CXCL8 (C-X-C motif chemokine ligand 8)

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Gene: CXCL8 (C-X-C motif chemokine ligand 8) Pan paniscus

Analyze

Symbol:

CXCL8

Name:

C-X-C motif chemokine ligand 8

RGD ID:

11766570

Description:

ENCODES a protein that exhibits chemokine activity (inferred); cytokine activity (inferred); heparin binding (inferred); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); cellular response to antibiotic (ortholog); cellular response to lipopolysaccharide (ortholog); PARTICIPATES IN chemokine (C-X-C motif) ligand 8 signaling pathway; mTOR signaling pathway; syndecan signaling pathway; ASSOCIATED WITH acute asthma (ortholog); Acute Lung Injury (ortholog); acute pyelonephritis (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

IL8; interleukin 8; interleukin-8

RGD Orthologs

Human

Mouse

Chinchilla

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	4	56,285,026 - 56,288,308 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	56,286,708 - 56,288,083 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	4	50,452,857 - 50,456,015 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute asthma (ISO)

Acute Lung Injury (ISO)

acute pyelonephritis (ISO)

Acute-On-Chronic Liver Failure (ISO)

adenocarcinoma (ISO)

adult respiratory distress syndrome (ISO)

alcoholic hepatitis (ISO)

allergic disease (ISO)

Anorexia (ISO)

autoimmune uveitis (ISO)

Bacterial Eye Infections (ISO)

bacterial gastritis (ISO)

Bacterial Lung Diseases (ISO)

Barrett's esophagus (ISO)

Behcet's disease (ISO)

biliary atresia (ISO)

Breast Neoplasms (ISO)

brucellosis (ISO)

bullous pemphigoid (ISO)

Cachexia (ISO)

Cardiotoxicity (ISO)

Chagas Cardiomyopathy (ISO)

chikungunya (ISO)

cholestasis (ISO)

Chronic Hepatitis B (ISO)

Chronic Hepatitis C (ISO)

chronic obstructive pulmonary disease (ISO)

colitis (ISO)

Colorectal Neoplasms (ISO)

common cold (ISO)

congestive heart failure (ISO)

COVID-19 (ISO)

cryptococcosis (ISO)

cutaneous leishmaniasis (ISO)

cystic fibrosis (ISO)

Down syndrome (ISO)

Edema (ISO)

Endometrial Neoplasms (ISO)

endometriosis (ISO)

Enterovirus Infections (ISO)

esophagus squamous cell carcinoma (ISO)

eumycotic mycetoma (ISO)

Experimental Colitis (ISO)

extrapulmonary tuberculosis (ISO)

fatty liver disease (ISO)

Fever (ISO)

gastritis (ISO)

gastroesophageal reflux disease (ISO)

glioblastoma (ISO)

glomerulonephritis (ISO)

head and neck cancer (ISO)

Helicobacter Infections (ISO)

hepatitis C (ISO)

hepatocellular carcinoma (ISO)

human immunodeficiency virus infectious disease (ISO)

Hyperalgesia (ISO)

Inflammation (ISO)

Inflammatory Breast Neoplasms (ISO)

intermediate coronary syndrome (ISO)

Intractable Pain (ISO)

intrahepatic cholestasis (ISO)

keratitis (ISO)

Klebsiella pneumonia (ISO)

leprosy (ISO)

lichen disease (ISO)

liver cirrhosis (ISO)

Liver Failure (ISO)

Liver Metastasis (ISO)

lung non-small cell carcinoma (ISO)

Lyme Neuroborreliosis (ISO)

malignant mesothelioma (ISO)

multiple sclerosis (ISO)

Mycobacterium avium complex disease (ISO)

Neoplasm Invasiveness (ISO)

Neoplastic Cell Transformation (ISO)

Neurosyphilis (ISO)

oral cavity cancer (ISO)

oral submucous fibrosis (ISO)

oropharynx cancer (ISO)

otitis media (ISO)

