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Gene: GDF11 (growth differentiation factor 11) Pan paniscus

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Symbol:

GDF11

Name:

growth differentiation factor 11

RGD ID:

11757629

Description:

ENCODES a protein that exhibits cytokine activity (inferred); growth factor activity (inferred); INVOLVED IN amacrine cell differentiation (ortholog); animal organ morphogenesis (ortholog); anterior/posterior pattern specification (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Myocardial Reperfusion Injury (ortholog); orofacial cleft (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); intracellular membrane-bounded organelle (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

growth/differentiation factor 11

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	38,571,240 - 38,585,080 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	38,568,010 - 38,581,811 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	33,154,530 - 33,168,427 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	33,879,143 - 33,893,027 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	33,879,180 - 33,893,252 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

Myocardial Reperfusion Injury (ISO)

orofacial cleft (ISO)

vertebral hypersegmentation and orofacial anomalies (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

activin receptor signaling pathway (IEA)

amacrine cell differentiation (IEA,ISO)

animal organ morphogenesis (IEA,ISO)

anterior/posterior pattern specification (IEA,ISO)

camera-type eye morphogenesis (IEA,ISO)

cell population proliferation (IEA,ISO)

metanephros development (IEA,ISO)

negative regulation of amacrine cell differentiation (IEA,ISO)

negative regulation of cell population proliferation (IEA,ISO)

negative regulation of neuron differentiation (IEA,ISO)

neuron differentiation (IEA,ISO)

pancreas development (IEA,ISO)

positive regulation of SMAD protein signal transduction (IEA)

roof of mouth development (IEA,ISO)

skeletal system development (IEA,ISO)

spinal cord anterior/posterior patterning (IEA,ISO)

type B pancreatic cell maturation (IEA,ISO)

ureteric bud development (IEA,ISO)

Cellular Component

extracellular region (IEA)

extracellular space (IEA)

intracellular membrane-bounded organelle (IEA)

nucleoplasm (IEA)

protein-containing complex (IEA)

Molecular Function

cytokine activity (IEA)

growth factor activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

GDF11
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	38,571,240 - 38,585,080 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	38,568,010 - 38,581,811 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	33,154,530 - 33,168,427 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	33,879,143 - 33,893,027 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	33,879,180 - 33,893,252 (-)	Ensembl	panpan1.1		panPan2

GDF11
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	55,743,122 - 55,757,264 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	55,743,122 - 55,757,264 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	56,136,906 - 56,151,048 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	54,423,331 - 54,430,332 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	54,423,333 - 54,430,332	NCBI
Celera	12	55,789,534 - 55,799,135 (+)	NCBI		Celera
Cytogenetic Map	12	q13.2	NCBI
HuRef	12	53,175,916 - 53,185,626 (+)	NCBI		HuRef
CHM1_1	12	56,103,813 - 56,113,414 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	55,709,757 - 55,723,906 (+)	NCBI		T2T-CHM13v2.0

Gdf11
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	128,716,393 - 128,727,587 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	128,718,164 - 128,727,587 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	128,880,524 - 128,891,718 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	128,882,295 - 128,891,718 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	128,321,602 - 128,328,774 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	128,287,495 - 128,294,634 (-)	NCBI		MGSCv36	mm8
Celera	10	131,277,119 - 131,314,308 (-)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI
cM Map	10	77.18	NCBI

Gdf11
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	1,896,229 - 1,909,147 (-)	NCBI		GRCr8
mRatBN7.2	7	1,311,732 - 1,325,211 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	1,311,732 - 1,320,725 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	4,076,094 - 4,085,087 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	5,951,755 - 5,960,748 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	6,253,020 - 6,262,013 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	3,306,863 - 3,315,856 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	3,306,863 - 3,315,856 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	3,277,923 - 3,286,916 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	2,182,467 - 2,191,454 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	2,185,253 - 2,191,265 (-)	NCBI
Celera	7	1,182,487 - 1,191,452 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

Gdf11
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	3,388,402 - 3,398,040 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	3,388,402 - 3,398,040 (+)	NCBI	ChiLan1.0	ChiLan1.0

GDF11
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	142,039 - 152,537 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	145,036 - 148,373 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	202,146 - 211,966 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	147,013 - 159,810 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	147,013 - 153,803 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	124,694 - 137,481 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	367,790 - 377,596 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	491,709 - 504,497 (+)	NCBI		UU_Cfam_GSD_1.0

Gdf11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	58,643,209 - 58,655,134 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936646	216,946 - 224,321 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936646	215,101 - 227,296 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GDF11
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	21,191,251 - 21,201,804 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	21,191,322 - 21,199,024 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	22,671,244 - 22,678,880 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GDF11
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	51,693,664 - 51,702,781 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	51,693,717 - 51,700,278 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	194,292,055 - 194,300,722 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gdf11
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624802	12,259,971 - 12,269,440 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008959698	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000050069 ⟹ ENSPPAP00000027230

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	12	33,879,180 - 33,893,252 (-)	Ensembl

RefSeq Acc Id:

XM_008959698 ⟹ XP_008957946

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	10	38,571,240 - 38,585,080 (-)	NCBI
NHGRI_mPanPan1	12	38,568,010 - 38,581,811 (-)	NCBI
Mhudiblu_PPA_v0	12	33,154,530 - 33,168,427 (-)	NCBI
PanPan1.1	12	33,879,143 - 33,893,027 (-)	NCBI

Sequence:

show sequence

AGCAAACTGCGGCTCAAGGAGGCGCCCAACATCAGCCGCGAGGTGGTGAAGCAGCTGCTGCCCA
AGGCGCCGCCGCTGCAGCAGATCCTGGACCTACACGACTTCCAGGGCGACGCGCTGCAGCCCGA
GGACTTCCTGGAGGAGGACGAGTACCACGCCACCACCGAGACCGTCATTAGCATGGCCCAGGAG
ACGGACCCAGCAGTACAGACAGATGGCAGCCCTCTCTGCTGCCATTTTCACTTCAGCCCCAAGG
TGATGTTCACAAAGGTACTGAAGGCCCAGCTGTGGGTGTACCTACGGCCTGTACCCCGCCCAGC
CACAGTCTACCTGCAGATCTTGCGACTAAAACCCCTAACTGGGGAAGGGACCGCAGGGGGAGGG
GGCGGAGGCCGGCGTCACATCCGTATCCGCTCACTGAAGATTGAGCTGCACTCACGCTCAGGCC
ATTGGCAGAGCATCGACTTCAAGCAAGTGCTACACAGCTGGTTCCGCCAGCCACAGAGCAACTG
GGGCATCGAGATCAACGCCTTTGATCCCAGTGGCACAGACCTGGCTGTCACCTCCCTGGGGCCG
GGAGCCGAGGGGCTGCATCCATTCATGGAGCTTCGAGTCCTAGAGAACACAAAACGTTCCCGGC
GGAACCTGGGTCTGGACTGCGACGAGCACTCAAGCGAGTCCCGCTGCTGCCGATATCCCCTCAC
AGTGGACTTTGAGGCTTTCGGCTGGGACTGGATCATCGCACCTAAGCGCTACAAGGCCAACTAC
TGCTCCGGCCAGTGCGAGTACATGTTCATGCAAAAATATCCGCATACCCATTTGGTGCAGCAGG
CCAATCCAAGAGGCTCTGCTGGGCCCTGTTGTACCCCCACCAAGATGTCCCCAATCAACATGCT
CTACTTCAATGACAAGCAGCAGATTATCTACGGCAAGATCCCTGGCATGGTGGTGGATCGCTGT
GGCTGCTCTTAAGCGGGTCACTACAAGCTGCTGGAGCAAAGACTTGGTGGGTGGGTAACTTAAC
CTCTTCACAGAGGATAAAAAATGCTTGTGAGTATGACAGAAGGGAATAAATAGGCTTAAAGGGT
AAACTCAATCCTTTTCCTTGTCTTCTCTTCTAAGGGATAAAGGTATTATGGCCAATTCTCTATC
ATATTTGCCCCTGAAGCTCCCCTTATCTGGTCTAATCTAGCTCCAATAAATCAAAGGAGCACCT
AATAAAACACATTGTTCTCTTTTCTATTTTTTTTATTAACAAGCAACATAATCAAAAACAAAAA
CACAACAACCTTAAAGCTGAAACAGCAATAAGTCAAACTGCTGCCGCAGTTCACGGATGTACCT
GGGGTACATGCTCCCTCATTGCGAGGCAGGACGTAGGCACATGACTGTGCATTTAGGCATATAT
GTGACCAAGAAGAAGGAGAGAAATGGAAAACACTGGAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_008957946	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000027230.1

RefSeq Acc Id:

XP_008957946 ⟸ XM_008959698

- Sequence:

show sequence

MAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQLWVYLRPVPRPATVYLQILRLKPLTGEGT
AGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVT
SLGPGAEGLHPFMELRVLENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRY
KANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMV
VDRCGCS

hide sequence

Ensembl Acc Id:

ENSPPAP00000027230 ⟸ ENSPPAT00000050069

Protein Domains

TGF-beta family profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000036686	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000050069.1	UniProtKB/TrEMBL
Gene3D-CATH	2.10.90.10	UniProtKB/TrEMBL
	2.60.120.970	UniProtKB/TrEMBL
InterPro	Cystine-knot_cytokine	UniProtKB/TrEMBL
	TGF-b_C	UniProtKB/TrEMBL
	TGF-b_propeptide	UniProtKB/TrEMBL
	TGF-beta-rel	UniProtKB/TrEMBL
	TGFb_CS	UniProtKB/TrEMBL
NCBI Gene	GDF11	ENTREZGENE
PANTHER	GROWTH/DIFFERENTIATION FACTOR 11	UniProtKB/TrEMBL
	PTHR11848	UniProtKB/TrEMBL
Pfam	TGF_beta	UniProtKB/TrEMBL
	TGFb_propeptide	UniProtKB/TrEMBL
PROSITE	TGF_BETA_1	UniProtKB/TrEMBL
	TGF_BETA_2	UniProtKB/TrEMBL
SMART	TGFB	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57501	UniProtKB/TrEMBL
UniProt	A0A2R9BKM4_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM