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Gene: CTSB (cathepsin B) Pan paniscus

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Symbol:

CTSB

Name:

cathepsin B

RGD ID:

11952204

Description:

ENCODES a protein that exhibits cysteine-type endopeptidase activity (ortholog); endopeptidase activity (ortholog); identical protein binding (ortholog); INVOLVED IN autophagy (ortholog); cellular response to mechanical stimulus (ortholog); decidualization (ortholog); PARTICIPATES IN chaperone mediated autophagy pathway; ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); Albuminuria (ortholog); atherosclerosis (ortholog); FOUND IN apical plasma membrane (ortholog); caveola (ortholog); cell surface (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CTSB (cathepsin B)	NCBI	Ortholog
Mus musculus (house mouse):	Ctsb (cathepsin B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Ctsb (cathepsin B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ctsb (cathepsin B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CTSB (cathepsin B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CTSB (cathepsin B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CTSB (cathepsin B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ctsb (cathepsin B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	28,312,794 - 28,336,877 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	4,339,018 - 4,363,094 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	7,333,498 - 7,359,264 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CTSB	Bonobo	acute necrotizing pancreatitis		ISO	Ctsb (Rattus norvegicus)	9068941	protein:increased activity:pancreas (rat)	RGD	PMID:17723883 and REF_RGD_ID:2315517
CTSB	Bonobo	Albuminuria		ISO	Ctsb (Rattus norvegicus)	9068941	associated with Hypertension	RGD	PMID:19023196 and REF_RGD_ID:2315726
CTSB	Bonobo	atherosclerosis		ISO	Apoe (Mus musculus)	9068941		RGD	PMID:12213722 and REF_RGD_ID:5687152
CTSB	Bonobo	brain infarction		ISO	Ctsb (Rattus norvegicus)	9068941	protein:increased expression:cerebral cortical segment and cytoplasm (rat)	RGD	PMID:19941836 and REF_RGD_ID:2315502
CTSB	Bonobo	brain ischemia		ISO	Ctsb (Rattus norvegicus)	9068941	protein:increased activity:cerebrum (rat)	RGD	PMID:18404379 and REF_RGD_ID:2315571
CTSB	Bonobo	breast cancer		ISO	CTSB (Homo sapiens)	9068941	protein:increased expression:breast carcinoma and cytosol (human)	RGD	PMID:9508185 and REF_RGD_ID:2315523
CTSB	Bonobo	colitis		ISO	Ctsb (Mus musculus)	9068941	protein:increased activity:cecum more ...	RGD	PMID:21802389 and REF_RGD_ID:5686873
CTSB	Bonobo	Contusions		ISO	Ctsb (Rattus norvegicus)	9068941	mRNA more ...	RGD	PMID:11788364 and REF_RGD_ID:631244
CTSB	Bonobo	COVID-19		ISO	CTSB (Homo sapiens)	9068941	mRNA:increased expression:peripheral blood mononuclear cell (human)	RGD	PMID:32228226 and REF_RGD_ID:28912744
CTSB	Bonobo	diabetes mellitus	onset	ISO	CTSB (Homo sapiens)	9068941	DNA:transversion:cds:p.L26V (human)	RGD	PMID:18706099 and REF_RGD_ID:2315528
CTSB	Bonobo	esophagus adenocarcinoma		ISO	CTSB (Homo sapiens)	9068941		RGD	PMID:9770500 and REF_RGD_ID:734853
CTSB	Bonobo	Experimental Arthritis		ISO	Ctsb (Rattus norvegicus)	9068941	mRNA:increased expression:knee joint and synovium (rat)	RGD	PMID:17195213 and REF_RGD_ID:2315521
CTSB	Bonobo	Experimental Diabetes Mellitus		ISO	Ctsb (Rattus norvegicus)	9068941	protein:decreased activity:glomerulus (rat)	RGD	PMID:10393385 and REF_RGD_ID:2315531
CTSB	Bonobo	fascioliasis		ISO	Ctsb (Rattus norvegicus)	9068941	protein:decreased activity:liver (rat)	RGD	PMID:19696938 and REF_RGD_ID:2315504