Ovarian Neoplasms (ISO)

pancreatic cancer (ISO)

peptic esophagitis (ISO)

Pneumococcal Pneumonia (ISO)

pneumonia (ISO)

Postherpetic Neuralgia (ISO)

primary biliary cholangitis (ISO)

Prostatic Neoplasms (ISO)

Pseudomonas Infections (ISO)

psoriatic arthritis (ISO)

pulmonary fibrosis (ISO)

pulmonary hypertension (ISO)

pulmonary tuberculosis (ISO)

Reperfusion Injury (ISO)

respiratory syncytial virus infectious disease (ISO)

rheumatoid arthritis (ISO)

Salmonella Infections, Animal (ISO)

Sepsis (ISO)

severe acute respiratory syndrome (ISO)

Spine Osteoarthritis (ISO)

squamous cell carcinoma (ISO)

Staphylococcal Infections (ISO)

stomach carcinoma (ISO)

Stomach Neoplasms (ISO)

Thyroid Neoplasms (ISO)

Tobacco Use Disorder (ISO)

tongue squamous cell carcinoma (ISO)

tonsil cancer (ISO)

Toxoplasma Chorioretinitis (ISO)

trachoma (ISO)

Triple Negative Breast Neoplasms (ISO)

tropical spastic paraparesis (ISO)

trypanosomiasis (ISO)

tuberculosis (ISO)

ulcerative colitis (ISO)

urinary bladder cancer (ISO)

urinary tract infection (ISO)

viral encephalitis (ISO)

viral pneumonia (ISO)

visceral leishmaniasis (ISO)

vulvovaginal candidiasis (ISO)

Wilson disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antimicrobial humoral immune response mediated by antimicrobial peptide (ISO)

cellular response to antibiotic (ISO)

cellular response to fibroblast growth factor stimulus (IEA)

cellular response to interleukin-1 (IEA)

cellular response to lipopolysaccharide (IEA,ISO)

cellular response to tumor necrosis factor (IEA)

cellular response to virus (ISO)

chemotaxis (IEA,ISO)

defense response (IEA)

embryonic digestive tract development (IEA)

hemopoiesis (ISO)

immune response (IEA)

induction of positive chemotaxis (IEA)

inflammatory response (IEA,ISO)

intracellular signal transduction (IEA)

killing of cells of another organism (ISO)

negative regulation of cell adhesion molecule production (IEA,ISO)

negative regulation of G protein-coupled receptor signaling pathway (IEA)

negative regulation of gene expression (IEA,ISO)

neutrophil activation (IEA)

neutrophil chemotaxis (IEA,ISO)

positive regulation of angiogenesis (IEA)

positive regulation of cellular biosynthetic process (IEA,ISO)

positive regulation of gene expression (IEA,ISO)

receptor internalization (IEA)

regulation of cell adhesion (IEA)

regulation of entry of bacterium into host cell (IEA)

regulation of single stranded viral RNA replication via double stranded DNA intermediate (IEA)

response to endoplasmic reticulum stress (IEA)

response to molecule of bacterial origin (IEA)

Cellular Component

extracellular region (IEA)

extracellular space (IEA)

Molecular Function

chemokine activity (IEA)

cytokine activity (IEA)

heparin binding (IEA)

interleukin-8 receptor binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

chemokine (C-X-C motif) ligand 8 signaling pathway (ISO)

mTOR signaling pathway (ISO)

syndecan signaling pathway (ISO)

References

Genomics

Comparative Map Data

CXCL8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	4	56,285,026 - 56,288,308 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	56,286,708 - 56,288,083 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	4	50,452,857 - 50,456,015 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

CXCL8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	73,740,569 - 73,743,716 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	4	73,740,519 - 73,743,716 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	74,606,286 - 74,609,433 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	74,825,139 - 74,828,297 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	4	74,971,309 - 74,974,466	NCBI
Celera	4	71,966,137 - 71,969,295 (+)	NCBI
Cytogenetic Map	4	q13.3	NCBI
HuRef	4	70,417,707 - 70,420,917 (+)	NCBI		HuRef
CHM1_1	4	74,642,243 - 74,645,454 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	77,084,334 - 77,087,480 (+)	NCBI

Cxcl15
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	90,942,393 - 90,950,926 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	5	90,942,393 - 90,950,926 (+)	Ensembl
GRCm38	5	90,794,534 - 90,803,067 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	90,794,534 - 90,803,067 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	91,223,560 - 91,232,093 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	5	91,869,771 - 91,877,088 (+)	NCBI			mm8
Celera	5	88,946,158 - 88,954,669 (+)	NCBI		Celera
Cytogenetic Map	5	E1	NCBI
cM Map	5	44.78	NCBI

Cxcl8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955474	241,501 - 250,643 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955474	247,326 - 250,355 (+)	NCBI	ChiLan1.0	ChiLan1.0

CXCL8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	13	62,435,035 - 62,438,354 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	13	62,434,422 - 62,438,354 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	13	62,104,414 - 62,107,728 (+)	NCBI
ROS_Cfam_1.0	13	63,245,400 - 63,248,688 (+)	NCBI
ROS_Cfam_1.0 Ensembl	13	63,244,998 - 63,248,244 (+)	Ensembl
UMICH_Zoey_3.1	13	62,855,624 - 62,858,940 (+)	NCBI
UNSW_CanFamBas_1.0	13	62,345,249 - 62,348,566 (+)	NCBI
UU_Cfam_GSD_1.0	13	63,485,538 - 63,488,849 (+)	NCBI

LOC101964975
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	13,326,322 - 13,329,490 (-)	NCBI
SpeTri2.0	NW_004936598	1,779,471 - 1,781,353 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CXCL8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	69,932,643 - 69,935,861 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	69,932,646 - 69,935,861 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	74,083,530 - 74,086,749 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CXCL8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	22,202,497 - 22,205,730 (+)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	7	22,202,527 - 22,204,068 (+)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666084	587,605 - 589,481 (-)	NCBI	Vero_WHO_p1.0

Cxcl8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624730	1,743,916 - 1,747,293 (-)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624730	1,744,097 - 1,747,206 (-)	NCBI	HetGla_female_1.0		hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003832335	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	SSBP01000170	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSPPAT00000035987 ⟹ ENSPPAP00000013317

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	4	56,286,708 - 56,288,083 (-)	Ensembl

RefSeq Acc Id:

XM_003832335 ⟹ XP_003832383

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1	4	56,285,026 - 56,288,308 (-)	NCBI
Mhudiblu_PPA_v0	4	50,452,857 - 50,456,015 (-)	NCBI

Sequence:

