AHR (aryl hydrocarbon receptor) - Rat Genome Database

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Gene: AHR (aryl hydrocarbon receptor) Homo sapiens
Symbol: AHR
Name: aryl hydrocarbon receptor
RGD ID: 731071
HGNC Page HGNC:348
Description: Enables several functions, including Hsp90 protein binding activity; general transcription initiation factor binding activity; and nuclear receptor activity. Involved in several processes, including cAMP-mediated signaling; cellular response to organic cyclic compound; and negative regulation of T cell mediated immune response to tumor cell. Located in cytosol and nucleus. Part of protein-containing complex. Implicated in retinitis pigmentosa 85. Biomarker of pancreatic cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ah receptor; AH-receptor; aromatic hydrocarbon receptor; bHLHe76; class E basic helix-loop-helix protein 76; RP85
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC100533655  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38717,298,652 - 17,346,147 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl716,916,359 - 17,346,152 (+)EnsemblGRCh38hg38GRCh38
GRCh37717,338,276 - 17,385,771 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36717,304,832 - 17,352,299 (+)NCBINCBI36Build 36hg18NCBI36
Build 34717,111,485 - 17,158,632NCBI
Celera717,318,278 - 17,365,781 (+)NCBICelera
Cytogenetic Map7p21.1NCBI
HuRef717,224,763 - 17,272,268 (+)NCBIHuRef
CHM1_1717,339,112 - 17,386,607 (+)NCBICHM1_1
T2T-CHM13v2.0717,428,395 - 17,475,891 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2717,391,672 - 17,439,185 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acanthosis nigricans  (EXP)
Adult Pancreatic Cancer  (EXP)
Animal Disease Models  (EXP)
atherosclerosis  (EXP)
atopic dermatitis  (EXP)
Atrophy  (EXP)
Behcet's disease  (EXP)
Birth Weight  (EXP)
bladder calculus  (EXP)
bone resorption disease  (EXP)
Breast Neoplasms  (EXP)
Cardiomegaly  (EXP)
Chemical and Drug Induced Liver Injury  (EXP)
Chronobiology Disorders  (EXP)
colitis  (EXP)
congenital heart disease  (EXP)
congenital nystagmus  (EXP)
contact dermatitis  (EXP)
disease of cellular proliferation  (EXP)
disease of metabolism  (EXP)
Dyslipidemias  (EXP)
Endotoxemia  (ISO)
Experimental Arthritis  (EXP)
Experimental Neoplasms  (EXP)
glucose intolerance  (EXP)
Growth Disorders  (EXP)
Hepatomegaly  (EXP)
Hyperoxia  (EXP)
Hyperpigmentation  (EXP)
hypertension  (EXP)
Hypertrophy  (EXP)
Hyperventilation  (EXP)
hypoglycemia  (EXP)
Inflammation  (EXP)
Insulin Resistance  (EXP)
keratosis  (EXP)
Left Ventricular Hypertrophy  (EXP)
liver cirrhosis  (EXP)
liver disease  (EXP)
Liver Neoplasms  (EXP)
lung adenocarcinoma  (EXP)
Lung Injury  (EXP)
male infertility  (EXP)
Necrosis  (EXP)
Neoplasm Invasiveness  (EXP)
Neoplasm Metastasis  (EXP)
non-alcoholic fatty liver disease  (EXP)
obesity  (EXP)
pancreatic cancer  (EXP,IEP)
peanut allergy  (EXP)
pleomorphic xanthoastrocytoma  (IAGP)
pneumonia  (EXP)
Prostatic Neoplasms  (EXP)
Pruritus  (EXP)
Pulmonary Arterial Hypertension  (EXP)
retinitis pigmentosa 85  (IAGP)
rheumatoid arthritis  (EXP)
Salmonella Infections, Animal  (ISO)
silicosis  (EXP)
splenic disease  (EXP)
Splenomegaly  (EXP)
Spontaneous Abortions  (EXP)
Stomach Neoplasms  (EXP)
Tachycardia  (EXP)
Tobacco Use Disorder  (EXP)
Ureteral Neoplasms  (EXP)
vascular disease  (EXP)
Weight Gain  (EXP)
Weight Loss  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-(S)-ar-turmerone  (EXP)
(+)-schisandrin B  (ISO)
(+)-taxifolin  (EXP)
(+)-Tetrandrine  (ISO)
(-)-anisomycin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(S)-colchicine  (EXP,ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP)
(Z)-3-butylidenephthalide  (EXP)
(Z)-ligustilide  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,10-phenanthroline  (EXP,ISO)
1,2,3,4,6,7,8-Heptachlorodibenzodioxin  (EXP,ISO)
1,2,3,4,6,7,8-Heptachlorodibenzofuran  (EXP,ISO)
1,2,3,4,7,8-Hexachlorodibenzodioxin  (ISO)
1,2,3,4,7,8-Hexachlorodibenzofuran  (EXP,ISO)
1,2,3,4-tetrahydroisoquinoline  (ISO)
1,2,3,6,7,8-Hexachlorodibenzodioxin  (EXP,ISO)
1,2,3,7,8-Pentachlorodibenzodioxin  (EXP,ISO)
1,2,3,7,8-Pentachlorodibenzofuran  (ISO)
1,2-benzoquinone  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (EXP,ISO)
1,2-phenylenediamine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,3-dicyclohexylurea  (ISO)
1,4-benzoquinone  (EXP,ISO)
1,4-dihydroxy-2-naphthoic acid  (EXP,ISO)
1,4-naphthoquinone  (EXP,ISO)
1,7-phenanthroline  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-benzofuran  (ISO)
1-hydroxy-2-naphthoic acid  (EXP,ISO)
1-Methylfluorene  (ISO)
1-methylnaphthalene  (ISO)
1-methylphenanthrene  (ISO)
1-naphthol  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-naphthylamine  (ISO)
1-nitropyrene  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
1H-indole  (EXP)
2,2',4,4',5,5'-hexabromobiphenyl  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',4,5-tetrachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)