GJA1 (gap junction protein alpha 1) - Rat Genome Database
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Gene: GJA1 (gap junction protein alpha 1) Pan paniscus
Analyze
Symbol: GJA1
Name: gap junction protein alpha 1
RGD ID: 11878782
Description: ENCODES a protein that exhibits alpha-tubulin binding (ortholog); beta-catenin binding (ortholog); beta-tubulin binding (ortholog); INVOLVED IN adult heart development (ortholog); apoptotic process (ortholog); ATP transport (ortholog); PARTICIPATES IN connexin signaling pathway; N-cadherin signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); adenoma (ortholog); Alopecia Congenita Keratosis Palmoplantaris (ortholog); FOUND IN apical plasma membrane (ortholog); cell junction (ortholog); cell-cell contact zone (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16123,348,744 - 123,360,887 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v06119,213,513 - 119,227,617 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
adenoma  (ISO)
Alopecia Congenita Keratosis Palmoplantaris  (ISO)
amnestic disorder  (ISO)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
atrial fibrillation  (ISO)
atrioventricular septal defect  (ISO)
Atrioventricular Septal Defect 3  (ISO)
autistic disorder  (ISO)
autoimmune thyroiditis  (ISO)
autosomal recessive craniometaphyseal dysplasia  (ISO)
Basaran Yilmaz Syndrome  (ISO)
borna disease  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
Cardiac Arrhythmias  (ISO)
Cardiac Fibrosis  (ISO)
chronic kidney disease  (ISO)
Chylothorax  (ISO)
cleft lip  (ISO)
coronary aneurysm  (ISO)
Diabetic Foot  (ISO)
Diaphragmatic Hernia  (ISO)
dilated cardiomyopathy  (ISO)
Disease Progression  (ISO)
epilepsy  (ISO)
erythrokeratodermia variabilis  (ISO)
erythrokeratodermia variabilis et progressiva 3  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
genetic disease  (ISO)
Hearing Loss  (ISO)
Hemorrhagic Shock  (ISO)
hereditary lymphedema IA  (ISO)
high grade glioma  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
hypoplastic left heart syndrome  (ISO)
Hypoplastic Left Heart Syndrome 1  (ISO)
impotence  (ISO)
intellectual disability  (ISO)
ischemia  (ISO)
Lung Neoplasms  (ISO)
Lymphatic Abnormalities  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Neuralgia  (ISO)
Nonsyndromic Sensorineural Hearing Loss  (ISO)
oculodentodigital dysplasia  (ISO)
Oculodentodigital Dysplasia, Autosomal Recessive  (ISO)
Overactive Urinary Bladder  (ISO)
palmoplantar keratoderma and congenital alopecia 1  (ISO)
palmoplantar keratosis  (ISO)
Parkinsonism  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (ISO)
renovascular hypertension  (ISO)
Schwartz-Lelek Syndrome  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
Sudden Cardiac Death  (ISO)
syndactyly  (ISO)
syndactyly type 3  (ISO)
syndactyly type 5  (ISO)
tetralogy of Fallot  (ISO)
tongue squamous cell carcinoma  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
urethral obstruction  (ISO)
visual epilepsy  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult heart development  (ISO)
apoptotic process  (ISO)
ATP transport  (ISO)
atrial ventricular junction remodeling  (ISO)
blood vessel morphogenesis  (ISO)
bone development  (ISO)
bone remodeling  (ISO)
cardiac conduction  (ISO)
cell communication  (ISO)
cell communication by chemical coupling  (ISO)
cell communication by electrical coupling  (ISO)
cell-cell junction organization  (ISO)
cell-cell signaling  (ISO)
cellular protein localization  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to parathyroid hormone stimulus  (ISO)
cellular response to pH  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
chronic inflammatory response  (ISO)
decidualization  (ISO)
embryonic digit morphogenesis  (ISO)
embryonic heart tube development  (ISO)
endothelium development  (ISO)
epididymis development  (ISO)
epithelial cell maturation  (ISO)
establishment of mitotic spindle orientation  (ISO)
export across plasma membrane  (ISO)
glutamate secretion  (ISO)
heart development  (ISO)
heart looping  (ISO)
in utero embryonic development  (ISO)
ion transmembrane transport  (ISO)
lens development in camera-type eye  (ISO)
maintenance of protein localization in endoplasmic reticulum  (ISO)
male gonad development  (ISO)
microtubule-based transport  (ISO)
milk ejection reflex  (ISO)
negative regulation of cardiac muscle cell proliferation  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA biosynthetic process  (ISO)
negative regulation of endothelial cell proliferation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of gonadotropin secretion  (ISO)
negative regulation of trophoblast cell migration  (ISO)
negative regulation of wound healing  (ISO)
neuron migration  (ISO)
neuron projection morphogenesis  (ISO)
obsolete positive regulation of blood vessel diameter  (ISO)
osteoblast differentiation  (ISO)
positive regulation of behavioral fear response  (ISO)
positive regulation of cell communication by chemical coupling  (ISO)
