TTN (titin) - Rat Genome Database

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Pathways
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Gene: TTN (titin) Pan paniscus
Analyze
Symbol: TTN
Name: titin
RGD ID: 11790549
Description: ENCODES a protein that exhibits actin filament binding (ortholog); actinin binding (ortholog); ankyrin binding (ortholog); INVOLVED IN adult heart development (ortholog); cardiac muscle cell development (ortholog); cardiac muscle contraction (ortholog); ASSOCIATED WITH arrhythmogenic right ventricular cardiomyopathy (ortholog); arrhythmogenic right ventricular dysplasia 1 (ortholog); arrhythmogenic right ventricular dysplasia 9 (ortholog); FOUND IN A band (ortholog); condensed nuclear chromosome (ortholog); I band (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21381,172,170 - 81,452,915 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B81,187,144 - 81,467,889 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B65,783,512 - 66,064,618 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B183,487,352 - 183,767,268 (-)NCBIpanpan1.1PanPan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 1  (ISO)
arrhythmogenic right ventricular dysplasia 9  (ISO)
atrial fibrillation  (ISO)
autosomal recessive centronuclear myopathy  (ISO)
autosomal recessive limb-girdle muscular dystrophy  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2J  (ISO)
Brugada syndrome  (ISO)
cardiac amyloidosis  (ISO)
cardiomyopathy  (ISO)
centronuclear myopathy  (ISO)
cerebral palsy  (ISO)
clubfoot  (ISO)
congenital muscular dystrophy  (ISO)
congenital myopathy  (ISO)
congenital myopathy 1B  (ISO)
congenital myopathy 5  (ISO)
congenital structural myopathy  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
Diastolic Dysfunction  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1A  (ISO)
dilated cardiomyopathy 1B  (ISO)
dilated cardiomyopathy 1G  (ISO)
dilated cardiomyopathy 1H  (ISO)
dilated cardiomyopathy 1S  (ISO)
Dilated Cardiomyopathy with Left Ventricular Noncompaction  (ISO)
distal myopathy  (ISO)
Dwarfism  (ISO)
dystonia 16  (ISO)
Failure to Thrive  (ISO)
Familial Amyloid Polyneuropathies  (ISO)
familial hypertrophic cardiomyopathy  (ISO)
Gaucher's disease  (ISO)
Gaucher's disease type I  (ISO)
genetic disease  (ISO)
Heart Block  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
hypertrophic cardiomyopathy 9  (ISO)
Left Ventricular Hypertrophy  (ISO)
left ventricular noncompaction  (ISO)
Left Ventricular Noncompaction 2  (ISO)
leukocyte adhesion deficiency 1  (ISO)
limb-girdle muscular dystrophy  (ISO)
long QT syndrome  (ISO)
mitral valve prolapse  (ISO)
Muscle Hypotonia  (ISO)
Muscle Weakness  (ISO)
muscular disease  (ISO)
muscular dystrophy  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
myofibrillar myopathy 1  (ISO)
myofibrillar myopathy 9  (ISO)
myopathy  (ISO)
neuromuscular disease  (ISO)
orofacial cleft 1  (ISO)
restrictive cardiomyopathy  (ISO)
speech disorder  (ISO)
Sudden Cardiac Death  (ISO)
sudden infant death syndrome  (ISO)
Sudden Unexpected Nocturnal Death Syndrome  (ISO)
Supraventricular Tachycardia  (ISO)
Syncope  (ISO)
systolic heart failure  (ISO)
third-degree atrioventricular block  (ISO)
tibial muscular dystrophy  (ISO)
transthyretin amyloidosis  (ISO)
Ventricular Fibrillation  (ISO)
Ventricular Premature Complexes  (ISO)
Ventricular Tachycardia  (ISO)
Wolff-Parkinson-White syndrome  (ISO)
X-linked Emery-Dreifuss muscular dystrophy 6  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
TTN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21381,172,170 - 81,452,915 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B81,187,144 - 81,467,889 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B65,783,512 - 66,064,618 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B183,487,352 - 183,767,268 (-)NCBIpanpan1.1PanPan1.1panPan2
TTN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382178,525,989 - 178,807,423 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2178,525,989 - 178,830,802 (-)EnsemblGRCh38hg38GRCh38
GRCh372179,390,716 - 179,672,150 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362179,098,962 - 179,380,395 (-)NCBINCBI36Build 36hg18NCBI36
Celera2172,993,600 - 173,266,525 (-)NCBICelera
