ATG7 (autophagy related 7) - Rat Genome Database

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Advanced Search (OLGA)
Gene: ATG7 (autophagy related 7) Pan paniscus
Analyze
Symbol: ATG7
Name: autophagy related 7
RGD ID: 11710724
Description: ENCODES a protein that exhibits Atg12 activating enzyme activity (inferred); Atg8 activating enzyme activity (inferred); protein homodimerization activity (inferred); INVOLVED IN adult walking behavior (ortholog); apoptotic process (ortholog); autophagosome assembly (ortholog); PARTICIPATES IN autophagy pathway; mitochondrial autophagy pathway; ASSOCIATED WITH alcoholic cardiomyopathy (ortholog); alcoholic hepatitis (ortholog); Alcoholic Liver Diseases (ortholog); FOUND IN axon (ortholog); axoneme (ortholog); dopaminergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ubiquitin-like modifier-activating enzyme ATG7
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2211,268,612 - 11,548,872 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1311,273,372 - 11,556,596 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0311,208,600 - 11,488,757 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1311,554,100 - 11,833,638 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl311,554,100 - 11,833,398 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult walking behavior  (ISO)
apoptotic process  (ISO)
autophagosome assembly  (IEA,ISO)
autophagy  (IEA,ISO)
autophagy of mitochondrion  (IEA,ISO)
cardiac muscle cell apoptotic process  (ISO)
cardiac muscle cell development  (ISO)
cell population proliferation  (ISO)
cellular response to hyperoxia  (IEA)
cellular response to morphine  (ISO)
cellular response to nitrogen starvation  (IEA)
cellular response to reactive oxygen species  (ISO)
cellular response to sodium arsenite  (ISO)
cellular response to starvation  (IEA,ISO)
cellular response to stress  (IEA)
central nervous system neuron axonogenesis  (ISO)
cerebellar Purkinje cell layer development  (ISO)
cerebral cortex development  (ISO)
chaperone-mediated autophagy  (ISO)
chromatin organization  (ISO)
circadian rhythm  (ISO)
defense response to virus  (IEA,ISO)
dendrite arborization  (ISO)
establishment of localization in cell  (ISO)
innate immune response  (ISO)
insulin secretion involved in cellular response to glucose stimulus  (ISO)
intracellular amino acid homeostasis  (ISO)
intracellular sphingolipid homeostasis  (ISO)
liver development  (ISO)
macroautophagy  (IEA,ISO)
membrane organization  (ISO)
mitochondrion organization  (ISO)
mitophagy  (IEA)
mucus secretion  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of dendrite extension  (ISO)
negative regulation of mitochondrial DNA replication  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of phagocytosis  (ISO)
negative regulation of programmed necrotic cell death  (ISO)
negative regulation of sphingolipid biosynthetic process  (ISO)
negative regulation of type B pancreatic cell apoptotic process  (ISO)
negative stranded viral RNA replication  (ISO)
nervous system process  (ISO)
neuron projection development  (ISO)
piecemeal microautophagy of the nucleus  (IEA)
positive regulation of apoptotic process  (IEA)
positive regulation of autophagosome assembly  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of insulin secretion involved in cellular response to glucose stimulus  (ISO)
positive regulation of mitophagy  (ISO)
positive regulation of mucus secretion  (ISO)
positive regulation of programmed cell death  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein catabolic process  (IEA)
positive regulation of protein modification process  (IEA,ISO)
post-embryonic development  (ISO)
protein catabolic process  (ISO)
protein lipidation  (ISO)
protein modification by small protein conjugation  (IEA,ISO)
protein transport  (IEA)
pyramidal neuron development  (ISO)
regulation of cell development  (ISO)
regulation of circadian rhythm  (ISO)
regulation of hemopoiesis  (ISO)
regulation of protein ubiquitination  (ISO)
response to alcohol  (ISO)
response to fluoride  (ISO)
response to glucose  (ISO)
response to nutrient levels  (ISO)
response to starvation  (ISO)
sphingolipid biosynthetic process  (ISO)
synaptic vesicle cycle  (ISO)
