PARP1 (poly(ADP-ribose) polymerase 1) - Rat Genome Database

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Gene: PARP1 (poly(ADP-ribose) polymerase 1) Pan paniscus
Analyze
Symbol: PARP1
Name: poly(ADP-ribose) polymerase 1
RGD ID: 12016268
Description: ENCODES a protein that exhibits histone deacetylase binding (ortholog); NAD binding (ortholog); NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity (ortholog); INVOLVED IN base-excision repair (ortholog); behavioral response to cocaine (ortholog); carbohydrate biosynthetic process (ortholog); PARTICIPATES IN ADP-ribosylation pathway, mono and poly-ribosylation; ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Experimental Pancreatitis (ortholog); acute kidney failure (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: poly [ADP-ribose] polymerase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2123,130,083 - 23,178,179 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1123,078,568 - 23,126,669 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01201,820,355 - 201,867,673 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11206,812,981 - 206,860,356 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1206,812,981 - 206,860,356 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Experimental Pancreatitis  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
adult respiratory distress syndrome  (ISO)
alopecia  (ISO)
Alveolar Bone Loss  (ISO)
Alzheimer's disease  (ISO)
anemia  (ISO)
arthritis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autoimmune disease  (ISO)
bacterial meningitis  (ISO)
borna disease  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
cardiomyopathy  (ISO)
Carotid Artery Injuries  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
dermatitis  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Mammary Neoplasms  (ISO)
Fibrosis  (ISO)
gastrointestinal stromal tumor  (ISO)
glomerulonephritis  (ISO)
hepatitis  (ISO)
hepatocellular carcinoma  (ISO)
hereditary renal cell carcinoma  (ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
Inflammation  (ISO)
intellectual disability  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
kyphosis  (ISO)
leiomyoma  (ISO)
liver cirrhosis  (ISO)
Lung Injury  (ISO)
malignant mesothelioma  (ISO)
melanoma  (ISO)
middle cerebral artery infarction  (ISO)
multiple myeloma  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neointima  (ISO)
Neoplastic Cell Transformation  (ISO)
nephritis  (ISO)
neuronal ceroid lipofuscinosis 1  (ISO)
obesity  (ISO)
pancreatitis  (ISO)
Paralysis  (ISO)
parathyroid carcinoma  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
perinatal necrotizing enterocolitis  (ISO)
periodontitis  (ISO)
periventricular leukomalacia  (ISO)
Plaque, Atherosclerotic  (ISO)
pneumonia  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary edema  (ISO)
pulmonary fibrosis  (ISO)
Reperfusion Injury  (ISO)
Spinal Cord Injuries  (ISO)
Spinal Cord Ischemia  (ISO)
Stevens-Johnson syndrome  (ISO)
stomach cancer  (ISO)
stomach carcinoma  (ISO)
systemic lupus erythematosus  (ISO)
toxic shock syndrome  (ISO)
transient cerebral ischemia  (ISO)
traumatic brain injury  (ISO)
type 2 diabetes mellitus  (ISO)
ureteral obstruction  (ISO)
Vitamin A Deficiency  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
ATP generation from poly-ADP-D-ribose  (IEA)
base-excision repair  (ISO)
behavioral response to cocaine  (ISO)
carbohydrate biosynthetic process  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to insulin stimulus  (IEA)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to oxidative stress  (IEA,ISO)
cellular response to superoxide  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to UV  (IEA)
cellular response to zinc ion  (ISO)
decidualization  (ISO)
DNA ADP-ribosylation  (IEA)
DNA damage response  (IEA,ISO)
DNA metabolic process  (ISO)
DNA repair  (IEA)
double-strand break repair  (IEA,ISO)
innate immune response  (IEA)
mitochondrial DNA metabolic process  (IEA,ISO)
mitochondrial DNA repair  (IEA,ISO)
mitochondrion organization  (IEA,ISO)
negative regulation of adipose tissue development  (ISO)
negative regulation of ATP biosynthetic process  (IEA)
negative regulation of cGAS/STING signaling pathway  (IEA)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of innate immune response  (IEA)
negative regulation of interleukin-17 production  (ISO)
