OAZ1 (ornithine decarboxylase antizyme 1)

Gene: OAZ1 (ornithine decarboxylase antizyme 1) Pan paniscus

Analyze

Symbol:

OAZ1

Name:

ornithine decarboxylase antizyme 1

RGD ID:

11797964

Description:

The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as by inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs, and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization (PMID:16120325). [provided by RefSeq, Jul 2014]

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	6,652,675 - 6,656,615 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	5,882,022 - 5,885,962 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	1,279,139 - 1,283,079 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	2,250,599 - 2,254,534 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	2,250,678 - 2,254,179 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

brain ischemia (ISO)

Coronary Disease (ISO)

coronary restenosis (ISO)

Neurodevelopmental Disorders (ISO)

progressive myoclonus epilepsy 9 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to leptomycin B (ISO)

cellular response to organic cyclic compound (ISO)

cellular response to oxygen-glucose deprivation (ISO)

cellular response to polyamine macromolecule (ISO)

negative regulation of ornithine catabolic process (ISO)

negative regulation of polyamine transmembrane transport (IEA,ISO)

polyamine biosynthetic process (IEA)

positive regulation of intracellular protein transport (IEA)

positive regulation of proteasomal protein catabolic process (ISO)

positive regulation of protein catabolic process (IEA)

response to ischemia (ISO)

Cellular Component

cytoplasm (IEA,ISO)

nucleus (IEA,ISO)

Molecular Function

enzyme binding (ISO)

ornithine decarboxylase inhibitor activity (IEA,ISO)

protein binding (ISO)

protein-containing complex binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

polyamine metabolic pathway (ISO)

References

Additional References at PubMed

PMID:16120325	PMID:17332016	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

OAZ1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	6,652,675 - 6,656,615 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	5,882,022 - 5,885,962 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	1,279,139 - 1,283,079 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	2,250,599 - 2,254,534 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	2,250,678 - 2,254,179 (+)	Ensembl	panpan1.1		panPan2

OAZ1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	2,269,486 - 2,273,488 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	2,269,509 - 2,273,490 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	2,269,485 - 2,273,487 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	2,220,520 - 2,224,487 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	2,220,519 - 2,224,487	NCBI
Celera	19	2,203,699 - 2,207,665 (+)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	2,040,604 - 2,044,469 (+)	NCBI		HuRef
CHM1_1	19	2,269,120 - 2,273,087 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	2,243,130 - 2,247,132 (+)	NCBI		T2T-CHM13v2.0

Oaz1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	80,662,490 - 80,665,124 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	80,662,516 - 80,665,124 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	80,826,656 - 80,829,290 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	80,826,656 - 80,829,290 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	80,289,401 - 80,292,035 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	80,229,785 - 80,232,414 (+)	NCBI		MGSCv36	mm8
Celera	10	81,845,454 - 81,848,088 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Oaz1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	9,534,530 - 9,536,990 (-)	NCBI		GRCr8
mRatBN7.2	7	8,883,855 - 8,886,315 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	8,883,851 - 8,886,310 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	11,767,904 - 11,770,365 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	13,643,408 - 13,645,869 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	11,509,938 - 11,512,399 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	11,752,127 - 11,754,587 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	11,752,412 - 11,754,508 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	11,919,843 - 11,922,300 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	10,394,495 - 10,396,952 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	10,394,494 - 10,396,952 (-)	NCBI
Celera	7	7,067,977 - 7,070,437 (-)	NCBI		Celera
RH 3.4 Map	7	40.6	RGD
Cytogenetic Map	7	q11	NCBI

Oaz1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	5,871,418 - 5,874,200 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	5,871,418 - 5,874,200 (-)	NCBI	ChiLan1.0	ChiLan1.0

OAZ1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	56,769,317 - 56,770,921 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	56,769,319 - 56,770,930 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	56,564,657 - 56,567,316 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	57,502,449 - 57,505,111 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	57,502,449 - 57,505,119 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	56,554,504 - 56,557,154 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	57,039,687 - 57,042,333 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	57,240,093 - 57,242,753 (-)	NCBI		UU_Cfam_GSD_1.0

Oaz1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	216,473,746 - 216,478,014 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	1,356,769 - 1,361,037 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	1,356,769 - 1,361,037 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

OAZ1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	76,293,150 - 76,296,620 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	76,293,142 - 76,296,626 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	76,854,941 - 76,858,425 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

OAZ1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	2,061,774 - 2,065,595 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	2,061,811 - 2,065,265 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666081	6,645,566 - 6,649,397 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Oaz1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	6,617,727 - 6,620,402 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	6,617,342 - 6,620,466 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001289721	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000045854 ⟹ ENSPPAP00000023035

