PTGER3 (prostaglandin E receptor 3) - Rat Genome Database

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Gene: PTGER3 (prostaglandin E receptor 3) Pan paniscus
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Symbol: PTGER3
Name: prostaglandin E receptor 3
RGD ID: 11692851
Description: ENCODES a protein that exhibits prostaglandin E receptor activity (ortholog); INVOLVED IN adenylate cyclase-modulating G protein-coupled receptor signaling pathway (ortholog); bicarbonate transport (ortholog); cAMP biosynthetic process (ortholog); ASSOCIATED WITH asthma (ortholog); Brain Injuries (ortholog); cicatricial pemphigoid (ortholog); FOUND IN brush border membrane (ortholog); cell surface (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: prostaglandin E2 receptor EP3 subtype
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21155,837,765 - 156,032,636 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11154,996,361 - 155,091,432 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0170,076,610 - 70,271,475 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1172,058,998 - 72,254,063 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl172,059,441 - 72,254,063 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (ISO)
bicarbonate transport  (ISO)
cAMP biosynthetic process  (ISO)
cAMP/PKA signal transduction  (ISO)
cellular response to forskolin  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to prostaglandin E stimulus  (ISO)
desensitization of G protein-coupled receptor signaling pathway  (ISO)
female pregnancy  (ISO)
fever generation  (ISO)
G protein-coupled receptor signaling pathway  (IEA)
inflammatory response  (IEA)
intestine smooth muscle contraction  (IEA,ISO)
maternal process involved in parturition  (ISO)
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
negative regulation of calcium ion transmembrane transport  (ISO)
negative regulation of circadian sleep/wake cycle, wakefulness  (ISO)
negative regulation of forebrain neuron differentiation  (ISO)
negative regulation of gastric acid secretion  (IEA)
negative regulation of gastrin-induced gastric acid secretion  (ISO)
negative regulation of insulin secretion  (ISO)
negative regulation of norepinephrine secretion  (ISO)
negative regulation of potassium ion transmembrane transport  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
positive regulation of calcitonin secretion  (ISO)
positive regulation of circadian sleep/wake cycle, non-REM sleep  (ISO)
positive regulation of colon smooth muscle contraction  (ISO)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO)
positive regulation of fever generation  (ISO)
positive regulation of gastric mucosal blood circulation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of inhibitory G protein-coupled receptor phosphorylation  (ISO)
positive regulation of myofibroblast contraction  (ISO)
positive regulation of neutrophil extravasation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle contraction involved in micturition  (ISO)
positive regulation of substance P secretion  (ISO)
positive regulation of urine volume  (ISO)
positive regulation of vasoconstriction  (ISO)
prostaglandin receptor internalization  (ISO)
receptor internalization  (ISO)
regulation of circadian sleep/wake cycle, wakefulness  (ISO)
regulation of norepinephrine secretion  (ISO)
response to estradiol  (ISO)
response to lipopolysaccharide  (ISO)
response to progesterone  (ISO)
response to salt  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)
urinary bladder smooth muscle contraction  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PTGER3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21155,837,765 - 156,032,636 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11154,996,361 - 155,091,432 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0170,076,610 - 70,271,475 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1172,058,998 - 72,254,063 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl172,059,441 - 72,254,063 (-)Ensemblpanpan1.1panPan2
PTGER3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38170,852,358 - 71,047,816 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl170,852,353 - 71,047,816 (-)EnsemblGRCh38hg38GRCh38
GRCh37171,318,041 - 71,513,499 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,090,624 - 71,286,079 (-)NCBINCBI36Build 36hg18NCBI36
Build 34171,188,848 - 71,225,512NCBI
Celera169,607,257 - 69,802,711 (-)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef169,428,653 - 69,623,748 (-)NCBIHuRef
CHM1_1171,432,956 - 71,628,842 (-)NCBICHM1_1
T2T-CHM13v2.0170,730,386 - 70,925,810 (-)NCBIT2T-CHM13v2.0
Ptger3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393157,272,459 - 157,350,392 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3157,272,529 - 157,351,525 (+)EnsemblGRCm39 Ensembl
GRCm383157,566,821 - 157,644,758 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3157,566,892 - 157,645,888 (+)EnsemblGRCm38mm10GRCm38
MGSCv373157,229,856 - 157,307,722 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363157,502,185 - 157,580,051 (+)NCBIMGSCv36mm8
Celera3164,034,893 - 164,113,113 (+)NCBICelera
Cytogenetic Map3H4NCBI
cM Map381.32NCBI
Ptger3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82249,264,985 - 249,409,966 (+)NCBIGRCr8
mRatBN7.22246,606,131 - 246,750,970 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2246,606,183 - 246,684,434 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2254,318,634 - 254,403,084 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02252,212,449 - 252,296,915 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02247,184,945 - 247,269,307 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02263,895,093 - 263,979,682 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2263,895,241 - 263,979,698 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02282,614,936 - 282,760,641 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42255,680,691 - 255,759,202 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12255,695,297 - 255,773,809 (+)NCBI
