Discovery-based Method. Li Z and Zhang H, J Addict Res Ther. 2013 May 14;Suppl 7:007.
22. Impact of SNP-SNP interaction among ABCB1, ARRB2, DRD1 and OPRD1 on methadone dosage requirement in Han Chinese patients. Luo R, etal., Pharmacogenomics. 2017 Dec;18(18):1659-1670. doi: 10.2217/pgs-2017-0072. Epub 2017 Nov 27.
23. Activation of peripheral delta opioid receptors eliminates cardiac electrical instability in a rat model of post-infarction cardiosclerosis via mitochondrial ATP-dependent K+ channels. Maslov LN, etal., Life Sci. 2003 Jul 4;73(7):947-52.
24. An analysis of genetic association in opioid dependence susceptibility. Nagaya D, etal., J Clin Pharm Ther. 2018 Feb;43(1):80-86. doi: 10.1111/jcpt.12585. Epub 2017 Jun 27.
25. Association of OPRD1 polymorphisms with heroin dependence in a large case-control series. Nelson EC, etal., Addict Biol. 2014 Jan;19(1):111-21. doi: 10.1111/j.1369-1600.2012.00445.x. Epub 2012 Apr 13.
26. Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction. Peart JN, etal., J Cardiovasc Pharmacol. 2004 Mar;43(3):410-5.
27. Predictors of treatment retention and survival among methadone-maintained patients: A possible role for a functional delta opioid receptor gene variant. Peles E, etal., Drug Alcohol Depend. 2023 Sep 1;250:110903. doi: 10.1016/j.drugalcdep.2023.110903. Epub 2023 Jul 22.
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. A commonly carried genetic variant in the delta opioid receptor gene, OPRD1, is associated with smaller regional brain volumes: replication in elderly and young populations. Roussotte FF, etal., Hum Brain Mapp. 2014 Apr;35(4):1226-36. doi: 10.1002/hbm.22247. Epub 2013 Feb 21.
31. Association of OPRD1 Gene Variants with Opioid Dependence in Addicted Male Individuals Undergoing Methadone Treatment in the North of Iran. Sharafshah A, etal., J Psychoactive Drugs. 2017 Jul-Aug;49(3):242-251. doi: 10.1080/02791072.2017.1290303. Epub 2017 Mar 1.
32. The OPRD1 rs678849 variant influences outcome of disulfiram treatment for cocaine dependency in methadone-maintained patients. Thomas PS, etal., Psychiatr Genet. 2021 Jun 1;31(3):88-94. doi: 10.1097/YPG.0000000000000279.
33. Expression of material mRNA in the hypothalamus and frontal cortex in a rat model of fatal hypothermia. Umehara T, etal., Leg Med (Tokyo). 2011 Jul;13(4):165-70. doi: 10.1016/j.legalmed.2011.01.005. Epub 2011 Mar 5.
34. Variations in opioid receptor genes in neonatal abstinence syndrome. Wachman EM, etal., Drug Alcohol Depend. 2015 Oct 1;155:253-9. doi: 10.1016/j.drugalcdep.2015.07.001. Epub 2015 Jul 8.
35. Methylation and expression quantitative trait loci rs1799971 in the OPRM1 gene and rs4654327 in the OPRD1 gene are associated with opioid use disorder. Yu J, etal., Neurosci Lett. 2023 Sep 25;814:137468. doi: 10.1016/j.neulet.2023.137468. Epub 2023 Sep 1.
36. The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk. Zhang H, etal., Mol Psychiatry. 2008 May;13(5):531-43. doi: 10.1038/sj.mp.4002035. Epub 2007 Jul 10.
37. Chronic Oxycodone Self-administration Altered Reward-related Genes in the Ventral and Dorsal Striatum of C57BL/6J Mice: An RNA-seq Analysis. Zhang Y, etal., Neuroscience. 2018 Nov 21;393:333-349. doi: 10.1016/j.neuroscience.2018.07.032. Epub 2018 Jul 29.