type B pancreatic cell apoptotic process  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ATG7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2211,268,612 - 11,548,872 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1311,273,372 - 11,556,596 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0311,208,600 - 11,488,757 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1311,554,100 - 11,833,638 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl311,554,100 - 11,833,398 (+)Ensemblpanpan1.1panPan2
ATG7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38311,272,397 - 11,576,353 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl311,272,309 - 11,557,665 (+)EnsemblGRCh38hg38GRCh38
GRCh37311,314,083 - 11,606,126 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36311,315,160 - 11,571,557 (+)NCBINCBI36Build 36hg18NCBI36
Build 34311,289,101 - 11,571,556NCBI
Celera311,249,448 - 11,534,544 (+)NCBICelera
Cytogenetic Map3p25.3NCBI
HuRef311,248,262 - 11,532,686 (+)NCBIHuRef
CHM1_1311,264,079 - 11,549,266 (+)NCBICHM1_1
T2T-CHM13v2.0311,267,348 - 11,571,596 (+)NCBIT2T-CHM13v2.0
Atg7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396114,620,075 - 114,837,565 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6114,620,058 - 114,837,575 (+)EnsemblGRCm39 Ensembl
GRCm386114,643,127 - 114,860,604 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6114,643,097 - 114,860,614 (+)EnsemblGRCm38mm10GRCm38
MGSCv376114,593,143 - 114,809,954 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366114,608,744 - 114,825,555 (+)NCBIMGSCv36mm8
Celera6116,482,450 - 116,697,418 (+)NCBICelera
Cytogenetic Map6E3NCBI
Atg7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84149,390,000 - 149,597,534 (+)NCBIGRCr8
mRatBN7.24147,718,663 - 147,925,656 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4147,718,752 - 147,925,593 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4153,970,841 - 154,149,831 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04149,753,892 - 149,932,881 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04148,377,731 - 148,556,715 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04146,570,113 - 146,777,093 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4146,598,413 - 146,777,124 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04209,861,459 - 210,067,618 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44150,814,706 - 150,992,704 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14151,059,546 - 151,153,422 (+)NCBI
Celera4136,643,475 - 136,821,326 (+)NCBICelera
Cytogenetic Map4q42NCBI
Atg7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542914,076,960 - 14,304,236 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542914,076,976 - 14,301,034 (+)NCBIChiLan1.0ChiLan1.0
ATG7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1206,916,354 - 7,154,849 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl206,916,515 - 7,154,800 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha206,951,793 - 7,189,666 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0206,945,628 - 7,184,158 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl206,944,407 - 7,184,165 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1206,661,904 - 6,900,228 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0207,018,478 - 7,256,616 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0206,989,268 - 7,228,243 (-)NCBIUU_Cfam_GSD_1.0
Atg7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494216,730,443 - 16,981,101 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366021,935,507 - 2,179,256 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366021,938,720 - 2,179,239 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATG7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1367,417,938 - 67,707,654 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11367,301,756 - 67,699,141 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21374,636,936 - 74,915,764 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATG7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12247,187,305 - 47,571,309 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2247,325,614 - 47,571,070 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041118,943,702 - 119,213,969 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atg7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624943232,618 - 481,290 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624943231,978 - 480,933 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000058046   ⟹   ENSPPAP00000035158
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl311,554,100 - 11,707,767 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000058052   ⟹   ENSPPAP00000035164
