MMP3 (matrix metallopeptidase 3) - Rat Genome Database

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Gene: MMP3 (matrix metallopeptidase 3) Pan paniscus
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Symbol: MMP3
Name: matrix metallopeptidase 3
RGD ID: 12013605
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN cellular response to amino acid stimulus (ortholog); cellular response to cell-matrix adhesion (ortholog); cellular response to interleukin-1 (ortholog); ASSOCIATED WITH abdominal aortic aneurysm (ortholog); Acute Otitis Media (ortholog); allergic contact dermatitis (ortholog); FOUND IN cell body (ortholog); dendrite (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: matrix metallopeptidase 3 (stromelysin 1, progelatinase); stromelysin-1
RGD Orthologs
Human
Mouse
Rat
Dog
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29103,629,536 - 103,637,408 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,717,742 - 104,725,633 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,776,729 - 97,784,549 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111101,267,561 - 101,275,432 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11101,267,566 - 101,275,354 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acute Otitis Media  (ISO)
allergic contact dermatitis  (ISO)
Alport syndrome  (ISO)
arteriosclerosis  (ISO)
asphyxiating thoracic dystrophy  (ISO)
ataxia telangiectasia  (ISO)
atrial fibrillation  (ISO)
Brain Hypoxia-Ischemia  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Carotid Artery Injuries  (ISO)
carotid stenosis  (ISO)
cartilage disease  (ISO)
cataract  (ISO)
celiac disease  (ISO)
Cerebral Hemorrhage  (ISO)
Chronic Allograft Nephropathy  (ISO)
cognitive disorder  (ISO)
colon cancer  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
conjunctivochalasis  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
coronary restenosis  (ISO)
crescentic glomerulonephritis  (ISO)
degenerative disc disease  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
dry eye syndrome  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Arthritis  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
glomerulonephritis  (ISO)
Gouty Arthritis  (ISO)
Hyperalgesia  (ISO)
idiopathic pulmonary fibrosis  (ISO)
immunoglobulin light chain amyloidosis  (ISO)
intellectual disability  (ISO)
Knee Osteoarthritis  (ISO)
lung cancer  (ISO)
lymphangioleiomyomatosis  (ISO)
Lymphatic Metastasis  (ISO)
malignant astrocytoma  (ISO)
myocardial infarction  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
osteoarthritis  (ISO)
Parkinsonism  (ISO)
Penetrating Wounds  (ISO)
periodontitis  (ISO)
Peripheral Nerve Injuries  (ISO)
peripheral nervous system disease  (ISO)
polymyalgia rheumatica  (ISO)
primary biliary cholangitis  (ISO)
psoriatic arthritis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary tuberculosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
rheumatoid arthritis  (ISO)
Sjogren's syndrome  (ISO)
Stroke  (ISO)
systemic scleroderma  (ISO)
Takayasu's arteritis  (ISO)
Tendon Injuries  (ISO)
thrombosis  (ISO)
Transplant Rejection  (ISO)
type 2 diabetes mellitus  (ISO)
Ulcer  (ISO)
Venous Thrombosis  (ISO)
von Hippel-Lindau disease  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MMP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29103,629,536 - 103,637,408 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,717,742 - 104,725,633 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,776,729 - 97,784,549 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111101,267,561 - 101,275,432 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11101,267,566 - 101,275,354 (-)Ensemblpanpan1.1panPan2
MMP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,835,801 - 102,843,609 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,835,801 - 102,843,609 (-)EnsemblGRCh38hg38GRCh38
GRCh3711102,706,532 - 102,714,340 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611102,211,738 - 102,219,552 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411102,211,742 - 102,219,550NCBI
Celera1199,868,135 - 99,875,949 (-)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,634,450 - 98,642,264 (-)NCBIHuRef
CHM1_111102,589,497 - 102,597,317 (-)NCBICHM1_1
T2T-CHM13v2.011102,839,570 - 102,847,378 (-)NCBIT2T-CHM13v2.0
Mmp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,445,845 - 7,455,975 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,445,822 - 7,455,975 (+)EnsemblGRCm39 Ensembl