Additional References at PubMed
PMID:1335167   PMID:1671672   PMID:2834384   PMID:7808419   PMID:8020949   PMID:8201839   PMID:8393523   PMID:8415697   PMID:9166747   PMID:9548483   PMID:10385123   PMID:10788493  
PMID:10982041   PMID:11040053   PMID:11054417   PMID:11069979   PMID:11076532   PMID:11076863   PMID:11078827   PMID:11085981   PMID:11259487   PMID:11259507   PMID:11278447   PMID:11316510  
PMID:12116270   PMID:12142540   PMID:12413885   PMID:12477932   PMID:12740597   PMID:12847517   PMID:14535952   PMID:14745298   PMID:14999000   PMID:15086532   PMID:15317820   PMID:16053916  
PMID:16325578   PMID:16331961   PMID:16710414   PMID:16741914   PMID:16806108   PMID:16808998   PMID:17374034   PMID:17503481   PMID:17550902   PMID:17565992   PMID:17588601   PMID:18182056  
PMID:18200497   PMID:18213616   PMID:18240029   PMID:18307412   PMID:18338799   PMID:18395423   PMID:18455254   PMID:18518925   PMID:18537939   PMID:18577758   PMID:18676680   PMID:18687376  
PMID:18703511   PMID:18753988   PMID:19000170   PMID:19032295   PMID:19058789   PMID:19086053   PMID:19170196   PMID:19183129   PMID:19344370   PMID:19416973   PMID:19520863   PMID:19581316  
PMID:19625176   PMID:19692168   PMID:19874574   PMID:20066010   PMID:20237496   PMID:20300121   PMID:20468064   PMID:20528919   PMID:20734064   PMID:21079607   PMID:21220103   PMID:21234650  
PMID:21361347   PMID:21464208   PMID:21483469   PMID:21810780   PMID:21873635   PMID:22101011   PMID:22184124   PMID:22235275   PMID:22752269   PMID:23222260   PMID:23318717   PMID:23836900  
PMID:23840749   PMID:24413399   PMID:24416361   PMID:24613828   PMID:24628261   PMID:24798333   PMID:25178105   PMID:25439010   PMID:26211551   PMID:26402014   PMID:26946441   PMID:27343248  
PMID:27665747   PMID:28035534   PMID:28041939   PMID:28049031   PMID:28253273   PMID:28388416   PMID:29055075   PMID:29097258   PMID:29768254   PMID:30066306   PMID:32228617   PMID:32296183  
PMID:33506435   PMID:34407719   PMID:34638633   PMID:34685631   PMID:35559673   PMID:35908776  


Genomics

Comparative Map Data
OPRD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38128,812,170 - 28,871,267 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl128,812,170 - 28,871,267 (+)EnsemblGRCh38hg38GRCh38
GRCh37129,138,682 - 29,197,779 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36129,011,241 - 29,062,795 (+)NCBINCBI36Build 36hg18NCBI36
Build 34128,959,269 - 29,010,821NCBI
Celera127,534,800 - 27,586,335 (+)NCBICelera
Cytogenetic Map1p35.3NCBI
HuRef127,391,067 - 27,442,611 (+)NCBIHuRef
CHM1_1129,254,016 - 29,305,583 (+)NCBICHM1_1
T2T-CHM13v2.0128,654,162 - 28,713,229 (+)NCBIT2T-CHM13v2.0
Oprd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394131,834,980 - 131,872,042 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4131,838,037 - 131,871,797 (-)EnsemblGRCm39 Ensembl
GRCm384132,110,188 - 132,144,486 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,110,726 - 132,144,486 (-)EnsemblGRCm38mm10GRCm38
MGSCv374131,666,641 - 131,700,401 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364131,382,802 - 131,416,562 (-)NCBIMGSCv36mm8
Celera4130,271,660 - 130,305,734 (-)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map464.78NCBI
Oprd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85149,590,244 - 149,624,999 (-)NCBIGRCr8
mRatBN7.25144,306,188 - 144,340,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,306,188 - 144,340,960 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5147,005,532 - 147,040,056 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05148,775,378 - 148,809,896 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05148,764,406 - 148,799,337 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05150,288,126 - 150,323,063 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,288,126 - 150,323,063 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05153,962,767 - 153,997,858 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45150,979,252 - 151,014,066 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15150,989,290 - 151,024,105 (-)NCBI
Celera5142,741,006 - 142,775,820 (-)NCBICelera
RH 3.4 Map5965.9RGD
Cytogenetic Map5q36NCBI
Oprd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554527,866,758 - 7,913,399 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554527,866,790 - 7,913,399 (+)NCBIChiLan1.0ChiLan1.0
OPRD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21197,970,746 - 198,030,027 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11197,090,112 - 197,149,063 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0128,068,053 - 28,143,053 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1129,112,328 - 29,163,464 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl129,112,152 - 29,163,464 (+)Ensemblpanpan1.1panPan2
