ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1)

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Gene: ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1) Pan paniscus

Analyze

Symbol:

ATP1A1

Name:

ATPase Na+/K+ transporting subunit alpha 1

RGD ID:

11673448

Description:

ENCODES a protein that exhibits ADP binding (ortholog); ankyrin binding (ortholog); ATP binding (ortholog); INVOLVED IN cellular potassium ion homeostasis (ortholog); cellular response to mechanical stimulus (ortholog); cellular response to steroid hormone stimulus (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH adenoma (ortholog); adrenal cortical adenoma (ortholog); Charcot-Marie-Tooth disease type 2DD (ortholog); FOUND IN apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); caveola (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

sodium/potassium-transporting ATPase subunit alpha-1

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	121,212,161 - 121,232,876 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	121,212,488 - 121,243,099 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	86,162,401 - 86,193,883 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenoma (ISO)

adrenal cortical adenoma (ISO)

Charcot-Marie-Tooth disease type 2DD (ISO)

hyperhomocysteinemia (ISO)

hypertension (ISO)

Hypomagnesemia, Seizures, and Mental Retardation 2 (ISO)

Marfanoid Mental Retardation Syndrome, Autosomal (ISO)

myocardial infarction (ISO)

Myocardial Ischemia (ISO)

Myocardial Reperfusion Injury (ISO)

primary hyperaldosteronism (ISO)

prostate cancer (ISO)

sensorineural hearing loss (ISO)

Transmissible Gastroenteritis, of Swine (ISO)

vestibular disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular potassium ion homeostasis (ISO)

cellular response to mechanical stimulus (ISO)

cellular response to steroid hormone stimulus (ISO)

cellular sodium ion homeostasis (ISO)

membrane hyperpolarization (ISO)

membrane repolarization (ISO)

negative regulation of glucocorticoid biosynthetic process (ISO)

negative regulation of heart contraction (ISO)

positive regulation of heart contraction (ISO)

positive regulation of striated muscle contraction (ISO)

potassium ion import across plasma membrane (ISO)

potassium ion transport (ISO)

regulation of blood pressure (ISO)

regulation of cardiac muscle cell contraction (ISO)

regulation of sodium ion transport (ISO)

regulation of the force of heart contraction (ISO)

response to drug (ISO)

response to glycoside (ISO)

sodium ion export across plasma membrane (ISO)

sodium ion transport (ISO)

transmembrane transport (ISO)

Cellular Component

apical plasma membrane (ISO)

basolateral plasma membrane (ISO)

caveola (ISO)

endoplasmic reticulum (ISO)

endosome (ISO)

exocytic vesicle (ISO)

Golgi apparatus (ISO)

intercalated disc (ISO)

lateral plasma membrane (ISO)

membrane (ISO)

membrane raft (ISO)

organelle membrane (ISO)

plasma membrane (ISO)

postsynaptic density (ISO)

protein-containing complex (ISO)

sarcolemma (ISO)

sodium:potassium-exchanging ATPase complex (ISO)

sperm flagellum (ISO)

T-tubule (ISO)

Molecular Function

ADP binding (ISO)

ankyrin binding (ISO)

ATP binding (ISO)

ATPase binding (ISO)

chaperone binding (ISO)

P-type sodium:potassium-exchanging transporter activity (ISO)

phosphatase activity (ISO)

phosphatidylinositol 3-kinase binding (ISO)

potassium ion binding (ISO)

protein binding (ISO)

protein domain specific binding (ISO)

protein heterodimerization activity (ISO)

protein kinase binding (ISO)

sodium ion binding (ISO)

steroid hormone binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acebutolol pharmacodynamics pathway (ISO)

adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway (ISO)

alfentanil pharmacodynamics pathway (ISO)

amiloride pharmacodynamics pathway (ISO)

amiodarone pharmacodynamics pathway (ISO)

amlodipine pharmacodynamics pathway (ISO)

atenolol pharmacodynamics pathway (ISO)

bendroflumethiazide pharmacodynamics pathway (ISO)

betaxolol pharmacodynamics pathway (ISO)

bisoprolol pharmacodynamics pathway (ISO)

bumetanide pharmacodynamics pathway (ISO)

bupivacaine pharmacodynamics pathway (ISO)

bupranolol drug pathway (ISO)

bupranolol pharmacodynamics pathway (ISO)

buprenorphine pharmacodynamics pathway (ISO)

carvedilol pharmacodynamics pathway (ISO)

chloroprocaine pharmacodynamics pathway (ISO)

chlorothiazide pharmacodynamics pathway (ISO)

chlorthalidone pharmacodynamics pathway (ISO)

citalopram pharmacodynamics pathway (ISO)

cocaine pharmacodynamics pathway (ISO)

codeine and morphine pharmacodynamics pathway (ISO)

cystinuria pathway (ISO)

desipramine pharmacodynamics pathway (ISO)

diltiazem pharmacodynamics pathway (ISO)

diphenoxylate pharmacodynamics pathway (ISO)

disopyramide pharmacodynamics pathway (ISO)

dobutamine pharmacodynamics pathway (ISO)

eplerenone pharmacodynamics pathway (ISO)

escitalopram pharmacodynamics pathway (ISO)

esmolol pharmacodynamics pathway (ISO)

etacrynic acid pharmacodynamics pathway (ISO)

ethylmorphine pharmacodynamics pathway (ISO)

fentanyl pharmacodynamics pathway (ISO)

flecainde pharmacodynamics pathway (ISO)

fluoxetine pharmacodynamics pathway (ISO)

fosphenytoin pharmacodynamics pathway (ISO)

furosemide pharmacodynamics pathway (ISO)

