ID3 (inhibitor of DNA binding 3) - Rat Genome Database

Name: ID3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: ID3 (inhibitor of DNA binding 3) Pan paniscus

Analyze

Symbol:

ID3

Name:

inhibitor of DNA binding 3

RGD ID:

11959011

Description:

ENCODES a protein that exhibits bHLH transcription factor binding (inferred); leptomycin B binding (inferred); protein dimerization activity (inferred); INVOLVED IN cellular response to leptomycin B (ortholog); epithelial cell differentiation (ortholog); heart development (ortholog); ASSOCIATED WITH 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency (ortholog); adenocarcinoma (ortholog); Animal Mammary Neoplasms (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DNA-binding protein inhibitor ID-3

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	203,379,403 - 203,384,318 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	202,485,663 - 202,487,260 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	22,748,714 - 22,750,582 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	23,734,263 - 23,736,175 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	23,734,263 - 23,736,175 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency (ISO)

adenocarcinoma (ISO)

Animal Mammary Neoplasms (ISO)

Burkitt lymphoma (ISO)

carcinoma (ISO)

Colonic Neoplasms (ISO)

Experimental Mammary Neoplasms (ISO)

genetic disease (ISO)

hereditary breast ovarian cancer syndrome (ISO)

Lung Neoplasms (ISO)

Myocardial Ischemia (ISO)

nervous system disease (ISO)

Prostatic Neoplasms (ISO)

Reperfusion Injury (ISO)

Sjogren's syndrome (ISO)

Spinal Cord Injuries (ISO)

thyroid gland disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IEA)

cellular response to leptomycin B (IEA,ISO)

central nervous system development (IEA)

circadian regulation of gene expression (IEA)

circadian rhythm (IEA)

epithelial cell differentiation (IEA,ISO)

heart development (IEA,ISO)

metanephros development (IEA)

negative regulation of DNA-templated transcription (IEA)

negative regulation of gene expression (IEA,ISO)

negative regulation of myoblast differentiation (IEA)

negative regulation of osteoblast differentiation (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

neuron differentiation (ISO)

notochord development (IEA)

odontogenesis (IEA)

positive regulation of apoptotic process (ISO)

positive regulation of gene expression (IEA)

regulation of DNA replication (ISO)

Cellular Component

cytoplasm (IEA)

nucleus (IEA)

Molecular Function

bHLH transcription factor binding (IEA)

leptomycin B binding (IEA)

protein binding (ISO)

protein dimerization activity (IEA)

protein domain specific binding (IEA)

transcription regulator inhibitor activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

ID3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	203,379,403 - 203,384,318 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	202,485,663 - 202,487,260 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	22,748,714 - 22,750,582 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	23,734,263 - 23,736,175 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	23,734,263 - 23,736,175 (-)	Ensembl	panpan1.1		panPan2

ID3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	23,557,926 - 23,559,501 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	23,557,926 - 23,559,501 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	23,884,417 - 23,885,992 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	23,756,996 - 23,758,909 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	23,629,761 - 23,631,591	NCBI
Celera	1	22,214,113 - 22,216,026 (-)	NCBI		Celera
Cytogenetic Map	1	p36.12	NCBI
HuRef	1	22,134,776 - 22,136,609 (-)	NCBI		HuRef
CHM1_1	1	23,997,097 - 23,998,961 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	23,392,495 - 23,394,070 (-)	NCBI		T2T-CHM13v2.0

Id3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	135,871,133 - 135,872,703 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	135,870,808 - 135,873,066 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	136,143,822 - 136,145,392 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	136,143,497 - 136,145,755 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	135,699,737 - 135,701,307 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	135,415,898 - 135,417,463 (+)	NCBI		MGSCv36	mm8
Celera	4	134,340,192 - 134,341,762 (+)	NCBI		Celera
Cytogenetic Map	4	D3	NCBI
cM Map	4	68.34	NCBI

Id3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	153,656,253 - 153,657,860 (+)	NCBI		GRCr8
mRatBN7.2	5	148,372,784 - 148,374,353 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	148,372,762 - 148,374,349 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	151,069,678 - 151,071,250 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	152,843,951 - 152,845,523 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	152,825,974 - 152,827,546 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	154,489,603 - 154,491,172 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	154,489,590 - 154,491,223 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	158,263,323 - 158,264,892 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	154,934,138 - 154,935,707 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	154,944,176 - 154,945,745 (+)	NCBI
Celera	5	146,776,457 - 146,778,028 (+)	NCBI		Celera
RH 3.4 Map	5	1002.7	RGD
Cytogenetic Map	5	q36	NCBI

Id3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955452	3,537,021 - 3,560,954 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955452	3,537,352 - 3,538,921 (-)	NCBI	ChiLan1.0	ChiLan1.0

ID3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	2	75,880,659 - 75,881,786 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	2	75,880,657 - 75,882,010 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	2	72,450,690 - 72,451,818 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	2	76,440,035 - 76,441,163 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	2	76,440,029 - 76,441,446 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	2	73,262,350 - 73,263,478 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	2	74,269,394 - 74,270,528 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	2	75,274,965 - 75,276,093 (+)	NCBI		UU_Cfam_GSD_1.0

Id3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	42,933,316 - 42,934,892 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	8,758,030 - 8,759,823 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	8,758,098 - 8,759,684 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ID3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	81,422,546 - 81,424,075 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	81,422,541 - 81,424,169 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

