RGD Reference Report - Periostin as a modulator of chronic cardiac remodeling after myocardial infarction. - Rat Genome Database

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Periostin as a modulator of chronic cardiac remodeling after myocardial infarction.

Authors: Minicucci, MF  Santos, PP  Rafacho, BP  Goncalves, AF  Ardisson, LP  Batista, DF  Azevedo, PS  Polegato, BF  Okoshi, K  Pereira, EJ  Paiva, SA  Zornoff, LA 
Citation: Minicucci MF, etal., Clinics (Sao Paulo). 2013 Oct;68(10):1344-9. doi: 10.6061/clinics/2013(10)09.
RGD ID: 10041024
Pubmed: PMID:24212842   (View Abstract at PubMed)
PMCID: PMC3798673   (View Article at PubMed Central)
DOI: DOI:10.6061/clinics/2013(10)09   (Journal Full-text)

OBJECTIVE: After acute myocardial infarction, during the cardiac repair phase, periostin is released into the infarct and activates signaling pathways that are essential for the reparative process. However, the role of periostin in chronic cardiac remodeling after myocardial infarction remains to be elucidated. Therefore, the objective of this study was to investigate the relationship between tissue periostin and cardiac variables in the chronic cardiac remodeling induced by myocardial infarction. METHODS: Male Wistar rats were assigned to 2 groups: a simulated surgery group (SHAM; n = 8) and a myocardial infarction group (myocardial infarction; n = 13). After 3 months, morphological, functional and biochemical analyses were performed. The data are expressed as means+/-SD or medians (including the lower and upper quartiles). RESULTS: Myocardial infarctions induced increased left ventricular diastolic and systolic areas associated with a decreased fractional area change and a posterior wall shortening velocity. With regard to the extracellular matrix variables, the myocardial infarction group presented with higher values of periostin and types I and III collagen and higher interstitial collagen volume fractions and myocardial hydroxyproline concentrations. In addition, periostin was positively correlated with type III collagen levels (r = 0.673, p = 0.029) and diastolic (r = 0.678, p = 0.036) and systolic (r = 0.795, p = 0.006) left ventricular areas. Considering the relationship between periostin and the cardiac function variables, periostin was inversely correlated with both the fractional area change (r = -0.783, p = 0.008) and the posterior wall shortening velocity (r = -0.767, p = 0.012). CONCLUSIONS: Periostin might be a modulator of deleterious cardiac remodeling in the chronic phase after myocardial infarction in rats.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
myocardial infarction  ISOPostn (Rattus norvegicus)10041024; 10041024protein:increased expression:heart:RGD 
myocardial infarction  IEP 10041024protein:increased expression:heart:RGD 
periodontitis  ISOPostn (Rattus norvegicus)10041024; 10041024protein:decreased expression:mandible:RGD 
periodontitis  IEP 10041024protein:decreased expression:mandible:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Postn  (periostin)

Genes (Mus musculus)
Postn  (periostin, osteoblast specific factor)

Genes (Homo sapiens)
POSTN  (periostin)


Additional Information