F12 (coagulation factor XII) - Rat Genome Database

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Gene: F12 (coagulation factor XII) Pan paniscus
Analyze
Symbol: F12
Name: coagulation factor XII
RGD ID: 12021489
Description: ENCODES a protein that exhibits calcium ion binding (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN blood coagulation (ortholog); PARTICIPATES IN acenocoumarol pharmacodynamics pathway; alteplase pharmacodynamics pathway; aminocaproic acid pharmacodynamics pathway; ASSOCIATED WITH acquired angioedema (ortholog); Acute Coronary Syndrome (ortholog); angioedema (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24172,486,323 - 172,511,069 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15170,625,862 - 170,650,653 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05172,703,724 - 172,711,618 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15179,766,089 - 179,773,854 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5179,766,243 - 179,773,485 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
F12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24172,486,323 - 172,511,069 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15170,625,862 - 170,650,653 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05172,703,724 - 172,711,618 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15179,766,089 - 179,773,854 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5179,766,243 - 179,773,485 (-)Ensemblpanpan1.1panPan2
F12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385177,402,141 - 177,409,564 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5177,402,133 - 177,416,583 (-)EnsemblGRCh38hg38GRCh38
GRCh375176,829,142 - 176,836,565 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365176,761,745 - 176,769,183 (-)NCBINCBI36Build 36hg18NCBI36
Build 345176,761,746 - 176,769,183NCBI
Celera5171,664,877 - 171,672,315 (+)NCBICelera
Cytogenetic Map5q35.3NCBI
HuRef5171,749,566 - 171,757,004 (-)NCBIHuRef
CHM1_15176,262,187 - 176,269,625 (-)NCBICHM1_1
T2T-CHM13v2.05177,945,359 - 177,952,782 (-)NCBIT2T-CHM13v2.0
F12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391355,565,771 - 55,574,617 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1355,565,771 - 55,574,606 (-)EnsemblGRCm39 Ensembl
GRCm381355,417,958 - 55,426,804 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1355,417,958 - 55,426,793 (-)EnsemblGRCm38mm10GRCm38
MGSCv371355,519,327 - 55,528,163 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361355,427,610 - 55,436,409 (-)NCBIMGSCv36mm8
Celera1356,472,191 - 56,480,813 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.06NCBI
F12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8179,212,819 - 9,220,664 (+)NCBIGRCr8
mRatBN7.2179,207,683 - 9,215,530 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl179,207,683 - 9,215,530 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx179,223,730 - 9,231,646 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01710,753,767 - 10,761,675 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0179,220,120 - 9,228,036 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0179,736,577 - 9,744,420 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl179,736,577 - 9,744,420 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01711,845,561 - 11,853,600 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41715,251,611 - 15,259,583 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11715,251,610 - 15,259,583 (+)NCBI
Celera179,286,222 - 9,294,037 (+)NCBICelera
Cytogenetic Map17p14NCBI
F12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540829,642,096 - 29,650,950 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540829,644,279 - 29,665,161 (-)NCBIChiLan1.0ChiLan1.0
F12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1435,950,642 - 35,968,137 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl435,950,695 - 35,998,025 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha435,918,068 - 35,935,563 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0436,316,872 - 36,334,363 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl436,316,904 - 36,324,807 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1436,142,096 - 36,159,589 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0436,328,310 - 36,345,800 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0436,837,547 - 36,855,039 (+)NCBIUU_Cfam_GSD_1.0
F12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213122,662,598 - 122,670,021 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365971,687,511 - 1,694,782 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
F12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl280,527,446 - 80,544,828 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1280,527,451 - 80,544,835 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
F12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12379,414,074 - 79,438,896 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2379,414,225 - 79,432,298 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607510,603,660 - 10,619,663 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
F12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473312,675,966 - 12,683,117 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473312,666,410 - 12,683,273 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000017441   ⟹   ENSPPAP00000003784
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5179,766,243 - 179,773,485 (-)Ensembl
RefSeq Acc Id: XM_034961069   ⟹   XP_034816960
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24172,486,323 - 172,511,069 (-)NCBI
NHGRI_mPanPan15170,625,862 - 170,650,653 (-)NCBI
Mhudiblu_PPA_v05172,703,724 - 172,711,599 (-)NCBI
RefSeq Acc Id: XM_055113053   ⟹   XP_054969028
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24172,486,323 - 172,511,069 (-)NCBI
NHGRI_mPanPan15170,625,862 - 170,650,653 (-)NCBI
RefSeq Acc Id: XM_055113054   ⟹   XP_054969029
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24172,486,323 - 172,511,069 (-)NCBI
NHGRI_mPanPan15170,625,862 - 170,650,653 (-)NCBI
RefSeq Acc Id: XM_063604317   ⟹   XP_063460387
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24172,486,323 - 172,502,122 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034816960 (Get FASTA)   NCBI Sequence Viewer  
  XP_054969028 (Get FASTA)   NCBI Sequence Viewer  
  XP_054969029 (Get FASTA)   NCBI Sequence Viewer  
  XP_063460387 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000003784.1
Reference Protein Sequences
RefSeq Acc Id: XP_034816960   ⟸   XM_034961069
- UniProtKB: A0A2R8ZG07 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000003784   ⟸   ENSPPAT00000017441
RefSeq Acc Id: XP_054969028   ⟸   XM_055113053
- UniProtKB: A0A2R8ZG07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054969029   ⟸   XM_055113054
- UniProtKB: A0A2R8ZG07 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063460387   ⟸   XM_063604317
- UniProtKB: A0A2R8ZG07 (UniProtKB/TrEMBL)
Protein Domains
EGF-like   Fibronectin type-I   Fibronectin type-II   Kringle   Peptidase S1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000015911 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000017441.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.10.10 UniProtKB/TrEMBL
  2.40.10.10 UniProtKB/TrEMBL
  2.40.20.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro Coagulation_fac_XII/HGFA UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  Fibronectin_type1 UniProtKB/TrEMBL
  FN_type2_dom UniProtKB/TrEMBL
  FN_type2_sf UniProtKB/TrEMBL
  Kringle UniProtKB/TrEMBL
  Kringle-like UniProtKB/TrEMBL
  Kringle_CS UniProtKB/TrEMBL
  Kringle_sf UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
NCBI Gene F12 ENTREZGENE
PANTHER COAGULATION FACTOR XII UniProtKB/TrEMBL
  TRYPSIN-RELATED UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  fn1 UniProtKB/TrEMBL
  fn2 UniProtKB/TrEMBL
  Kringle UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PIRSF Factor_XII_HGFA UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
  FNTYPEII UniProtKB/TrEMBL
  KRINGLE UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  FN1_1 UniProtKB/TrEMBL
  FN1_2 UniProtKB/TrEMBL
  FN2_1 UniProtKB/TrEMBL
  FN2_2 UniProtKB/TrEMBL
  KRINGLE_1 UniProtKB/TrEMBL
  KRINGLE_2 UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  FN1 UniProtKB/TrEMBL
  FN2 UniProtKB/TrEMBL
  SM00130 UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  SSF50494 UniProtKB/TrEMBL
  SSF57440 UniProtKB/TrEMBL
UniProt A0A2R8ZG07 ENTREZGENE, UniProtKB/TrEMBL