OPRD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,685,129 - 71,721,692 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,689,084 - 71,721,875 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,264,922 - 68,297,415 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,248,368 - 72,280,856 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,247,773 - 72,281,077 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,077,265 - 69,109,751 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0270,084,707 - 70,117,198 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0271,082,831 - 71,115,319 (-)NCBIUU_Cfam_GSD_1.0
Oprd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505847,035,433 - 47,078,632 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647412,860,293 - 12,903,466 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647412,860,293 - 12,902,389 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPRD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl685,785,276 - 85,830,877 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1685,775,576 - 85,827,170 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2679,611,950 - 79,662,042 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OPRD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120103,950,505 - 104,002,459 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603312,520,984 - 12,574,525 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Oprd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476412,604,164 - 12,676,279 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476412,604,051 - 12,676,368 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in OPRD1
26 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p36.11-35.2(chr1:26963045-32279045)x3 copy number gain See cases [RCV000051801] Chr1:26963045..32279045 [GRCh38]
Chr1:27289536..32744646 [GRCh37]
Chr1:27162123..32517233 [NCBI36]
Chr1:1p36.11-35.2		 pathogenic
NM_000911.3(OPRD1):c.912C>T (p.Ile304=) single nucleotide variant Malignant melanoma [RCV000064707] Chr1:28863076 [GRCh38]
Chr1:29189588 [GRCh37]
Chr1:29062175 [NCBI36]
Chr1:1p35.3		 not provided
NM_000911.3(OPRD1):c.227+12879G>T single nucleotide variant Lung cancer [RCV000090798] Chr1:28825489 [GRCh38]
Chr1:29152001 [GRCh37]
Chr1:1p35.3		 uncertain significance
GRCh38/hg38 1p35.3-35.1(chr1:28424867-33122854)x1 copy number loss See cases [RCV000135447] Chr1:28424867..33122854 [GRCh38]
Chr1:28751378..33588455 [GRCh37]
Chr1:28623965..33361042 [NCBI36]
Chr1:1p35.3-35.1		 pathogenic
GRCh38/hg38 1p36.11-34.2(chr1:24381206-41401517)x3 copy number gain See cases [RCV000138891] Chr1:24381206..41401517 [GRCh38]
Chr1:24707696..41886350 [GRCh37]
Chr1:24580283..41658937 [NCBI36]
Chr1:1p36.11-34.2		 pathogenic
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12		 likely benign
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
NM_000911.4(OPRD1):c.121C>T (p.Arg41Trp) single nucleotide variant Inborn genetic diseases [RCV003245087] Chr1:28812504 [GRCh38]
Chr1:29139016 [GRCh37]
Chr1:1p35.3		 uncertain significance
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1		 uncertain significance
NM_000911.4(OPRD1):c.227+6066C>T single nucleotide variant buprenorphine response - Efficacy [RCV000786627] Chr1:28818676 [GRCh38]
Chr1:29145188 [GRCh37]
Chr1:1p35.3		 drug response
GRCh37/hg19 1p35.3(chr1:28493687-29242679)x1 copy number loss not provided [RCV001836514] Chr1:28493687..29242679 [GRCh37]
Chr1:1p35.3		 uncertain significance
GRCh37/hg19 1p36.11-35.1(chr1:27543877-32819121) copy number gain not specified [RCV002052559] Chr1:27543877..32819121 [GRCh37]
Chr1:1p36.11-35.1		 uncertain significance
NM_000911.4(OPRD1):c.13C>T (p.Pro5Ser) single nucleotide variant Inborn genetic diseases [RCV002947048] Chr1:28812396 [GRCh38]
Chr1:29138908 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_000911.4(OPRD1):c.338C>T (p.Thr113Met) single nucleotide variant Inborn genetic diseases [RCV002989859] Chr1:28859064 [GRCh38]
Chr1:29185576 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_000911.4(OPRD1):c.478C>T (p.Arg160Cys) single nucleotide variant Inborn genetic diseases [RCV002778583] Chr1:28859204 [GRCh38]
Chr1:29185716 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_000911.4(OPRD1):c.307C>A (p.Pro103Thr) single nucleotide variant Inborn genetic diseases [RCV002689648] Chr1:28859033 [GRCh38]
Chr1:29185545 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_000911.4(OPRD1):c.698A>G (p.Tyr233Cys) single nucleotide variant Inborn genetic diseases [RCV002884445] Chr1:28862862 [GRCh38]
Chr1:29189374 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_000911.4(OPRD1):c.811G>T (p.Val271Leu) single nucleotide variant Inborn genetic diseases [RCV002739277] Chr1:28862975 [GRCh38]
Chr1:29189487 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_000911.4(OPRD1):c.71C>T (p.Pro24Leu) single nucleotide variant Inborn genetic diseases [RCV002821364] Chr1:28812454 [GRCh38]
