GDF11 (growth differentiation factor 11) - Rat Genome Database

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Gene: GDF11 (growth differentiation factor 11) Sus scrofa
Analyze
Symbol: GDF11
Name: growth differentiation factor 11
RGD ID: 13994181
Description: ENCODES a protein that exhibits growth factor activity (inferred); INVOLVED IN amacrine cell differentiation (ortholog); animal organ morphogenesis (ortholog); anterior/posterior pattern specification (ortholog); ASSOCIATED WITH COVID-19 (ortholog); Myocardial Reperfusion Injury (ortholog); orofacial cleft (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); intracellular membrane-bounded organelle (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BMP11; bone morphogenetic protein 11; growth/differentiation factor 11
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,191,251 - 21,201,804 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,191,322 - 21,199,024 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2522,671,244 - 22,678,880 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:12718768   PMID:15771745   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GDF11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,191,251 - 21,201,804 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,191,322 - 21,199,024 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2522,671,244 - 22,678,880 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GDF11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381255,743,122 - 55,757,264 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1255,743,122 - 55,757,264 (+)EnsemblGRCh38hg38GRCh38
GRCh371256,136,906 - 56,151,048 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,423,331 - 54,430,332 (+)NCBINCBI36Build 36hg18NCBI36
Build 341254,423,333 - 54,430,332NCBI
Celera1255,789,534 - 55,799,135 (+)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1253,175,916 - 53,185,626 (+)NCBIHuRef
CHM1_11256,103,813 - 56,113,414 (+)NCBICHM1_1
T2T-CHM13v2.01255,709,757 - 55,723,906 (+)NCBIT2T-CHM13v2.0
Gdf11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,716,393 - 128,727,587 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,718,164 - 128,727,587 (-)EnsemblGRCm39 Ensembl
GRCm3810128,880,524 - 128,891,718 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,882,295 - 128,891,718 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710128,321,602 - 128,328,774 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610128,287,495 - 128,294,634 (-)NCBIMGSCv36mm8
Celera10131,277,119 - 131,314,308 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.18NCBI
Gdf11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,896,229 - 1,909,147 (-)NCBIGRCr8
mRatBN7.271,311,732 - 1,325,211 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl71,311,732 - 1,320,725 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx74,076,094 - 4,085,087 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,951,755 - 5,960,748 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.076,253,020 - 6,262,013 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.073,306,863 - 3,315,856 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl73,306,863 - 3,315,856 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.073,277,923 - 3,286,916 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.472,182,467 - 2,191,454 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.172,185,253 - 2,191,265 (-)NCBI
Celera71,182,487 - 1,191,452 (-)NCBICelera
Cytogenetic Map7q11NCBI
Gdf11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,388,402 - 3,398,040 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,388,402 - 3,398,040 (+)NCBIChiLan1.0ChiLan1.0
GDF11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21038,571,240 - 38,585,080 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11238,568,010 - 38,581,811 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01233,154,530 - 33,168,427 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11233,879,143 - 33,893,027 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,879,180 - 33,893,252 (-)Ensemblpanpan1.1panPan2
GDF11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110142,039 - 152,537 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10145,036 - 148,373 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10202,146 - 211,966 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010147,013 - 159,810 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10147,013 - 153,803 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110124,694 - 137,481 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010367,790 - 377,596 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010491,709 - 504,497 (+)NCBIUU_Cfam_GSD_1.0
Gdf11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,643,209 - 58,655,134 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646216,946 - 224,321 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646215,101 - 227,296 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GDF11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11151,693,664 - 51,702,781 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1151,693,717 - 51,700,278 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037194,292,055 - 194,300,722 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gdf11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480212,259,971 - 12,269,440 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GDF11
90 total Variants

Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 5 14 12 23 3 6 1

Sequence


Ensembl Acc Id: ENSSSCT00000000386   ⟹   ENSSSCP00000000380
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl521,191,251 - 21,201,804 (+)Ensembl
RefSeq Acc Id: NM_001244310   ⟹   NP_001231239
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1521,191,388 - 21,199,024 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021091131   ⟹   XP_020946790
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1521,191,322 - 21,198,780 (+)NCBI
Sequence:
RefSeq Acc Id: XP_020946790   ⟸   XM_021091131
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001231239   ⟸   NM_001244310
- Peptide Label: precursor
- UniProtKB: E7ECV9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000000380   ⟸   ENSSSCT00000000386

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000000363 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00025037064 UniProtKB/TrEMBL
  ENSSSCG00030043831 UniProtKB/TrEMBL
  ENSSSCG00035026722 UniProtKB/TrEMBL
  ENSSSCG00040001730 UniProtKB/TrEMBL
  ENSSSCG00045034074 UniProtKB/TrEMBL
  ENSSSCG00050075568 UniProtKB/TrEMBL
  ENSSSCG00055011384 UniProtKB/TrEMBL
  ENSSSCG00060069251 UniProtKB/TrEMBL
  ENSSSCG00065043863 UniProtKB/TrEMBL
  ENSSSCG00070029808 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000000386 ENTREZGENE
  ENSSSCT00000000386.5 UniProtKB/TrEMBL
  ENSSSCT00025050444.1 UniProtKB/TrEMBL
  ENSSSCT00030061116.1 UniProtKB/TrEMBL
  ENSSSCT00035035265.1 UniProtKB/TrEMBL
  ENSSSCT00040002050.1 UniProtKB/TrEMBL
  ENSSSCT00045058300.1 UniProtKB/TrEMBL
  ENSSSCT00050103653.1 UniProtKB/TrEMBL
  ENSSSCT00055022380.1 UniProtKB/TrEMBL
  ENSSSCT00060094530.1 UniProtKB/TrEMBL
  ENSSSCT00065059987.1 UniProtKB/TrEMBL
  ENSSSCT00070059940.1 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
  2.60.120.970 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  TGF-b_C UniProtKB/TrEMBL
  TGF-b_propeptide UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/TrEMBL
  TGFb_CS UniProtKB/TrEMBL
KEGG Report ssc:397254 UniProtKB/TrEMBL
NCBI Gene GDF11 ENTREZGENE
PANTHER GROWTH/DIFFERENTIATION FACTOR 11 UniProtKB/TrEMBL
  PTHR11848 UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
  TGFb_propeptide UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/TrEMBL
SMART TGFB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A4X1W425_PIG UniProtKB/TrEMBL
  E7ECV9 ENTREZGENE, UniProtKB/TrEMBL
  F1SPJ6_PIG UniProtKB/TrEMBL
  Q647I3_PIG UniProtKB/TrEMBL
  Q9BG54_PIG UniProtKB/TrEMBL
VGNC ID VGNC:88398 ENTREZGENE