CTSB	Bonobo	glioblastoma		ISO	CTSB (Homo sapiens)	9068941	protein:increased expression:glioma cell (human)	RGD	PMID:17898873 and REF_RGD_ID:2315515
CTSB	Bonobo	Guillain-Barre syndrome		ISO	CTSB (Homo sapiens)	9068941	protein:increased expression:cerebrospinal fluid	RGD	PMID:11134381 and REF_RGD_ID:5686395
CTSB	Bonobo	hepatocellular carcinoma		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:15641152 and REF_RGD_ID:2315605
CTSB	Bonobo	high grade glioma		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:17287256 and REF_RGD_ID:2315520
CTSB	Bonobo	intracranial aneurysm		ISO	CTSB (Homo sapiens)	9068941	protein:increased expression:cerebral aneurysm (human)	RGD	PMID:18635848 and REF_RGD_ID:2306495
CTSB	Bonobo	intracranial aneurysm		ISO	Ctsb (Rattus norvegicus)	9068941	mRNA more ...	RGD	PMID:18635848 and REF_RGD_ID:2306495
CTSB	Bonobo	Mercury Poisoning, Nervous System		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:18638529 and REF_RGD_ID:2315510
CTSB	Bonobo	metabolic dysfunction and alcohol associated liver disease		ISO	Ctsb (Rattus norvegicus)	9068941	protein:increased activity:liver and cytosol (rat)	RGD	PMID:17850215 and REF_RGD_ID:2315516
CTSB	Bonobo	multiple sclerosis		ISO	CTSB (Homo sapiens)	9068941	protein:increased expression:cerebrospinal fluid	RGD	PMID:11134381 and REF_RGD_ID:5686395
CTSB	Bonobo	multiple sclerosis		ISO	Ctsb (Mus musculus)	9068941		RGD	PMID:17086443 and REF_RGD_ID:5686392
CTSB	Bonobo	myocardial infarction		ISO	Ctsb (Rattus norvegicus)	9068941	protein:increased activity:serum and heart (rat)	RGD	PMID:19958779 and REF_RGD_ID:2315501
CTSB	Bonobo	Neoplasm Metastasis		ISO	CTSB (Homo sapiens)	9068941	protein:increased expression:cerebrospinal fluid	RGD	PMID:12589965 and REF_RGD_ID:5686394
CTSB	Bonobo	Optic Nerve Injuries		ISO	Ctsb (Rattus norvegicus)	9068941	protein:increased expression:retina (rat)	RGD	PMID:18775855 and REF_RGD_ID:2315508
CTSB	Bonobo	otitis media		ISO	Ctsb (Rattus norvegicus)	9068941	mRNA:increased expression:middle ear mucosa (rat)	RGD	PMID:15179208 and REF_RGD_ID:1342442
CTSB	Bonobo	polycystic kidney disease		ISO	Ctsb (Rattus norvegicus)	9068941	protein:increased expression:kidney proximal tubule	RGD	PMID:8840269 and REF_RGD_ID:5686402
CTSB	Bonobo	renal tubular acidosis		ISO	Ctsb (Rattus norvegicus)	9068941	protein:decreased activity:renal proximal tubule (rat)	RGD	PMID:7873730 and REF_RGD_ID:2315534
CTSB	Bonobo	Reoviridae Infections		ISO	Ctsb (Mus musculus)	9068941		RGD	PMID:19640986 and REF_RGD_ID:5686877
CTSB	Bonobo	Reperfusion Injury		ISO	Ctsb (Rattus norvegicus)	9068941	protein:increased expression:cerebral cortex and mitochondrion (rat)	RGD	PMID:18938146 and REF_RGD_ID:2315506
CTSB	Bonobo	Skeletal Muscle Injuries		ISO	Ctsb (Rattus norvegicus)	9068941	protein:increased activity:gastrocnemius (rat)	RGD	PMID:11788364 and REF_RGD_ID:631244
CTSB	Bonobo	steatotic liver disease		ISO	Ctsb (Rattus norvegicus)	9068941	mRNA more ...	RGD	PMID:18452148 and REF_RGD_ID:2315513
CTSB	Bonobo	transitional cell carcinoma		ISO	CTSB (Homo sapiens)	9068941	protein:increased expression:urinary bladder	RGD	PMID:15183956 and REF_RGD_ID:2315615
CTSB	Bonobo	type 1 diabetes mellitus	susceptibility	ISO	Ctsb (Mus musculus)	9068941		RGD	PMID:19664906 and REF_RGD_ID:2315524
CTSB	Bonobo	type 2 diabetes mellitus		ISO	CTSB (Homo sapiens)	9068941	mRNA:decreased expression:pancreatic islet (human)	RGD	PMID:19367387 and REF_RGD_ID:2315527
CTSB	Bonobo	urinary bladder cancer		ISO	CTSB (Homo sapiens)	9068941	protein:increased activity:transitional cell carcinoma (human)	RGD	PMID:15183956 and REF_RGD_ID:2315615