Chr1:29138966 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_000911.4(OPRD1):c.583G>A (p.Ala195Thr) single nucleotide variant Inborn genetic diseases [RCV002645248] Chr1:28862747 [GRCh38]
Chr1:29189259 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_000911.4(OPRD1):c.396G>C (p.Met132Ile) single nucleotide variant Inborn genetic diseases [RCV002930992] Chr1:28859122 [GRCh38]
Chr1:29185634 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_000911.4(OPRD1):c.1040G>A (p.Arg347His) single nucleotide variant Inborn genetic diseases [RCV003277482] Chr1:28863204 [GRCh38]
Chr1:29189716 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_000911.4(OPRD1):c.41C>T (p.Pro14Leu) single nucleotide variant Inborn genetic diseases [RCV003173876] Chr1:28812424 [GRCh38]
Chr1:29138936 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_000911.4(OPRD1):c.193C>G (p.Leu65Val) single nucleotide variant Inborn genetic diseases [RCV003186325] Chr1:28812576 [GRCh38]
Chr1:29139088 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_000911.4(OPRD1):c.1082C>T (p.Thr361Ile) single nucleotide variant Inborn genetic diseases [RCV003207772] Chr1:28863246 [GRCh38]
Chr1:29189758 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_000911.4(OPRD1):c.1067G>A (p.Arg356His) single nucleotide variant Inborn genetic diseases [RCV003212448] Chr1:28863231 [GRCh38]
Chr1:29189743 [GRCh37]
Chr1:1p35.3		 uncertain significance
NM_000911.4(OPRD1):c.59C>G (p.Ser20Trp) single nucleotide variant Inborn genetic diseases [RCV003370621] Chr1:28812442 [GRCh38]
Chr1:29138954 [GRCh37]
Chr1:1p35.3		 uncertain significance
GRCh38/hg38 1p36.33-35.1(chr1:99125-34026935)x3 copy number gain Trisomy 12p [RCV003447845] Chr1:99125..34026935 [GRCh38]
Chr1:1p36.33-35.1		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:293
Count of miRNA genes:244
Interacting mature miRNAs:268
Transcripts:ENST00000234961
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
GDB:511375  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1p36.1-p34.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 2 19 3 23 1 20
Low 240 7 53 3 44 3 296 82 1499 20 81 68 1 2 63
Below cutoff 2096 2761 1415 417 1548 268 3733 2027 2164 157 1179 1362 163 1 1183 2497 3

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000234961   ⟹   ENSP00000234961
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl128,812,170 - 28,871,267 (+)Ensembl
RefSeq Acc Id: ENST00000621425   ⟹   ENSP00000477970
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl128,812,142 - 28,863,283 (+)Ensembl
RefSeq Acc Id: NM_000911   ⟹   NP_000902
RefSeq Status: VALIDATED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38128,812,170 - 28,871,267 (+)NCBI
GRCh37129,138,654 - 29,190,208 (+)ENTREZGENE
Build 36129,011,241 - 29,062,795 (+)NCBI Archive
HuRef127,391,067 - 27,442,611 (+)ENTREZGENE
CHM1_1129,254,016 - 29,305,583 (+)NCBI
T2T-CHM13v2.0128,654,162 - 28,713,229 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_000902   ⟸   NM_000911
- UniProtKB: B5B0B8 (UniProtKB/Swiss-Prot),   P41143 (UniProtKB/Swiss-Prot),   D2CGC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000477970   ⟸   ENST00000621425
RefSeq Acc Id: ENSP00000234961   ⟸   ENST00000234961
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41143-F1-model_v2 AlphaFold P41143 1-372 view protein structure

Promoters
RGD ID:6854750
Promoter ID:EPDNEW_H540
Type:initiation region
Name:OPRD1_1
Description:opioid receptor delta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38128,812,170 - 28,812,230EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:8153 AgrOrtholog
COSMIC OPRD1 COSMIC
Ensembl Genes ENSG00000116329 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000234961 ENTREZGENE
  ENST00000234961.7 UniProtKB/Swiss-Prot
Gene3D-CATH 6.20.400.20 UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000116329 GTEx
HGNC ID HGNC:8153 ENTREZGENE
Human Proteome Map OPRD1 Human Proteome Map
InterPro Delta_opi_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Opioid_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4985 UniProtKB/Swiss-Prot
NCBI Gene 4985 ENTREZGENE
OMIM 165195 OMIM
PANTHER DELTA-TYPE OPIOID RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NEUROPEPTIDES RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB OPRD1 RGD, PharmGKB
PRINTS DELTAOPIOIDR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OPIOIDR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A346G5W5_HUMAN UniProtKB/TrEMBL
  A0A346G5W6_HUMAN UniProtKB/TrEMBL
  A0A346G5W7_HUMAN UniProtKB/TrEMBL
  A0A346G5W8_HUMAN UniProtKB/TrEMBL
  B5B0B8 ENTREZGENE
  D2CGC9 ENTREZGENE, UniProtKB/TrEMBL
  OPRD_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary B5B0B8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-12 OPRD1  opioid receptor delta 1    opioid receptor, delta 1  Symbol and/or name change 5135510 APPROVED