positive regulation of cold-induced thermogenesis  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glomerular filtration  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of insulin secretion  (ISO)
positive regulation of mesodermal cell differentiation  (ISO)
positive regulation of morphogenesis of an epithelium  (ISO)
positive regulation of protein catabolic process  (ISO)
positive regulation of smooth muscle cell chemotaxis  (ISO)
positive regulation of stem cell proliferation  (ISO)
positive regulation of striated muscle tissue development  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
positive regulation of vasoconstriction  (ISO)
regulation of apoptotic process  (ISO)
regulation of atrial cardiac muscle cell membrane depolarization  (ISO)
regulation of bicellular tight junction assembly  (ISO)
regulation of bone mineralization  (ISO)
regulation of bone remodeling  (ISO)
regulation of calcium ion transport  (ISO)
regulation of cell communication by electrical coupling  (ISO)
regulation of heart contraction  (ISO)
regulation of transmembrane transporter activity  (ISO)
regulation of ventricular cardiac muscle cell membrane depolarization  (ISO)
regulation of ventricular cardiac muscle cell membrane repolarization  (ISO)
response to estradiol  (ISO)
response to fluid shear stress  (ISO)
response to glucose  (ISO)
response to ischemia  (ISO)
response to lipopolysaccharide  (ISO)
response to peptide hormone  (ISO)
response to pH  (ISO)
response to retinoic acid  (ISO)
response to wounding  (ISO)
signal transduction  (ISO)
skeletal muscle tissue regeneration  (ISO)
spermatogenesis  (ISO)
T cell activation  (ISO)
T cell proliferation  (ISO)
transmembrane transport  (ISO)
vascular transport  (ISO)
xenobiotic transport  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
GJA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16123,348,744 - 123,360,887 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v06119,213,513 - 119,227,617 (+)NCBIMhudiblu_PPA_v0panPan3
GJA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6121,435,595 - 121,449,727 (+)EnsemblGRCh38hg38GRCh38
GRCh386121,435,646 - 121,449,727 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh376121,756,792 - 121,770,873 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366121,798,444 - 121,812,572 (+)NCBINCBI36hg18NCBI36
Build 346121,798,486 - 121,812,571NCBI
Celera6122,501,175 - 122,515,303 (+)NCBI
Cytogenetic Map6q22.31NCBI
HuRef6119,340,180 - 119,354,307 (+)NCBIHuRef
CHM1_16122,020,528 - 122,034,696 (+)NCBICHM1_1
Gja1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391056,253,297 - 56,266,519 (+)NCBIGRCm39mm39
GRCm39 Ensembl1056,253,426 - 56,278,609 (+)Ensembl
GRCm381056,377,300 - 56,390,419 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1056,377,330 - 56,402,513 (+)EnsemblGRCm38mm10GRCm38
MGSCv371056,097,106 - 56,110,225 (+)NCBIGRCm37mm9NCBIm37
MGSCv361056,065,762 - 56,078,833 (+)NCBImm8
Celera1057,194,935 - 57,208,041 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1028.64NCBI
Gja1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22035,756,007 - 35,768,481 (+)NCBI
Rnor_6.0 Ensembl2037,876,650 - 37,889,089 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02037,876,650 - 37,889,097 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02039,612,080 - 39,624,555 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42035,409,815 - 35,422,262 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12035,423,614 - 35,436,057 (+)NCBI
Celera2037,095,121 - 37,107,568 (+)NCBICelera
Cytogenetic Map20q11NCBI
Gja1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554363,612,533 - 3,618,095 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554363,612,533 - 3,618,095 (+)NCBIChiLan1.0ChiLan1.0
GJA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl160,929,097 - 60,942,936 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1160,941,772 - 60,944,694 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
GJA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl140,988,515 - 41,002,137 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1140,988,818 - 41,002,129 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2145,543,880 - 45,557,193 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GJA1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11352,397,291 - 52,410,341 (-)NCBI
Gja1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247989,358,996 - 9,364,413 (-)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003827735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_003827735   ⟹   XP_003827783
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.16123,348,744 - 123,360,887 (+)NCBI
Mhudiblu_PPA_v06119,213,513 - 119,227,617 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003827783 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003827783   ⟸   XM_003827735
- Sequence:


Additional Information

Database Acc Id Source(s)
NCBI Gene GJA1 ENTREZGENE