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CTSB	Bonobo	Atrioventricular Septal Defect 4		ISO	CTSB (Homo sapiens)	8554872	ClinVar Annotator: match by term: Atrioventricular septal defect 4	ClinVar	PMID:19353638 more ...
CTSB	Bonobo	Keratolytic Winter Erythema		ISO	CTSB (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:25741868 and PMID:28492532
CTSB	Bonobo	Neurodevelopmental Disorders		ISO	CTSB (Homo sapiens)	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868
CTSB	Bonobo	Squalene Synthase Deficiency		ISO	CTSB (Homo sapiens)	8554872	ClinVar Annotator: match by term: Squalene synthase deficiency	ClinVar	PMID:25741868 and PMID:29909962
CTSB	Bonobo	thoracic aortic aneurysm		ISO	CTSB (Homo sapiens)	8554872	ClinVar Annotator: match by term: Thoracic aortic aneurysms and dissections	ClinVar	PMID:32748548

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CTSB	Bonobo	Disease Progression		ISO	CTSB (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:22287159
CTSB	Bonobo	glioblastoma		ISO	CTSB (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:22287159
CTSB	Bonobo	Inflammatory Breast Neoplasms		ISO	CTSB (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:32512068
CTSB	Bonobo	muscular disease		ISO	CTSB (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:7099197
CTSB	Bonobo	Necrosis		ISO	CTSB (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:22287159
CTSB	Bonobo	Neoplasm Invasiveness		ISO	CTSB (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:19700239 and PMID:19747051
CTSB	Bonobo	Prostatic Neoplasms		ISO	CTSB (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:19503093
CTSB	Bonobo	proteinuria		ISO	CTSB (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:3669494
CTSB	Bonobo	renal cell carcinoma		ISO	CTSB (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:15108329

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CTSB	Bonobo	Keratolytic Winter Erythema		ISO	CTSB (Homo sapiens)	7240710		OMIM

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CTSB	Bonobo	autophagy		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:18567942 and REF_RGD_ID:2315511
CTSB	Bonobo	cellular response to mechanical stimulus		ISO	Ctsb (Rattus norvegicus)	9068941	cyclic tensile stress	RGD	PMID:18464888 and REF_RGD_ID:2315512
CTSB	Bonobo	cellular response to thyroid hormone stimulus	involved_in	IEA	UniProtKB:P07858 and ensembl:ENSP00000345672	150520179		Ensembl	GO_REF:0000107
CTSB	Bonobo	collagen catabolic process	involved_in	IEA	UniProtKB:P07858 and ensembl:ENSP00000345672	150520179		Ensembl	GO_REF:0000107
CTSB	Bonobo	decidualization	acts_upstream_of_or_within	ISO	MGI:88564	9068941	PMID:9310336	MGI	PMID:9310336
CTSB	Bonobo	epithelial cell differentiation	involved_in	IEA	UniProtKB:P07858 and ensembl:ENSP00000345672	150520179		Ensembl	GO_REF:0000107
CTSB	Bonobo	neuron apoptotic process		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:19420257 and REF_RGD_ID:2315505
CTSB	Bonobo	protein catabolic process		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:11687729 more ...
CTSB	Bonobo	proteolysis	involved_in	IEA	InterPro:IPR000668	150520179		InterPro	GO_REF:0000002
CTSB	Bonobo	proteolysis	involved_in	IEA	UniProtKB:P07858 and ensembl:ENSP00000345672	150520179		Ensembl	GO_REF:0000107
CTSB	Bonobo	proteolysis	involved_in	IEA	UniProtKB-KW:KW-0645	150520179		UniProt	GO_REF:0000043
CTSB	Bonobo	proteolysis involved in protein catabolic process	involved_in	IEA	UniProtKB:P07858 and ensembl:ENSP00000345672	150520179		Ensembl	GO_REF:0000107
CTSB	Bonobo	response to amine		ISO	Ctsb (Rattus norvegicus)	9068941	polyamine depletion	RGD	PMID:17371271 and REF_RGD_ID:2315519
CTSB	Bonobo	response to cytokine		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:19893052 and REF_RGD_ID:2315503
CTSB	Bonobo	response to dexamethasone		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:8717430 and REF_RGD_ID:1625507
CTSB	Bonobo	response to ethanol		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:17935147 and REF_RGD_ID:2307058
CTSB	Bonobo	response to glucose		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:14722017 and REF_RGD_ID:2315529
CTSB	Bonobo	response to interleukin-4		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:18464888 and REF_RGD_ID:2315512
CTSB	Bonobo	response to kainic acid		ISO	Ctsb (Rattus norvegicus)	9068941	kainic acid	RGD	PMID:18094625 and REF_RGD_ID:2315514
CTSB	Bonobo	response to mechanical stimulus		ISO	Ctsb (Rattus norvegicus)	9068941	controlled mechanical breathing	RGD	PMID:17379854 and REF_RGD_ID:2315518
CTSB	Bonobo	response to peptide hormone		ISO	Ctsb (Rattus norvegicus)	9068941	angiotensin II	RGD	PMID:18676994 and REF_RGD_ID:2315509
CTSB	Bonobo	skeletal muscle tissue development		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:16497156 and REF_RGD_ID:1599532
CTSB	Bonobo	spermatogenesis		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:9238520 and REF_RGD_ID:5686401
CTSB	Bonobo	symbiont entry into host cell	involved_in	ISO	Ctsb (Mus musculus)	9068941	PMID:15831716	CACAO	PMID:15831716
CTSB	Bonobo	thyroid hormone generation	involved_in	ISO	Ctsb (Mus musculus)	9068941	PMID:12782676	UniProt	PMID:12782676

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CTSB	Bonobo	apical plasma membrane		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:12432075 and REF_RGD_ID:734525
CTSB	Bonobo	apical plasma membrane	located_in	IEA	UniProtKB-SubCell:SL-0015	150520179		UniProt	GO_REF:0000044
CTSB	Bonobo	caveola	located_in	ISO	Cav3 (Rattus norvegicus)	9068941		RGD	PMID:16497156 and REF_RGD_ID:1599532
CTSB	Bonobo	cell surface		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:12432075 and REF_RGD_ID:734525
CTSB	Bonobo	external side of plasma membrane		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:2432075 and REF_RGD_ID:728174
CTSB	Bonobo	external side of plasma membrane	located_in	ISO	Ctsb (Mus musculus)	9068941	PMID:12782676	UniProt	PMID:12782676
CTSB	Bonobo	extracellular region		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:12432075 and REF_RGD_ID:734525
CTSB	Bonobo	extracellular space		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:19958779 more ...
CTSB	Bonobo	extracellular space	located_in	IEA	UniProtKB:P07858 and ensembl:ENSP00000345672	150520179		Ensembl	GO_REF:0000107
CTSB	Bonobo	lysosome	located_in	IEA	UniProtKB-SubCell:SL-0158	150520179		UniProt	GO_REF:0000044
CTSB	Bonobo	lysosome	located_in	IEA	UniProtKB:P07858 and ensembl:ENSP00000345672	150520179		Ensembl	GO_REF:0000107
CTSB	Bonobo	lysosome	located_in	IEA	UniProtKB-KW:KW-0458	150520179		UniProt	GO_REF:0000043
CTSB	Bonobo	lysosome	located_in	IEA	ARBA:ARBA00028565	150520179		UniProt	GO_REF:0000117
CTSB	Bonobo	peptidase inhibitor complex	part_of	IEA	UniProtKB:P07858 and ensembl:ENSP00000345672	150520179		Ensembl	GO_REF:0000107
CTSB	Bonobo	perinuclear region of cytoplasm	located_in	IEA	UniProtKB:P07858 and ensembl:ENSP00000345672	150520179		Ensembl	GO_REF:0000107
CTSB	Bonobo	sarcolemma		ISO	Ctsb (Rattus norvegicus)	9068941	subsarcolemmal region	RGD	PMID:7043996 and REF_RGD_ID:2315538

