CXCL8 (C-X-C motif chemokine ligand 8) - Rat Genome Database

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Gene: CXCL8 (C-X-C motif chemokine ligand 8) Pan paniscus
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Symbol: CXCL8
Name: C-X-C motif chemokine ligand 8
RGD ID: 11766570
Description: ENCODES a protein that exhibits chemokine activity (inferred); cytokine activity (inferred); heparin binding (inferred); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); cellular response to antibiotic (ortholog); cellular response to lipopolysaccharide (ortholog); PARTICIPATES IN chemokine (C-X-C motif) ligand 8 signaling pathway; mTOR signaling pathway; syndecan signaling pathway; ASSOCIATED WITH acute asthma (ortholog); Acute Lung Injury (ortholog); acute pyelonephritis (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: IL8; interleukin 8; interleukin-8
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1456,285,026 - 56,288,308 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl456,286,708 - 56,288,083 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0450,452,857 - 50,456,015 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute asthma  (ISO)
Acute Lung Injury  (ISO)
acute pyelonephritis  (ISO)
Acute-On-Chronic Liver Failure  (ISO)
adenocarcinoma  (ISO)
adult respiratory distress syndrome  (ISO)
alcoholic hepatitis  (ISO)
allergic disease  (ISO)
Anorexia  (ISO)
autoimmune uveitis  (ISO)
Bacterial Eye Infections  (ISO)
bacterial gastritis  (ISO)
Bacterial Lung Diseases  (ISO)
Barrett's esophagus  (ISO)
Behcet's disease  (ISO)
biliary atresia  (ISO)
Breast Neoplasms  (ISO)
brucellosis  (ISO)
bullous pemphigoid  (ISO)
Cachexia  (ISO)
Cardiotoxicity  (ISO)
Chagas Cardiomyopathy  (ISO)
chikungunya  (ISO)
cholestasis  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (ISO)
Colorectal Neoplasms  (ISO)
common cold  (ISO)
congestive heart failure  (ISO)
COVID-19  (ISO)
cryptococcosis  (ISO)
cutaneous leishmaniasis  (ISO)
cystic fibrosis  (ISO)
Down syndrome  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Edema  (ISO)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
Enterovirus Infections  (ISO)
esophagus squamous cell carcinoma  (ISO)
eumycotic mycetoma  (ISO)
Experimental Colitis  (ISO)
extrapulmonary tuberculosis  (ISO)
fatty liver disease  (ISO)
Fever  (ISO)
gastritis  (ISO)
gastroesophageal reflux disease  (ISO)
glioblastoma  (ISO)
glomerulonephritis  (ISO)
head and neck cancer  (ISO)
Helicobacter Infections  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperalgesia  (ISO)
Inflammation  (ISO)
Inflammatory Breast Neoplasms  (ISO)
intermediate coronary syndrome  (ISO)
Intractable Pain  (ISO)
intrahepatic cholestasis  (ISO)
keratitis  (ISO)
Klebsiella pneumonia  (ISO)
leprosy  (ISO)
lichen disease  (ISO)
liver cirrhosis  (ISO)
Liver Failure  (ISO)
Liver Metastasis  (ISO)
lung non-small cell carcinoma  (ISO)
Lyme Neuroborreliosis  (ISO)
malignant mesothelioma  (ISO)
multiple sclerosis  (ISO)
Mycobacterium avium complex disease  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplastic Cell Transformation  (ISO)
Neurosyphilis  (ISO)
oral cavity cancer  (ISO)
oral submucous fibrosis  (ISO)
oropharynx cancer  (ISO)
otitis media  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
peptic esophagitis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
Postherpetic Neuralgia  (ISO)
primary biliary cholangitis  (ISO)
Prostatic Neoplasms  (ISO)
Pseudomonas Infections  (ISO)
psoriatic arthritis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
Reperfusion Injury  (ISO)
respiratory syncytial virus infectious disease  (ISO)
rheumatoid arthritis  (ISO)
Salmonella Infections, Animal  (ISO)
Sepsis  (ISO)
severe acute respiratory syndrome  (ISO)
Spine Osteoarthritis  (ISO)
squamous cell carcinoma  (ISO)
Staphylococcal Infections  (ISO)
stomach carcinoma  (ISO)
Stomach Neoplasms  (ISO)
Thyroid Neoplasms  (ISO)
Tobacco Use Disorder  (ISO)
tongue squamous cell carcinoma  (ISO)
tonsil cancer  (ISO)
Toxoplasma Chorioretinitis  (ISO)
trachoma  (ISO)
Triple Negative Breast Neoplasms  (ISO)
tropical spastic paraparesis  (ISO)
trypanosomiasis  (ISO)
tuberculosis  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
urinary tract infection  (ISO)
viral encephalitis  (ISO)
viral pneumonia  (ISO)
visceral leishmaniasis  (ISO)
vulvovaginal candidiasis  (ISO)
