CTSB (cathepsin B) - Rat Genome Database

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Gene: CTSB (cathepsin B) Canis lupus familiaris
Analyze
Symbol: CTSB
Name: cathepsin B
RGD ID: 12243179
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activity (ortholog); endopeptidase activity (ortholog); identical protein binding (ortholog); INVOLVED IN autophagy (ortholog); cellular response to mechanical stimulus (ortholog); decidualization (ortholog); PARTICIPATES IN chaperone mediated autophagy pathway; ASSOCIATED WITH acute necrotizing pancreatitis (ortholog); Albuminuria (ortholog); atherosclerosis (ortholog); FOUND IN apical plasma membrane (ortholog); caveola (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12526,048,237 - 26,056,570 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2526,048,253 - 26,055,801 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2526,693,298 - 26,713,566 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02526,191,391 - 26,211,634 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2526,190,645 - 26,292,033 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12526,136,951 - 26,157,236 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02526,041,126 - 26,061,383 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02526,192,122 - 26,212,434 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22278224   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CTSB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12526,048,237 - 26,056,570 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2526,048,253 - 26,055,801 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2526,693,298 - 26,713,566 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02526,191,391 - 26,211,634 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2526,190,645 - 26,292,033 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12526,136,951 - 26,157,236 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02526,041,126 - 26,061,383 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02526,192,122 - 26,212,434 (+)NCBIUU_Cfam_GSD_1.0
CTSB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38811,842,524 - 11,868,087 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl811,842,524 - 11,869,533 (-)EnsemblGRCh38hg38GRCh38
GRCh37811,700,033 - 11,725,596 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36811,737,442 - 11,763,055 (-)NCBINCBI36Build 36hg18NCBI36
Build 34811,739,235 - 11,763,044NCBI
Celera810,829,316 - 10,854,967 (-)NCBICelera
Cytogenetic Map8p23.1NCBI
HuRef810,630,970 - 10,656,616 (-)NCBIHuRef
CHM1_1811,765,442 - 11,791,090 (-)NCBICHM1_1
T2T-CHM13v2.087,872,212 - 7,897,789 (+)NCBIT2T-CHM13v2.0
Ctsb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391463,359,911 - 63,383,372 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1463,359,911 - 63,383,372 (+)EnsemblGRCm39 Ensembl
GRCm381463,122,462 - 63,145,923 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1463,122,462 - 63,145,923 (+)EnsemblGRCm38mm10GRCm38
MGSCv371463,741,302 - 63,764,758 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361462,076,575 - 62,100,031 (+)NCBIMGSCv36mm8
Celera1460,885,230 - 60,908,693 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.24NCBI
Ctsb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81541,565,607 - 41,586,479 (+)NCBIGRCr8
mRatBN7.21537,389,636 - 37,410,508 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1537,389,629 - 37,410,500 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1539,242,069 - 39,263,185 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01540,392,878 - 40,413,994 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01538,850,264 - 38,871,139 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01546,316,741 - 46,337,613 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1546,316,741 - 46,337,612 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01550,081,535 - 50,102,407 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41542,402,829 - 42,423,701 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11542,418,600 - 42,439,400 (+)NCBI
Celera1537,073,910 - 37,094,782 (+)NCBICelera
Cytogenetic Map15p12NCBI
Ctsb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540353,085,574 - 53,093,809 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540353,086,236 - 53,100,217 (-)NCBIChiLan1.0ChiLan1.0
CTSB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2728,312,794 - 28,336,877 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan184,339,018 - 4,363,094 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v087,333,498 - 7,359,264 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
CTSB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1415,011,711 - 15,033,877 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11415,014,139 - 15,035,081 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21416,202,844 - 16,223,498 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CTSB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.187,246,076 - 7,269,655 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl87,246,013 - 7,268,854 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605235,165,795 - 35,191,160 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ctsb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475825,366,840 - 25,373,954 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475825,366,120 - 25,384,554 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CTSB
