ITGB3 (integrin subunit beta 3) - Rat Genome Database

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Gene: ITGB3 (integrin subunit beta 3) Pan paniscus
Analyze
Symbol: ITGB3
Name: integrin subunit beta 3
RGD ID: 11969517
Description: ENCODES a protein that exhibits C-X3-C chemokine binding (ortholog); fibrinogen binding (ortholog); fibroblast growth factor binding (ortholog); INVOLVED IN cell-matrix adhesion (ortholog); cell-substrate junction assembly (ortholog); cellular response to insulin-like growth factor stimulus (ortholog); PARTICIPATES IN abciximab pharmacodynamics pathway; ephrin - ephrin receptor bidirectional signaling axis; eptifibatide pharmacodynamics pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); acute myeloid leukemia (ortholog); Arterial Occlusive Diseases (ortholog); FOUND IN apical plasma membrane (ortholog); cell surface (ortholog); focal adhesion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: integrin beta-3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11710,353,111 - 10,388,924 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1710,353,111 - 10,392,382 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01710,134,450 - 10,194,596 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
acute myeloid leukemia  (ISO)
Arterial Occlusive Diseases  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
autoimmune thrombocytopenic purpura  (ISO)
bacterial pneumonia  (ISO)
Banti's Syndrome  (ISO)
Bronchial Hyperreactivity  (ISO)
Carotid Artery Injuries  (ISO)
carotid artery thrombosis  (ISO)
carotid stenosis  (ISO)
Cerebral Hemorrhage  (ISO)
colorectal carcinoma  (ISO)
Coronary Disease  (ISO)
coronary thrombosis  (ISO)
diabetic retinopathy  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Mammary Neoplasms  (ISO)
focal segmental glomerulosclerosis  (ISO)
Glanzmann Thrombasthenia 1  (ISO)
Glanzmann Thrombasthenia 2  (ISO)
Glanzmann's thrombasthenia  (ISO)
Gliosis  (ISO)
glomerulonephritis  (ISO)
Graves' disease  (ISO)
Hantavirus hemorrhagic fever with renal syndrome  (ISO)
Hantavirus Infections  (ISO)
Hemorrhage  (ISO)
hemorrhagic disease  (ISO)
Hip Fractures  (ISO)
lung disease  (ISO)
lung non-small cell carcinoma  (ISO)
myelodysplastic syndrome  (ISO)
myocardial infarction  (ISO)
Neonatal Alloimmune Thrombocytopenia  (ISO)
Neoplasm Metastasis  (ISO)
non-arteritic anterior ischemic optic neuropathy  (ISO)
Pathologic Constriction  (ISO)
Plaque, Atherosclerotic  (ISO)
platelet-type bleeding disorder 16  (ISO)
Platelet-Type Bleeding Disorder 24  (ISO)
pneumonia  (ISO)
Posttransfusion Purpura  (ISO)
Prostatic Neoplasms  (ISO)
Reperfusion Injury  (ISO)
Stroke  (ISO)
Sudden Cardiac Death  (ISO)
thrombocytopenia  (ISO)
Thrombocytopenic Purpura  (ISO)
Thrombotic Microangiopathies  (ISO)
transient cerebral ischemia  (ISO)
Ulcer  (ISO)
Venous Thrombosis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (IEA)
apolipoprotein A-I-mediated signaling pathway  (IEA)
apoptotic cell clearance  (IEA)
cell adhesion  (IEA)
cell adhesion mediated by integrin  (IEA)
cell-matrix adhesion  (IEA,ISO)
cell-substrate adhesion  (IEA)
cell-substrate junction assembly  (IEA,ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to platelet-derived growth factor stimulus  (IEA,ISO)
cellular response to xenobiotic stimulus  (ISO)
embryo implantation  (ISO)
heterotypic cell-cell adhesion  (IEA)
integrin-mediated signaling pathway  (IEA)
maintenance of postsynaptic specialization structure  (ISO)
mesodermal cell differentiation  (IEA)
negative chemotaxis  (IEA)
negative regulation of cell death  (ISO)
negative regulation of lipid storage  (IEA)
negative regulation of lipid transport  (IEA)
negative regulation of lipoprotein metabolic process  (IEA)
negative regulation of low-density lipoprotein receptor activity  (IEA,ISO)
negative regulation of macrophage derived foam cell differentiation  (IEA)
platelet activation  (IEA)
platelet aggregation  (IEA,ISO)
platelet-derived growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathway  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of bone resorption  (ISO)
positive regulation of cell adhesion mediated by integrin  (ISO)
positive regulation of cell migration  (IEA)
positive regulation of cell-matrix adhesion  (IEA,ISO)
positive regulation of endothelial cell migration  (IEA)
positive regulation of endothelial cell proliferation  (IEA)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast migration  (IEA,ISO)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA)
positive regulation of glomerular mesangial cell proliferation  (ISO)
positive regulation of leukocyte migration  (ISO)
positive regulation of osteoblast proliferation  (IEA)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (IEA,ISO)
positive regulation of T cell migration  (IEA)
regulation of actin cytoskeleton organization  (IEA)
regulation of extracellular matrix organization  (IEA,ISO)
regulation of G protein-coupled receptor signaling pathway  (ISO)
regulation of postsynaptic neurotransmitter receptor diffusion trapping  (ISO)
regulation of postsynaptic neurotransmitter receptor internalization  (IEA)
regulation of protein localization  (IEA)
regulation of protein tyrosine kinase activity  (IEA,ISO)
regulation of release of sequestered calcium ion into cytosol  (ISO)
regulation of serotonin uptake  (IEA)
regulation of trophoblast cell migration  (IEA,ISO)
response to activity  (ISO)
response to platelet-derived growth factor  (ISO)
response to radiation  (ISO)
smooth muscle cell migration  (IEA)
substrate adhesion-dependent cell spreading  (IEA)
viral entry into host cell  (IEA)