Cytogenetic Map2q31.2NCBI
HuRef2171,261,156 - 171,540,118 (-)NCBIHuRef
CHM1_12179,396,760 - 179,678,208 (-)NCBICHM1_1
T2T-CHM13v2.02179,008,783 - 179,290,485 (-)NCBIT2T-CHM13v2.0
Ttn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39276,534,324 - 76,812,901 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl276,534,324 - 76,812,891 (-)EnsemblGRCm39 Ensembl
GRCm38276,703,980 - 76,982,557 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl276,703,980 - 76,982,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv37276,542,041 - 76,820,604 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36276,504,823 - 76,783,386 (-)NCBIMGSCv36mm8
Celera278,365,659 - 78,644,178 (-)NCBICelera
Cytogenetic Map2C3NCBI
cM Map245.13NCBI
Ttn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8382,059,648 - 82,332,130 (-)NCBIGRCr8
mRatBN7.2361,652,432 - 61,924,912 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl361,652,439 - 61,924,741 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0363,565,160 - 63,837,815 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0370,138,896 - 70,408,647 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4359,404,023 - 59,665,308 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1359,490,644 - 59,514,338 (-)NCBI
Celera361,137,881 - 61,409,292 (-)NCBICelera
Cytogenetic Map3q24NCBI
Ttn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540318,057,344 - 18,328,389 (+)NCBIChiLan1.0ChiLan1.0
TTN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13622,146,870 - 22,417,858 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3622,147,824 - 22,417,826 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3622,165,230 - 22,439,415 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03622,290,643 - 22,564,715 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3622,291,570 - 22,564,719 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13622,399,838 - 22,673,559 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03622,362,753 - 22,636,976 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03622,479,043 - 22,752,940 (-)NCBIUU_Cfam_GSD_1.0
Ttn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303139,179,523 - 139,445,548 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365097,733,426 - 7,999,503 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11584,226,953 - 84,501,320 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21593,758,133 - 93,780,787 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TTN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11064,074,994 - 64,379,055 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1064,076,021 - 64,347,205 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040135,225,819 - 135,499,926 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ttn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624844484,593 - 760,155 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_034954590   ⟹   XP_034810481
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21381,390,511 - 81,452,915 (-)NCBI
NHGRI_mPanPan12B81,405,527 - 81,467,889 (-)NCBI
Mhudiblu_PPA_v02B66,002,380 - 66,064,618 (-)NCBI
RefSeq Acc Id: XM_063595464   ⟹   XP_063451534
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21381,172,170 - 81,452,915 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034810481 (Get FASTA)   NCBI Sequence Viewer  
  XP_063451534 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000023910.1
Reference Protein Sequences
RefSeq Acc Id: XP_034810481   ⟸   XM_034954590
- Peptide Label: isoform X2
- UniProtKB: A0A2R9B6Q0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063451534   ⟸   XM_063595464
- Peptide Label: isoform X1
Protein Domains
Ig-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034897 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000046735.1 UniProtKB/TrEMBL
Gene3D-CATH Immunoglobulins UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Titin_Z_rpt UniProtKB/TrEMBL
NCBI Gene TTN ENTREZGENE
PANTHER MICROFIBRIL-ASSOCIATED GLYCOPROTEIN 3 UniProtKB/TrEMBL
  PTHR14340:SF24 UniProtKB/TrEMBL
Pfam I-set UniProtKB/TrEMBL
  Titin_Z UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP Immunoglobulin UniProtKB/TrEMBL
UniProt A0A2R9B6Q0 ENTREZGENE, UniProtKB/TrEMBL