Hartnup disease pathway (ISO)

heroin pharmacodynamics pathway (ISO)

hydrochlorothiazide pharmacodynamics pathway (ISO)

hydrocodone pharmacodynamics pathway (ISO)

hydroflumethiazide pharmacodynamics pathway (ISO)

hydromorphone pharmacodynamics pathway (ISO)

ibutilide pharmacodynamics pathway (ISO)

iminoglycinuria pathway (ISO)

imipramine pharmacodynamics pathway (ISO)

isoprenaline pharmacodynamics pathway (ISO)

isradipine pharmacodynamics pathway (ISO)

lactose degradation pathway (ISO)

levacetylmethadol pharmacodynamics pathway (ISO)

levobunolol pharmacodynamics pathway (ISO)

levobupivacaine phgarmacodynamics pathway (ISO)

levorphanol pharmacodynamics pathway (ISO)

lidocaine pharmacodynamics pathway (ISO)

lysinuric protein intolerance pathway (ISO)

mepivacaine pharmacodynamics pathway (ISO)

methadone pharmacodynamics pathway (ISO)

metolazone pharmacodynamics pathway (ISO)

metoprolol pharmacodynamics pathway (ISO)

mexiletine pharmacodynamics pathway (ISO)

nadolol pharmacodynamics pathway (ISO)

nalbuphine pharmacodynamics pathway (ISO)

naloxone pharmacodynamics pathway (ISO)

naltrexone pharmacodynamics pathway (ISO)

nebivolol pharmacodynamics pathway (ISO)

nicotine pharmacodynamics pathway (ISO)

nifedipine pharmacodynamics pathway (ISO)

nimodipine pharmacodynamics pathway (ISO)

nisoldipine pharmacodynamics pathway (ISO)

nitrendipine pharmacodynamics pathway (ISO)

oxybuprocaine pharmacodynamics pathway (ISO)

oxycodone pharmacodynamics pathway (ISO)

oxymorphone pharmacodynamics pathway (ISO)

penbutolol pharmacodynamics pathway (ISO)

pentazocine pharmacodynamics pathway (ISO)

phenytoin pharmacodynamics pathway (ISO)

pindolol pharmacodynamics pathway (ISO)

prilocaine pharmacodynamics pathway (ISO)

procainamide pharmacodynamics pathway (ISO)

procaine pharmacodynamics pathway (ISO)

propranolol pharmacodynamics pathway (ISO)

quinidine pharmacodynamics pathway (ISO)

remifentanil pharmacodynamics pathway (ISO)

ropivacaine pharmacodynamics pathway (ISO)

sotalol pharmacodynamics pathway (ISO)

spironolactone pharmacodynamics pathway (ISO)

timolol pharmacodynamics pathway (ISO)

torasemide pharmacodynamics pathway (ISO)

tramadol pharmacodynamics pathway (ISO)

trehalose degradation pathway (ISO)

triamterene pharmacodynamics pathway (ISO)

trichlormethiazide pharmacodynamics pathway (ISO)

verapamil pharmacodynamics pathway (ISO)

References

Genomics

Comparative Map Data

ATP1A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	121,212,161 - 121,232,876 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	121,212,488 - 121,243,099 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	86,162,401 - 86,193,883 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

ATP1A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	1	116,372,668 - 116,410,261 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	1	116,372,986 - 116,410,259 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	1	116,915,866 - 116,947,396 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	116,717,359 - 116,748,919 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	1	116,627,877 - 116,659,436	NCBI
Celera	1	115,144,421 - 115,176,022 (+)	NCBI
Cytogenetic Map	1	p13.1	NCBI
HuRef	1	114,773,961 - 114,805,562 (+)	NCBI		HuRef
CHM1_1	1	117,030,620 - 117,062,221 (+)	NCBI		CHM1_1

Atp1a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	101,483,535 - 101,512,023 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	3	101,483,535 - 101,512,000 (-)	Ensembl
GRCm38	3	101,576,219 - 101,604,707 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	101,576,219 - 101,604,684 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	101,380,146 - 101,408,580 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	3	101,705,284 - 101,733,721 (-)	NCBI			mm8
Celera	3	103,788,093 - 103,816,528 (-)	NCBI		Celera
Cytogenetic Map	3	F2.2	NCBI
cM Map	3	44.3	NCBI

Atp1a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	189,020,722 - 189,048,826 (-)	NCBI
Rnor_6.0 Ensembl	2	204,003,742 - 204,032,023 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	2	204,003,742 - 204,032,023 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	2	223,440,514 - 223,469,880 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	196,657,749 - 196,687,242 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	2	196,620,502 - 196,649,996 (-)	NCBI
Celera	2	181,455,492 - 181,483,650 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

