CRK (CRK proto-oncogene, adaptor protein) - Rat Genome Database

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Advanced Search (OLGA)
Gene: CRK (CRK proto-oncogene, adaptor protein) Pan paniscus
Analyze
Symbol: CRK
Name: CRK proto-oncogene, adaptor protein
RGD ID: 11987047
Description: ENCODES a protein that exhibits cytoskeletal protein binding (ortholog); enzyme binding (ortholog); insulin-like growth factor receptor binding (ortholog); INVOLVED IN activation of GTPase activity (ortholog); cell chemotaxis (ortholog); cellular response to endothelin (ortholog); PARTICIPATES IN E-cadherin signaling pathway; endothelin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH chromosome 17p13.3 duplication syndrome (ortholog); degenerative disc disease (ortholog); Myocardial Ischemia (ortholog); FOUND IN neuromuscular junction (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: adapter molecule crk; v-crk sarcoma virus CT10 oncogene homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2198,993,868 - 9,026,236 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11710,960,254 - 10,992,510 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0171,406,335 - 1,438,587 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1171,304,309 - 1,336,698 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,306,509 - 1,336,569 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA)
activation of GTPase activity  (ISO)
cell chemotaxis  (IEA,ISO)
cell migration  (IEA)
cell population proliferation  (IEA)
cellular response to endothelin  (ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to nitric oxide  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cerebellar neuron development  (IEA,ISO)
cerebral cortex development  (IEA,ISO)
dendrite development  (IEA,ISO)
enzyme-linked receptor protein signaling pathway  (IEA)
ephrin receptor signaling pathway  (IEA)
establishment of cell polarity  (IEA,ISO)
helper T cell diapedesis  (IEA,ISO)
hippocampus development  (IEA,ISO)
lipid metabolic process  (IEA,ISO)
negative regulation of cell motility  (IEA)
negative regulation of natural killer cell mediated cytotoxicity  (ISO)
negative regulation of wound healing  (IEA)
neuron migration  (IEA,ISO)
positive regulation of cell growth  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of Rac protein signal transduction  (IEA)
positive regulation of skeletal muscle acetylcholine-gated channel clustering  (IEA)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (IEA)
postsynaptic specialization assembly  (IEA)
protein localization to membrane  (ISO)
reelin-mediated signaling pathway  (IEA,ISO)
regulation of actin cytoskeleton organization  (IEA,ISO)
regulation of cell adhesion mediated by integrin  (IEA,ISO)
regulation of cell motility  (IEA,ISO)
regulation of cell shape  (IEA)
regulation of dendrite development  (IEA,ISO)
regulation of intracellular signal transduction  (IEA)
regulation of leukocyte migration  (IEA,ISO)
regulation of Rac protein signal transduction  (ISO)
regulation of signal transduction  (IEA)
regulation of T cell migration  (IEA,ISO)
regulation of wound healing  (ISO)
response to cholecystokinin  (ISO)
response to hepatocyte growth factor  (ISO)
response to hydrogen peroxide  (ISO)
response to peptide  (ISO)
response to yeast  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
CRK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2198,993,868 - 9,026,236 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11710,960,254 - 10,992,510 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0171,406,335 - 1,438,587 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1171,304,309 - 1,336,698 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl171,306,509 - 1,336,569 (-)Ensemblpanpan1.1panPan2
CRK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38171,420,693 - 1,456,232 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl171,420,689 - 1,463,162 (-)EnsemblGRCh38hg38GRCh38
GRCh37171,323,987 - 1,359,526 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,272,190 - 1,306,294 (-)NCBINCBI36Build 36hg18NCBI36
Build 34171,272,198 - 1,306,294NCBI
Celera171,340,062 - 1,374,733 (-)NCBICelera
Cytogenetic Map17p13.3NCBI
HuRef171,225,393 - 1,259,684 (-)NCBIHuRef
CHM1_1171,333,439 - 1,368,323 (-)NCBICHM1_1
T2T-CHM13v2.0171,309,416 - 1,344,954 (-)NCBIT2T-CHM13v2.0
Crk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,570,020 - 75,599,254 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,570,085 - 75,597,734 (+)EnsemblGRCm39 Ensembl
GRCm381175,679,194 - 75,708,428 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,679,259 - 75,706,908 (+)EnsemblGRCm38mm10GRCm38
MGSCv371175,492,812 - 75,519,594 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361175,495,505 - 75,522,289 (+)NCBIMGSCv36mm8
