RGD Reference Report - CrkII signals from epidermal growth factor receptor to Ras. - Rat Genome Database

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CrkII signals from epidermal growth factor receptor to Ras.

Authors: Kizaka-Kondoh, S  Matsuda, M  Okayama, H 
Citation: Kizaka-Kondoh S, etal., Proc Natl Acad Sci U S A 1996 Oct 29;93(22):12177-82.
RGD ID: 1298801
Pubmed: PMID:8901553   (View Abstract at PubMed)
PMCID: PMC37963   (View Article at PubMed Central)

A rat fibroblast mutant defective in oncogenic transformation and signaling from epidermal growth factor receptor to Ras has been isolated. The mutant contains dominant negative-type point mutations in the C-terminal SH3 domain of one crkII gene. Among the adapters tested, the mutant is complemented only by crkII cDNA. Expression of the mutated crkII in parent cells generates the phenotype indistinguishable from the mutant cell. Yet overexpression or reduced expression of Grb2 in the mutant before and after complementation with crkII have little effect on its phenotype. We conclude that adapter molecules are highly specific and that the oncogenic growth signal from epidermal growth factor receptor to Ras is predominantly mediated by CrkII in rat fibroblast.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
CrkRatprotein-macromolecule adaptor activity  IMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Crk  (CRK proto-oncogene, adaptor protein)


Additional Information