Celera2238,415,230 - 238,493,209 (+)NCBICelera
Cytogenetic Map2q45NCBI
Ptger3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542321,096,926 - 21,164,435 (+)NCBIChiLan1.0ChiLan1.0
PTGER3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1674,932,789 - 74,986,573 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha677,575,622 - 77,753,496 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0675,490,852 - 75,668,770 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl675,490,852 - 75,714,812 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1675,042,922 - 75,220,964 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0674,940,272 - 75,118,118 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0675,437,418 - 75,616,001 (+)NCBIUU_Cfam_GSD_1.0
Ptger3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505883,239,312 - 83,315,450 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365911,174,069 - 1,249,410 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365911,174,364 - 1,250,233 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGER3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6141,958,955 - 142,161,286 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16141,958,955 - 142,160,437 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26131,574,664 - 131,776,520 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTGER3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12062,093,830 - 62,293,360 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2062,095,458 - 62,174,959 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603355,495,971 - 55,576,801 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptger3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474225,177,340 - 25,356,911 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000063682   ⟹   ENSPPAP00000040763
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl172,059,441 - 72,253,857 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000063689   ⟹   ENSPPAP00000040770
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl172,059,484 - 72,253,857 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000063691   ⟹   ENSPPAP00000040772
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl172,160,433 - 72,253,857 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000063692   ⟹   ENSPPAP00000040773
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl172,178,278 - 72,253,857 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000063695   ⟹   ENSPPAP00000040776
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl172,203,686 - 72,253,857 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000063700   ⟹   ENSPPAP00000040781
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl172,218,730 - 72,254,063 (-)Ensembl
RefSeq Acc Id: XM_003830598   ⟹   XP_003830646
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21155,837,765 - 155,932,841 (+)NCBI
NHGRI_mPanPan11154,996,361 - 155,091,432 (+)NCBI
Mhudiblu_PPA_v0170,176,405 - 70,271,475 (-)NCBI
PanPan1.1172,159,078 - 72,254,063 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014345714   ⟹   XP_014201200
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21155,837,765 - 155,916,873 (+)NCBI
NHGRI_mPanPan11154,996,361 - 155,075,463 (+)NCBI
Mhudiblu_PPA_v0170,193,101 - 70,271,475 (-)NCBI
PanPan1.1172,177,446 - 72,254,057 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063607265   ⟹   XP_063463335
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21155,837,765 - 156,032,636 (+)NCBI
RefSeq Acc Id: XP_003830646   ⟸   XM_003830598
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CIC2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_014201200   ⟸   XM_014345714
- Peptide Label: isoform X2
- UniProtKB: A0A2R9CIB3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000040763   ⟸   ENSPPAT00000063682
Ensembl Acc Id: ENSPPAP00000040770   ⟸   ENSPPAT00000063689
Ensembl Acc Id: ENSPPAP00000040772   ⟸   ENSPPAT00000063691
Ensembl Acc Id: ENSPPAP00000040773   ⟸   ENSPPAT00000063692
Ensembl Acc Id: ENSPPAP00000040776   ⟸   ENSPPAT00000063695
Ensembl Acc Id: ENSPPAP00000040781   ⟸   ENSPPAT00000063700
RefSeq Acc Id: XP_063463335   ⟸   XM_063607265
- Peptide Label: isoform X3
- UniProtKB: A0A2R9CIC2 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000043015 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000063682.1 UniProtKB/TrEMBL
  ENSPPAT00000063689.1 UniProtKB/TrEMBL
  ENSPPAT00000063691.1 UniProtKB/TrEMBL
  ENSPPAT00000063692.1 UniProtKB/TrEMBL
  ENSPPAT00000063695.1 UniProtKB/TrEMBL
  ENSPPAT00000063700.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro EP3_rcpt_2 UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
  Prostanoid_rcpt UniProtKB/TrEMBL
  Prostglndn_DP_rcpt UniProtKB/TrEMBL
  Prostglndn_EP3_rcpt UniProtKB/TrEMBL
NCBI Gene PTGER3 ENTREZGENE
PANTHER PTHR11866 UniProtKB/TrEMBL
  PTHR11866:SF10 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS GPCRRHODOPSN UniProtKB/TrEMBL
  PROSTAGLNDNR UniProtKB/TrEMBL
  PROSTANOIDR UniProtKB/TrEMBL
  PRSTNOIDE32R UniProtKB/TrEMBL
  PRSTNOIDEP3R UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A2R9CFN2_PANPA UniProtKB/TrEMBL
  A0A2R9CFN5_PANPA UniProtKB/TrEMBL
  A0A2R9CFQ1_PANPA UniProtKB/TrEMBL
  A0A2R9CIB3 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CIC2 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CQ64_PANPA UniProtKB/TrEMBL