AHR (aryl hydrocarbon receptor) - Rat Genome Database

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Gene: AHR (aryl hydrocarbon receptor) Pan paniscus
Analyze
Symbol: AHR
Name: aryl hydrocarbon receptor
RGD ID: 11708998
Description: ENCODES a protein that exhibits arachidonate omega-hydroxylase activity (ortholog); aryl hydrocarbon receptor binding (ortholog); DNA-binding transcription factor activity, RNA polymerase II-specific (ortholog); INVOLVED IN aflatoxin metabolic process (ortholog); B cell homeostasis (ortholog); blood circulation (ortholog); PARTICIPATES IN aryl hydrocarbon receptor signaling pathway; ASSOCIATED WITH acanthosis nigricans (ortholog); Adult Pancreatic Cancer (ortholog); alcohol dependence (ortholog); FOUND IN cytoplasm (ortholog); nuclear aryl hydrocarbon receptor complex (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2622,129,950 - 22,179,006 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1770,455,241 - 70,502,308 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0717,949,254 - 17,998,737 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1717,278,637 - 17,326,171 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl717,278,637 - 17,326,171 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acanthosis nigricans  (ISO)
Adult Pancreatic Cancer  (ISO)
alcohol dependence  (ISO)
alcoholic hepatitis  (ISO)
Alcoholic Liver Diseases  (ISO)
Animal Disease Models  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
Atrophy  (ISO)
autism spectrum disorder  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
Behcet's disease  (ISO)
Birth Weight  (ISO)
bladder calculus  (ISO)
bone disease  (ISO)
bone resorption disease  (ISO)
Breast Neoplasms  (ISO)
Cardiac Fibrosis  (ISO)
Cardiomegaly  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Intermittent Hypoxia  (ISO)
chronic kidney disease  (ISO)
Chronobiology Disorders  (ISO)
colitis  (ISO)
congenital heart disease  (ISO)
congenital nystagmus  (ISO)
contact dermatitis  (ISO)
Craniofacial Abnormalities  (ISO)
disease of cellular proliferation  (ISO)
disease of metabolism  (ISO)
Dyslipidemias  (ISO)
Edema  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Neoplasms  (ISO)
Female Infertility  (ISO)
Foveal Hypoplasia 3  (ISO)
glucose intolerance  (ISO)
Growth Disorders  (ISO)
Hepatomegaly  (ISO)
Hyperoxia  (ISO)
Hyperpigmentation  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypertrophy  (ISO)
Hyperventilation  (ISO)
hypoglycemia  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
Intestinal Reperfusion Injury  (ISO)
keratosis  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Injury  (ISO)
male infertility  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Myocardial Reperfusion Injury  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neoplasm Recurrence, Local  (ISO)
nephrotoxicity  (ISO)
nicotine dependence  (ISO)
non-alcoholic fatty liver  (ISO)
obesity  (ISO)
pancreatic cancer  (ISO)
Patent Ductus Venosus  (ISO)
peanut allergy  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
pneumonia  (ISO)
Prenatal Exposure Delayed Effects  (ISO)
Prostatic Neoplasms  (ISO)
Pruritus  (ISO)
Pulmonary Arterial Hypertension  (ISO)
pulmonary hypertension  (ISO)
Pulmonary Hypertension, Hypoxia-Induced  (ISO)
retinitis pigmentosa 85  (ISO)
rheumatoid arthritis  (ISO)
Salmonella Infections, Animal  (ISO)
silicosis  (ISO)
splenic disease  (ISO)
Splenomegaly  (ISO)
Spontaneous Abortions  (ISO)
Stomach Neoplasms  (ISO)
Tachycardia  (ISO)
Teratogenesis  (ISO)
transient cerebral ischemia  (ISO)
traumatic brain injury  (ISO)
Ureteral Neoplasms  (ISO)
vascular disease  (ISO)
Ventricular Remodeling  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aflatoxin metabolic process  (ISO)
B cell homeostasis  (ISO)
blood circulation  (ISO)
blood vessel development  (ISO)
blood vessel morphogenesis  (ISO)
blood vessel remodeling  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
camera-type eye development  (ISO)
cardiac left ventricle morphogenesis  (ISO)
cell morphogenesis  (ISO)
cellular response to 2,3,7,8-tetrachlorodibenzodioxine  (IEA)
cellular response to 3-methylcholanthrene  (ISO)
cellular response to cAMP  (IEA)
cellular response to dexamethasone stimulus  (ISO)
cellular response to forskolin  (IEA)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to molecule of bacterial origin  (IEA)
cellular response to toxic substance  (ISO)
circadian regulation of gene expression  (ISO)
circadian rhythm  (ISO)
circumferential growth involved in left ventricle morphogenesis  (ISO)
conditioned taste aversion  (ISO)
contact inhibition  (ISO)
estrogen receptor signaling pathway  (ISO)
female pregnancy  (ISO)
gland development  (ISO)
glomerulus morphogenesis  (ISO)
immune system process  (ISO)
intracellular receptor signaling pathway  (IEA)
kidney morphogenesis  (ISO)
liver development  (ISO)
lymphocyte homeostasis  (ISO)
mammary duct terminal end bud growth  (ISO)
negative regulation of alkaline phosphatase activity  (ISO)
negative regulation of calcium ion transmembrane transport  (ISO)
negative regulation of DNA biosynthetic process  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of epithelial cell proliferation  (ISO)
negative regulation of inflammatory response  (IEA)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of osteoblast proliferation  (ISO)
negative regulation of systemic arterial blood pressure  (ISO)
negative regulation of T cell mediated immune response to tumor cell  (IEA)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vasoconstriction  (ISO)
nitric oxide metabolic process  (ISO)
omega-hydroxylase P450 pathway  (ISO)
ovarian follicle development  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell size  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of growth rate  (ISO)
positive regulation of mating-type specific transcription, DNA-templated  (ISO)
positive regulation of RNA polymerase II transcription preinitiation complex assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA)
post-embryonic hemopoiesis  (ISO)
prostate gland development  (ISO)
protein localization to nucleus  (ISO)
reactive oxygen species biosynthetic process  (ISO)
regulation of adaptive immune response  (IEA)
regulation of B cell proliferation  (IEA)
regulation of cytokine production  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of eating behavior  (ISO)
regulation of gene expression  (IEA)
regulation of transcription by RNA polymerase II  (IEA)
reproductive structure development  (ISO)