ID3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	109,120,403 - 109,122,269 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	109,120,691 - 109,123,210 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	7,205,391 - 7,212,042 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Id3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624764	8,175,372 - 8,177,451 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624764	8,175,841 - 8,177,444 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003810755	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000012491 ⟹ ENSPPAP00000002630

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	23,734,263 - 23,736,175 (-)	Ensembl

RefSeq Acc Id:

XM_003810755 ⟹ XP_003810803

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	203,379,403 - 203,384,318 (+)	NCBI
NHGRI_mPanPan1	1	202,485,663 - 202,487,260 (+)	NCBI
Mhudiblu_PPA_v0	1	22,748,714 - 22,750,582 (-)	NCBI
PanPan1.1	1	23,734,263 - 23,736,175 (-)	NCBI

Sequence:

show sequence

GTGTTGGGCTAAAGGCGGACTGGCAGGGGGCCGGGAAGCTCAAAGATCTGGGGCGCTGCCAGGA
AAAAGCAAATTCTGGAAGTTAATGGTTTTGAGTGATTTTTAAATCCTTGCTGGCGGAGAGGCCC
GCCTCTCCCCAGTATCAGCGCTTCCTCATTCTTTGAATCTGCGGCTCCGCGGTCTTCGGCGTCA
GACCAGCCGGAGGAAGCCTGTTTGCAATTTAAGCGGGCTGTGAACGCCCAGGGCCGGCGGGGGC
GGGGCCGAGGCGGGCCATTTTGAATAAAGAGGCGTGCCTTCCAGGCAAGCTCTATAAGTGCCCG
CGGCGGCGAGCGTGCGCGCGTTGCAGGTCACTGTAGCGGGACTTCTTTTGGTTTTCTTTCTTTT
TGGGGCACCTCTGAACTCACTCCCCAGCATGAAGGCGCTGAGCCCGGTGCGCGGCTGCTACGAG
GCGGTGTGCTGCCTGTCGGAACGCAGTCTGGCCATCGCCCGGGGCCGAGGGAAGGGCCCGGCAG
CTGAGGAGCCGCTGAGCTTGCTGGACGACATGAACCACTGCTACTCCCGCCTGCGGGAACTGGT
ACCCGGAGTCCCGAGAGGCACTCAGCTTAGCCAGGTGGAAATCCTACAGCGCGTCATCGACTAC
ATTCTCGACCTGCAGGTAGTCCTGGCTGAGCCAGTCCCTGGACCCCCTGATGGCCCCCACCTTC
CCATCCAGACAGCCGAGCTCGCTCCGGAACTTGTCATCTCCAACGACAAAAGGAGCTTTTGCCA
CTGACTCGGCCGTGTCCTGACACCTCCAGAACGCAGGTGCTGGCGCCCGTTCTGCCTGGGACCC
CGGGAACCTCTCCTGCCGGAAGCCGGACGGCAGGGATGGGCCCCAACTTCGCCCTGCCCACTTG
ACTTCACCAAACCCCTTCCTGGAGACTGAACCTGGTGCTCAGGAGCGAAGGACTGTGAACTTGT
GGCCTGAAGAGCCAGAGCTAGCTCTGGCCACCAGCTGGGCGACGTCACCCTGCTCCCACCCCAC
CCCCAAGTTCTAAGGTCTTTTCAGAGCGTGGAGGTGTGGAAGGAGTGGCTGCTCTCCAAACTAT
GCCAAGGCGGCGGCAGAGCTGGTCTTCTGGTCTCCTTGGAGAAAGGTTCTGTTGCCCTGATTTA
TGAACTCTATAATAGAGTATATAGGTTTTGTACCTTTTTTACGGGAAGGTGACTTTCTGTAACA
ATGCGATGTATATTAAACTTTTTATAAAAGTTAACATTTTGCATAATAAACGATTTTTAAACAC
TTATGTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003810803	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000002630
	ENSPPAP00000002630.1

RefSeq Acc Id:	XP_003810803 ⟸ XM_003810755
- UniProtKB:	A0A2R8ZC46 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKALSPVRGCYEAVCCLSERSLAIARGRGKGPAAEEPLSLLDDMNHCYSRLRELVPGVPRGTQL SQVEILQRVIDYILDLQVVLAEPVPGPPDGPHLPIQTAELAPELVISNDKRSFCH hide sequence

RefSeq Acc Id:

ENSPPAP00000002630 ⟸ ENSPPAT00000012491

Protein Domains

bHLH

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000011462	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000012491.1	UniProtKB/TrEMBL
Gene3D-CATH	4.10.280.10	UniProtKB/TrEMBL
InterPro	bHLH_dom	UniProtKB/TrEMBL
	DNA-bd_prot-inh	UniProtKB/TrEMBL
	HLH_DNA-bd_sf	UniProtKB/TrEMBL
KEGG Report	pps:100984742	UniProtKB/TrEMBL
NCBI Gene	ID3	ENTREZGENE
PANTHER	DNA-BINDING PROTEIN INHIBITOR ID-3	UniProtKB/TrEMBL
	PTHR11723	UniProtKB/TrEMBL
Pfam	HLH	UniProtKB/TrEMBL
PROSITE	BHLH	UniProtKB/TrEMBL
SMART	HLH	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47459	UniProtKB/TrEMBL
UniProt	A0A2R8ZC46	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-04-25	ID3	inhibitor of DNA binding 3	ID3	inhibitor of DNA binding 3, HLH protein	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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