Atp1a1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955435	19,536,634 - 19,564,580 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955435	19,537,224 - 19,563,631 (+)	NCBI	ChiLan1.0	ChiLan1.0

ATP1A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	17	53,813,976 - 53,847,167 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	17	53,828,482 - 53,847,043 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Atp1a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936627	1,555,151 - 1,584,370 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ATP1A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	104,353,506 - 104,384,606 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	104,353,506 - 104,384,321 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	114,431,993 - 114,451,892 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	4	q1.6-q2.3	NCBI

ATP1A1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	17,319,440 - 17,351,054 (-)	NCBI
ChlSab1.1 Ensembl	20	17,315,117 - 17,351,054 (-)	Ensembl

Atp1a1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624772	12,099,523 - 12,127,437 (+)	NCBI

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_034929861	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	SSBP01000070	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSPPAT00000057170 ⟹ ENSPPAP00000034289

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	121,212,488 - 121,243,099 (-)	Ensembl

RefSeq Acc Id:

ENSPPAT00000057188 ⟹ ENSPPAP00000034307

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	121,212,488 - 121,233,755 (-)	Ensembl

RefSeq Acc Id:

ENSPPAT00000057191 ⟹ ENSPPAP00000034310

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	121,212,488 - 121,233,556 (-)	Ensembl

RefSeq Acc Id:

ENSPPAT00000057198 ⟹ ENSPPAP00000034317

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	121,212,488 - 121,232,894 (-)	Ensembl

RefSeq Acc Id:

ENSPPAT00000057205 ⟹ ENSPPAP00000034324

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	121,215,099 - 121,232,863 (-)	Ensembl

RefSeq Acc Id:

XM_034929861 ⟹ XP_034785752

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
Mhudiblu_PPA_v0	1	86,162,401 - 86,193,883 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_034785752	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_034785752 ⟸ XM_034929861

RefSeq Acc Id:

ENSPPAP00000034289 ⟸ ENSPPAT00000057170

RefSeq Acc Id:

ENSPPAP00000034307 ⟸ ENSPPAT00000057188

RefSeq Acc Id:

ENSPPAP00000034317 ⟸ ENSPPAT00000057198

RefSeq Acc Id:

ENSPPAP00000034310 ⟸ ENSPPAT00000057191

RefSeq Acc Id:

ENSPPAP00000034324 ⟸ ENSPPAT00000057205

Protein Domains

Cation_ATPase_N

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000039938	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSPPAP00000034289	UniProtKB/TrEMBL
	ENSPPAP00000034307	UniProtKB/TrEMBL
	ENSPPAP00000034310	UniProtKB/TrEMBL
	ENSPPAP00000034317	UniProtKB/TrEMBL
	ENSPPAP00000034324	UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000057170	UniProtKB/TrEMBL
	ENSPPAT00000057188	UniProtKB/TrEMBL
	ENSPPAT00000057191	UniProtKB/TrEMBL
	ENSPPAT00000057198	UniProtKB/TrEMBL
	ENSPPAT00000057205	UniProtKB/TrEMBL
Gene3D-CATH	3.40.1110.10	UniProtKB/TrEMBL
	3.40.50.1000	UniProtKB/TrEMBL
InterPro	ATPase_P-typ_cation-transptr_C	UniProtKB/TrEMBL
	ATPase_P-typ_cation-transptr_N	UniProtKB/TrEMBL
	ATPase_P-typ_cyto_dom_N	UniProtKB/TrEMBL
	ATPase_P-typ_P_site	UniProtKB/TrEMBL
	ATPase_P-typ_TM_dom_sf	UniProtKB/TrEMBL
	ATPase_P-typ_transduc_dom_A_sf	UniProtKB/TrEMBL
	HAD-like_sf	UniProtKB/TrEMBL
	HAD_sf	UniProtKB/TrEMBL
	P-type_ATPase_IIC	UniProtKB/TrEMBL
	P_typ_ATPase	UniProtKB/TrEMBL
NCBI Gene	ATP1A1	ENTREZGENE
Pfam	Cation_ATPase_C	UniProtKB/TrEMBL
	Cation_ATPase_N	UniProtKB/TrEMBL
PROSITE	ATPASE_E1_E2	UniProtKB/TrEMBL
SMART	Cation_ATPase_N	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56784	UniProtKB/TrEMBL
	SSF81653	UniProtKB/TrEMBL
	SSF81660	UniProtKB/TrEMBL
	SSF81665	UniProtKB/TrEMBL
TIGRFAMs	ATPase-IIC_X-K	UniProtKB/TrEMBL
	ATPase_P-type	UniProtKB/TrEMBL
UniProt	A0A2R9BX94_PANPA	UniProtKB/TrEMBL
	A0A2R9BXA3_PANPA	UniProtKB/TrEMBL
	A0A2R9C0M5_PANPA	UniProtKB/TrEMBL
	A0A2R9C6X8_PANPA	UniProtKB/TrEMBL
	A0A2R9C713_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB