HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2) - Rat Genome Database

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Gene: HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2) Pan paniscus
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Symbol: HMGCS2
Name: 3-hydroxy-3-methylglutaryl-CoA synthase 2
RGD ID: 11847066
Description: ENCODES a protein that exhibits hydroxymethylglutaryl-CoA synthase activity (ortholog); INVOLVED IN adipose tissue development (ortholog); brain development (ortholog); cellular response to amino acid stimulus (ortholog); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; ASSOCIATED WITH 3-Hydroxy-3-Methylglutaryl-CoA Synthase 2 Deficiency (ortholog); Colonic Neoplasms (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN mitochondrial matrix (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: hydroxymethylglutaryl-CoA synthase, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11117,776,165 - 117,796,679 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,775,770 - 117,796,679 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0182,778,489 - 82,798,987 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acetyl-CoA metabolic process  (IEA)
adipose tissue development  (ISO)
brain development  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to fatty acid  (ISO)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to hormone stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to organic cyclic compound  (ISO)
cholesterol biosynthetic process  (IEA)
cholesterol metabolic process  (IEA)
farnesyl diphosphate biosynthetic process, mevalonate pathway  (IEA)
isoprenoid biosynthetic process  (IEA)
ketone body biosynthetic process  (IEA,ISO)
kidney development  (ISO)
lipid metabolic process  (IEA)
liver development  (ISO)
lung development  (ISO)
midgut development  (ISO)
multicellular organismal response to stress  (ISO)
response to bacterium  (ISO)
response to cAMP  (ISO)
response to ethanol  (ISO)
response to fatty acid  (ISO)
response to glucagon  (ISO)
response to glucocorticoid  (ISO)
response to growth hormone  (ISO)
response to insulin  (ISO)
response to linoleic acid  (ISO)
response to metal ion  (ISO)
response to monosaccharide  (ISO)
response to nutrient  (ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (ISO)
response to prostaglandin F  (ISO)
response to starvation  (ISO)
response to temperature stimulus  (ISO)
response to testosterone  (ISO)
response to triglyceride  (ISO)
response to xenobiotic stimulus  (ISO)
steroid biosynthetic process  (IEA)
steroid metabolic process  (IEA)
sterol biosynthetic process  (IEA)

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
HMGCS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11117,776,165 - 117,796,679 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,775,770 - 117,796,679 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0182,778,489 - 82,798,987 (+)NCBIMhudiblu_PPA_v0panPan3
HMGCS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1119,748,002 - 119,768,905 (-)EnsemblGRCh38hg38GRCh38
GRCh381119,747,996 - 119,768,932 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371120,290,619 - 120,311,555 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361120,092,525 - 120,113,041 (-)NCBINCBI36hg18NCBI36
Build 341120,003,046 - 120,023,560NCBI
Celera1118,521,355 - 118,542,283 (-)NCBI
Cytogenetic Map1p12NCBI
HuRef1118,149,159 - 118,170,093 (-)NCBIHuRef
CHM1_11120,406,161 - 120,427,088 (-)NCBICHM1_1
Hmgcs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39398,187,747 - 98,218,054 (+)NCBIGRCm39mm39
GRCm39 Ensembl398,187,751 - 98,218,054 (+)Ensembl
GRCm38398,280,431 - 98,310,738 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl398,280,435 - 98,310,738 (+)EnsemblGRCm38mm10GRCm38
MGSCv37398,084,354 - 98,114,661 (+)NCBIGRCm37mm9NCBIm37
MGSCv36398,365,840 - 98,396,137 (+)NCBImm8
Celera399,679,562 - 99,709,869 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map342.74NCBI
Hmgcs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22185,875,609 - 185,903,505 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2185,875,616 - 185,902,130 (+)Ensembl
Rnor_6.02200,452,623 - 200,480,785 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2200,452,624 - 200,479,423 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02219,928,546 - 219,956,233 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42193,128,736 - 193,143,106 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12193,091,489 - 193,105,860 (+)NCBI
Celera2178,363,353 - 178,390,245 (+)NCBICelera
Cytogenetic Map2q34NCBI
Hmgcs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543522,804,484 - 22,821,482 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543522,804,484 - 22,820,807 (-)NCBIChiLan1.0ChiLan1.0
HMGCS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11756,679,942 - 56,698,521 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1756,680,301 - 56,698,419 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1756,315,432 - 56,328,270 (-)NCBI
ROS_Cfam_1.01757,558,992 - 57,577,456 (-)NCBI
ROS_Cfam_1.0 Ensembl1757,554,455 - 57,577,399 (-)Ensembl
UMICH_Zoey_3.11756,594,625 - 56,613,171 (-)NCBI
UNSW_CanFamBas_1.01756,620,825 - 56,639,082 (-)NCBI
UU_Cfam_GSD_1.01757,237,948 - 57,256,436 (-)NCBI
Hmgcs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505810,015,851 - 10,037,163 (+)NCBI
SpeTri2.0NW_0049366274,451,847 - 4,473,163 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110260333
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4101,385,512 - 101,443,405 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14101,385,486 - 101,404,273 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HMGCS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12014,018,669 - 14,040,934 (+)NCBIChlSab1.1chlSab2
ChlSab1.12014,018,669 - 14,040,934 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2014,019,692 - 14,041,016 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603816,649,801 - 16,670,981 (+)NCBIVero_WHO_p1.0
Hmgcs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477215,432,612 - 15,464,343 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000043109   ⟹   ENSPPAP00000020317
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1117,775,770 - 117,796,679 (+)Ensembl
RefSeq Acc Id: XM_003806304   ⟹   XP_003806352
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11117,776,165 - 117,796,679 (+)NCBI
Mhudiblu_PPA_v0182,778,489 - 82,798,987 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008952148   ⟹   XP_008950396
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11117,776,165 - 117,796,679 (+)NCBI
Mhudiblu_PPA_v0182,778,489 - 82,798,987 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003806352 (Get FASTA)   NCBI Sequence Viewer  
  XP_008950396 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003806352   ⟸   XM_003806304
- Sequence:
RefSeq Acc Id: XP_008950396   ⟸   XM_008952148
- Sequence:
RefSeq Acc Id: ENSPPAP00000020317   ⟸   ENSPPAT00000043109
Protein Domains
HMG_CoA_synt_C   HMG_CoA_synt_N


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000033384 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000020317 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000043109 UniProtKB/TrEMBL
Gene3D-CATH 3.40.47.10 UniProtKB/TrEMBL
InterPro HMG_CoA_synt_AS UniProtKB/TrEMBL
  HMG_CoA_synt_C_dom UniProtKB/TrEMBL
  HMG_CoA_synth_N UniProtKB/TrEMBL
  HMG_CoA_synthase_euk UniProtKB/TrEMBL
  Thiolase-like UniProtKB/TrEMBL
KEGG Report pps:100986030 UniProtKB/TrEMBL
NCBI Gene HMGCS2 ENTREZGENE
Pfam HMG_CoA_synt_C UniProtKB/TrEMBL
  HMG_CoA_synt_N UniProtKB/TrEMBL
PROSITE HMG_COA_SYNTHASE UniProtKB/TrEMBL
Superfamily-SCOP SSF53901 UniProtKB/TrEMBL
TIGRFAMs HMG-CoA-S_euk UniProtKB/TrEMBL
UniProt A0A2R9ASK2_PANPA UniProtKB/TrEMBL