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	19	2,250,678 - 2,254,179 (+)	Ensembl

RefSeq Acc Id:

NM_001289721 ⟹ NP_001276650

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	20	6,652,675 - 6,656,615 (+)	NCBI
NHGRI_mPanPan1	19	5,882,022 - 5,885,962 (+)	NCBI
Mhudiblu_PPA_v0	19	1,279,139 - 1,283,079 (+)	NCBI
PanPan1.1	19	2,250,599 - 2,254,534 (+)	NCBI

Sequence:

show sequence

ATTTTGCGAACGGCGAGCAGCGGCGGCGGCGCGGAGAGACGCAGCGGAGGTTTTCCTGGTTTCG
GACCCCAGCGGCCGGATGGTGAAATCCTCCCTGCAGCGGATCCTCAATAGCCACTGCTTCGCCA
GAGAGAAGGAAGGGGATAAACCCAGCGCCACCATCCACGCCAGCCGCACCATGCCGCTCCTAAG
CCTGCACAGCCGCGGCGGCAGCAGCAGTGAGAGTTCCAGGGTCTCCCTCCACTGCTGTAGTAAC
CCGGGTCCGGGGCCTCGGTGGTGCTCCTGATGCCCCTCACCCACCCCTGAAGATCCCAGGTGGG
CGAGGGAATAGTCAGAGGGATCACAATCTTTCAGCTAACTTATTCTACTCCGATGATCGGCTGA
ATGTAACAGAGGAACTAACGTCCAACGACAAGACGAGGATTCTCAACGTCCAGTCCAGGCTCAC
AGACGCCAAACGCATTAACTGGCGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGATCCCG
GGCGGCGCGCTGCCCGAGGGGAGCAAGGACAGCTTTGCAGTTCTCCTGGAGTTCGCTGAGGAGC
AGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACAAGAACCGCGAGGACAGAGCCGCCTTGCT
CCGAACCTTCAGCTTTTTGGGCTTTGAGATTGTGAGACCGGGGCATCCCCTTGTCCCCAAGAGA
CCCGACGCTTGCTTCATGGCCTACACGTTCGAGAGAGAGTCTTCGGGAGAGGAGGAGGAGTAGG
GCCGCCTCGGGGCTGGGCATCCGGCCCCTGGGGACACCCCTTGTCAGCCGGGTGGGTAGGAACC
GTAGACTCGCTCATCTCGCCTGGGTTTGTCCGCATGTTGTAATCGTGCAAATAAACGCTCACTC
CGAATTGGTGTATTTCTTGAAGTTTAATATTGTGTTTGTGATACTGAAGTATTTGCTTTAATTC
TAAATAAAAATTTATATTTTACTTTTTTATTGCTGGTTTAAGATTGAGGAGAAGTTTCTTATTT
GGAGTCTTTTGGAAACAGTCTTAGTCTTTTAACTTGGAAAGATGAGGTATTAATCCCCTCCATT
GCTCTCCAAAAGCCAATAAAGTGATTACACCCGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001276650	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000023035
	ENSPPAP00000023035.1

RefSeq Acc Id:

NP_001276650 ⟸ NM_001289721

- UniProtKB:

A0A2R9B0A3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVKSSLQRILNSHCFAREKEGDKPSATIHASRTMPLLSLHSRGGSSSESSRVSLHCCSNPGPGP
RWCSDAPHPPLKIPGGRGNSQRDHNLSANLFYSDDRLNVTEELTSNDKTRILNVQSRLTDAKRI
NWRTVLSGGSLYIEIPGGALPEGSKDSFAVLLEFAEEQLRADHVFICFHKNREDRAALLRTFSF
LGFEIVRPGHPLVPKRPDACFMAYTFERESSGEEEE

hide sequence

RefSeq Acc Id:

ENSPPAP00000023035 ⟸ ENSPPAT00000045854

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000034691	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000045854	ENTREZGENE
	ENSPPAT00000045854.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.630.60	UniProtKB/TrEMBL
InterPro	Acyl_CoA_acyltransferase	UniProtKB/TrEMBL
	ODC_AZ	UniProtKB/TrEMBL
	ODC_AZ_sf	UniProtKB/TrEMBL
KEGG Report	pps:100981773	UniProtKB/TrEMBL
NCBI Gene	OAZ1	ENTREZGENE
PANTHER	PTHR10279	UniProtKB/TrEMBL
	PTHR10279:SF8	UniProtKB/TrEMBL
Pfam	ODC_AZ	UniProtKB/TrEMBL
PROSITE	ODC_AZ	UniProtKB/TrEMBL
Superfamily-SCOP	SSF55729	UniProtKB/TrEMBL
UniProt	A0A2R9B0A3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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