RGD Reference Report - Fcgamma receptor IIIA polymorphism as a risk-factor for coronary artery disease. - Rat Genome Database

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Fcgamma receptor IIIA polymorphism as a risk-factor for coronary artery disease.

Authors: Gavasso, S  Nygard, O  Pedersen, ER  Aarseth, JH  Bleie, O  Myhr, KM  Vedeler, CA 
Citation: Gavasso S, etal., Atherosclerosis. 2005 Jun;180(2):277-82. Epub 2005 Jan 25.
RGD ID: 5508464
Pubmed: PMID:15910853   (View Abstract at PubMed)
DOI: DOI:10.1016/j.atherosclerosis.2004.12.011   (Journal Full-text)

BACKGROUND: Inflammation is important in the pathogenesis of atherosclerosis. Polymorphisms of Fc receptors for IgG (FcgammaR) are associated with modifying effects of several infectious and autoimmune diseases. We have assessed the relationship between polymorphisms in three different FcgammaR genes and coronary artery disease (CAD). METHODS AND RESULTS: We genotyped for the FcgammaRIIA-R/H131, the FcgammaRIIIB-Na1/Na2, and the FcgammaRIIIA-F/V158 polymorphisms in 882 patients undergoing diagnostic coronary angiography. Significant CAD was defined as >/=50% lumen diameter stenosis in at least one coronary artery. In the analysis, no association was found between the FcgammaRIIA and FcgammaRIIIB genotypes and CAD, whereas the FcgammaRIIIA genotype was strongly related. Compared to those being heterozygous, or homozygous for the F allele, patients homozygous for the V allele had significantly reduced risk: OR, 0.53; (CI, 0.32-0.90). Additional adjustment for classical risk factors and sedimentation rate did not affect the results. The V/V genotype was also inversely related to the extent of CAD defined as no CAD, single, double or triple vessel disease (P trend=0.002). CONCLUSIONS: Our data provide evidence for an association between FcgammaRIIIA allelic variants and coronary atherosclerosis. Genetic variation in this IgG-receptor may influence the clearance of antibodies by monocyte-derived macrophages involved in the pathogenesis of CAD.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FCGR3AHumancoronary artery disease susceptibilityIAGP DNA:SNP:exon:p.F158V (rs396991)(human)RGD 
Fcgr3aRatcoronary artery disease susceptibilityISOFCGR3A (Homo sapiens)DNA:SNP:exon:p.F158V (rs396991)(human)RGD 
Fcgr4Mousecoronary artery disease susceptibilityISOFCGR3A (Homo sapiens)DNA:SNP:exon:p.F158V (rs396991)(human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fcgr3a  (Fc gamma receptor 3A)

Genes (Mus musculus)
Fcgr4  (Fc receptor, IgG, low affinity IV)

Genes (Homo sapiens)
FCGR3A  (Fc gamma receptor IIIa)


Additional Information