negative regulation of telomere maintenance via telomere lengthening  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA)
negative regulation of transcription elongation by RNA polymerase II  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of cardiac muscle hypertrophy  (ISO)
positive regulation of cellular process  (ISO)
positive regulation of DNA-templated transcription, elongation  (IEA)
positive regulation of double-strand break repair via homologous recombination  (IEA)
positive regulation of intracellular estrogen receptor signaling pathway  (ISO)
positive regulation of mitochondrial depolarization  (ISO)
positive regulation of myofibroblast differentiation  (ISO)
positive regulation of necroptotic process  (ISO)
positive regulation of protein localization to nucleus  (ISO)
positive regulation of single strand break repair  (IEA)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
protein auto-ADP-ribosylation  (IEA)
protein autoprocessing  (ISO)
protein localization to chromatin  (IEA)
protein modification process  (IEA,ISO)
protein poly-ADP-ribosylation  (IEA,ISO)
regulation of base-excision repair  (IEA)
regulation of catalytic activity  (IEA)
regulation of circadian sleep/wake cycle, non-REM sleep  (ISO)
regulation of growth rate  (ISO)
regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (ISO)
regulation of protein localization  (IEA,ISO)
regulation of single strand break repair  (ISO)
replication fork reversal  (IEA)
response to aldosterone  (ISO)
response to gamma radiation  (ISO)
signal transduction involved in regulation of gene expression  (ISO)
telomere maintenance  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)
voluntary musculoskeletal movement  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PARP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2123,130,083 - 23,178,179 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1123,078,568 - 23,126,669 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01201,820,355 - 201,867,673 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11206,812,981 - 206,860,356 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1206,812,981 - 206,860,356 (-)Ensemblpanpan1.1panPan2
PARP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381226,360,691 - 226,408,093 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1226,360,210 - 226,408,154 (-)EnsemblGRCh38hg38GRCh38
GRCh371226,548,392 - 226,595,794 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361224,615,015 - 224,662,424 (-)NCBINCBI36Build 36hg18NCBI36
Build 341222,855,240 - 222,902,526NCBI
Celera1199,739,310 - 199,786,722 (-)NCBICelera
Cytogenetic Map1q42.12NCBI
HuRef1197,065,678 - 197,113,094 (-)NCBIHuRef
CHM1_11227,821,256 - 227,868,667 (-)NCBICHM1_1
T2T-CHM13v2.01225,548,804 - 225,596,198 (-)NCBIT2T-CHM13v2.0
Parp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391180,396,456 - 180,428,564 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1180,396,489 - 180,428,819 (+)EnsemblGRCm39 Ensembl
GRCm381180,568,891 - 180,600,999 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1180,568,924 - 180,601,254 (+)EnsemblGRCm38mm10GRCm38
MGSCv371182,499,106 - 182,531,385 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361182,405,650 - 182,437,929 (+)NCBIMGSCv36mm8
Celera1187,634,811 - 187,667,071 (+)NCBICelera
Cytogenetic Map1H4NCBI
cM Map184.44NCBI
Parp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81394,839,484 - 94,871,295 (+)NCBIGRCr8
mRatBN7.21392,307,593 - 92,339,406 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1392,307,586 - 92,339,404 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1394,812,753 - 94,844,565 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01396,212,939 - 96,244,750 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01393,387,644 - 93,419,455 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01398,857,255 - 98,889,444 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1398,857,177 - 98,889,716 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013103,859,760 - 103,891,949 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41396,309,670 - 96,341,486 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11396,498,605 - 96,530,421 (+)NCBI
Celera1391,853,812 - 91,885,580 (+)NCBICelera
Cytogenetic Map13q26NCBI
