BDNF (brain derived neurotrophic factor) - Rat Genome Database

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Gene: BDNF (brain derived neurotrophic factor) Pan paniscus
Analyze
Symbol: BDNF
Name: brain derived neurotrophic factor
RGD ID: 11730749
Description: ENCODES a protein that exhibits neurotrophin TRKB receptor binding (ortholog); INVOLVED IN aging (ortholog); axon extension (ortholog); axon guidance (ortholog); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; ASSOCIATED WITH acoustic neuroma (ortholog); alcohol use disorder (ortholog); alopecia (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); cytoplasmic vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: brain-derived neurotrophic factor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11127,520,306 - 27,589,239 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,520,312 - 27,589,239 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01127,618,322 - 27,687,661 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
alcohol use disorder  (ISO)
alopecia  (ISO)
Alzheimer's disease  (ISO)
amnestic disorder  (ISO)
amphetamine abuse  (ISO)
Amyloid Plaques  (ISO)
anxiety disorder  (ISO)
asthma  (ISO)
Ataxia  (ISO)
atopic dermatitis  (ISO)
attention deficit hyperactivity disorder  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
bacterial meningitis  (ISO)
bipolar disorder  (ISO)
Body Weight  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Cerebral Hemorrhage  (ISO)
Chronic Pain  (ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
colitis  (ISO)
color blindness  (ISO)
congenital central hypoventilation syndrome  (ISO)
cystitis  (ISO)
Deafness  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
Drug Eruptions  (ISO)
epilepsy  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Frontotemporal Lobar Degeneration  (ISO)
genetic disease  (ISO)
glaucoma  (ISO)
Gliosis  (ISO)
Hearing Loss  (ISO)
Hearing Loss, Noise-Induced  (ISO)
heroin dependence  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
Hyperoxia  (ISO)
hypertensive encephalopathy  (ISO)
hypothyroidism  (ISO)
Hypoxia  (ISO)
Inflammation  (ISO)
inner ear disease  (ISO)
intellectual disability  (ISO)
intermediate coronary syndrome  (ISO)
interstitial lung disease  (ISO)
Intervertebral Disc Displacement  (ISO)
irritable bowel syndrome  (ISO)
keratoconus  (ISO)
Leukoencephalopathies  (ISO)
low tension glaucoma  (ISO)
major depressive disorder  (ISO)
Memory Disorders  (ISO)
mental depression  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
morbid obesity  (ISO)
multiple sclerosis  (ISO)
Nasal Polyps  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
Nerve Degeneration  (ISO)
Nerve Injuries  (ISO)
nervous system disease  (ISO)
nicotine dependence  (ISO)
obesity  (ISO)
obsessive-compulsive disorder  (ISO)
obstructive sleep apnea  (ISO)
Optic Nerve Injuries  (ISO)
Pain  (ISO)
Pain, Referred  (ISO)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
Peripheral Nerve Injuries  (ISO)
post-traumatic stress disorder  (ISO)
Presbycusis  (ISO)
primary open angle glaucoma  (ISO)
psychotic disorder  (ISO)
pulmonary fibrosis  (ISO)
pulmonary sarcoidosis  (ISO)
Radiation Injuries  (ISO)
Reperfusion Injury  (ISO)
Respiration Disorders  (ISO)
Respiratory Tract Infections  (ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
rhinitis  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
Seasonal Allergic Rhinitis  (ISO)
sensorineural hearing loss  (ISO)
Sjogren's syndrome  (ISO)
Sleep Deprivation  (ISO)
Spinal Cord Injuries  (ISO)
Spinal Cord Reperfusion Injury  (ISO)
status epilepticus  (ISO)
Stomach Neoplasms  (ISO)
systemic scleroderma  (ISO)
Tinnitus  (ISO)
Tobacco Use Disorder  (ISO)
type 2 diabetes mellitus  (ISO)
urticaria  (ISO)
vascular dementia  (ISO)
Visceral Pain  (ISO)
visual epilepsy  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
axon extension  (ISO)
axon guidance  (ISO)
axon target recognition  (ISO)
behavioral fear response  (ISO)
behavioral response to cocaine  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to norepinephrine stimulus  (ISO)
cellular response to potassium ion  (ISO)
cellular response to tumor necrosis factor  (ISO)
chronic inflammatory response  (ISO)
circadian rhythm  (ISO)
cognition  (ISO)
collateral sprouting  (ISO)
conditioned place preference  (ISO)
dendrite development  (ISO)
dendrite extension  (ISO)
excitatory postsynaptic potential  (ISO)
fear response  (ISO)
feeding behavior  (ISO)
gamma-aminobutyric acid signaling pathway  (ISO)
glutamate secretion  (ISO)
inhibitory postsynaptic potential  (ISO)
inner ear development  (ISO)
learning  (ISO)
learning or memory  (ISO)
mechanoreceptor differentiation  (ISO)
mitochondrial electron transport, NADH to ubiquinone  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of cell death  (ISO)
negative regulation of myotube differentiation  (ISO)
negative regulation of neuroblast proliferation  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of striated muscle tissue development  (ISO)