Celera1183,188,410 - 83,215,203 (+)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.92NCBI
Crk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81061,028,736 - 61,054,971 (+)NCBIGRCr8
mRatBN7.21060,530,469 - 60,556,703 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1060,530,464 - 60,553,406 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1065,177,353 - 65,200,104 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01064,682,772 - 64,705,523 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01060,145,348 - 60,168,099 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01063,829,731 - 63,855,999 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1063,829,807 - 63,852,780 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01064,149,243 - 64,175,511 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41063,017,662 - 63,040,420 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11063,031,284 - 63,054,043 (+)NCBI
Celera1059,556,811 - 59,579,568 (+)NCBICelera
Cytogenetic Map10q24NCBI
Crk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554811,705,520 - 1,734,859 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554811,705,595 - 1,748,363 (+)NCBIChiLan1.0ChiLan1.0
CRK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1945,594,657 - 45,627,499 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl945,598,899 - 45,627,589 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha944,745,712 - 44,779,594 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0946,417,939 - 46,455,274 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1945,192,581 - 45,225,775 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0945,487,008 - 45,520,232 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0945,560,222 - 45,573,637 (-)NCBIUU_Cfam_GSD_1.0
Crk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560244,703,503 - 44,731,611 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365387,581,498 - 7,609,544 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365387,581,453 - 7,609,543 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1247,657,865 - 47,685,908 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11247,656,805 - 47,685,641 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21249,779,584 - 49,779,938 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CRK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1161,102,485 - 1,135,225 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl161,102,348 - 1,135,166 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605920,858,701 - 20,893,884 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247864,153,889 - 4,177,716 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247864,153,783 - 4,177,611 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000036346   ⟹   ENSPPAP00000013673
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl171,306,509 - 1,336,569 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000036365   ⟹   ENSPPAP00000013691
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl171,307,106 - 1,336,569 (-)Ensembl
RefSeq Acc Id: XM_003816839   ⟹   XP_003816887
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2198,993,868 - 9,026,236 (-)NCBI
NHGRI_mPanPan11710,960,254 - 10,992,510 (-)NCBI
Mhudiblu_PPA_v0171,406,335 - 1,438,587 (-)NCBI
PanPan1.1171,304,309 - 1,336,698 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034941220   ⟹   XP_034797111
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2198,993,868 - 9,026,233 (-)NCBI
NHGRI_mPanPan11710,960,254 - 10,992,504 (-)NCBI
Mhudiblu_PPA_v0171,406,335 - 1,438,581 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003816887 (Get FASTA)   NCBI Sequence Viewer  
  XP_034797111 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000013673.1
  ENSPPAP00000013691
  ENSPPAP00000013691.1
RefSeq Acc Id: XP_003816887   ⟸   XM_003816839
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A9X4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034797111   ⟸   XM_034941220
- Peptide Label: isoform X2
Ensembl Acc Id: ENSPPAP00000013691   ⟸   ENSPPAT00000036365
Ensembl Acc Id: ENSPPAP00000013673   ⟸   ENSPPAT00000036346
Protein Domains
SH2   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029995 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000036346.1 UniProtKB/TrEMBL
  ENSPPAT00000036365.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro CRK_SH3_C UniProtKB/TrEMBL
  CRK_SH3_N UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Tyrosine-phos_adapter UniProtKB/TrEMBL
KEGG Report pps:100976587 UniProtKB/TrEMBL
NCBI Gene CRK ENTREZGENE
PANTHER ADAPTER MOLECULE CRK UniProtKB/TrEMBL
  SH2-SH3 ADAPTOR PROTEIN-RELATED UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A2R9A9X4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9ADT4_PANPA UniProtKB/TrEMBL