GRCm3897,445,822 - 7,455,975 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,445,822 - 7,455,975 (+)EnsemblGRCm38mm10GRCm38
MGSCv3797,445,822 - 7,455,975 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,445,822 - 7,455,975 (+)NCBIMGSCv36mm8
Celera94,846,374 - 4,856,527 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Mmp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8812,925,267 - 12,938,828 (+)NCBIGRCr8
mRatBN7.284,640,397 - 4,653,963 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,640,416 - 4,653,961 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,600,140 - 8,613,640 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.086,897,910 - 6,911,412 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.084,900,079 - 4,913,622 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,676,608 - 5,698,579 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,676,665 - 5,698,579 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,680,382 - 5,701,427 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,315,601 - 4,329,146 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,315,600 - 4,329,146 (+)NCBI
Celera86,200,234 - 6,213,783 (+)NCBICelera
Cytogenetic Map8q11NCBI
MMP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1528,949,631 - 28,957,915 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl528,949,631 - 28,958,222 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha528,898,123 - 28,906,399 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,000,797 - 29,009,079 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,000,797 - 29,009,386 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,035,847 - 29,044,131 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0528,915,267 - 28,923,546 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,090,249 - 29,098,533 (+)NCBIUU_Cfam_GSD_1.0
MMP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,216,156 - 94,224,437 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,216,173 - 94,224,264 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604331,654,560 - 31,662,871 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462487839,358 - 47,075 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462487839,282 - 47,386 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000048938   ⟹   ENSPPAP00000026106
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl11101,267,566 - 101,275,354 (-)Ensembl
RefSeq Acc Id: XM_003828377   ⟹   XP_003828425
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v29103,629,536 - 103,637,408 (-)NCBI
NHGRI_mPanPan111104,717,742 - 104,725,633 (-)NCBI
Mhudiblu_PPA_v01197,776,729 - 97,784,549 (-)NCBI
PanPan1.111101,267,561 - 101,275,432 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003828425 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAT27324 (Get FASTA)   NCBI Sequence Viewer  
  AAT27325 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000026106
  ENSPPAP00000026106.1
RefSeq Acc Id: XP_003828425   ⟸   XM_003828377
- UniProtKB: A0A2R9BCT7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000026106   ⟸   ENSPPAT00000048938
Protein Domains
Peptidase metallopeptidase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036174 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000048938.1 UniProtKB/TrEMBL
Gene3D-CATH 2.110.10.10 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro Hemopexin-like_dom UniProtKB/TrEMBL
  Hemopexin-like_dom_sf UniProtKB/TrEMBL
  Hemopexin-like_repeat UniProtKB/TrEMBL
  Hemopexin_CS UniProtKB/TrEMBL
  M10A_MMP UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/TrEMBL
  Pept_M10A UniProtKB/TrEMBL
  Pept_M10A_Zn_BS UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/TrEMBL
  Peptidoglycan-bd-like UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/TrEMBL
KEGG Report pps:100995831 UniProtKB/TrEMBL
NCBI Gene MMP3 ENTREZGENE
PANTHER MATRIX METALLOPROTEINASE UniProtKB/TrEMBL
  STROMELYSIN-1 UniProtKB/TrEMBL
Pfam Hemopexin UniProtKB/TrEMBL
  Peptidase_M10 UniProtKB/TrEMBL
  PG_binding_1 UniProtKB/TrEMBL
PIRSF Peptidase_M10A_matrix UniProtKB/TrEMBL
PRINTS MATRIXIN UniProtKB/TrEMBL
PROSITE CYSTEINE_SWITCH UniProtKB/TrEMBL
  HEMOPEXIN UniProtKB/TrEMBL
  HEMOPEXIN_2 UniProtKB/TrEMBL
SMART SM00120 UniProtKB/TrEMBL
  ZnMc UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF47090 UniProtKB/TrEMBL
  SSF50923 UniProtKB/TrEMBL
UniProt A0A2R9BCT7 ENTREZGENE, UniProtKB/TrEMBL