BCHE (butyrylcholinesterase) - Rat Genome Database
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Gene: BCHE (butyrylcholinesterase) Pan paniscus
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Symbol: BCHE
Name: butyrylcholinesterase
RGD ID: 12010583
Description: ENCODES a protein that exhibits acetylcholinesterase activity (ortholog); choline binding (ortholog); cholinesterase activity (ortholog); INVOLVED IN choline metabolic process (ortholog); learning (ortholog); negative regulation of cell population proliferation (ortholog); PARTICIPATES IN heroin pharmacodynamics pathway; heroin pharmacokinetics pathway; irinotecan pharmacodynamics pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); amnestic disorder (ortholog); Amyloid Plaques (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum lumen (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: cholinesterase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13170,845,494 - 170,910,662 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3170,845,494 - 170,911,481 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03162,794,184 - 162,858,574 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Alzheimer's disease  (ISO)
amnestic disorder  (ISO)
Amyloid Plaques  (ISO)
Apnea  (ISO)
bacterial meningitis  (ISO)
Bamforth-Lazarus syndrome  (ISO)
Breast Neoplasms  (ISO)
Butyrylcholinesterase Deficiency  (ISO)
Butyrylcholinesterase Deficiency, Fluoride-Resistant, Japanese Type  (ISO)
Cardiotoxicity  (ISO)
Cocaine-Related Disorders  (ISO)
cognitive disorder  (ISO)
congenital merosin-deficient muscular dystrophy 1A  (ISO)
coronary artery disease  (ISO)
coronary restenosis  (ISO)
Death  (ISO)
dementia  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
dystonia  (ISO)
Endotoxemia  (ISO)
epilepsy  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
Experimental Diabetes Mellitus  (ISO)
familial hyperlipidemia  (ISO)
Fasciculation  (ISO)
glioblastoma  (ISO)
Huntington's disease  (ISO)
hyperhomocysteinemia  (ISO)
Hyperkinesis  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
inherited metabolic disorder  (ISO)
Insulin Resistance  (ISO)
leptospirosis  (ISO)
Metabolic Syndrome  (ISO)
multiple sclerosis  (ISO)
muscular dystrophy  (ISO)
neuroblastoma  (ISO)
obesity  (ISO)
Organophosphate Poisoning  (ISO)
Paralysis  (ISO)
Paresis  (ISO)
Poisoning  (ISO)
Postoperative Complications  (ISO)
primary progressive multiple sclerosis  (ISO)
renal cell carcinoma  (ISO)
schizophrenia  (ISO)
secondary Parkinson disease  (ISO)
sleep apnea  (ISO)
Stroke  (ISO)
Tachycardia  (ISO)
toxic encephalopathy  (ISO)
Trismus  (ISO)
trypanosomiasis  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
visual epilepsy  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
BCHE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13170,845,494 - 170,910,662 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3170,845,494 - 170,911,481 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03162,794,184 - 162,858,574 (-)NCBIMhudiblu_PPA_v0panPan3
BCHE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3165,772,904 - 165,837,462 (-)EnsemblGRCh38hg38GRCh38
GRCh383165,772,904 - 165,837,423 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373165,490,692 - 165,555,211 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh373165,490,692 - 165,555,260 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363166,973,386 - 167,037,947 (-)NCBINCBI36hg18NCBI36
Build 343166,973,394 - 167,037,952NCBI
Celera3163,889,280 - 163,954,027 (-)NCBI
Cytogenetic Map3q26.1NCBI
HuRef3162,859,251 - 162,924,002 (-)NCBIHuRef
CHM1_13165,453,437 - 165,518,145 (-)NCBICHM1_1
Bche
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39373,543,138 - 73,615,767 (-)NCBIGRCm39mm39
GRCm38373,635,805 - 73,708,436 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl373,635,808 - 73,708,415 (-)EnsemblGRCm38mm10GRCm38
MGSCv37373,439,731 - 73,512,337 (-)NCBIGRCm37mm9NCBIm37
MGSCv36373,721,734 - 73,794,168 (-)NCBImm8
Celera373,748,016 - 73,817,761 (-)NCBICelera
Cytogenetic Map3E3NCBI
Bche
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22158,308,674 - 158,401,148 (-)NCBI
Rnor_6.0 Ensembl2171,100,140 - 171,196,395 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02171,104,476 - 171,196,186 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02190,443,044 - 190,536,106 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42164,329,613 - 164,427,994 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12164,279,575 - 164,377,957 (-)NCBI
Celera2152,547,587 - 152,638,478 (-)NCBICelera
Cytogenetic Map2q32NCBI
Bche
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544815,329,273 - 15,396,970 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544815,327,374 - 15,396,827 (-)NCBIChiLan1.0ChiLan1.0
BCHE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3430,912,632 - 30,977,583 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13430,912,632 - 30,977,624 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Bche
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367071,784,338 - 1,913,401 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCHE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.113104,946,732 - 105,007,568 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213113,411,303 - 113,471,727 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCHE
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11523,708,121 - 23,778,027 (+)NCBI
ChlSab1.1 Ensembl1523,708,155 - 23,778,286 (+)Ensembl
Bche
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473043,793,550 - 43,849,169 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000049662   ⟹   ENSPPAP00000026826
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3170,845,494 - 170,911,481 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000049665   ⟹   ENSPPAP00000026829
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3170,901,209 - 170,904,229 (-)Ensembl
RefSeq Acc Id: XM_003817698   ⟹   XP_003817746
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.13170,845,494 - 170,910,662 (-)NCBI
Mhudiblu_PPA_v03162,794,184 - 162,858,574 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003817746 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003817746   ⟸   XM_003817698
- Sequence:
RefSeq Acc Id: ENSPPAP00000026826   ⟸   ENSPPAT00000049662
RefSeq Acc Id: ENSPPAP00000026829   ⟸   ENSPPAT00000049665
Protein Domains
AChE_tetra   COesterase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036501 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000026826 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000026829 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000049662 UniProtKB/TrEMBL
  ENSPPAT00000049665 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  AChE_tetra UniProtKB/TrEMBL
  CarbesteraseB UniProtKB/TrEMBL
  Carboxylesterase_B_AS UniProtKB/TrEMBL
  Carboxylesterase_B_CS UniProtKB/TrEMBL
  Cholinesterase UniProtKB/TrEMBL
KEGG Report pps:100972372 UniProtKB/TrEMBL
NCBI Gene BCHE ENTREZGENE
Pfam AChE_tetra UniProtKB/TrEMBL
  COesterase UniProtKB/TrEMBL
PRINTS CHOLNESTRASE UniProtKB/TrEMBL
PROSITE CARBOXYLESTERASE_B_1 UniProtKB/TrEMBL
  CARBOXYLESTERASE_B_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF53474 UniProtKB/TrEMBL
UniProt A0A2R9BB38_PANPA UniProtKB/TrEMBL
  A0A2R9BEU4_PANPA UniProtKB/TrEMBL