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Gene: FCGR3A (Fc fragment of IgG receptor IIIa) Homo sapiens
Symbol: FCGR3A
Name: Fc fragment of IgG receptor IIIa
Description: Predicted to have IgG binding activity. Predicted to be involved in Fc-gamma receptor signaling pathway involved in phagocytosis and immune response. Localizes to the external side of plasma membrane. Implicated in several diseases, including arthritis (multiple); autoimmune hypersensitivity disease (multiple); glomerulonephritis (multiple); hematologic cancer (multiple); and vasculitis (multiple). Biomarker of ankylosing spondylitis; multiple sclerosis; rheumatoid arthritis; and systemic lupus erythematosus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD16; CD16A; CD16a antigen; Fc fragment of IgG low affinity IIIa receptor; Fc fragment of IgG, low affinity III, receptor for (CD16); Fc fragment of IgG, low affinity IIIa, receptor (CD16a); Fc gamma receptor III-A; Fc gamma receptor IIIa; fc receptor, igg, low affinity iii; Fc-gamma receptor III-2 (CD 16); Fc-gamma receptor IIIb (CD16); fc-gamma RIII; Fc-gamma RIII-alpha; Fc-gamma RIIIa; FCG3; FcgammaRIIIA; FCGR3; FCGRIII; FCR-10; FCRIII; FCRIIIA; IGFR3; igG Fc receptor III-2; IMD20; immunoglobulin G Fc receptor III; low affinity immunoglobulin gamma Fc region receptor III-A; low affinity immunoglobulin gamma receptor III-a Fc fragment; neutrophil-specific antigen NA
Mus musculus (house mouse) : Fcgr4 (Fc receptor, IgG, low affinity IV)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fcgr3a (Fc fragment of IgG receptor IIIa)  Alliance
Canis lupus familiaris (dog) : LOC478984 (low affinity immunoglobulin gamma Fc region receptor III)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fcgr3a (Fc fragment of IgG receptor IIIa)
Sus scrofa (pig) : FCGR3A (Fc fragment of IgG receptor IIIa)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1161,541,759 - 161,550,737 (-)Ensembl
GRCh381161,541,759 - 161,550,737 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371161,511,549 - 161,520,413 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,778,173 - 159,786,442 (-)NCBINCBI36hg18NCBI36
Build 341158,324,607 - 158,332,873NCBI
Cytogenetic Map1q23.3NCBI
HuRef1132,836,941 - 132,843,979 (-)NCBIHuRef
CHM1_11162,933,382 - 162,942,246 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on FCGR3A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736450
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.