show sequence

ACTCAGGTTTGCCCTGAGGGGATGGGCCATCAGTTGCAAATCGTGGAATTTCCTCTGACATAAT
GAAAAGATGAGGGTGCATAAGTTCTCTAGTGGGGCGATGATATAAAAAGCCACCGGAGCACTCC
ATAAGGCACAAACTTTCAGAGACAGCAGAGCACACAAGCTTCTAGGACAAGAGCCAGAAAGAAA
CCACCGGAAGGAACCATCTCACTGTGTGTAAACATGACTTCCAAGCTGGCCGTGGCTCTCTTGG
CAGCCTTCCTGATTTCTGCAGCTCTGTGTGAAGGTGCAGTTTTGCCAAGGAGTGCTAAAGAACT
TAGATGTCAGTGCATAAAGACATACTCCAAACCTTTCCACCCCAAATTTATCAAAGAACTGAGA
GTGATTGAGAGTGGACCACACTGCGCCAATACAGAAATTATTGTAAAGCTTTCTGATGGAAGAG
AGCTCTGTCTGGACCCCAAGGAAAACTGGGTGCAGAGGGTTGTGGAGAAGTTTTTGAAGAGGGC
TGAGAATTCATAAAAAAATTCATTCTCTGTGGTATCCAAGAATCAGTGAAGATGCCAGTGAAAC
TTCAAGCAAATCTACTTCAACACTTCATGTATTGTGTGGGTCTGTTGTAGGGTTGCCAGATGCA
ATACAAGATTCCTGGTTAAATTTGAATTTCAGTAAACAATGAATAGTTTTTCATTGTACCATGA
AATATCCAGAACATACTTATATGTAAAGTATTATTTATTTGAATCTACAAAAAACAACAAATAA
TTTTTAAATATAAGGATTTTCCTAGATATTGCACGGGAGAATATACAAATAGCAAAATTGAGGC
CAAGGGCCAAGAGAATATCGGAACTTTAATTTCAGGAATTGAATGGGTTTGCTAGAATGTGATA
TTTGAAGCATCACATAAAAATGATGAGACAATAAATTTTGCCATAAAGTCAAATTTAGCTGGAA
ATCCTGGATTTTTTTCTGTTAAATCTGGCAACCCTAGTCTGCTAGCCAGGATCCACAAGTCCTT
GTTCCACTGTGCCTTGGTTTCTCCTTTATTTCTAAGTGGAAAAAGTATTAGCCACCATCTTACC
TCACAGTGATGTTGTGAGGACATGTGGAAGCACTTTAAGTTTTTTCATCATAACATAAATTATT
TTCAAGTGTAACTTATTTACCTATTTATTATTTATGTATTTATTTAAGCATCAAATATTTGTGC
AAGAATTTGGAAAAATAGAAGATGAAGAATCATTGATTGAATAGTTATAAAGATGTTATAGTAA
ATTTATTTTATTTTAGATATTAAATGATGTTTTATTAGATAAATTTTAATCAGGGTTTTTAGAT
TAAACAAACAAACAATTGGGTACCCAGTTAAATTTTCATTTCAGATAAACAAAAAATAATTCTT
TAGTATAAGTACATTGTTGTTTATCTGAAATTTTAATTGAACTAACAATCCTAGTTTGATACTC
CCAGTCTTGTCATTGCCAGCTGTGTTGGCAGTGCTGTGTTGAATTACGGAATAATGAGTTAGAA
CTATTAAAACAGCCAAAACTCCACAGTCAATATTAGTAATTTCTTGCTGGCTGAAACTTGTTTA
TTATGTACAAATAAATTCTTATAATATTATTTAAATGACTGCATTTTTAAATACAACGCTTTAT
ATTTTTAACTTTAAGATGTTTTTATGTGTTCTCCAAATTTTTTTTACTGTTTCTGATTGTATGG
AAATATAAAAGTAAATATGAAACATTTAAAATATAATTTGCTGTCAAAGTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003832383	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	XP_003832383 ⟸ XM_003832335
- Sequence:	show sequence MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELRVIESGPHCANT EIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS hide sequence

RefSeq Acc Id:

ENSPPAP00000013317 ⟸ ENSPPAT00000035987

Protein Domains

SCY

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000029838	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSPPAP00000013317	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000035987	UniProtKB/TrEMBL
InterPro	Chemokine_CXC	UniProtKB/TrEMBL
	Chemokine_CXC_CS	UniProtKB/TrEMBL
	Chemokine_IL8-like_dom	UniProtKB/TrEMBL
	CXC_Chemokine_domain	UniProtKB/TrEMBL
	Interleukin-8	UniProtKB/TrEMBL
	Interleukin_8-like_sf	UniProtKB/TrEMBL
NCBI Gene	CXCL8	ENTREZGENE
PANTHER	PTHR10179	UniProtKB/TrEMBL
	PTHR10179:SF42	UniProtKB/TrEMBL
Pfam	IL8	UniProtKB/TrEMBL
PRINTS	SMALLCYTKCXC	UniProtKB/TrEMBL
PROSITE	SMALL_CYTOKINES_CXC	UniProtKB/TrEMBL
SMART	SCY	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54117	UniProtKB/TrEMBL
UniProt	A0A2R9ACW3_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - PID (archival)