RGD Reference Report - The IL-10-1082 (rs1800896) G allele is associated with a decreased risk of developing premature coronary artery disease and some IL-10 polymorphisms were associated with clinical and metabolic parameters. The GEA study. - Rat Genome Database

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The IL-10-1082 (rs1800896) G allele is associated with a decreased risk of developing premature coronary artery disease and some IL-10 polymorphisms were associated with clinical and metabolic parameters. The GEA study.

Authors: Posadas-Sánchez, Rosalinda  Angeles-Martínez, Javier  Pérez-Hernández, Nonanzit  Rodríguez-Pérez, José Manuel  López-Bautista, Fabiola  Flores-Dominguez, Carmina  Fragoso, José Manuel  Posadas-Romero, Carlos  Vargas-Alarcón, Gilberto 
Citation: Posadas-Sánchez R, etal., Cytokine. 2018 Jun;106:12-18. doi: 10.1016/j.cyto.2018.02.028. Epub 2018 Mar 9.
RGD ID: 14975129
Pubmed: PMID:29525679   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cyto.2018.02.028   (Journal Full-text)

Interleukin 10 (IL-10) is an anti-inflammatory cytokine with a protective role in the formation and the development of the atherosclerotic plaque. The aim of the present study was to establish if IL-10 gene polymorphisms are associated with the development of premature coronary artery disease (pCAD) and cardiovascular risk factors in Mexican individuals. Three IL-10 gene polymorphisms [-592C/A (rs1800872), -819C/T (rs1800871), and -1082 A/G (rs1800896)] and IL-10 plasma levels were analyzed in 2266 individuals (1160 pCAD patients and 1106 healthy controls). Under recessive and co-dominant2 models, the -1082 A/G (rs1800896) G allele was associated with decreased risk of developing pCAD (OR = 0.572, Prec = 0.022 and OR = 0.567, Pcod2 = 0.023). In pCAD patients, the polymorphisms were associated with hyperinsulinemia, small and dense LDLs, hypertension, and diabetes mellitus. In the control group, the polymorphisms were associated with hypertension, hyperuricemia, and small and dense LDLs. pCAD patients have significantly higher IL-10 plasma levels than healthy controls [0.91 (0.55-1.67) pg/mL vs 0.45 (0.24-0.98) pg/mL, respectively, P < 0.0001]. Nevertheless, these levels were not associated with the genotypes analyzed in the present study. The results suggest that the IL-10-1082 A/G (rs1800896) G allele is associated with a decreased risk of developing pCAD. In patients and controls, the polymorphisms analyzed were associated with some cardiovascular risk factors. Although, in pCAD patients the IL-10 plasma levels were higher, they were not associated with the genotypes of the polymorphisms examined.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
coronary artery disease no_associationIAGP 14975129DNA:SNPs:promoter:-592C>A (rs1800872), -819C>T (rs1800871) (human)RGD 
coronary artery disease susceptibilityIAGP 14975129DNA:SNP:promoter:-1082A>G (rs1800896) (human)RGD 
coronary artery disease no_associationISOIL10 (Homo sapiens)14975129; 14975129DNA:SNPs:promoter:-592C>A (rs1800872), -819C>T (rs1800871) (human)RGD 
coronary artery disease susceptibilityISOIL10 (Homo sapiens)14975129; 14975129DNA:SNP:promoter:-1082A>G (rs1800896) (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il10  (interleukin 10)

Genes (Mus musculus)
Il10  (interleukin 10)

Genes (Homo sapiens)
IL10  (interleukin 10)


Additional Information