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CTSB	Bonobo	collagen binding	enables	IEA	UniProtKB:P07858 and ensembl:ENSP00000345672	150520179		Ensembl	GO_REF:0000107
CTSB	Bonobo	cysteine-type endopeptidase activity		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:16960372 and REF_RGD_ID:2315574
CTSB	Bonobo	cysteine-type endopeptidase activity	enables	IEA	UniProtKB:P07858 and ensembl:ENSP00000345672	150520179		Ensembl	GO_REF:0000107
CTSB	Bonobo	cysteine-type endopeptidase activity	enables	IEA	EC:3.4.22.1	150520179		UniProt	GO_REF:0000003
CTSB	Bonobo	cysteine-type endopeptidase activity	enables	IEA	InterPro:IPR012599	150520179		InterPro	GO_REF:0000002
CTSB	Bonobo	cysteine-type peptidase activity	enables	IEA	UniProtKB-KW:KW-0788	150520179		UniProt	GO_REF:0000043
CTSB	Bonobo	cysteine-type peptidase activity	enables	IEA	InterPro:IPR000668 and InterPro:IPR013128	150520179		InterPro	GO_REF:0000002
CTSB	Bonobo	cysteine-type peptidase activity	enables	IEA	ARBA:ARBA00027409	150520179		UniProt	GO_REF:0000117
CTSB	Bonobo	cysteine-type peptidase activity	enables	IEA	UniProtKB:P07858 and ensembl:ENSP00000345672	150520179		Ensembl	GO_REF:0000107
CTSB	Bonobo	endopeptidase activity		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:11687729 more ...
CTSB	Bonobo	endopeptidase activity	enables	ISO	Ctsb (Mus musculus)	9068941	PMID:28835281	UniProt	PMID:28835281
CTSB	Bonobo	hydrolase activity	enables	IEA	UniProtKB-KW:KW-0378	150520179		UniProt	GO_REF:0000043
CTSB	Bonobo	identical protein binding		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:7550115 and REF_RGD_ID:5686403
CTSB	Bonobo	kininogen binding		ISO	Kng2 (Rattus norvegicus)	9068941		RGD	PMID:3356189 and REF_RGD_ID:1600550
CTSB	Bonobo	peptidase activity	enables	IEA	UniProtKB:P07858 and ensembl:ENSP00000345672	150520179		Ensembl	GO_REF:0000107
CTSB	Bonobo	peptidase activity	enables	IEA	UniProtKB-KW:KW-0645	150520179		UniProt	GO_REF:0000043
CTSB	Bonobo	peptide binding		ISO	Ctsb (Rattus norvegicus)	9068941		RGD	PMID:8702598 and REF_RGD_ID:1625498
CTSB	Bonobo	protein binding	enables	ISO	UniProtKB:Q96IK1-2	9068941	PMID:32814053	IntAct	PMID:32814053
CTSB	Bonobo	protein binding	enables	ISO	UniProtKB:P02760 and UniProtKB:Q6UY14	9068941	PMID:16364318	IntAct	PMID:16364318
CTSB	Bonobo	protein binding	enables	ISO	UniProtKB:P28325	9068941	PMID:8083219	UniProt	PMID:8083219
CTSB	Bonobo	protein binding	enables	ISO	UniProtKB:Q6UY14	9068941	PMID:16364318	IntAct	PMID:16364318
CTSB	Bonobo	protein binding	enables	ISO	UniProtKB:P01040	9068941	PMID:20860624 and PMID:33961781	IntAct	PMID:20860624 and PMID:33961781
CTSB	Bonobo	protein binding	enables	ISO	UniProtKB:P01034	9068941	PMID:6203523 and PMID:7890620	BHF-UCL	PMID:6203523 and PMID:7890620
CTSB	Bonobo	protein binding	enables	ISO	UniProtKB:Q9NYA1	9068941	PMID:17064696	IntAct	PMID:17064696
CTSB	Bonobo	protein binding		ISO	Aifm1 (Rattus norvegicus)	9068941		RGD	PMID:18938146 and REF_RGD_ID:2315506
CTSB	Bonobo	protein binding	enables	ISO	UniProtKB:O60687	9068941	PMID:18718938	UniProt	PMID:18718938
CTSB	Bonobo	protein binding	enables	ISO	UniProtKB:P40692	9068941	PMID:20706999	IntAct	PMID:20706999
CTSB	Bonobo	protein binding	enables	ISO	UniProtKB:P0C045	9068941	PMID:16237761	AgBase	PMID:16237761
CTSB	Bonobo	protein-containing complex binding		ISO	Ctsh (Rattus norvegicus) more ...	9068941		RGD	PMID:2470410 and REF_RGD_ID:2315535
CTSB	Bonobo	proteoglycan binding	enables	IEA	UniProtKB:P07858 and ensembl:ENSP00000345672	150520179		Ensembl	GO_REF:0000107