negative regulation of synaptic transmission, GABAergic  (ISO)
nerve development  (ISO)
nervous system development  (ISO)
neuron apoptotic process  (ISO)
neuron projection extension  (ISO)
neuron recognition  (ISO)
peptidyl-serine phosphorylation  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of collateral sprouting  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of glucocorticoid receptor signaling pathway  (ISO)
positive regulation of long-term neuronal synaptic plasticity  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of receptor binding  (ISO)
positive regulation of synapse assembly  (ISO)
regeneration  (ISO)
regulation of axon extension  (ISO)
regulation of collateral sprouting  (ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of neuron apoptotic process  (ISO)
regulation of retinal cell programmed cell death  (ISO)
regulation of short-term neuronal synaptic plasticity  (ISO)
regulation of synaptic plasticity  (ISO)
response to activity  (ISO)
response to anesthetic  (ISO)
response to auditory stimulus  (ISO)
response to electrical stimulus  (ISO)
response to food  (ISO)
response to hormone  (ISO)
response to hyperoxia  (ISO)
response to hypoxia  (ISO)
response to L-glutamate  (ISO)
response to light intensity  (ISO)
response to light stimulus  (ISO)
response to nerve growth factor  (ISO)
response to nutrient levels  (ISO)
response to potassium ion  (ISO)
response to tumor necrosis factor  (ISO)
response to vitamin A  (ISO)
response to xenobiotic stimulus  (ISO)
retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission  (ISO)
signal transduction  (IEA)
synapse assembly  (ISO)
taste bud development  (ISO)
trans-synaptic signaling by BDNF, modulating synaptic transmission  (ISO)
ureteric bud development  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
BDNF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11127,520,306 - 27,589,239 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,520,312 - 27,589,239 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01127,618,322 - 27,687,661 (-)NCBIMhudiblu_PPA_v0panPan3
BDNF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381127,654,893 - 27,722,030 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1127,654,893 - 27,722,058 (-)EnsemblGRCh38hg38GRCh38
GRCh371127,676,440 - 27,743,577 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361127,633,016 - 27,699,872 (-)NCBINCBI36hg18NCBI36
Build 341127,633,019 - 27,637,249NCBI
Celera1127,822,548 - 27,889,725 (-)NCBI
Cytogenetic Map11p14.1NCBI
HuRef1127,374,586 - 27,441,772 (-)NCBIHuRef
CHM1_11127,675,184 - 27,742,527 (-)NCBICHM1_1
T2T-CHM13v2.01127,795,301 - 27,862,460 (-)NCBI
Bdnf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392109,505,045 - 109,557,388 (+)NCBIGRCm39mm39
GRCm39 Ensembl2109,505,045 - 109,557,352 (+)Ensembl
GRCm382109,674,700 - 109,727,043 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2109,674,700 - 109,727,007 (+)EnsemblGRCm38mm10GRCm38
MGSCv372109,514,857 - 109,567,200 (+)NCBIGRCm37mm9NCBIm37
MGSCv362109,475,539 - 109,527,845 (+)NCBImm8
Celera2110,835,441 - 110,887,723 (+)NCBICelera
Cytogenetic Map2E3NCBI
cM Map256.63NCBI
Bdnf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2396,165,042 - 96,215,621 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl396,165,042 - 96,215,615 (+)Ensembl
Rnor_6.03100,768,637 - 100,819,216 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3100,768,637 - 100,819,210 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03107,371,329 - 107,421,908 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera395,191,318 - 95,241,949 (+)NCBICelera
Cytogenetic Map3q34NCBI
Bdnf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554766,772,088 - 6,822,588 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554766,773,244 - 6,822,201 (-)NCBIChiLan1.0ChiLan1.0
BDNF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12148,191,580 - 48,243,699 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2148,192,670 - 48,204,480 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2147,689,871 - 47,691,000 (-)NCBI
ROS_Cfam_1.02149,335,793 - 49,386,964 (-)NCBI
UMICH_Zoey_3.12148,338,131 - 48,339,260 (-)NCBI
UNSW_CanFamBas_1.02148,489,388 - 48,490,517 (-)NCBI
UU_Cfam_GSD_1.02149,083,467 - 49,084,596 (-)NCBI
Bdnf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494736,374,992 - 36,427,979 (+)NCBI
SpeTri2.0NW_0049365405,530,081 - 5,582,765 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BDNF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl232,624,048 - 32,679,765 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1232,623,668 - 32,679,293 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2235,206,996 - 35,265,002 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BDNF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1137,386,825 - 37,451,380 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl137,449,593 - 37,450,336 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038134,690,869 - 134,762,531 (+)NCBIVero_WHO_p1.0