Wilson disease  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
CXCL8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1456,285,026 - 56,288,308 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl456,286,708 - 56,288,083 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0450,452,857 - 50,456,015 (-)NCBIMhudiblu_PPA_v0panPan3
CXCL8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38473,740,569 - 73,743,716 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl473,740,519 - 73,743,716 (+)EnsemblGRCh38hg38GRCh38
GRCh37474,606,286 - 74,609,433 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36474,825,139 - 74,828,297 (+)NCBINCBI36hg18NCBI36
Build 34474,971,309 - 74,974,466NCBI
Celera471,966,137 - 71,969,295 (+)NCBI
Cytogenetic Map4q13.3NCBI
HuRef470,417,707 - 70,420,917 (+)NCBIHuRef
CHM1_1474,642,243 - 74,645,454 (+)NCBICHM1_1
T2T-CHM13v2.0477,084,334 - 77,087,480 (+)NCBI
Cxcl15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39590,942,393 - 90,950,926 (+)NCBIGRCm39mm39
GRCm39 Ensembl590,942,393 - 90,950,926 (+)Ensembl
GRCm38590,794,534 - 90,803,067 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl590,794,534 - 90,803,067 (+)EnsemblGRCm38mm10GRCm38
MGSCv37591,223,560 - 91,232,093 (+)NCBIGRCm37mm9NCBIm37
MGSCv36591,869,771 - 91,877,088 (+)NCBImm8
Celera588,946,158 - 88,954,669 (+)NCBICelera
Cytogenetic Map5E1NCBI
cM Map544.78NCBI
Cxcl8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955474241,501 - 250,643 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955474247,326 - 250,355 (+)NCBIChiLan1.0ChiLan1.0
CXCL8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11362,435,035 - 62,438,354 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1362,434,422 - 62,438,354 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1362,104,414 - 62,107,728 (+)NCBI
ROS_Cfam_1.01363,245,400 - 63,248,688 (+)NCBI
ROS_Cfam_1.0 Ensembl1363,244,998 - 63,248,244 (+)Ensembl
UMICH_Zoey_3.11362,855,624 - 62,858,940 (+)NCBI
UNSW_CanFamBas_1.01362,345,249 - 62,348,566 (+)NCBI
UU_Cfam_GSD_1.01363,485,538 - 63,488,849 (+)NCBI
LOC101964975
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528513,326,322 - 13,329,490 (-)NCBI
SpeTri2.0NW_0049365981,779,471 - 1,781,353 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CXCL8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl869,932,643 - 69,935,861 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1869,932,646 - 69,935,861 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2874,083,530 - 74,086,749 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CXCL8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1722,202,497 - 22,205,730 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl722,202,527 - 22,204,068 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666084587,605 - 589,481 (-)NCBIVero_WHO_p1.0
Cxcl8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247301,743,916 - 1,747,293 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247301,744,097 - 1,747,206 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003832335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000035987   ⟹   ENSPPAP00000013317
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl456,286,708 - 56,288,083 (-)Ensembl
RefSeq Acc Id: XM_003832335   ⟹   XP_003832383
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1456,285,026 - 56,288,308 (-)NCBI
Mhudiblu_PPA_v0450,452,857 - 50,456,015 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003832383 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003832383   ⟸   XM_003832335
- Sequence:
RefSeq Acc Id: ENSPPAP00000013317   ⟸   ENSPPAT00000035987
Protein Domains
SCY


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029838 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000013317 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000035987 UniProtKB/TrEMBL
InterPro Chemokine_CXC UniProtKB/TrEMBL
  Chemokine_CXC_CS UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/TrEMBL
  CXC_Chemokine_domain UniProtKB/TrEMBL
  Interleukin-8 UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/TrEMBL
NCBI Gene CXCL8 ENTREZGENE
PANTHER PTHR10179 UniProtKB/TrEMBL
  PTHR10179:SF42 UniProtKB/TrEMBL
Pfam IL8 UniProtKB/TrEMBL
PRINTS SMALLCYTKCXC UniProtKB/TrEMBL
PROSITE SMALL_CYTOKINES_CXC UniProtKB/TrEMBL
SMART SCY UniProtKB/TrEMBL
Superfamily-SCOP SSF54117 UniProtKB/TrEMBL
UniProt A0A2R9ACW3_PANPA UniProtKB/TrEMBL