GPX1 (glutathione peroxidase 1) - Rat Genome Database
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Gene: GPX1 (glutathione peroxidase 1) Pan paniscus
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Symbol: GPX1
Name: glutathione peroxidase 1
RGD ID: 11781213
Description: ENCODES a protein that exhibits glutathione peroxidase activity (ortholog); phospholipid-hydroperoxide glutathione peroxidase activity (ortholog); SH3 domain binding (ortholog); INVOLVED IN aging (ortholog); angiogenesis involved in wound healing (ortholog); apoptotic process (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); alpha thalassemia (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); Lewy body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1350,360,736 - 50,362,274 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,360,947 - 50,361,826 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0349,280,038 - 49,281,455 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
alpha thalassemia  (ISO)
anemia  (ISO)
Anorexia  (ISO)
arteriosclerosis  (ISO)
autistic disorder  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2P  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
Cadmium Poisoning  (ISO)
calcinosis  (ISO)
Cardiovascular Abnormalities  (ISO)
cardiovascular system disease  (ISO)
carotid stenosis  (ISO)
cataract  (ISO)
Chronic Hepatitis  (ISO)
chronic kidney disease  (ISO)
chronic myeloid leukemia  (ISO)
coronary artery disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
epilepsy  (ISO)
Experimental Diabetes Mellitus  (ISO)
fatty liver disease  (ISO)
gestational diabetes  (ISO)
Glutathione Peroxidase Deficiency, Hemolytic Anemia possibly due to  (ISO)
hairy cell leukemia  (ISO)
Head and Neck Neoplasms  (ISO)
Hemolysis  (ISO)
Huntington's disease  (ISO)
hyperglycemia  (ISO)
hyperhomocysteinemia  (ISO)
hyperinsulinism  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
hypothyroidism  (ISO)
iron deficiency anemia  (ISO)
Iron Overload  (ISO)
Keshan disease  (ISO)
leukemia  (ISO)
Liver Injury  (ISO)
Lung Neoplasms  (ISO)
mental depression  (ISO)
Mercury Poisoning  (ISO)
multiple myeloma  (ISO)
myeloid neoplasm  (ISO)
myocardial infarction  (ISO)
nephrosis  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (ISO)
osteoporosis  (ISO)
Parkinson's disease  (ISO)
pseudoxanthoma elasticum  (ISO)
Reperfusion Injury  (ISO)
Reticulocytosis  (ISO)
senile cataract  (ISO)
sickle cell anemia  (ISO)
squamous cell carcinoma  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
vascular dementia  (ISO)
Venous Thrombosis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
angiogenesis involved in wound healing  (ISO)
apoptotic process  (ISO)
arachidonic acid metabolic process  (ISO)
biological process involved in interaction with symbiont  (ISO)
blood vessel endothelial cell migration  (ISO)
cell population proliferation  (ISO)
cell redox homeostasis  (ISO)
cellular response to glucose stimulus  (ISO)
endothelial cell development  (ISO)
fat cell differentiation  (ISO)
glutathione metabolic process  (ISO)
heart contraction  (ISO)
hydrogen peroxide catabolic process  (ISO)
intrinsic apoptotic signaling pathway in response to oxidative stress  (ISO)
lipid metabolic process  (ISO)
lipoxygenase pathway  (ISO)
myoblast proliferation  (ISO)
myotube differentiation  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of inflammatory response to antigenic stimulus  (ISO)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of release of cytochrome c from mitochondria  (ISO)
neuron apoptotic process  (ISO)
positive regulation of protein kinase B signaling  (ISO)
protein oxidation  (ISO)
regulation of gene expression, epigenetic  (ISO)
regulation of mammary gland epithelial cell proliferation  (ISO)
regulation of proteasomal protein catabolic process  (ISO)
response to estradiol  (ISO)
response to folic acid  (ISO)
response to gamma radiation  (ISO)
response to glucose  (ISO)
response to hormone  (ISO)
response to hydrogen peroxide  (ISO)
response to hydroperoxide  (ISO)
response to nicotine  (ISO)
response to organic cyclic compound  (ISO)
response to oxidative stress  (ISO)
response to reactive oxygen species  (ISO)
response to selenium ion  (ISO)
response to symbiotic bacterium  (ISO)
response to toxic substance  (ISO)
response to wounding  (ISO)
response to xenobiotic stimulus  (ISO)
sensory perception of sound  (ISO)
skeletal muscle fiber development  (ISO)
skeletal muscle tissue regeneration  (ISO)
temperature homeostasis  (ISO)
triglyceride metabolic process  (ISO)
UV protection  (ISO)
vasodilation  (ISO)

Cellular Component
cytoplasm  (ISO)
cytosol  (ISO)
Lewy body  (ISO)
mitochondrion  (ISO)
nucleus  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
GPX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1350,360,736 - 50,362,274 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl350,360,947 - 50,361,826 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0349,280,038 - 49,281,455 (-)NCBIMhudiblu_PPA_v0panPan3
GPX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl349,357,176 - 49,358,353 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl349,357,176 - 49,358,358 (-)EnsemblGRCh38hg38GRCh38
GRCh38349,357,176 - 49,358,353 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37349,394,609 - 49,395,786 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,369,613 - 49,370,795 (-)NCBINCBI36hg18NCBI36
Build 34349,369,614 - 49,370,795NCBI
Celera349,359,484 - 49,360,663 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef349,454,091 - 49,455,270 (-)NCBIHuRef
CHM1_1349,347,422 - 49,348,601 (-)NCBICHM1_1
Gpx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,216,279 - 108,217,541 (+)NCBIGRCm39mm39
GRCm39 Ensembl9108,216,102 - 108,217,542 (+)Ensembl
GRCm389108,339,080 - 108,340,342 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,338,903 - 108,340,343 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,241,607 - 108,242,671 (+)NCBIGRCm37mm9NCBIm37
MGSCv369108,197,368 - 108,198,432 (+)NCBImm8
Celera9107,948,378 - 107,949,442 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.24NCBI
Gpx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28109,026,905 - 109,028,031 (+)NCBI
Rnor_6.0 Ensembl8117,117,430 - 117,118,522 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08117,117,430 - 117,118,528 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08116,466,118 - 116,467,216 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,329,847 - 108,330,945 (+)ENTREZGENECelera
Cytogenetic Map8q32NCBI
Gpx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555321,298,336 - 1,298,830 (-)NCBIChiLan1.0ChiLan1.0
GPX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2039,889,174 - 39,890,260 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12039,889,165 - 39,890,253 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Gpx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936529997,943 - 999,123 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,914,932 - 31,917,335 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,916,269 - 31,917,337 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,147,277 - 35,148,345 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPX1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,754,976 - 10,756,617 (-)NCBI
Gpx1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247303,313,773 - 3,314,870 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000061156   ⟹   ENSPPAP00000038253
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl350,360,947 - 50,361,826 (-)Ensembl
RefSeq Acc Id: XM_003818370   ⟹   XP_003818418
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1350,360,736 - 50,362,274 (-)NCBI
Mhudiblu_PPA_v0349,280,038 - 49,281,455 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024928097   ⟹   XP_024783865
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1350,361,065 - 50,362,274 (-)NCBI
Mhudiblu_PPA_v0349,280,367 - 49,281,455 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003818418 (Get FASTA)   NCBI Sequence Viewer  
  XP_024783865 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003818418   ⟸   XM_003818370
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_024783865   ⟸   XM_024928097
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSPPAP00000038253   ⟸   ENSPPAT00000061156


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000041840 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000038253 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000061156 UniProtKB/TrEMBL
Gene3D-CATH 3.40.30.10 UniProtKB/TrEMBL
InterPro Glutathione_peroxidase UniProtKB/TrEMBL
  GPX_CS UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
NCBI Gene GPX1 ENTREZGENE
PANTHER PTHR11592 UniProtKB/TrEMBL
Pfam GSHPx UniProtKB/TrEMBL
PIRSF Glutathion_perox UniProtKB/TrEMBL
PRINTS GLUTPROXDASE UniProtKB/TrEMBL
PROSITE GLUTATHIONE_PEROXID_2 UniProtKB/TrEMBL
  GLUTATHIONE_PEROXID_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF52833 UniProtKB/TrEMBL
UniProt A0A2R9CBA8_PANPA UniProtKB/TrEMBL