response to arsenic-containing substance  (ISO)
response to estradiol  (ISO)
response to toxic substance  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)
rhythmic process  (IEA)
spleen development  (ISO)
T cell homeostasis  (ISO)
tissue remodeling  (ISO)
transcription by RNA polymerase II  (ISO)
vasculature development  (ISO)
xenobiotic metabolic process  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AHR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2622,129,950 - 22,179,006 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1770,455,241 - 70,502,308 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0717,949,254 - 17,998,737 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1717,278,637 - 17,326,171 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl717,278,637 - 17,326,171 (+)Ensemblpanpan1.1panPan2
AHR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38717,298,652 - 17,346,147 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl716,916,359 - 17,346,152 (+)EnsemblGRCh38hg38GRCh38
GRCh37717,338,276 - 17,385,771 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36717,304,832 - 17,352,299 (+)NCBINCBI36Build 36hg18NCBI36
Build 34717,111,485 - 17,158,632NCBI
Celera717,318,278 - 17,365,781 (+)NCBICelera
Cytogenetic Map7p21.1NCBI
HuRef717,224,763 - 17,272,268 (+)NCBIHuRef
CHM1_1717,339,112 - 17,386,607 (+)NCBICHM1_1
T2T-CHM13v2.0717,428,395 - 17,475,891 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2717,391,672 - 17,439,185 (+)NCBI
Ahr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391235,547,978 - 35,584,988 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1235,547,973 - 35,585,037 (-)EnsemblGRCm39 Ensembl
GRCm381235,497,979 - 35,534,989 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1235,497,974 - 35,535,038 (-)EnsemblGRCm38mm10GRCm38
MGSCv371236,182,651 - 36,219,661 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361236,083,094 - 36,119,976 (-)NCBIMGSCv36mm8
Celera1236,948,584 - 36,984,257 (-)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1215.78NCBI
Ahr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8657,961,423 - 57,998,901 (-)NCBIGRCr8
mRatBN7.2652,234,089 - 52,271,568 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl652,234,089 - 52,271,568 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx652,513,201 - 52,550,666 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0652,828,075 - 52,865,540 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0652,285,311 - 52,322,845 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0654,963,990 - 55,001,806 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl654,963,990 - 55,001,464 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0664,589,066 - 64,624,078 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4654,205,104 - 54,240,268 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1654,206,846 - 54,243,423 (-)NCBI
Celera651,391,870 - 51,429,719 (-)NCBICelera
RH 3.4 Map6350.2RGD
Cytogenetic Map6q16NCBI
Ahr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541020,428,546 - 20,456,836 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541020,428,531 - 20,459,482 (+)NCBIChiLan1.0ChiLan1.0
AHR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11431,743,704 - 31,793,484 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1431,686,170 - 31,791,444 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1431,264,779 - 31,314,544 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01431,661,762 - 31,711,544 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1431,661,088 - 31,711,540 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11431,766,284 - 31,816,050 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01431,476,179 - 31,525,758 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01431,792,396 - 31,842,188 (+)NCBIUU_Cfam_GSD_1.0
Ahr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511876,062,814 - 76,108,403 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365463,737,851 - 3,783,588 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365463,737,908 - 3,783,492 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AHR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl986,511,369 - 86,555,943 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1986,511,866 - 86,555,950 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2995,511,269 - 95,542,794 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AHR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12140,778,198 - 40,826,491 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2140,778,218 - 40,826,478 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604263,692,229 - 63,740,600 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ahr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473912,942,165 - 12,987,973 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473912,939,183 - 12,987,574 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000036855   ⟹   ENSPPAP00000014177
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl717,278,637 - 17,326,171 (+)Ensembl
RefSeq Acc Id: XM_003825022   ⟹   XP_003825070
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2622,129,950 - 22,179,006 (+)NCBI
NHGRI_mPanPan1770,455,241 - 70,502,308 (+)NCBI
Mhudiblu_PPA_v0717,951,539 - 17,998,737 (+)NCBI
PanPan1.1717,278,637 - 17,326,171 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003825070 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000014177
  ENSPPAP00000014177.1
RefSeq Acc Id: XP_003825070   ⟸   XM_003825022
- UniProtKB: A0A2R9AFN6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000014177   ⟸   ENSPPAT00000036855
Protein Domains
bHLH   PAS


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030245 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000036855.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
  PAS domain UniProtKB/TrEMBL
InterPro AHR UniProtKB/TrEMBL
  AHR/AHRR UniProtKB/TrEMBL
  bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  PAC UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/TrEMBL
  PAS_fold UniProtKB/TrEMBL
  PAS_fold_3 UniProtKB/TrEMBL
KEGG Report pps:100994782 UniProtKB/TrEMBL
NCBI Gene AHR ENTREZGENE
PANTHER PTHR10649 UniProtKB/TrEMBL
  PTHR10649:SF9 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS_3 UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
  PAC UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
  SSF55785 UniProtKB/TrEMBL
UniProt A0A2R9AFN6 ENTREZGENE, UniProtKB/TrEMBL