AHR (aryl hydrocarbon receptor) - Rat Genome Database

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Gene: AHR (aryl hydrocarbon receptor) Canis lupus familiaris
Analyze
Symbol: AHR
Name: aryl hydrocarbon receptor
RGD ID: 12178044
Description: ENCODES a protein that exhibits aryl hydrocarbon receptor binding (ortholog); chaperone binding (ortholog); cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN B cell homeostasis (ortholog); blood circulation (ortholog); blood vessel development (ortholog); PARTICIPATES IN aryl hydrocarbon receptor signaling pathway; ASSOCIATED WITH acanthosis nigricans (ortholog); Adult Pancreatic Cancer (ortholog); Animal Disease Models (ortholog); FOUND IN cytosol (ortholog); nucleus (ortholog); protein-containing complex (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; Aroclor 1254; iprodione
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11431,743,704 - 31,793,484 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1431,686,170 - 31,791,444 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1431,264,779 - 31,314,544 (+)NCBI
ROS_Cfam_1.01431,661,762 - 31,711,544 (+)NCBI
ROS_Cfam_1.0 Ensembl1431,661,088 - 31,711,540 (+)Ensembl
UMICH_Zoey_3.11431,766,284 - 31,816,050 (+)NCBI
UNSW_CanFamBas_1.01431,476,179 - 31,525,758 (+)NCBI
UU_Cfam_GSD_1.01431,792,396 - 31,842,188 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acanthosis nigricans  (ISO)
Adult Pancreatic Cancer  (ISO)
Animal Disease Models  (ISO)
atherosclerosis  (ISO)
atopic dermatitis  (ISO)
Atrophy  (ISO)
Behcet's disease  (ISO)
Birth Weight  (ISO)
bladder calculus  (ISO)
bone resorption disease  (ISO)
Breast Neoplasms  (ISO)
Cardiomegaly  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronobiology Disorders  (ISO)
colitis  (ISO)
congenital heart disease  (ISO)
congenital nystagmus  (ISO)
contact dermatitis  (ISO)
disease of cellular proliferation  (ISO)
disease of metabolism  (ISO)
Dyslipidemias  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Neoplasms  (ISO)
glucose intolerance  (ISO)
Growth Disorders  (ISO)
Hepatomegaly  (ISO)
Hyperoxia  (ISO)
Hyperpigmentation  (ISO)
hypertension  (ISO)
Hypertrophy  (ISO)
Hyperventilation  (ISO)
hypoglycemia  (ISO)
Inflammation  (ISO)
Insulin Resistance  (ISO)
keratosis  (ISO)
Left Ventricular Hypertrophy  (ISO)
liver cirrhosis  (ISO)
liver disease  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Injury  (ISO)
male infertility  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
pancreatic cancer  (ISO)
peanut allergy  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
pneumonia  (ISO)
Prostatic Neoplasms  (ISO)
Pruritus  (ISO)
Pulmonary Arterial Hypertension  (ISO)
retinitis pigmentosa 85  (ISO)
rheumatoid arthritis  (ISO)
Salmonella Infections, Animal  (ISO)
silicosis  (ISO)
splenic disease  (ISO)
Splenomegaly  (ISO)
Spontaneous Abortions  (ISO)
Stomach Neoplasms  (ISO)
Tachycardia  (ISO)
Tobacco Use Disorder  (ISO)
Ureteral Neoplasms  (ISO)
vascular disease  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell homeostasis  (ISO)
blood circulation  (ISO)
blood vessel development  (ISO)
blood vessel diameter maintenance  (ISO)
blood vessel morphogenesis  (ISO)
blood vessel remodeling  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
camera-type eye development  (ISO)
cAMP-mediated signaling  (ISO)
cardiac left ventricle morphogenesis  (ISO)
cell morphogenesis  (ISO)
cellular response to 2,3,7,8-tetrachlorodibenzodioxine  (ISO)
cellular response to 3-methylcholanthrene  (ISO)
cellular response to cAMP  (ISO)
cellular response to forskolin  (ISO)
cellular response to glucocorticoid stimulus  (ISO)
circadian regulation of gene expression  (ISO)
circumferential growth involved in left ventricle morphogenesis  (ISO)
common bile duct development  (ISO)
embryonic hemopoiesis  (ISO)
gland development  (ISO)
glomerulus morphogenesis  (ISO)
immune system process  (ISO)
intracellular receptor signaling pathway  (IEA)
kidney morphogenesis  (ISO)
liver development  (ISO)
lymphocyte homeostasis  (ISO)
negative regulation of alkaline phosphatase activity  (ISO)
negative regulation of calcium ion transmembrane transport  (ISO)
