KCNJ2 (potassium inwardly rectifying channel subfamily J member 2) - Rat Genome Database

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Gene: KCNJ2 (potassium inwardly rectifying channel subfamily J member 2) Pan paniscus
Analyze
Symbol: KCNJ2
Name: potassium inwardly rectifying channel subfamily J member 2
RGD ID: 11909387
Description: ENCODES a protein that exhibits identical protein binding (inferred); inward rectifier potassium channel activity (inferred); phosphatidylinositol-4,5-bisphosphate binding (inferred); INVOLVED IN cardiac muscle cell action potential (ortholog); cellular response to mechanical stimulus (ortholog); magnesium ion transport (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; ASSOCIATED WITH Andersen-Tawil syndrome (ortholog); Arsenic Poisoning (ortholog); atrial fibrillation (ortholog); FOUND IN dendrite (ortholog); dendritic spine (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: inward rectifier potassium channel 2; potassium inwardly-rectifying channel, subfamily J, member 2; potassium voltage-gated channel subfamily J member 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11769,482,344 - 69,492,838 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1769,487,846 - 69,489,129 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01764,097,908 - 64,112,914 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
neuron-to-neuron signaling pathway via the chemical synapse  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

Genomics

Comparative Map Data
KCNJ2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11769,482,344 - 69,492,838 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1769,487,846 - 69,489,129 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01764,097,908 - 64,112,914 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
KCNJ2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381770,169,532 - 70,180,044 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1770,168,673 - 70,180,044 (+)EnsemblGRCh38hg38GRCh38
GRCh371768,165,673 - 68,176,185 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361765,677,271 - 65,687,780 (+)NCBINCBI36Build 36hg18NCBI36
Build 341765,677,270 - 65,687,776NCBI
Celera1764,737,556 - 64,748,065 (+)NCBICelera
Cytogenetic Map17q24.3NCBI
HuRef1763,551,441 - 63,561,946 (+)NCBIHuRef
CHM1_11768,231,773 - 68,242,282 (+)NCBICHM1_1
T2T-CHM13v2.01771,047,853 - 71,058,363 (+)NCBIT2T-CHM13v2.0
Kcnj2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911110,956,990 - 110,967,651 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11110,956,990 - 110,967,647 (+)EnsemblGRCm39 Ensembl
GRCm3811111,066,164 - 111,076,825 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11111,066,164 - 111,076,821 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711110,927,478 - 110,938,139 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611110,882,254 - 110,891,741 (+)NCBIMGSCv36mm8
Celera11122,816,654 - 122,827,315 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1175.23NCBI
Kcnj2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21096,060,849 - 96,071,401 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1096,060,821 - 96,071,445 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10101,129,119 - 101,130,402 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.010100,592,089 - 100,593,372 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01096,000,266 - 96,001,549 (+)NCBIRnor_WKY
Rnor_6.01099,429,337 - 99,442,520 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1099,437,436 - 99,439,114 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01099,125,234 - 99,134,077 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410100,574,985 - 100,576,268 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110100,589,354 - 100,590,638 (+)NCBI
Celera1094,712,069 - 94,713,352 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
Kcnj2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554782,734,795 - 2,745,217 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554782,734,795 - 2,745,217 (-)NCBIChiLan1.0ChiLan1.0
KCNJ2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1916,468,938 - 16,475,722 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl916,468,938 - 16,475,722 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha917,360,013 - 17,366,796 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0918,122,955 - 18,129,749 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl918,122,955 - 18,129,749 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1917,067,115 - 17,073,888 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0910,461,025 - 10,467,799 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0910,426,806 - 10,433,589 (-)NCBIUU_Cfam_GSD_1.0
Kcnj2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056029,949,176 - 9,968,112 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366553,447,321 - 3,458,312 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366553,447,026 - 3,459,569 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNJ2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1210,351,699 - 10,362,244 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11210,351,959 - 10,380,631 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KCNJ2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11651,448,821 - 51,461,801 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1651,452,567 - 51,453,850 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607722,340,093 - 22,354,971 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnj2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624801365,361 - 374,487 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624801365,393 - 375,802 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003808946 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000009494   ⟹   ENSPPAP00000001931
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1769,487,846 - 69,489,129 (+)Ensembl
RefSeq Acc Id: XM_003808946   ⟹   XP_003808994
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11769,482,344 - 69,492,838 (+)NCBI
Mhudiblu_PPA_v01764,097,908 - 64,112,914 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003808994 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003808994   ⟸   XM_003808946
- UniProtKB: A0A2J8KKW9 (UniProtKB/TrEMBL),   A0A2R8ZA76 (UniProtKB/TrEMBL),   A0A6D2Y6Z2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000001931   ⟸   ENSPPAT00000009494
Protein Domains
IRK   IRK_C   IRK_N


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000008705 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000001931 ENTREZGENE
  ENSPPAP00000001931.1 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000009494.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.1400 UniProtKB/TrEMBL
InterPro Ig_E-set UniProtKB/TrEMBL
  IRK_C UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir2.1 UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir_cyto UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir_N UniProtKB/TrEMBL
  Kir_TM UniProtKB/TrEMBL
KEGG Report pps:100973351 UniProtKB/TrEMBL
NCBI Gene KCNJ2 ENTREZGENE
PANTHER PTHR11767 UniProtKB/TrEMBL
  PTHR11767:SF43 UniProtKB/TrEMBL
Pfam IRK UniProtKB/TrEMBL
  IRK_C UniProtKB/TrEMBL
  IRK_N UniProtKB/TrEMBL
PIRSF GIRK_kir UniProtKB/TrEMBL
PRINTS KIR21CHANNEL UniProtKB/TrEMBL
  KIRCHANNEL UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/TrEMBL
UniProt A0A2J8KKW9 ENTREZGENE
  A0A2R8ZA76 ENTREZGENE, UniProtKB/TrEMBL
  A0A6D2Y6Z2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-23 KCNJ2  potassium inwardly rectifying channel subfamily J member 2  KCNJ2  potassium voltage-gated channel subfamily J member 2  Symbol and/or name change 5135510 APPROVED