References

Genomics

Comparative Map Data
ITGB3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11710,353,111 - 10,388,924 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1710,353,111 - 10,392,382 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01710,134,450 - 10,194,596 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ITGB3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381747,253,827 - 47,313,743 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1747,253,827 - 47,313,743 (+)EnsemblGRCh38hg38GRCh38
GRCh371745,331,193 - 45,391,109 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361742,686,207 - 42,745,076 (+)NCBINCBI36Build 36hg18NCBI36
Build 341742,686,206 - 42,745,076NCBI
Celera1741,781,276 - 41,840,192 (+)NCBICelera
Cytogenetic Map17q21.32NCBI
HuRef1740,709,287 - 40,768,167 (+)NCBIHuRef
CHM1_11745,396,156 - 45,455,032 (+)NCBICHM1_1
T2T-CHM13v2.01748,116,181 - 48,176,126 (+)NCBIT2T-CHM13v2.0
Itgb3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911104,498,826 - 104,561,302 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11104,498,826 - 104,561,302 (+)EnsemblGRCm39 Ensembl
GRCm3811104,608,000 - 104,670,476 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11104,608,000 - 104,670,476 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711104,469,314 - 104,531,787 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611104,424,146 - 104,483,465 (+)NCBIMGSCv36mm8
Celera11116,336,310 - 116,392,711 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1167.84NCBI
Itgb3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21089,509,917 - 89,564,679 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1089,509,989 - 89,564,679 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1094,545,884 - 94,600,315 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01094,009,074 - 94,063,507 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01089,414,016 - 89,475,939 (+)NCBIRnor_WKY
Rnor_6.01092,667,869 - 92,783,413 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1092,667,869 - 92,783,410 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01092,424,545 - 92,538,859 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1088,202,821 - 88,257,185 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
Itgb3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554789,788,149 - 9,823,746 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554789,788,192 - 9,830,254 (-)NCBIChiLan1.0ChiLan1.0
ITGB3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.199,179,667 - 9,231,061 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl99,182,562 - 9,231,451 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha911,065,645 - 11,114,120 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0910,772,116 - 10,823,763 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl910,772,333 - 10,825,024 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.199,787,282 - 9,835,753 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0917,686,480 - 17,734,963 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0917,635,354 - 17,683,846 (+)NCBIUU_Cfam_GSD_1.0
Itgb3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560216,320,810 - 16,379,027 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365412,822,789 - 2,871,069 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGB3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1216,693,514 - 16,752,292 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11216,694,466 - 16,752,228 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21216,718,915 - 16,775,379 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITGB3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11659,372,171 - 59,431,434 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1659,374,889 - 59,410,857 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607730,082,743 - 30,143,493 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itgb3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248491,895,914 - 1,952,665 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248491,895,378 - 1,952,755 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034941547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000037148   ⟹   ENSPPAP00000014462
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1710,353,111 - 10,388,927 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000037153   ⟹   ENSPPAP00000014467
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1710,353,351 - 10,392,382 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000037156   ⟹   ENSPPAP00000014470
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1710,353,351 - 10,391,394 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000037164   ⟹   ENSPPAP00000014478
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1710,353,351 - 10,382,096 (-)Ensembl
RefSeq Acc Id: XM_034941547   ⟹   XP_034797438
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01710,134,450 - 10,194,596 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034797438 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_034797438   ⟸   XM_034941547
RefSeq Acc Id: ENSPPAP00000014467   ⟸   ENSPPAT00000037153
RefSeq Acc Id: ENSPPAP00000014478   ⟸   ENSPPAT00000037164
RefSeq Acc Id: ENSPPAP00000014462   ⟸   ENSPPAT00000037148
RefSeq Acc Id: ENSPPAP00000014470   ⟸   ENSPPAT00000037156
Protein Domains
INB   Integrin_b_cyt   Integrin_B_tail   PSI