negative regulation of DNA biosynthetic process  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of necrotic cell death  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of osteoblast proliferation  (ISO)
negative regulation of systemic arterial blood pressure  (ISO)
negative regulation of T cell mediated immune response to tumor cell  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vasoconstriction  (ISO)
ovarian follicle development  (ISO)
positive regulation of cell size  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of growth rate  (ISO)
positive regulation of RNA polymerase II transcription preinitiation complex assembly  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
post-embryonic hemopoiesis  (ISO)
prostate gland development  (ISO)
regulation of adaptive immune response  (ISO)
regulation of B cell proliferation  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of gene expression  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
reproductive structure development  (ISO)
response to estradiol  (ISO)
response to organic cyclic compound  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (IEA,ISO)
rhythmic process  (IEA)
smooth muscle tissue development  (ISO)
spleen development  (ISO)
T cell homeostasis  (ISO)
transcription by RNA polymerase II  (ISO)
venous blood vessel development  (ISO)
xenobiotic metabolic process  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:25403511  


Genomics

Comparative Map Data
AHR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11431,743,704 - 31,793,484 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1431,686,170 - 31,791,444 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1431,264,779 - 31,314,544 (+)NCBI
ROS_Cfam_1.01431,661,762 - 31,711,544 (+)NCBI
ROS_Cfam_1.0 Ensembl1431,661,088 - 31,711,540 (+)Ensembl
UMICH_Zoey_3.11431,766,284 - 31,816,050 (+)NCBI
UNSW_CanFamBas_1.01431,476,179 - 31,525,758 (+)NCBI
UU_Cfam_GSD_1.01431,792,396 - 31,842,188 (+)NCBI
AHR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38717,298,652 - 17,346,147 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl716,916,359 - 17,346,152 (+)EnsemblGRCh38hg38GRCh38
GRCh37717,338,276 - 17,385,771 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36717,304,832 - 17,352,299 (+)NCBINCBI36hg18NCBI36
Build 34717,111,485 - 17,158,632NCBI
Celera717,318,278 - 17,365,781 (+)NCBI
Cytogenetic Map7p21.1NCBI
HuRef717,224,763 - 17,272,268 (+)NCBIHuRef
CHM1_1717,339,112 - 17,386,607 (+)NCBICHM1_1
T2T-CHM13v2.0717,428,395 - 17,475,891 (+)NCBI
CRA_TCAGchr7v2717,391,672 - 17,439,185 (+)NCBI
Ahr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391235,547,978 - 35,584,988 (-)NCBIGRCm39mm39
GRCm39 Ensembl1235,547,973 - 35,585,037 (-)Ensembl
GRCm381235,497,979 - 35,534,989 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1235,497,974 - 35,535,038 (-)EnsemblGRCm38mm10GRCm38
MGSCv371236,182,651 - 36,219,661 (-)NCBIGRCm37mm9NCBIm37
MGSCv361236,083,094 - 36,119,976 (-)NCBImm8
Celera1236,948,584 - 36,984,257 (-)NCBICelera
Cytogenetic Map12A3NCBI
cM Map1215.78NCBI
Ahr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2652,234,089 - 52,271,568 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl652,234,089 - 52,271,568 (-)Ensembl
Rnor_6.0654,963,990 - 55,001,806 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl654,963,990 - 55,001,464 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0664,589,066 - 64,624,078 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4654,205,104 - 54,240,268 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1654,206,846 - 54,243,423 (-)NCBI
Celera651,391,870 - 51,429,719 (-)NCBICelera
RH 3.4 Map6350.2RGD
Cytogenetic Map6q16NCBI
Ahr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541020,428,546 - 20,456,836 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541020,428,531 - 20,459,482 (+)NCBIChiLan1.0ChiLan1.0
AHR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1717,278,637 - 17,326,171 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl717,278,637 - 17,326,171 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0717,949,254 - 17,998,737 (+)NCBIMhudiblu_PPA_v0panPan3
Ahr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511876,062,814 - 76,108,403 (+)NCBI