Bdnf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476617,279,630 - 17,330,490 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462476617,281,882 - 17,330,601 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000034750   ⟹   ENSPPAP00000012088
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1127,520,312 - 27,589,239 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000034753   ⟹   ENSPPAP00000012091
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1127,520,312 - 27,567,159 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000034758   ⟹   ENSPPAP00000012096
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1127,523,215 - 27,541,829 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000034759   ⟹   ENSPPAP00000012097
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1127,523,215 - 27,524,043 (-)Ensembl
RefSeq Acc Id: XM_008955891   ⟹   XP_008954139
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11127,520,306 - 27,589,239 (-)NCBI
Mhudiblu_PPA_v01127,618,322 - 27,687,661 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008955892   ⟹   XP_008954140
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11127,520,306 - 27,567,880 (-)NCBI
Mhudiblu_PPA_v01127,618,322 - 27,666,087 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008955893   ⟹   XP_008954141
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11127,520,306 - 27,568,969 (-)NCBI
Mhudiblu_PPA_v01127,619,439 - 27,667,228 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008955894   ⟹   XP_008954142
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11127,520,413 - 27,567,880 (-)NCBI
Mhudiblu_PPA_v01127,619,439 - 27,666,087 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034932314   ⟹   XP_034788205
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01127,618,322 - 27,686,373 (-)NCBI
RefSeq Acc Id: XM_034932315   ⟹   XP_034788206
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01127,618,322 - 27,686,373 (-)NCBI
RefSeq Acc Id: XM_034932316   ⟹   XP_034788207
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01127,618,322 - 27,686,373 (-)NCBI
RefSeq Acc Id: XM_034932317   ⟹   XP_034788208
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01127,618,322 - 27,685,346 (-)NCBI
RefSeq Acc Id: XM_034932318   ⟹   XP_034788209
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01127,619,439 - 27,639,870 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_008954139   ⟸   XM_008955891
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008954141   ⟸   XM_008955893
- Peptide Label: isoform X4
- UniProtKB: Q5IS78 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008954142   ⟸   XM_008955894
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008954140   ⟸   XM_008955892
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_034788207   ⟸   XM_034932316
- Peptide Label: isoform X4
- UniProtKB: Q5IS78 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_034788206   ⟸   XM_034932315
- Peptide Label: isoform X4
- UniProtKB: Q5IS78 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_034788205   ⟸   XM_034932314
- Peptide Label: isoform X4
- UniProtKB: Q5IS78 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_034788208   ⟸   XM_034932317
- Peptide Label: isoform X4
- UniProtKB: Q5IS78 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_034788209   ⟸   XM_034932318
- Peptide Label: isoform X5
RefSeq Acc Id: ENSPPAP00000012096   ⟸   ENSPPAT00000034758
RefSeq Acc Id: ENSPPAP00000012097   ⟸   ENSPPAT00000034759
RefSeq Acc Id: ENSPPAP00000012088   ⟸   ENSPPAT00000034750
RefSeq Acc Id: ENSPPAP00000012091   ⟸   ENSPPAT00000034753
Protein Domains
NGF


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029232 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000012088 ENTREZGENE
  ENSPPAP00000012088.1 UniProtKB/TrEMBL
  ENSPPAP00000012091.1 UniProtKB/TrEMBL
  ENSPPAP00000012096.1 UniProtKB/TrEMBL
  ENSPPAP00000012097.1 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000034750.1 UniProtKB/TrEMBL
  ENSPPAT00000034753.1 UniProtKB/TrEMBL
  ENSPPAT00000034758.1 UniProtKB/TrEMBL
  ENSPPAT00000034759.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Brain-der_neurotrophic_factor UniProtKB/TrEMBL
  Cystine-knot_cytokine UniProtKB/TrEMBL
  Nerve_growth_factor-like UniProtKB/TrEMBL
  Nerve_growth_factor-rel UniProtKB/TrEMBL
  Nerve_growth_factor_CS UniProtKB/TrEMBL
KEGG Report pps:100983866 UniProtKB/TrEMBL
NCBI Gene BDNF ENTREZGENE
PANTHER PTHR11589 UniProtKB/TrEMBL
  PTHR11589:SF3 UniProtKB/TrEMBL
Pfam NGF UniProtKB/TrEMBL
PIRSF NGF UniProtKB/TrEMBL
PRINTS BDNFACTOR UniProtKB/TrEMBL
  NGF UniProtKB/TrEMBL
PROSITE NGF_1 UniProtKB/TrEMBL
SMART NGF UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A2R9A467_PANPA UniProtKB/TrEMBL
  A0A2R9A9J4_PANPA UniProtKB/TrEMBL
  A0A2R9A9K0_PANPA UniProtKB/TrEMBL
  Q5IS78 ENTREZGENE