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
CTSB	Bonobo	chaperone mediated autophagy pathway		ISO	CTSB (Homo sapiens)	9068941		RGD	PMID:24323530 and REF_RGD_ID:10755730

PMID:22301074	PMID:30032202

CTSB
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	28,312,794 - 28,336,877 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	4,339,018 - 4,363,094 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	7,333,498 - 7,359,264 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

CTSB
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	11,842,524 - 11,868,087 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	11,842,524 - 11,869,533 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	11,700,033 - 11,725,596 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	11,737,442 - 11,763,055 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	11,739,235 - 11,763,044	NCBI
Celera	8	10,829,316 - 10,854,967 (-)	NCBI		Celera
Cytogenetic Map	8	p23.1	NCBI
HuRef	8	10,630,970 - 10,656,616 (-)	NCBI		HuRef
CHM1_1	8	11,765,442 - 11,791,090 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	7,872,212 - 7,897,789 (+)	NCBI		T2T-CHM13v2.0

Ctsb
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	63,359,911 - 63,383,372 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	63,359,911 - 63,383,372 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	63,122,462 - 63,145,923 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	63,122,462 - 63,145,923 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	63,741,302 - 63,764,758 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	62,076,575 - 62,100,031 (+)	NCBI		MGSCv36	mm8
Celera	14	60,885,230 - 60,908,693 (+)	NCBI		Celera
Cytogenetic Map	14	D1	NCBI
cM Map	14	33.24	NCBI

Ctsb
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	41,565,607 - 41,586,479 (+)	NCBI		GRCr8
mRatBN7.2	15	37,389,636 - 37,410,508 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	37,389,629 - 37,410,500 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	39,242,069 - 39,263,185 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	40,392,878 - 40,413,994 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	38,850,264 - 38,871,139 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	46,316,741 - 46,337,613 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	46,316,741 - 46,337,612 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	50,081,535 - 50,102,407 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	42,402,829 - 42,423,701 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	42,418,600 - 42,439,400 (+)	NCBI
Celera	15	37,073,910 - 37,094,782 (+)	NCBI		Celera
Cytogenetic Map	15	p12	NCBI

Ctsb
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	53,085,574 - 53,093,809 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	53,086,236 - 53,100,217 (-)	NCBI	ChiLan1.0	ChiLan1.0

CTSB
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	26,048,237 - 26,056,570 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	26,048,253 - 26,055,801 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	26,693,298 - 26,713,566 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	26,191,391 - 26,211,634 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	26,190,645 - 26,292,033 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	26,136,951 - 26,157,236 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	26,041,126 - 26,061,383 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	26,192,122 - 26,212,434 (+)	NCBI		UU_Cfam_GSD_1.0

CTSB
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	15,011,711 - 15,033,877 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	15,014,139 - 15,035,081 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	16,202,844 - 16,223,498 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CTSB
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	7,246,076 - 7,269,655 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	7,246,013 - 7,268,854 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666052	35,165,795 - 35,191,160 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ctsb
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624758	25,366,840 - 25,373,954 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624758	25,366,120 - 25,384,554 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_024927442	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034965608	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034965609	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034965610	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055116255	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055116257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055116258	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055116259	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055116260	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_024927442 ⟹ XP_024783210