Parp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955489520,875 - 557,615 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955489520,875 - 557,609 (-)NCBIChiLan1.0ChiLan1.0
PARP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1738,503,072 - 38,542,556 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl738,503,067 - 38,542,127 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha737,984,470 - 38,024,231 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0738,336,543 - 38,376,496 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl738,336,478 - 38,376,795 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1738,175,521 - 38,215,272 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0738,182,459 - 38,222,219 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0738,453,305 - 38,493,301 (+)NCBIUU_Cfam_GSD_1.0
Parp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934451,599,711 - 51,644,827 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365263,102,039 - 3,147,642 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365263,102,468 - 3,147,601 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PARP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1014,203,160 - 14,241,196 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11014,203,157 - 14,241,164 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21016,598,164 - 16,636,214 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PARP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1253,350,798 - 3,405,040 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660553,353,198 - 3,400,806 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Parp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624807446,647 - 479,069 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624807446,662 - 478,571 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003814928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000059059   ⟹   ENSPPAP00000036168
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1206,812,981 - 206,860,356 (-)Ensembl
RefSeq Acc Id: XM_003814928   ⟹   XP_003814976
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2123,130,083 - 23,178,179 (+)NCBI
NHGRI_mPanPan1123,078,568 - 23,126,669 (+)NCBI
Mhudiblu_PPA_v01201,820,355 - 201,867,673 (-)NCBI
PanPan1.11206,812,981 - 206,860,356 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003814976 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000036168
  ENSPPAP00000036168.1
RefSeq Acc Id: XP_003814976   ⟸   XM_003814928
- UniProtKB: A0A2R9C5K0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000036168   ⟸   ENSPPAT00000059059
Protein Domains
BRCT   PARP alpha-helical   PARP catalytic   PARP-type   WGR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000040862 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000059059.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.130 UniProtKB/TrEMBL
  1.20.142.10 UniProtKB/TrEMBL
  2.20.25.630 UniProtKB/TrEMBL
  3.30.1740.10 UniProtKB/TrEMBL
  3.40.50.10190 UniProtKB/TrEMBL
  3.90.228.10 UniProtKB/TrEMBL
InterPro ARTD/PARP UniProtKB/TrEMBL
  BRCT_dom UniProtKB/TrEMBL
  BRCT_dom_sf UniProtKB/TrEMBL
  PADR1 UniProtKB/TrEMBL
  PADR1_dom_sf UniProtKB/TrEMBL
  PARP UniProtKB/TrEMBL
  PARP1-like_PADR1_N UniProtKB/TrEMBL
  Poly(ADP-ribose)pol_cat_dom UniProtKB/TrEMBL
  Poly(ADP-ribose)pol_reg_dom UniProtKB/TrEMBL
  Poly(ADP-ribose)pol_reg_dom_sf UniProtKB/TrEMBL
  WGR_dom_sf UniProtKB/TrEMBL
  WGR_domain UniProtKB/TrEMBL
  Znf_PARP UniProtKB/TrEMBL
  Znf_PARP_sf UniProtKB/TrEMBL
KEGG Report pps:100973976 UniProtKB/TrEMBL
NCBI Gene PARP1 ENTREZGENE
PANTHER DNA LIGASE UniProtKB/TrEMBL
  POLY [ADP-RIBOSE] POLYMERASE 1 UniProtKB/TrEMBL
Pfam BRCT UniProtKB/TrEMBL
  PADR1 UniProtKB/TrEMBL
  PADR1_N UniProtKB/TrEMBL
  PARP UniProtKB/TrEMBL
  PARP_reg UniProtKB/TrEMBL
  WGR UniProtKB/TrEMBL
  zf-PARP UniProtKB/TrEMBL
PIRSF NAD_ADPRT UniProtKB/TrEMBL
PROSITE BRCT UniProtKB/TrEMBL
  PADR1 UniProtKB/TrEMBL
  PARP_ALPHA_HD UniProtKB/TrEMBL
  PARP_CATALYTIC UniProtKB/TrEMBL
  PARP_ZN_FINGER_1 UniProtKB/TrEMBL
  PARP_ZN_FINGER_2 UniProtKB/TrEMBL
  WGR UniProtKB/TrEMBL
SMART BRCT UniProtKB/TrEMBL
  PADR1 UniProtKB/TrEMBL
  WGR UniProtKB/TrEMBL
  zf-PARP UniProtKB/TrEMBL
Superfamily-SCOP ADP-ribosylation UniProtKB/TrEMBL
  Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/TrEMBL
  SSF142921 UniProtKB/TrEMBL
  SSF47587 UniProtKB/TrEMBL
  SSF52113 UniProtKB/TrEMBL
UniProt A0A2R9C5K0 ENTREZGENE, UniProtKB/TrEMBL