Ctsb (cathepsin B) - Rat Genome Database

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Gene: Ctsb (cathepsin B) Chinchilla lanigera
Analyze
Symbol: Ctsb
Name: cathepsin B
RGD ID: 8810989
Description: ENCODES a protein that exhibits collagen binding (ortholog); cysteine-type endopeptidase activity (ortholog); cysteine-type peptidase activity (ortholog); INVOLVED IN autophagy (ortholog); cellular response to mechanical stimulus (ortholog); cellular response to thyroid hormone stimulus (ortholog); PARTICIPATES IN chaperone mediated autophagy pathway; ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); Albuminuria (ortholog); atherosclerosis (ortholog); FOUND IN apical plasma membrane (ortholog); caveola (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540353,085,574 - 53,093,809 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540353,086,236 - 53,100,217 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ctsb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540353,085,574 - 53,093,809 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540353,086,236 - 53,100,217 (-)NCBIChiLan1.0ChiLan1.0
CTSB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38811,842,524 - 11,868,087 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl811,842,524 - 11,869,533 (-)EnsemblGRCh38hg38GRCh38
GRCh37811,700,033 - 11,725,596 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36811,737,442 - 11,763,055 (-)NCBINCBI36Build 36hg18NCBI36
Build 34811,739,235 - 11,763,044NCBI
Celera810,829,316 - 10,854,967 (-)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef810,630,970 - 10,656,616 (-)NCBIHuRef
CHM1_1811,765,442 - 11,791,090 (-)NCBICHM1_1
T2T-CHM13v2.087,872,212 - 7,897,789 (+)NCBIT2T-CHM13v2.0
Ctsb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391463,359,911 - 63,383,372 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1463,359,911 - 63,383,372 (+)EnsemblGRCm39 Ensembl
GRCm381463,122,462 - 63,145,923 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1463,122,462 - 63,145,923 (+)EnsemblGRCm38mm10GRCm38
MGSCv371463,741,302 - 63,764,758 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361462,076,575 - 62,100,031 (+)NCBIMGSCv36mm8
Celera1460,885,230 - 60,908,693 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.24NCBI
Ctsb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81541,565,607 - 41,586,479 (+)NCBIGRCr8
mRatBN7.21537,389,636 - 37,410,508 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1537,389,629 - 37,410,500 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1539,242,069 - 39,263,185 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01540,392,878 - 40,413,994 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01538,850,264 - 38,871,139 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01546,316,741 - 46,337,613 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1546,316,741 - 46,337,612 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01550,081,535 - 50,102,407 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41542,402,829 - 42,423,701 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11542,418,600 - 42,439,400 (+)NCBI
Celera1537,073,910 - 37,094,782 (+)NCBICelera
Cytogenetic Map15p12NCBI
CTSB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2728,312,794 - 28,336,877 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan184,339,018 - 4,363,094 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v087,333,498 - 7,359,264 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CTSB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12526,048,237 - 26,056,570 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2526,048,253 - 26,055,801 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2526,693,298 - 26,713,566 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02526,191,391 - 26,211,634 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2526,190,645 - 26,292,033 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12526,136,951 - 26,157,236 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02526,041,126 - 26,061,383 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02526,192,122 - 26,212,434 (+)NCBIUU_Cfam_GSD_1.0
CTSB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1415,011,711 - 15,033,877 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11415,014,139 - 15,035,081 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21416,202,844 - 16,223,498 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTSB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.187,246,076 - 7,269,655 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl87,246,013 - 7,268,854 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605235,165,795 - 35,191,160 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctsb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475825,366,840 - 25,373,954 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475825,366,120 - 25,384,554 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000021606   ⟹   ENSCLAP00000021403
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540353,085,574 - 53,093,809 (-)Ensembl
RefSeq Acc Id: XM_005373830   ⟹   XP_005373887
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540353,086,236 - 53,100,217 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005373887 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000021403
  ENSCLAP00000021403.1
RefSeq Acc Id: XP_005373887   ⟸   XM_005373830
- UniProtKB: A0A8C2VVY0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000021403   ⟸   ENSCLAT00000021606

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014656 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000021606 ENTREZGENE
  ENSCLAT00000021606.1 UniProtKB/TrEMBL
Gene3D-CATH Cysteine proteinases UniProtKB/TrEMBL
InterPro Papain-like_cys_pep_sf UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/TrEMBL
  Pept_cys_AS UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/TrEMBL
  Propeptide_C1A UniProtKB/TrEMBL
NCBI Gene Ctsb ENTREZGENE
PANTHER CATHEPSIN B UniProtKB/TrEMBL
  CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/TrEMBL
Pfam Peptidase_C1 UniProtKB/TrEMBL
  Propeptide_C1 UniProtKB/TrEMBL
PRINTS PAPAIN UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/TrEMBL
  THIOL_PROTEASE_CYS UniProtKB/TrEMBL
  THIOL_PROTEASE_HIS UniProtKB/TrEMBL
SMART Pept_C1 UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A0A8C2VVY0 ENTREZGENE, UniProtKB/TrEMBL