FAS (Fas cell surface death receptor) - Rat Genome Database
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Gene: FAS (Fas cell surface death receptor) Pan paniscus
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Symbol: FAS
Name: Fas cell surface death receptor
RGD ID: 11746152
Description: ENCODES a protein that exhibits calmodulin binding (ortholog); identical protein binding (ortholog); kinase binding (ortholog); INVOLVED IN activation-induced cell death of T cells (ortholog); aging (ortholog); apoptotic process (ortholog); PARTICIPATES IN extrinsic apoptotic pathway; FasL mediated signaling pathway; intrinsic apoptotic pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome 1 (ortholog); acute kidney failure (ortholog); Acute Liver Failure (ortholog); FOUND IN apical dendrite (ortholog); apical plasma membrane (ortholog); CD95 death-inducing signaling complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: Fas (TNF receptor superfamily, member 6); tumor necrosis factor receptor superfamily member 6
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11089,199,070 - 89,244,884 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1089,217,949 - 89,243,612 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01085,707,457 - 85,741,539 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome 1  (ISO)
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adult T-cell leukemia  (ISO)
alcoholic hepatitis  (ISO)
Alcoholic Liver Diseases  (ISO)
Alzheimer's disease  (ISO)
Animal Disease Models  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
aplastic anemia  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
autoimmune disease  (ISO)
autoimmune hepatitis  (ISO)
autoimmune lymphoproliferative syndrome  (ISO)
Autoimmune Lymphoproliferative Syndrome, Type IA  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Barrett's esophagus  (ISO)
Behcet's disease  (ISO)
brain glioma  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
cardiomyopathy  (ISO)
Cardiovascular Pregnancy Complications  (ISO)
cataract  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chest Trauma  (ISO)
chorioamnionitis  (ISO)
chronic conjunctivitis  (ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
Chronic Uveitis  (ISO)
clonorchiasis  (ISO)
Colonic Neoplasms  (ISO)
congestive heart failure  (ISO)
corneal neovascularization  (ISO)
cryptorchidism  (ISO)
cutaneous T cell lymphoma  (ISO)
cystic fibrosis  (ISO)
dermatomyositis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diffuse large B-cell lymphoma  (ISO)
dilated cardiomyopathy  (ISO)
Disease Progression  (ISO)
endophthalmitis  (ISO)
Endotoxemia  (ISO)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Allergic Asthma  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Pancreatitis, Acute  (ISO)
Fetal Growth Retardation  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
glomerulonephritis  (ISO)
Graft vs Host Disease  (ISO)
Graves' disease  (ISO)
Hashimoto Disease  (ISO)
HELLP syndrome  (ISO)
hematopoietic system disease  (ISO)
hepatitis B  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
heroin dependence  (ISO)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Huntington's disease  (ISO)
Hyperoxia  (ISO)
hypersplenism  (ISO)
Hypothermia  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
idiopathic pulmonary fibrosis  (ISO)
IgA glomerulonephritis  (ISO)
inclusion body myositis  (ISO)
infectious mononucleosis  (ISO)
Insulin Resistance  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
Kashin-Beck Disease  (ISO)
Kidney Reperfusion Injury  (ISO)
limited scleroderma  (ISO)
liver disease  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
Lung Neoplasms  (ISO)
Lymphatic Metastasis  (ISO)
Lymphomatoid Papulosis  (ISO)
lymphoproliferative syndrome  (ISO)
macular degeneration  (ISO)
male infertility  (ISO)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (ISO)
Metabolic Brain Diseases  (ISO)
mixed connective tissue disease  (ISO)
Moyamoya disease  (ISO)
multiple sclerosis  (ISO)
multiple system atrophy  (ISO)
Multisystemic Smooth Muscle Dysfunction Syndrome  (ISO)
myasthenia gravis  (ISO)
myelodysplastic syndrome  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
Necrosis  (ISO)
Neoplasm Metastasis  (ISO)
nephritis  (ISO)
non-alcoholic fatty liver disease  (ISO)
ocular hypertension  (ISO)
ovarian cancer  (ISO)
Oxygen-Induced Retinopathy  (ISO)
Parkinson's disease  (ISO)
peripheral vascular disease  (ISO)