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	7	28,312,794 - 28,319,437 (-)	NCBI
NHGRI_mPanPan1	8	4,339,018 - 4,345,667 (-)	NCBI
Mhudiblu_PPA_v0	8	7,350,888 - 7,359,264 (+)	NCBI

Sequence:

show sequence

ATGCACGGGAACAATGGCCACAGTGTCCCACCATCAAAGAGATCAGAGACCAGGGCTCCTGTGGCTCCTGCTGGCTGTAATGGTGGCTATCCTGCTGAAGCTTGGAACTTCTGGACAAGAAAAGGCCT
GGTTTCTGGTGGCCTCTATGAATCCCATGTAGGGTGCAGACCGTACTCCATCCCTCCCTGTGAGCACCACGTCAACGGCTCCCGGCCCCCATGCACGGGGGAGGGAGATACCCCCAAGTGTAGCAAGA
TCTGTGAGCCTGGCTACAGCCCGACCTACAAACAGGACAAGCACTACGGATACAATTCCTACAGCGTCTCCAATAGCGAGAAGGACATCATGGCCGAGATCTACAAAAACGGCCCCGTGGAGGGAGCT
TTCTCTGTGTATTCGGACTTCCTGCTGTACAAGTCAGGAGTGTACCAACACGTCACCGGAGAGATGATGGGCGGCCATGCCATCCGCATCCTGGGCTGGGGAGTGGAGAATGGCACACCCTACTGGCT
GGTTGCCAACTCCTGGAACACTGACTGGGGTGATAATGGCTTCTTTAAAATACTCAGAGGACAGGATCACTGTGGAATCGAATCAGAAGTGGTGGCTGGAATTCCACGCACCGATCAGTACTGGGAAA
AGATCTAATCTGCCGTGGGCCTGTCGTGCCAGTCCTGGGGGTGAGATGGGGGTAGAAATGCATTTTATTCTTTGAGTTCACGTAACATACAAGTTTTAGACAGGGTCTGAAGGACTGGATTGGCCAAA
CATCAGACCTGTCTTCCAAGGAGACCAAGTCCTGGCTACATCCAAGCCTGTGGTTACAGTGCAGACAGGCCATGTGAGCCACCGCTGCCAGCACAGAGCGTCTTTCCCCCTGTAGACTAGTGCCGTAG
GGAGTACCTGCTGCCCCAGCTGACTGTGGCCCCCTCCGTGATCCATCCACCTCCAGGGAGCAAGACAGAGACCCAGGAATGGAGGAATGGAAAGCGGAGTTCCTAACAGGATGAAAGATCCCCCAGTA
CCTCCAAGCAAGTAGCTTTCCACATTTGTCACAAAAATCAGAGGAGAGATGGTGTTGGGAGCCCTTTGGAGAACGCCAGTCTCCCAGGCCCCCTGCATCTATCGAGTTTGCAATGTCACCACCTCTCT
GATCTTGTGCTCAGCATGATTCTTTAATAGAAGTTTTATTTTTTCGTGCACTCTGCTAATCATGTGGGTGAGCCAGTCGAACAGCTGGGAGATCTGTGCTAGTTTTACAGATTGCCTCCTAATGACGC
GGCTCAAAAGGAAACCAAGTGGTCAGGAGTTGTTTCTGACCAACTGATCTCTACTACCACAAGGAAGAAACCAGCTTTTACTGTTTTTTAAAAATTACAGCTTCACCCTGTCAAGTTAACAAGGAATG
CCTGTGCCAATAAAAGGTTTCTCCAACTTGAAGTCTA

hide sequence

RefSeq Acc Id:

XM_034965608 ⟹ XP_034821499

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	7	28,312,794 - 28,336,877 (-)	NCBI
NHGRI_mPanPan1	8	4,339,018 - 4,363,094 (-)	NCBI
Mhudiblu_PPA_v0	8	7,333,498 - 7,359,264 (+)	NCBI

RefSeq Acc Id:

XM_034965610 ⟹ XP_034821501

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	7	28,312,794 - 28,336,876 (-)	NCBI
NHGRI_mPanPan1	8	4,339,018 - 4,363,067 (-)	NCBI
Mhudiblu_PPA_v0	8	7,333,498 - 7,359,264 (+)	NCBI

RefSeq Acc Id:

XM_055116255 ⟹ XP_054972230

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	7	28,312,794 - 28,336,058 (-)	NCBI
NHGRI_mPanPan1	8	4,339,018 - 4,362,692 (-)	NCBI

RefSeq Acc Id:

XM_055116257 ⟹ XP_054972232

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	7	28,312,794 - 28,336,471 (-)	NCBI
NHGRI_mPanPan1	8	4,339,018 - 4,363,002 (-)	NCBI

RefSeq Acc Id:

XM_055116258 ⟹ XP_054972233

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	7	28,312,794 - 28,336,815 (-)	NCBI
NHGRI_mPanPan1	8	4,339,018 - 4,363,047 (-)	NCBI

RefSeq Acc Id:

XM_055116259 ⟹ XP_054972234

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	7	28,312,794 - 28,336,058 (-)	NCBI
NHGRI_mPanPan1	8	4,339,018 - 4,362,689 (-)	NCBI

RefSeq Acc Id:

XM_055116260 ⟹ XP_054972235

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	7	28,312,794 - 28,321,897 (-)	NCBI
NHGRI_mPanPan1	8	4,339,018 - 4,348,127 (-)	NCBI


Protein RefSeqs	XP_024783210	(Get FASTA)	NCBI Sequence Viewer
	XP_034821499	(Get FASTA)	NCBI Sequence Viewer
	XP_034821501	(Get FASTA)	NCBI Sequence Viewer
	XP_054972230	(Get FASTA)	NCBI Sequence Viewer
	XP_054972232	(Get FASTA)	NCBI Sequence Viewer
	XP_054972233	(Get FASTA)	NCBI Sequence Viewer
	XP_054972234	(Get FASTA)	NCBI Sequence Viewer
	XP_054972235	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000012415.1
	ENSPPAP00000012417.1

RefSeq Acc Id:	XP_034821499 ⟸ XM_034965608
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9A6B0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_034821501 ⟸ XM_034965610
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9A6B0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_024783210 ⟸ XM_024927442
- Peptide Label:	isoform X3
- UniProtKB:	A0A2R9AAE6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MHGNNGHSVPPSKRSETRAPVAPAGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGA FSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI hide sequence

RefSeq Acc Id:	XP_054972233 ⟸ XM_055116258
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9A6B0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054972232 ⟸ XM_055116257
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9A6B0 (UniProtKB/TrEMBL)

Protein Domains

Peptidase C1A papain C-terminal

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000029390	UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000035080.1	UniProtKB/TrEMBL
	ENSPPAT00000035082.1	UniProtKB/TrEMBL
Gene3D-CATH	Cysteine proteinases	UniProtKB/TrEMBL
InterPro	Papain-like_cys_pep_sf	UniProtKB/TrEMBL
	Pept_asp_AS	UniProtKB/TrEMBL
	Pept_cys_AS	UniProtKB/TrEMBL
	Pept_his_AS	UniProtKB/TrEMBL
	Peptidase_C1A	UniProtKB/TrEMBL
	Peptidase_C1A_C	UniProtKB/TrEMBL
	Propeptide_C1A	UniProtKB/TrEMBL
NCBI Gene	CTSB	ENTREZGENE
PANTHER	CYSTEINE PROTEASE FAMILY C1-RELATED	UniProtKB/TrEMBL
Pfam	Peptidase_C1	UniProtKB/TrEMBL
	Propeptide_C1	UniProtKB/TrEMBL
PRINTS	PAPAIN	UniProtKB/TrEMBL
PROSITE	THIOL_PROTEASE_ASN	UniProtKB/TrEMBL
	THIOL_PROTEASE_CYS	UniProtKB/TrEMBL
	THIOL_PROTEASE_HIS	UniProtKB/TrEMBL
SMART	Pept_C1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54001	UniProtKB/TrEMBL
UniProt	A0A2R9A6B0	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9AAE6	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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