RGD Reference Report - Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules. - Rat Genome Database

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Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules.

Authors: Nakamura, T  Komiya, M  Sone, K  Hirose, E  Gotoh, N  Morii, H  Ohta, Y  Mori, N 
Citation: Nakamura T, etal., Mol Cell Biol. 2002 Dec;22(24):8721-34.
RGD ID: 11568687
Pubmed: PMID:12446789   (View Abstract at PubMed)
PMCID: PMC139861   (View Article at PubMed Central)

Neurotrophins are key regulators of the fate and shape of neuronal cells and act as guidance cues for growth cones by remodeling the actin cytoskeleton. Actin dynamics is controlled by Rho GTPases. We identified a novel Rho GTPase-activating protein (Grit) for Rho/Rac/Cdc42 small GTPases. Grit was abundant in neuronal cells and directly interacted with TrkA, a high-affinity receptor for nerve growth factor (NGF). Another pool of Grit was recruited to the activated receptor tyrosine kinase through its binding to N-Shc and CrkL/Crk, adapter molecules downstream of activated receptor tyrosine kinases. Overexpression of the TrkA-binding region of Grit inhibited NGF-induced neurite elongation. Further, we found some tendency for neurite promotion in full-length Grit-overexpressing PC12 cells upon NGF stimulation. These results suggest that Grit, a novel TrkA-interacting protein, regulates neurite outgrowth by modulating the Rho family of small GTPases.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CrkRatprotein binding  IPIARHGAP32 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Crk  (CRK proto-oncogene, adaptor protein)


Additional Information