SpeTri2.0NW_0049365463,737,908 - 3,783,492 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AHR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl986,511,369 - 86,555,943 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1986,511,866 - 86,555,950 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2995,511,269 - 95,542,794 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AHR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12140,778,198 - 40,826,491 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2140,778,218 - 40,826,478 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604263,692,229 - 63,740,600 (+)NCBIVero_WHO_p1.0
Ahr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473912,942,165 - 12,987,973 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462473912,939,183 - 12,987,574 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 18 6 6 6 6 6 10 6
Low 2 5 4 6 6 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000003863   ⟹   ENSCAFP00000003573
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1431,686,170 - 31,791,444 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000079152   ⟹   ENSCAFP00000052303
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1431,742,919 - 31,791,444 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845010390   ⟹   ENSCAFP00845008074
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1431,661,088 - 31,711,540 (+)Ensembl
RefSeq Acc Id: XM_038494734   ⟹   XP_038350662
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11431,766,284 - 31,816,050 (+)NCBI
RefSeq Acc Id: XM_038557017   ⟹   XP_038412945
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01431,792,396 - 31,842,188 (+)NCBI
RefSeq Acc Id: XM_038620952   ⟹   XP_038476880
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01431,476,179 - 31,525,758 (+)NCBI
RefSeq Acc Id: XM_038686645   ⟹   XP_038542573
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01431,661,762 - 31,711,544 (+)NCBI
RefSeq Acc Id: XM_532485   ⟹   XP_532485
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11431,743,704 - 31,793,484 (+)NCBI
Dog10K_Boxer_Tasha1431,264,779 - 31,314,544 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038350662 (Get FASTA)   NCBI Sequence Viewer  
  XP_038412945 (Get FASTA)   NCBI Sequence Viewer  
  XP_038476880 (Get FASTA)   NCBI Sequence Viewer  
  XP_038542573 (Get FASTA)   NCBI Sequence Viewer  
  XP_532485 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_532485   ⟸   XM_532485
- UniProtKB: E2QWU8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000052303   ⟸   ENSCAFT00000079152
RefSeq Acc Id: ENSCAFP00000003573   ⟸   ENSCAFT00000003863
RefSeq Acc Id: XP_038350662   ⟸   XM_038494734
RefSeq Acc Id: XP_038476880   ⟸   XM_038620952
RefSeq Acc Id: XP_038542573   ⟸   XM_038686645
RefSeq Acc Id: XP_038412945   ⟸   XM_038557017
RefSeq Acc Id: ENSCAFP00845008074   ⟸   ENSCAFT00845010390
Protein Domains
bHLH   PAS

Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
14 31769980 31769981 T G snv Basenji (BJ004), Basenji (BJ006)
14 31776407 31776408 G C snv West Highland White Terrier (WW64), West Highland White Terrier (WW361)
14 31787540 31787541 G A snv Tibetan Mastiff (TM7)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000002448 Ensembl
  ENSCAFG00845005867 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00845008074 ENTREZGENE
  ENSCAFP00845008074.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00845010390 ENTREZGENE
  ENSCAFT00845010390.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro AHR UniProtKB/TrEMBL
  AHR/AHRR UniProtKB/TrEMBL
  bHLH_dom UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  PAC UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS-like_dom_sf UniProtKB/TrEMBL
  PAS_fold UniProtKB/TrEMBL
  PAS_fold_3 UniProtKB/TrEMBL
NCBI Gene AHR ENTREZGENE
PANTHER PTHR10649 UniProtKB/TrEMBL
  PTHR10649:SF9 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
  PAS_3 UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
  PAC UniProtKB/TrEMBL
  PAS UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
  SSF55785 UniProtKB/TrEMBL
UniProt A0A8I3RSX6_CANLF UniProtKB/TrEMBL
  E2QWU8 ENTREZGENE
VGNC ID VGNC:54752 ENTREZGENE