174 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022410039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038435237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038435238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038458195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038510183 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038510184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038573646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038573647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038637947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038637948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_543203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000302 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000012692   ⟹   ENSCAFP00000011755
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2526,048,253 - 26,055,801 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000064880   ⟹   ENSCAFP00000059573
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2526,048,253 - 26,055,801 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845033017   ⟹   ENSCAFP00845025839
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2526,190,645 - 26,292,033 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845033096   ⟹   ENSCAFP00845025905
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2526,190,645 - 26,211,633 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845033154   ⟹   ENSCAFP00845025954
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2526,191,439 - 26,211,634 (+)Ensembl
RefSeq Acc Id: XM_022410039   ⟹   XP_022265747
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12526,050,802 - 26,056,570 (+)NCBI
Dog10K_Boxer_Tasha2526,707,802 - 26,713,566 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038435237   ⟹   XP_038291165
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02526,191,391 - 26,211,634 (+)NCBI
RefSeq Acc Id: XM_038435238   ⟹   XP_038291166
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02526,205,875 - 26,211,634 (+)NCBI
RefSeq Acc Id: XM_038458195   ⟹   XP_038314123
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha2526,693,298 - 26,713,566 (+)NCBI
RefSeq Acc Id: XM_038510183   ⟹   XP_038366111
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12526,136,951 - 26,157,236 (+)NCBI
RefSeq Acc Id: XM_038510184   ⟹   XP_038366112
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.12526,151,469 - 26,157,236 (+)NCBI
RefSeq Acc Id: XM_038573646   ⟹   XP_038429574
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02526,192,122 - 26,212,434 (+)NCBI
RefSeq Acc Id: XM_038573647   ⟹   XP_038429575
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.02526,206,660 - 26,212,434 (+)NCBI
RefSeq Acc Id: XM_038637947   ⟹   XP_038493875
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02526,041,126 - 26,061,383 (+)NCBI
RefSeq Acc Id: XM_038637948   ⟹   XP_038493876
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.02526,055,619 - 26,061,383 (+)NCBI
RefSeq Acc Id: XP_022265747   ⟸   XM_022410039
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSCAFP00000059573   ⟸   ENSCAFT00000064880
Ensembl Acc Id: ENSCAFP00000011755   ⟸   ENSCAFT00000012692
RefSeq Acc Id: XP_038366111   ⟸   XM_038510183
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038366112   ⟸   XM_038510184
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038493875   ⟸   XM_038637947
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038493876   ⟸   XM_038637948
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038291165   ⟸   XM_038435237
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NN14 (UniProtKB/TrEMBL),   A0A8C0QZE3 (UniProtKB/TrEMBL),   A0A8I3P7H9 (UniProtKB/TrEMBL),   A0A8I3P7L9 (UniProtKB/TrEMBL),   A0A8P0SD21 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038291166   ⟸   XM_038435238
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038314123   ⟸   XM_038458195
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NN14 (UniProtKB/TrEMBL),   A0A8C0QZE3 (UniProtKB/TrEMBL),   A0A8I3P7H9 (UniProtKB/TrEMBL),   A0A8I3P7L9 (UniProtKB/TrEMBL),   A0A8P0SD21 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038429574   ⟸   XM_038573646
- Peptide Label: isoform X1
- UniProtKB: A0A8I3P7L9 (UniProtKB/TrEMBL),   A0A8P0SD21 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038429575   ⟸   XM_038573647
- Peptide Label: isoform X2
Ensembl Acc Id: ENSCAFP00845025839   ⟸   ENSCAFT00845033017
Ensembl Acc Id: ENSCAFP00845025954   ⟸   ENSCAFT00845033154
Ensembl Acc Id: ENSCAFP00845025905   ⟸   ENSCAFT00845033096

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007934 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030018340 UniProtKB/TrEMBL
  ENSCAFG00845018672 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000012692.5 UniProtKB/TrEMBL
  ENSCAFT00000064880.2 UniProtKB/TrEMBL
  ENSCAFT00030033765.1 UniProtKB/TrEMBL
  ENSCAFT00030033837.1 UniProtKB/TrEMBL
  ENSCAFT00030033938.1 UniProtKB/TrEMBL
  ENSCAFT00030034024.1 UniProtKB/TrEMBL
  ENSCAFT00845033017.1 UniProtKB/TrEMBL
  ENSCAFT00845033096 ENTREZGENE
  ENSCAFT00845033096.1 UniProtKB/TrEMBL
  ENSCAFT00845033154.1 UniProtKB/TrEMBL
Gene3D-CATH Cysteine proteinases UniProtKB/TrEMBL
InterPro Papain-like_cys_pep_sf UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/TrEMBL
  Pept_cys_AS UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/TrEMBL
  Propeptide_C1A UniProtKB/TrEMBL
NCBI Gene CTSB ENTREZGENE
PANTHER CATHEPSIN B UniProtKB/TrEMBL
  CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/TrEMBL
Pfam Peptidase_C1 UniProtKB/TrEMBL
  Propeptide_C1 UniProtKB/TrEMBL
PRINTS PAPAIN UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/TrEMBL
  THIOL_PROTEASE_CYS UniProtKB/TrEMBL
  THIOL_PROTEASE_HIS UniProtKB/TrEMBL
SMART Pept_C1 UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A0A8C0NMI5_CANLF UniProtKB/TrEMBL
  A0A8C0NN14 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0NU46_CANLF UniProtKB/TrEMBL
  A0A8C0P4G7_CANLF UniProtKB/TrEMBL
  A0A8C0QZE3 ENTREZGENE
  A0A8I3P7H9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3P7L9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3S0M3_CANLF UniProtKB/TrEMBL
  A0A8P0SD21 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:39709 ENTREZGENE