RGD Reference Report - Role of histamine H3 receptors during ischemia/reperfusion in isolated rat hearts. - Rat Genome Database

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Role of histamine H3 receptors during ischemia/reperfusion in isolated rat hearts.

Authors: Yamamoto, S  Tamai, I  Takaoka, M  Matsumura, Y 
Citation: Yamamoto S, etal., J Cardiovasc Pharmacol. 2004 Mar;43(3):353-7.
RGD ID: 1626433
Pubmed: (View Article at PubMed) PMID:15076218

Histamine H3 receptors are involved in regulating the release of norepinephrine (NE), in both central and peripheral nervous systems. We investigated the effect of R-alpha-methylhistamine (R-HA), a selective H3 receptor agonist, and thioperamide (Thiop), a selective H3 receptor antagonist, on ischemia/reperfusion-induced changes in carrier-mediated NE release and cardiac function in isolated rat heart. Hearts were subjected to 40-minute ischemia followed by 30-minute reperfusion. Ischemia/reperfusion evoked massive NE release, which was markedly suppressed by the treatment with desipramine (DMI), a neuronal NE transporter blocker. Ischemia/reperfusion-induced cardiac dysfunction (decreases in left ventricular developed pressure, LVDP, and the first derivative of left ventricular pressure, dP/dt, and a rise in left ventricular end diastolic pressure, LVEDP) was also improved by the DMI treatment. The treatment with R-HA also significantly decreased the excessive NE release induced by the ischemia/reperfusion, improved the recovery of LVDP and dP/dt, and suppressed the rise in LVEDP. Thiop did not affect NE release and cardiac function after the reperfusion. When R-HA was administered concomitantly with Thiop, R-HA failed to attenuate ischemia/reperfusion-induced NE release and cardiac dysfunction. Thus, it seems likely that the ischemia/reperfusion-induced carrier-mediated NE release in rat hearts is negatively regulated by the activation of H3 receptors, probably located on cardiac noradrenergic nerve endings.


Disease Annotations    

Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Hrh3  (histamine receptor H3)

Genes (Mus musculus)
Hrh3  (histamine receptor H3)

Genes (Homo sapiens)
HRH3  (histamine receptor H3)

Additional Information