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl311,579,786 - 11,833,398 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000058055   ⟹   ENSPPAP00000035167
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl311,579,786 - 11,833,398 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000058057   ⟹   ENSPPAP00000035169
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl311,579,786 - 11,833,398 (+)Ensembl
RefSeq Acc Id: XM_003826264   ⟹   XP_003826312
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2211,268,613 - 11,548,872 (+)NCBI
NHGRI_mPanPan1311,273,373 - 11,556,596 (+)NCBI
Mhudiblu_PPA_v0311,208,600 - 11,488,757 (+)NCBI
PanPan1.1311,554,100 - 11,833,638 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008951717   ⟹   XP_008949965
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2211,268,613 - 11,442,600 (+)NCBI
NHGRI_mPanPan1311,273,373 - 11,447,356 (+)NCBI
Mhudiblu_PPA_v0311,208,600 - 11,382,521 (+)NCBI
PanPan1.1311,554,100 - 11,727,302 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055109489   ⟹   XP_054965464
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2211,275,896 - 11,442,600 (+)NCBI
NHGRI_mPanPan1311,282,325 - 11,447,356 (+)NCBI
RefSeq Acc Id: XM_055109490   ⟹   XP_054965465
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2211,268,743 - 11,442,600 (+)NCBI
NHGRI_mPanPan1311,273,503 - 11,447,356 (+)NCBI
RefSeq Acc Id: XM_055109492   ⟹   XP_054965467
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2211,275,908 - 11,548,872 (+)NCBI
NHGRI_mPanPan1311,282,331 - 11,556,596 (+)NCBI
RefSeq Acc Id: XM_055109493   ⟹   XP_054965468
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2211,268,741 - 11,548,872 (+)NCBI
NHGRI_mPanPan1311,273,501 - 11,556,596 (+)NCBI
RefSeq Acc Id: XM_055109494   ⟹   XP_054965469
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2211,268,612 - 11,442,600 (+)NCBI
NHGRI_mPanPan1311,273,372 - 11,447,355 (+)NCBI
RefSeq Acc Id: XM_055109495   ⟹   XP_054965470
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2211,268,613 - 11,548,872 (+)NCBI
NHGRI_mPanPan1311,273,373 - 11,556,596 (+)NCBI
RefSeq Acc Id: XP_003826312   ⟸   XM_003826264
- Peptide Label: isoform X2
- UniProtKB: A0A2R9C9V9 (UniProtKB/TrEMBL),   A0A2R9BZQ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008949965   ⟸   XM_008951717
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BZQ3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000035158   ⟸   ENSPPAT00000058046
Ensembl Acc Id: ENSPPAP00000035169   ⟸   ENSPPAT00000058057
Ensembl Acc Id: ENSPPAP00000035167   ⟸   ENSPPAT00000058055
Ensembl Acc Id: ENSPPAP00000035164   ⟸   ENSPPAT00000058052
RefSeq Acc Id: XP_054965469   ⟸   XM_055109494
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054965470   ⟸   XM_055109495
- Peptide Label: isoform X4
- UniProtKB: A0A2R9BZS3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054965468   ⟸   XM_055109493
- Peptide Label: isoform X2
- UniProtKB: A0A2R9C9V9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054965465   ⟸   XM_055109490
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054965464   ⟸   XM_055109489
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054965467   ⟸   XM_055109492
- Peptide Label: isoform X2
- UniProtKB: A0A2R9C9V9 (UniProtKB/TrEMBL)
Protein Domains
THIF-type NAD/FAD binding fold   Ubiquitin-like modifier-activating enzyme Atg7 N-


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000040386 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000058046.1 UniProtKB/TrEMBL
  ENSPPAT00000058052.1 UniProtKB/TrEMBL
  ENSPPAT00000058055.1 UniProtKB/TrEMBL
  ENSPPAT00000058057.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.140.100 UniProtKB/TrEMBL
  3.40.140.70 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro Atg7 UniProtKB/TrEMBL
  Atg7_N UniProtKB/TrEMBL
  Atg7_N_1 UniProtKB/TrEMBL
  Atg7_N_2 UniProtKB/TrEMBL
  ThiF/MoeB/HesA UniProtKB/TrEMBL
  ThiF_NAD_FAD-bd UniProtKB/TrEMBL
  Ubiquitin-activating_enz UniProtKB/TrEMBL
KEGG Report pps:100977190 UniProtKB/TrEMBL
NCBI Gene ATG7 ENTREZGENE
PANTHER PTHR10953 UniProtKB/TrEMBL
  UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7 UniProtKB/TrEMBL
Pfam ATG7_N UniProtKB/TrEMBL
  ThiF UniProtKB/TrEMBL
Superfamily-SCOP SSF69572 UniProtKB/TrEMBL
UniProt A0A2R9BZQ3 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BZS3 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9C9V9 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9C9W6_PANPA UniProtKB/TrEMBL