Plasmodium falciparum malaria  (ISO)
pre-eclampsia  (ISO)
pre-malignant neoplasm  (ISO)
primary biliary cholangitis  (ISO)
primary immunodeficiency disease  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
proteinuria  (ISO)
Puromycin Aminonucleoside Nephrosis  (ISO)
Radiation Injuries, Experimental  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
retinal detachment  (ISO)
retinoblastoma  (ISO)
rheumatoid arthritis  (ISO)
sciatic neuropathy  (ISO)
seminoma  (ISO)
Sepsis  (ISO)
Sjogren's syndrome  (ISO)
Spinal Cord Compression  (ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (ISO)
squamous cell carcinoma  (ISO)
systemic lupus erythematosus  (ISO)
Taste Disorders  (ISO)
Temporomandibular Joint Osteoarthritis  (ISO)
Testicular Injury  (ISO)
thoracic aortic aneurysm  (ISO)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
varicocele  (ISO)
Ventricular Dysfunction, Left  (ISO)
Viral Bronchiolitis  (ISO)
visual epilepsy  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation-induced cell death of T cells  (ISO)
aging  (ISO)
apoptotic process  (ISO)
apoptotic signaling pathway  (ISO)
B cell mediated immunity  (ISO)
cellular response to amino acid starvation  (ISO)
cellular response to cobalt ion  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to estrogen stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hydrostatic pressure  (ISO)
cellular response to hyperoxia  (ISO)
cellular response to hypoxia  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to lithium ion  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to phenylalanine  (ISO)
cellular response to tumor necrosis factor  (ISO)
chordate embryonic development  (ISO)
circadian rhythm  (ISO)
dendrite regeneration  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
Fas signaling pathway  (ISO)
gene expression  (ISO)
hepatocyte apoptotic process  (ISO)
inflammatory cell apoptotic process  (ISO)
lipid localization  (ISO)
liver regeneration  (ISO)
lymphocyte apoptotic process  (ISO)
maternal process involved in female pregnancy  (ISO)
motor neuron apoptotic process  (ISO)
necroptotic signaling pathway  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of B cell activation  (ISO)
negative regulation of Schwann cell migration  (ISO)
negative regulation of Schwann cell proliferation  (ISO)
negative thymic T cell selection  (ISO)
neuron apoptotic process  (ISO)
ovarian follicle atresia  (ISO)
ovulation cycle  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of apoptotic signaling pathway  (ISO)
positive regulation of cell death  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
regulation of apoptotic process  (ISO)
regulation of cell population proliferation  (ISO)
regulation of gene expression  (ISO)
regulation of lipid storage  (ISO)
regulation of lymphocyte differentiation  (ISO)
regulation of myeloid cell differentiation  (ISO)
regulation of stress-activated MAPK cascade  (ISO)
response to cycloheximide  (ISO)
response to cytokine  (ISO)
response to drug  (ISO)
response to estrogen  (ISO)
response to ethanol  (ISO)
response to fluoride  (ISO)
response to glucocorticoid  (ISO)
response to growth factor  (ISO)
response to hypoxia  (ISO)
response to inorganic substance  (ISO)
response to lipopolysaccharide  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (ISO)
response to toxic substance  (ISO)
spermatogenesis  (ISO)
spleen development  (ISO)
T cell homeostasis  (ISO)
telencephalon development  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
FAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11089,199,070 - 89,244,884 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1089,217,949 - 89,243,612 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01085,707,457 - 85,741,539 (+)NCBIMhudiblu_PPA_v0panPan3
FAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1088,990,531 - 89,017,059 (+)EnsemblGRCh38hg38GRCh38
GRCh381088,968,429 - 89,017,059 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371090,750,555 - 90,776,816 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361090,740,268 - 90,765,522 (+)NCBINCBI36hg18NCBI36
Build 341090,740,267 - 90,765,521NCBI
Celera1084,497,075 - 84,522,333 (+)NCBI
Cytogenetic Map10q23.31NCBI
HuRef1084,384,755 - 84,410,009 (+)NCBIHuRef
CHM1_11091,032,376 - 91,058,878 (+)NCBICHM1_1
Fas
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391934,267,926 - 34,305,175 (+)NCBIGRCm39mm39
GRCm39 Ensembl1934,268,066 - 34,305,172 (+)Ensembl
GRCm381934,290,647 - 34,327,775 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1934,290,666 - 34,327,772 (+)EnsemblGRCm38mm10GRCm38
MGSCv371934,365,149 - 34,402,260 (+)NCBIGRCm37mm9NCBIm37
MGSCv361934,356,663 - 34,393,767 (+)NCBImm8
Celera1935,067,780 - 35,104,920 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1929.48NCBI
Fas
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21231,798,963 - 231,832,591 (+)NCBI
Rnor_6.0 Ensembl1252,589,785 - 252,624,790 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01252,589,785 - 252,624,790 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01259,812,248 - 259,846,107 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41238,259,443 - 238,274,745 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11238,423,465 - 238,438,767 (+)NCBI
Celera1228,912,823 - 228,946,152 (+)NCBICelera
Cytogenetic Map1q52NCBI
Fas
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554253,961,013 - 3,987,455 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554253,961,671 - 3,987,513 (-)NCBIChiLan1.0ChiLan1.0
FAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2638,737,611 - 38,763,321 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12638,738,811 - 38,763,298 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Fas
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936735209,369 - 234,582 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.114100,927,305 - 100,954,781 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214109,911,730 - 109,939,489 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Fas
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479115,290,022 - 15,315,848 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000048139   ⟹   ENSPPAP00000025312
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1089,217,949 - 89,243,612 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000048145   ⟹   ENSPPAP00000025318
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1089,218,764 - 89,242,284 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000048150   ⟹   ENSPPAP00000025323
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1089,218,764 - 89,241,964 (+)Ensembl
RefSeq Acc Id: XM_003810516   ⟹   XP_003810564
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11089,217,949 - 89,244,884 (+)NCBI
Mhudiblu_PPA_v01085,714,004 - 85,741,539 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008962851   ⟹   XP_008961099
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11089,218,810 - 89,243,612 (+)NCBI
Mhudiblu_PPA_v01085,715,466 - 85,741,539 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034931063   ⟹   XP_034786954
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01085,707,457 - 85,741,539 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003810564 (Get FASTA)   NCBI Sequence Viewer  
  XP_008961099 (Get FASTA)   NCBI Sequence Viewer  
  XP_034786954 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003810564   ⟸   XM_003810516
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008961099   ⟸   XM_008962851
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_034786954   ⟸   XM_034931063
- Peptide Label: isoform X3
RefSeq Acc Id: ENSPPAP00000025312   ⟸   ENSPPAT00000048139
RefSeq Acc Id: ENSPPAP00000025318   ⟸   ENSPPAT00000048145
RefSeq Acc Id: ENSPPAP00000025323   ⟸   ENSPPAT00000048150
Protein Domains
Death   TNFR-Cys


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035792 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000025312 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000025318 UniProtKB/TrEMBL
  ENSPPAP00000025323 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000048139 UniProtKB/TrEMBL
  ENSPPAT00000048145 UniProtKB/TrEMBL
  ENSPPAT00000048150 UniProtKB/TrEMBL
InterPro DEATH-like_dom_sf UniProtKB/TrEMBL
  Death_domain UniProtKB/TrEMBL
  Fas_rcpt UniProtKB/TrEMBL
  TNFR/NGFR_Cys_rich_reg UniProtKB/TrEMBL
  TNFRSF6_death UniProtKB/TrEMBL
  TNFRSF6_N UniProtKB/TrEMBL
KEGG Report pps:100988526 UniProtKB/TrEMBL
NCBI Gene FAS ENTREZGENE
PANTHER PTHR46874 UniProtKB/TrEMBL
Pfam Death UniProtKB/TrEMBL
  TNFR_c6 UniProtKB/TrEMBL
PRINTS TNFACTORR6 UniProtKB/TrEMBL
PROSITE DEATH_DOMAIN UniProtKB/TrEMBL
  TNFR_NGFR_2 UniProtKB/TrEMBL
SMART DEATH UniProtKB/TrEMBL
  TNFR UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
UniProt A0A2R9B6U6_PANPA UniProtKB/TrEMBL
  A0A2R9B6V8_PANPA UniProtKB/TrEMBL
  A0A2R9B6W3_PANPA UniProtKB/TrEMBL