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030328 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000014462.1 UniProtKB/TrEMBL
  ENSPPAP00000014467.1 UniProtKB/TrEMBL
  ENSPPAP00000014470.1 UniProtKB/TrEMBL
  ENSPPAP00000014478.1 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000037148.1 UniProtKB/TrEMBL
  ENSPPAT00000037153.1 UniProtKB/TrEMBL
  ENSPPAT00000037156.1 UniProtKB/TrEMBL
  ENSPPAT00000037164.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/TrEMBL
InterPro EGF_extracell UniProtKB/TrEMBL
  I-EGF_1 UniProtKB/TrEMBL
  Integrin_beta-3 UniProtKB/TrEMBL
  Integrin_beta_N UniProtKB/TrEMBL
  Integrin_bsu UniProtKB/TrEMBL
  Integrin_bsu_cyt_dom UniProtKB/TrEMBL
  Integrin_bsu_tail UniProtKB/TrEMBL
  Integrin_bsu_tail_dom_sf UniProtKB/TrEMBL
  Integrin_bsu_VWA UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/TrEMBL
  PSI UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
NCBI Gene ITGB3 ENTREZGENE
PANTHER PTHR10082 UniProtKB/TrEMBL
  PTHR10082:SF25 UniProtKB/TrEMBL
Pfam EGF_2 UniProtKB/TrEMBL
  I-EGF_1 UniProtKB/TrEMBL
  Integrin_b_cyt UniProtKB/TrEMBL
  Integrin_B_tail UniProtKB/TrEMBL
  Integrin_beta UniProtKB/TrEMBL
  PSI_integrin UniProtKB/TrEMBL
PIRSF Integrin_B UniProtKB/TrEMBL
PRINTS INTEGRINB UniProtKB/TrEMBL
PROSITE INTEGRIN_BETA UniProtKB/TrEMBL
SMART INB UniProtKB/TrEMBL
  Integrin_b_cyt UniProtKB/TrEMBL
  Integrin_B_tail UniProtKB/TrEMBL
  PSI UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
  SSF69179 UniProtKB/TrEMBL
  SSF69687 UniProtKB/TrEMBL
UniProt A0A2R9AB30_PANPA UniProtKB/TrEMBL
  A0A2R9AG10_PANPA UniProtKB/TrEMBL
  A0A2R9AGM6_PANPA UniProtKB/TrEMBL
  A0A2R9AGN4_PANPA UniProtKB/TrEMBL